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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109060152.

METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy

Fangfang Wang, Juan Bai, Xin Zhang, Dali Wang, Xin Zhang, Jingwen Xue, Haoyang Chen, Shuxiang Wang, Baojin Chi, Jing Li, Xiaoru Ma

J Diabetes Investig. 2024 Mar; 15(3): 288–299. Published online 2023 Nov 28. doi: 10.1111/jdi.14113

PMCID:: PMC10906015

Abstract Article PDF–3.8M

Select item 107211503.

Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m⁶A/YTHDF2 drives extrinsic radioresistance

Liangliang Wang, Wei Si, Xianbin Yu, Andras Piffko, Xiaoyang Dou, Xingchen Ding, Jason Bugno, Kaiting Yang, Chuangyu Wen, Linda Zhang, Dapeng Chen, Xiaona Huang, Jiaai Wang, Ainhoa Arina, Sean Pitroda, Steven J. Chmura, Chuan He, Hua Laura Liang, Ralph Weichselbaum

J Clin Invest. 2023 Dec 15; 133(24): e172919. Published online 2023 Dec 15. doi: 10.1172/JCI172919

PMCID:: PMC10721150

Abstract Article PDF–2.8M

Select item 105436434.

Mettl14-mediated m⁶A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112596. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112596

PMCID:: PMC10543643

Abstract Article PDF–3.9M

Select item 99753175.

Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages

Li Hu, Yanfang Yu, Yueyao Shen, Huijie Huang, Donghai Lin, Kang Wang, Youjia Yu, Kai Li, Yue Cao, Qiang Wang, Xiaoxuan Sun, Zhibing Qiu, Dong Wei, Bin Shen, Jingyu Chen, David Fulton, Yong Ji, Jie Wang, Feng Chen

Redox Biol. 2023 May; 61: 102638. Published online 2023 Feb 15. doi: 10.1016/j.redox.2023.102638

PMCID:: PMC9975317

Abstract Article PDF–17M

Select item 96038606.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 94189167.

m⁶A regulation of cortical and retinal neurogenesis is mediated by the redundant m⁶A readers YTHDFs

Fugui Niu, Pengfei Che, Zhuoxuan Yang, Jian Zhang, Lixin Yang, Mengru Zhuang, Xijun Ou, Sheng-Jian Ji

iScience. 2022 Sep 16; 25(9): 104908. Published online 2022 Aug 11. doi: 10.1016/j.isci.2022.104908

PMCID:: PMC9418916

Abstract Article PDF–7.5M

Select item 93010118.

The Maternal Microbiome Programs the m⁶A Epitranscriptome of the Mouse Fetal Brain and Intestine

Zhuoyu Xiao, Sun Liu, Zengguang Li, Jinru Cui, Hailan Wang, Zihan Wang, Qihuan Ren, Laixin Xia, Zhijian Wang, Yuan Li

Front Cell Dev Biol. 2022; 10: 882994. Published online 2022 Jul 7. doi: 10.3389/fcell.2022.882994

PMCID:: PMC9301011

Abstract Article PDF–2.5M

Select item 91085519.

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation

Amalie Grenov, Hadas Hezroni, Lior Lasman, Jacob H. Hanna, Ziv Shulman

Cell Rep. 2022 May 3; 39(5): 110778. Published online 2022 May 6. doi: 10.1016/j.celrep.2022.110778

PMCID:: PMC9108551

Abstract Article

Select item 910632910.

A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

David J Turner, Alexander Saveliev, Fiamma Salerno, Louise S Matheson, Michael Screen, Hannah Lawson, David Wotherspoon, Kamil R Kranc, Martin Turner

eLife. 2022; 11: e72313. Published online 2022 Apr 22. doi: 10.7554/eLife.72313

PMCID:: PMC9106329

Abstract Article PDF–4.5M

Select item 890680711.

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

Fugui Niu, Peng Han, Jian Zhang, Yuanchu She, Lixin Yang, Jun Yu, Mengru Zhuang, Kezhen Tang, Yuwei Shi, Baisheng Yang, Chunqiao Liu, Bo Peng, Sheng-Jian Ji

eLife. 2022; 11: e75827. Published online 2022 Feb 18. doi: 10.7554/eLife.75827

PMCID:: PMC8906807

Abstract Article PDF–14M

Select item 878089812.

m⁶A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase‐specific transcripts

Meijie Qi, Haifeng Sun, Yueshuai Guo, Yu Zhou, Xueying Gu, Jiachuan Jin, Xiaoxu Chen, Fangzhu Wang, Honghui Ma, Xuejiang Guo, Hao Chen, Bin Shen

Cell Prolif. 2022 Jan; 55(1): e13164. Published online 2021 Nov 30. doi: 10.1111/cpr.13164

PMCID:: PMC8780898

Abstract Article PDF–1.9M

Select item 859612613.

The m⁶A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons

Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen, Chunxuan Jiang, Yujia Zhang, Yujing Yuan, Sheng‐Jian Ji

Adv Sci (Weinh) 2021 Nov; 8(22): 2101329. Published online 2021 Oct 12. doi: 10.1002/advs.202101329

PMCID:: PMC8596126

Abstract Article PDF–7.9M

Select item 826661714.

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins

Benjamin Lang, Jae-Seong Yang, Mireia Garriga-Canut, Silvia Speroni, Moritz Aschern, Maria Gili, Tobias Hoffmann, Gian Gaetano Tartaglia, Sebastian P Maurer

Nucleic Acids Res. 2021 Jul 9; 49(12): 6702–6721. Published online 2021 Jun 16. doi: 10.1093/nar/gkab490

PMCID:: PMC8266617

Abstract Article PDF–4.0M

Select item 822568015.

The RNA m⁶A reader YTHDF2 controls NK cell antitumor and antiviral immunity

Shoubao Ma, Jiazhuo Yan, Tasha Barr, Jianying Zhang, Zhenhua Chen, Li-Shu Wang, Joseph C. Sun, Jianjun Chen, Michael A. Caligiuri, Jianhua Yu

J Exp Med. 2021 Aug 2; 218(8): e20210279. Published online 2021 Jun 23. doi: 10.1084/jem.20210279

PMCID:: PMC8225680

Abstract Article PDF–6.8M

Select item 765368416.

The mRNA m⁶A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

Christopher Mapperley, Louie N. van de Lagemaat, Hannah Lawson, Andrea Tavosanis, Jasmin Paris, Joana Campos, David Wotherspoon, Jozef Durko, Annika Sarapuu, Junho Choe, Ivayla Ivanova, Daniela S. Krause, Alex von Kriegsheim, Christian Much, Marcos Morgan, Richard I. Gregory, Adam J. Mead, Dónal O’Carroll, Kamil R. Kranc

J Exp Med. 2021 Mar 1; 218(3): e20200829. Published online 2020 Nov 6. doi: 10.1084/jem.20200829

PMCID:: PMC7653684

Abstract Article PDF–4.6M

Select item 752869717.

Context-dependent functional compensation between Ythdf m⁶A reader proteins

Lior Lasman, Vladislav Krupalnik, Sergey Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Dan Schneir, Jonathan Bayerl, Orel Mizrahi, Shani Peles, Shadi Tawil, Shashank Sathe, Aharon Nachshon, Tom Shani, Mirie Zerbib, Itay Kilimnik, Stefan Aigner, Archana Shankar, Jasmine R. Mueller, Schraga Schwartz, Noam Stern-Ginossar, Gene W. Yeo, Shay Geula, Noa Novershtern, Jacob H. Hanna

Genes Dev. 2020 Oct 1; 34(19-20): 1373–1391. doi: 10.1101/gad.340695.120

PMCID:: PMC7528697

Abstract Article PDF–11M

Select item 737115218.

Control of Early B Cell Development by the RNA N⁶-Methyladenosine Methylation

Zhong Zheng, Linda Zhang, Xiao-Long Cui, Xianbin Yu, Phillip J. Hsu, Ruitu Lyu, Haiyan Tan, Malay Mandal, Michelle Zhang, Hui-Lung Sun, Arantxa Sanchez Castillo, Junmin Peng, Marcus R. Clark, Chuan He, Haochu Huang

Cell Rep. Author manuscript; available in PMC 2020 Jul 20.

Published in final edited form as: Cell Rep. 2020 Jun 30; 31(13): 107819. doi: 10.1016/j.celrep.2020.107819

PMCID:: PMC7371152

Abstract Article PDF–3.3M

Select item 723606019.

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell

iScience. 2020 May 22; 23(5): 101132. Published online 2020 May 1. doi: 10.1016/j.isci.2020.101132

PMCID:: PMC7236060

Abstract Article PDF–6.1M

Select item 709336920.

Binding to m⁶A RNA promotes YTHDF2-mediated phase separation

Jiahua Wang, Liyong Wang, Jianbo Diao, Yujiang Geno Shi, Yang Shi, Honghui Ma, Hongjie Shen

Protein Cell. 2020 Apr; 11(4): 304–307. Published online 2019 Oct 22. doi: 10.1007/s13238-019-00660-2

PMCID:: PMC7093369

Article PDF–1.3M

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