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Items: 1 to 20 of 161

1.
Identification of the Axis β-Catenin–BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment
Imane Mihoub, Tareck Rharass, Souhaïl Ouriemmi, Antonin Oudar, Laure Aubard, Valérie Gratio, Gregory Lazarian, Jordan Ferreira, Elisabetta Dondi, Florence Cymbalista, Vincent Levy, Fanny Baran-Marszak, Nadine Varin-Blank, Dominique Ledoux, Christine Le Roy, Laura Gardano
Int J Mol Sci. 2023 Dec; 24(24): 17623. Published online 2023 Dec 18. doi: 10.3390/ijms242417623
PMCID:
PMC10744074
AbstractArticlePDF–2.7M
2.
Resisting the Resistance: Navigating BTK Mutations in Chronic Lymphocytic Leukemia (CLL)
Alexandra Chirino, Skye Montoya, Anita Safronenka, Justin Taylor
Genes (Basel) 2023 Dec; 14(12): 2182. Published online 2023 Dec 6. doi: 10.3390/genes14122182
PMCID:
PMC10742473
AbstractArticlePDF–4.3M
3.
Expression of Bruton´s tyrosine kinase in different type of brain lesions of multiple sclerosis patients and during experimental demyelination
Maria L. Elkjaer, Mie R. Waede, Christina Kingo, Karina Damsbo, Zsolt Illes
Front Immunol. 2023; 14: 1264128. Published online 2023 Nov 13. doi: 10.3389/fimmu.2023.1264128
PMCID:
PMC10679451
AbstractArticlePDF–734K
4.
Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC)
Franziska Leichtle, Annika C. Betzler, Carlotta Eizenberger, Kristina Lesakova, Jasmin Ezić, Robert Drees, Jens Greve, Patrick J. Schuler, Simon Laban, Thomas K. Hoffmann, Nils Cordes, Marialuisa Lavitrano, Emanuela Grassilli, Cornelia Brunner
Int J Mol Sci. 2023 Sep; 24(17): 13133. Published online 2023 Aug 23. doi: 10.3390/ijms241713133
PMCID:
PMC10487612
AbstractArticlePDF–3.5M
5.
Overexpression of Bruton Tyrosine Kinase Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer Cells
Wenjia Ren, Cheng Yue, Linjun Liu, Licheng Du, Ke Xu, Yubai Zhou
Anal Cell Pathol (Amst) 2023; 2023: 3377316. Published online 2023 Aug 18. doi: 10.1155/2023/3377316
PMCID:
PMC10457169
AbstractArticlePDF–1.9M
6.
BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib
Silvia Bonfiglio, Lesley-Ann Sutton, Viktor Ljungström, Antonella Capasso, Tatjana Pandzic, Simone Weström, Hassan Foroughi-Asl, Aron Skaftason, Anna Gellerbring, Anna Lyander, Francesca Gandini, Gianluca Gaidano, Livio Trentin, Lisa Bonello, Gianluigi Reda, Csaba Bödör, Niki Stavroyianni, Constantine S. Tam, Roberto Marasca, Francesco Forconi, Panayiotis Panayiotidis, Ingo Ringshausen, Ozren Jaksic, Anna Maria Frustaci, Sunil Iyengar, Marta Coscia, Stephen P. Mulligan, Loïc Ysebaert, Vladimir Strugov, Carolina Pavlovsky, Renata Walewska, Anders Österborg, Diego Cortese, Pamela Ranghetti, Panagiotis Baliakas, Kostas Stamatopoulos, Lydia Scarfò, Richard Rosenquist, Paolo Ghia
Blood Adv. 2023 Jun 27; 7(12): 2794–2806. Published online 2023 Jan 31. doi: 10.1182/bloodadvances.2022008821
PMCID:
PMC10279547
AbstractArticlePDF–430K
7.
Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy
Weiguo Zhang, Guopan Yu, Hongying Zhang, Mahesh Basyal, Charlie Ly, Bin Yuan, Vivian Ruvolo, Sujan Piya, Seemana Bhattacharya, Qi Zhang, Gautam Borthakur, Venkata L. Battula, Marina Konopleva, William G. Rice, Michael Andreeff
Haematologica. 2023 Jun 1; 108(6): 1500–1514. Published online 2022 Oct 13. doi: 10.3324/haematol.2022.280884
PMCID:
PMC10230429
AbstractArticlePDF–3.0M
8.
Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets
Pengyu Zhang, Fiorella A. Solari, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, Albert Sickmann, Ulrich Walter, Kerstin Jurk
Int J Mol Sci. 2023 May; 24(9): 7776. Published online 2023 Apr 24. doi: 10.3390/ijms24097776
PMCID:
PMC10178361
AbstractArticlePDF–3.2M
9.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
10.
ROR1/CD19 receptor complex promotes growth of mantle cell lymphoma cells independently of the B Cell Receptor-BTK signaling pathway
Qian Zhang, Hong Y Wang, Xiaobin Liu, Selene Nunez-Cruz, Mowafaq Jillab, Olga Melnikov, Kavindra Nath, Jerry Glickson, Mariusz A Wasik
J Immunol. Author manuscript; available in PMC 2023 Mar 14.
Published in final edited form as: J Immunol. 2019 Oct 15; 203(8): 2043–2048. Published online 2019 Sep 18. doi: 10.4049/jimmunol.1801327
PMCID:
PMC10013414
AbstractArticlePDF–808K
11.
Cotargeting of BTK and MALT1 overcomes resistance to BTK inhibitors in mantle cell lymphoma
Vivian Changying Jiang, Yang Liu, Junwei Lian, Shengjian Huang, Alexa Jordan, Qingsong Cai, Ruitao Lin, Fangfang Yan, Joseph McIntosh, Yijing Li, Yuxuan Che, Zhihong Chen, Jovanny Vargas, Maria Badillo, John Nelson Bigcal, Heng-Huan Lee, Wei Wang, Yixin Yao, Lei Nie, Christopher R. Flowers, Michael Wang
J Clin Invest. 2023 Feb 1; 133(3): e165694. Published online 2023 Feb 1. doi: 10.1172/JCI165694
PMCID:
PMC9888382
AbstractArticlePDF–2.3M
12.
Palmitoylation of the Alternative Amino Terminus of the BTK-C Isoform Controls Subcellular Distribution and Signaling
MOSTAFA KOKABEE, XIANHUI WANG, ELENA VOORAND, EDEN ALIN, LEILA KOKABEE, FAIZA KHAN, SOPHIA DESROSIERS, DOUGLAS S. CONKLIN
Cancer Genomics Proteomics. 2022 Jul-Aug; 19(4): 415–427. Published online 2022 Jul 3. doi: 10.21873/cgp.20329
PMCID:
PMC9247882
AbstractArticlePDF–5.2M
13.
Btk supports autoreactive B cell development and protects against apoptosis but is expendable for antigen-presentation
Lindsay E. Nyhoff, Amber S. Griffith, Emily S. Clark, James W. Thomas, Wasif N. Khan, Peggy L. Kendall
J Immunol. Author manuscript; available in PMC 2022 Dec 15.
Published in final edited form as: J Immunol. 2021 Dec 15; 207(12): 2922–2932. Published online 2021 Nov 19. doi: 10.4049/jimmunol.2000558
PMCID:
PMC9117567
AbstractArticlePDF–2.1M
14.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
15.
Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors
Eric Wang, Xiaoli Mi, Meghan C. Thompson, Skye Montoya, Ryan Q. Notti, Jumana Afaghani, Benjamin H. Durham, Alex Penson, Matthew T. Witkowski, Sydney X. Lu, Jessie Bourcier, Simon J. Hogg, Caroline Erickson, Dan Cui, Hana Cho, Michael Singer, Tulasigeri M. Totiger, Sana Chaudhry, Mark Geyer, Alvaro Alencar, Adam J. Linley, M. Lia Palomba, Catherine C. Coombs, Jae H. Park, Andrew Zelenetz, Lindsey Roeker, Mary Rosendahl, Donald E. Tsai, Kevin Ebata, Barbara Brandhuber, David M. Hyman, Iannis Aifantis, Anthony Mato, Justin Taylor, Omar Abdel-Wahab
N Engl J Med. Author manuscript; available in PMC 2022 May 6.
Published in final edited form as: N Engl J Med. 2022 Feb 24; 386(8): 735–743. doi: 10.1056/NEJMoa2114110
PMCID:
PMC9074143
AbstractArticlePDF–1014K
16.
Spontaneous Platelet Aggregation in Blood Is Mediated by FcγRIIA Stimulation of Bruton’s Tyrosine Kinase
Rundan Duan, Luise Goldmann, Ya Li, Christian Weber, Wolfgang Siess, Philipp von Hundelshausen
Int J Mol Sci. 2022 Jan; 23(1): 76. Published online 2021 Dec 22. doi: 10.3390/ijms23010076
PMCID:
PMC8744796
AbstractArticlePDF–1.1M
17.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber
J Exp Med. 2021 Nov 1; 218(11): e20201656. Published online 2021 Sep 23. doi: 10.1084/jem.20201656
PMCID:
PMC8480672
AbstractArticlePDF–6.7M
18.
MARCKS affects cell motility and response to BTK inhibitors in CLL
Laura Beckmann, Valeska Berg, Clarissa Dickhut, Clare Sun, Olaf Merkel, Johannes Bloehdorn, Sandra Robrecht, Marc Seifert, Alexandra da Palma Guerreiro, Julia Claasen, Stefan Loroch, Matteo Oliverio, Chingiz Underbayev, Lauren Vaughn, Daniel Thomalla, Malte F. Hülsemann, Eugen Tausch, Kirsten Fischer, Anna Maria Fink, Barbara Eichhorst, Albert Sickmann, Clemens M. Wendtner, Stephan Stilgenbauer, Michael Hallek, Adrian Wiestner, René P. Zahedi, Lukas P. Frenzel
Blood. 2021 Aug 19; 138(7): 544–556. Prepublished online 2021 Mar 18. doi: 10.1182/blood.2020009165
PMCID:
PMC8377477
AbstractArticle
19.
Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia
David H. Gray, Isaac Villegas, Joseph Long, Jasmine Santos, Alexandra Keir, Alison Abele, Caroline Y. Kuo, Donald B. Kohn
CRISPR J. April 2021; 4(2): 191–206. Published online 2021 Apr 20. doi: 10.1089/crispr.2020.0080
PMCID:
PMC8336228
AbstractArticlePDF–751K
20.
Acalabrutinib plus Obinutuzumab in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia
Jennifer A. Woyach, James S. Blachly, Kerry A. Rogers, Seema A. Bhat, Mojgan Jianfar, Gerard Lozanski, David M. Weiss, Barbara L. Andersen, Michael Gulrajani, Melanie M. Frigault, Ahmed Hamdy, Raquel Izumi, Veerendra Munugalavadla, Cheng Quah, Min-Hui Wang, John C. Byrd
Cancer Discov. Author manuscript; available in PMC 2021 Jun 4.
Published in final edited form as: Cancer Discov. 2020 Mar; 10(3): 394–405. Published online 2020 Jan 8. doi: 10.1158/2159-8290.CD-19-1130
PMCID:
PMC8176161
AbstractArticlePDF–835K

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