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Select item 108664331.

Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4

Qing Ji, Le Zhang, Hui Ye

Aging (Albany NY) 2024 Jan 31; 16(2): 1925–1937. Published online 2024 Jan 29. doi: 10.18632/aging.205469

PMCID:: PMC10866433

Abstract Article PDF–1.2M

Select item 108283112.

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

Georgia L. Nolt, Alexander R. Keeble, Yuan Wen, Aubrey C. Strong, Nicholas T. Thomas, Taylor R. Valentino, Camille R. Brightwell, Kevin A. Murach, Sini Patrizia, Harald Weinstabl, Andreas Gollner, John J. McCarthy, Christopher S. Fry, Michael Franti, Antonio Filareto, Charlotte A. Peterson, Cory M. Dungan

GeroScience. 2024 Apr; 46(2): 2153–2176. Published online 2023 Oct 24. doi: 10.1007/s11357-023-00976-2

PMCID:: PMC10828311

Abstract Article PDF–2.4M

Select item 108072483.

USP13 regulates cell senescence through mediating MDM2 stability

Jinshan He, Boina Baoyinna, Sarah J. Taleb, Jing Zhao, Yutong Zhao

Life Sci. Author manuscript; available in PMC 2024 Jan 24.

Published in final edited form as: Life Sci. 2023 Oct 15; 331: 122044. Published online 2023 Aug 25. doi: 10.1016/j.lfs.2023.122044

PMCID:: PMC10807248

Abstract Article PDF–1.6M

Select item 106916644.

MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy

Puneeth Shridhar, Michael S. Glennon, Soumojit Pal, Christina J. Waldron, Ethan J. Chetkof, Payel Basak, Nicolas G. Clavere, Dipanjan Banerjee, Sebastien Gingras, Jason R. Becker

Circulation. 2023 Dec 5; 148(23): 1870–1886. Published online 2023 Oct 27. doi: 10.1161/CIRCULATIONAHA.123.064332

PMCID:: PMC10691664

Abstract Article PDF–4.8M

Select item 105244445.

MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production

Marlene Langenbach, Sophie Giesler, Stefan Richtsfeld, Sara Costa-Pereira, Lukas Rindlisbacher, Tobias Wertheimer, Lukas M. Braun, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Nadine M. Woessner, Hans D. Menssen, Sanaz Taromi, Justus Duyster, Melanie Börries, Tilman Brummer, Bruce R. Blazar, Susana Minguet, Patrick Turko, Mitchell P. Levesque, Burkhard Becher, Robert Zeiser

Mol Cancer Res. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Mol Cancer Res. 2023 Aug 1; 21(8): 849–864. doi: 10.1158/1541-7786.MCR-22-0898

PMCID:: PMC10524444

Abstract Article PDF–3.0M

Select item 104474336.

Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis

Fenyong Yao, Shisheng Huang, Jiahui Liu, Chunhua Tan, Mengqi Xu, Dengkui Wang, Maoqing Huang, Yiyao Zhu, Xingxu Huang, Shuijin He

Cell Death Dis. 2023 Aug; 14(8): 543. Published online 2023 Aug 23. doi: 10.1038/s41419-023-06071-w

PMCID:: PMC10447433

Abstract Article PDF–9.2M

Select item 103675667.

MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism

Guowen Ren, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Yue Pu, Li-Jie Chen, Joong Sup Shim

Int J Biol Sci. 2023; 19(11): 3544–3557. Published online 2023 Jul 9. doi: 10.7150/ijbs.82566

PMCID:: PMC10367566

Abstract Article PDF–8.2M

Select item 102900708.

Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage

Rasoul Pourebrahim, Rafael Heinz Montoya, Zoe Alaniz, Lauren Ostermann, Patrick P. Lin, Bin Liu, Edward Ayoub, Jared K. Burks, Michael Andreeff

Cell Death Dis. 2023 Jun; 14(6): 371. Published online 2023 Jun 23. doi: 10.1038/s41419-023-05844-7

PMCID:: PMC10290070

Abstract Article PDF–9.7M

Select item 100932699.

Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance

Andrea Kuzelova, Naoko Dupacova, Barbora Antosova, Sweetu Susan Sunny, Zbynek Kozmik, Jr., Jan Paces, Arthur I. Skoultchi, Tomas Stopka, Zbynek Kozmik

Cells. 2023 Apr; 12(7): 1035. Published online 2023 Mar 28. doi: 10.3390/cells12071035

PMCID:: PMC10093269

Abstract Article PDF–21M

Select item 996020910.

Solution-state preorganization of cyclic β-hairpin ligands determines binding mechanism and affinities for MDM2

Yunui Ge, Si Zhang, Mate Erdelyi, Vincent A. Voelz

J Chem Inf Model. Author manuscript; available in PMC 2023 Feb 25.

Published in final edited form as: J Chem Inf Model. 2021 May 24; 61(5): 2353–2367. Published online 2021 Apr 27. doi: 10.1021/acs.jcim.1c00029

PMCID:: PMC9960209

Abstract Article PDF–2.5M

Select item 979331811.

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway

Derek A. Franklin, Shijie Liu, Aiwen Jin, Pengfei Cui, Zengli Guo, Kyle C. Arend, Nathaniel J. Moorman, Shenghui He, Gang Greg Wang, Yisong Y. Wan, Yanping Zhang

J Biol Chem. 2023 Jan; 299(1): 102739. Published online 2022 Nov 23. doi: 10.1016/j.jbc.2022.102739

PMCID:: PMC9793318

Abstract Article PDF–4.3M

Select item 949010012.

Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis

Han Qiu, Erfei Song, Yue Hu, Tengfei Li, Kam Ching Ku, Cunchuan Wang, Bernard M.Y. Cheung, Lai Yee Cheong, Qin Wang, Xiaoping Wu, Ruby L.C. Hoo, Yong Wang, Aimin Xu

Cell Mol Gastroenterol Hepatol. 2022; 14(5): 1003–1023. Published online 2022 Aug 2. doi: 10.1016/j.jcmgh.2022.07.012

PMCID:: PMC9490100

Abstract Article PDF–5.2M

Select item 940942613.

Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion

Marie-Claude Beauchamp, Alexia Boucher, Yanchen Dong, Rachel Aber, Loydie A. Jerome-Majewska

Int J Mol Sci. 2022 Aug; 23(16): 9033. Published online 2022 Aug 12. doi: 10.3390/ijms23169033

PMCID:: PMC9409426

Abstract Article PDF–4.4M

Select item 937936614.

Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis

Yuki Makino, Hayato Hikita, Kenji Fukumoto, Ji Hyun Sung, Yoshihiro Sakano, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Jumpei Kondo, Shogo Kobayashi, Tomohide Tatsumi, Tetsuo Takehara

Cancer Res. 2022 Aug 16; 82(16): 2860–2873. Published online 2022 Jun 13. doi: 10.1158/0008-5472.CAN-21-4390

PMCID:: PMC9379366

Abstract Article PDF–2.6M

Select item 930440815.

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Tamar Sapir, Aditya Kshirsagar, Anna Gorelik, Tsviya Olender, Ziv Porat, Ingrid E. Scheffer, David B. Goldstein, Orrin Devinsky, Orly Reiner

Nat Commun. 2022; 13: 4209. Published online 2022 Jul 21. doi: 10.1038/s41467-022-31752-z

PMCID:: PMC9304408

Abstract Article PDF–13M

Select item 928413916.

Hepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride‐VLDL Secretion via ApoB Degradation

Huige Lin, Lin Wang, Zhuohao Liu, Kekao Long, Mengjie Kong, Dewei Ye, Xi Chen, Kai Wang, Kelvin KL Wu, Mengqi Fan, Erfei Song, Cunchuan Wang, Ruby LC Hoo, Xiaoyan Hui, Philip Hallenborg, Hailong Piao, Aimin Xu, Kenneth KY Cheng

Adv Sci (Weinh) 2022 Jul; 9(20): 2200742. Published online 2022 May 7. doi: 10.1002/advs.202200742

PMCID:: PMC9284139

Abstract Article PDF–6.3M

Select item 927871117.

Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer

Xinyu Wang, Peng Xu, Yuying Jiao, Sha Luan, Yue Gao, Changjiu Zhao, Peng Fu

Nucl Med Commun. 2022 Aug; 43(8): 869–876. Published online 2022 May 18. doi: 10.1097/MNM.0000000000001582

PMCID:: PMC9278711

Abstract Article PDF–1.2M

Select item 923587518.

Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis

Sabrina Shameen Alam, Shruti Kumar, Marie-Claude Beauchamp, Eric Bareke, Alexia Boucher, Nadine Nzirorera, Yanchen Dong, Reinnier Padilla, Si Jing Zhang, Jacek Majewski, Loydie A. Jerome-Majewska

Dis Model Mech. 2022 Jun 1; 15(6): dmm049544. Published online 2022 Jun 23. doi: 10.1242/dmm.049544

PMCID:: PMC9235875

Abstract Article

Select item 911954619.

MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

Meenalakshmi Chinnam, Chao Xu, Rati Lama, Xiaojing Zhang, Carlos D. Cedeno, Yanqing Wang, Aimee B. Stablewski, David W. Goodrich, Xinjiang Wang

PLoS Genet. 2022 May; 18(5): e1010171. Published online 2022 May 19. doi: 10.1371/journal.pgen.1010171

Correction in:: PLoS Genet. 2022 Jun; 18(6): e1010293.

PMCID:: PMC9119546

Abstract Article PDF–2.6M

Select item 911747920.

Differential gain-of-function activity of three p53 hotspot mutants in vivo

Shunbin Xiong, Dhruv Chachad, Yun Zhang, Jovanka Gencel-Augusto, Mario Sirito, Vinod Pant, Peirong Yang, Chang Sun, Gilda Chau, Yuan Qi, Xiaoping Su, Elizabeth M Whitley, Adel K. El-Naggar, Guillermina Lozano

Cancer Res. Author manuscript; available in PMC 2022 Nov 16.

Published in final edited form as: Cancer Res. 2022 May 16; 82(10): 1926–1936. doi: 10.1158/0008-5472.CAN-21-3376

PMCID:: PMC9117479

Abstract Article PDF–791K

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