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Select item 102359851.

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett

Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2220979120. Published online 2023 May 22. doi: 10.1073/pnas.2220979120

PMCID:: PMC10235985

Abstract Article PDF–8.3M

Select item 97399672.

TGF-β2 Regulates Transcription of the K⁺/Cl⁻ Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons

Anastasia Rigkou, Attila Magyar, Jan Manuel Speer, Eleni Roussa

Cells. 2022 Dec; 11(23): 3861. Published online 2022 Nov 30. doi: 10.3390/cells11233861

PMCID:: PMC9739967

Abstract Article PDF–3.4M

Select item 96683363.

Molecular and anatomical characterization of parabrachial neurons and their axonal projections

Jordan L Pauli, Jane Y Chen, Marcus L Basiri, Sekun Park, Matthew E Carter, Elisenda Sanz, G Stanley McKnight, Garret D Stuber, Richard D Palmiter

eLife. 2022; 11: e81868. Published online 2022 Nov 1. doi: 10.7554/eLife.81868

PMCID:: PMC9668336

Abstract Article PDF–6.0M

Select item 96298274.

Microglia shape the embryonic development of mammalian respiratory networks

Marie-Jeanne Cabirol, Laura Cardoit, Gilles Courtand, Marie-Eve Mayeur, John Simmers, Olivier Pascual, Muriel Thoby-Brisson

eLife. 2022; 11: e80352. Published online 2022 Nov 2. doi: 10.7554/eLife.80352

PMCID:: PMC9629827

Abstract Article PDF–4.3M

Select item 95855495.

Upregulated expression of substance P and NK1R in blood monocytes and B cells of patients with allergic rhinitis and asthma

Peixuan Han, Liping Chen, Dong Chen, Ruiming Yang, Wei Wang, Jingyu Liu, Shaoheng He, Huiyun Zhang

Clin Exp Immunol. 2022 Oct; 210(1): 39–52. Published online 2022 Aug 24. doi: 10.1093/cei/uxac074

PMCID:: PMC9585549

Abstract Article PDF–1.9M

Select item 93810386.

Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice

Taylor Follansbee, Dan Domocos, Eileen Nguyen, Amanda Nguyen, Aristea Bountouvas, Lauren Velasquez, Mirela Iodi Carstens, Keiko Takanami, Sarah E Ross, Earl Carstens

eLife. 2022; 11: e69626. Published online 2022 Aug 16. doi: 10.7554/eLife.69626

PMCID:: PMC9381038

Abstract Article PDF–6.0M

Select item 85659047.

Astrocytes contribute to pain gating in the spinal cord

Qian Xu, Neil C. Ford, Shaoqiu He, Qian Huang, Michael Anderson, Zhiyong Chen, Fei Yang, LaTasha K. Crawford, Michael J. Caterina, Yun Guan, Xinzhong Dong

Sci Adv. 2021 Nov; 7(45): eabi6287. Published online 2021 Nov 3. doi: 10.1126/sciadv.abi6287

PMCID:: PMC8565904

Abstract Article PDF–8.5M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82017709.

Neural basis of opioid-induced respiratory depression and its rescue

Shijia Liu, Dong-Il Kim, Tae Gyu Oh, Gerald M. Pao, Jong-Hyun Kim, Richard D. Palmiter, Matthew R. Banghart, Kuo-Fen Lee, Ronald M. Evans, Sung Han

Proc Natl Acad Sci U S A. 2021 Jun 8; 118(23): e2022134118. Published online 2021 May 31. doi: 10.1073/pnas.2022134118

PMCID:: PMC8201770

Abstract Article PDF–2.2M

Select item 817253910.

Control of impulsivity by G_i-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex

Bastiaan van der Veen, Sampath K. T. Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M. Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam, Janet R. Nicholson, Birgit Liss, Wiebke Nissen, Anton Pekcec, Dennis Kätzel

Commun Biol. 2021; 4: 662. Published online 2021 Jun 2. doi: 10.1038/s42003-021-02188-w

PMCID:: PMC8172539

Abstract Article PDF–6.1M

Select item 771370611.

Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

R. Brian Roome, Farin B. Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, Annie Dumouchel, Charleen Salesse, W. Scott Thompson, Megan Brookbank, Yorick Gitton, Lino Tessarollo, Martyn Goulding, Jane E. Johnson, Marie Kmita, Alain Chédotal, Artur Kania

Cell Rep. Author manuscript; available in PMC 2020 Dec 3.

Published in final edited form as: Cell Rep. 2020 Nov 24; 33(8): 108425. doi: 10.1016/j.celrep.2020.108425

PMCID:: PMC7713706

Abstract Article PDF–4.9M

Select item 766611012.

Parallel ascending spinal pathways for affective touch and pain

Seungwon Choi, Junichi Hachisuka, Matthew A. Brett, Alexandra Magee, Yu Omori, Noor-ul-Aine Iqbal, Dawei Zhang, Michelle M. DeLisle, Rachel L. Wolfson, Ling Bai, Celine Santiago, Shiaoching Gong, Martyn Goulding, Nathaniel Heintz, H. Richard Koerber, Sarah E. Ross, David D. Ginty

Nature. Author manuscript; available in PMC 2021 Apr 28.

Published in final edited form as: Nature. 2020 Nov; 587(7833): 258–263. Published online 2020 Oct 28. doi: 10.1038/s41586-020-2860-1

PMCID:: PMC7666110

Abstract Article PDF–4.2M

Select item 765945013.

The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch

Tayler D. Sheahan, Charles A. Warwick, Louis G. Fanien, Sarah E. Ross

J Neurosci. 2020 Nov 11; 40(46): 8816–8830. doi: 10.1523/JNEUROSCI.1832-20.2020

PMCID:: PMC7659450

Abstract Article PDF–4.7M

Select item 759272114.

Knockout of the Tachykinin Receptor 1 in the Mdr2^−/− (Abcb4^−/−) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis

Ludovica Ceci, Heather Francis, Tianhao Zhou, Thao Giang, Zhihong Yang, Fanyin Meng, Nan Wu, Lindsey Kennedy, Konstantina Kyritsi, Vik Meadows, Chaodong Wu, Suthat Liangpunsakul, Antonio Franchitto, Amelia Sybenga, Burcin Ekser, Romina Mancinelli, Paolo Onori, Eugenio Gaudio, Shannon Glaser, Gianfranco Alpini

Am J Pathol. 2020 Nov; 190(11): 2251–2266. doi: 10.1016/j.ajpath.2020.07.007

PMCID:: PMC7592721

Abstract Article PDF–7.9M

Select item 716937815.

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells

Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Jr., Adriana T. Larregina

Cell Rep. Author manuscript; available in PMC 2020 Apr 20.

Published in final edited form as: Cell Rep. 2020 Mar 10; 30(10): 3448–3465.e8. doi: 10.1016/j.celrep.2020.02.054

PMCID:: PMC7169378

Abstract Article PDF–3.1M

Select item 679017716.

Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3^Cre mouse

Alastair J. Tulloch, Shaun Teo, Brigett V. Carvajal, Marc Tessier-Lavigne, Alexander Jaworski

J Comp Neurol. Author manuscript; available in PMC 2020 Dec 15.

Published in final edited form as: J Comp Neurol. 2019 Dec 15; 527(18): 2948–2972. Published online 2019 Jun 14. doi: 10.1002/cne.24720

PMCID:: PMC6790177

Abstract Article PDF–3.4M

Select item 676387317.

5-Hydroxytryptamine (5-HT)_1A Autoreceptor Adaptive Changes in Substance P (Neurokinin 1) Receptor Knock-Out Mice Mimic Antidepressant-Induced Desensitization

Nicolas Froger, Alain M. Gardier, Rosario Moratalla, Israel Alberti, Isabelle Lena, Claudette Boni, Carmen De Felipe, Nadia M. J. Rupniak, Stephen P. Hunt, Christian Jacquot, Michel Hamon, Laurence Lanfumey

J Neurosci. 2001 Oct 15; 21(20): 8188–8197. doi: 10.1523/JNEUROSCI.21-20-08188.2001