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Select item 109441061.

Differential responses to UCP1 ablation in classical brown versus beige fat, despite a parallel increase in sympathetic innervation

Qimuge Naren, Erik Lindsund, Muhammad Hamza Bokhari, Weijun Pang, Natasa Petrovic

J Biol Chem. 2024 Mar; 300(3): 105760. Published online 2024 Feb 16. doi: 10.1016/j.jbc.2024.105760

PMCID:: PMC10944106

Abstract Article PDF–9.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106653203.

Mirabegron displays anticancer effects by globally browning adipose tissues

Xiaoting Sun, Wenhai Sui, Zepeng Mu, Sisi Xie, Jinxiu Deng, Sen Li, Takahiro Seki, Jieyu Wu, Xu Jing, Xingkang He, Yangang Wang, Xiaokun Li, Yunlong Yang, Ping Huang, Minghua Ge, Yihai Cao

Nat Commun. 2023; 14: 7610. Published online 2023 Nov 22. doi: 10.1038/s41467-023-43350-8

PMCID:: PMC10665320

Abstract Article PDF–5.0M

Select item 103623574.

Kappa opioid receptor activation increases thermogenic energy expenditure which drives increased feeding

Aaron L. Cone, Kenny K. Wu, Alexxai V. Kravitz, Aaron J. Norris

iScience. 2023 Jul 21; 26(7): 107241. Published online 2023 Jun 28. doi: 10.1016/j.isci.2023.107241

PMCID:: PMC10362357

Abstract Article PDF–4.5M

Select item 102937735.

Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1

Fan Li, Fenglin Zhang, Xin Yi, Lu Lu Quan, Xiaohua Yang, Cong Yin, Zewei Ma, Ruifan Wu, Weijie Zhao, Mingfa Ling, Limin Lang, Abdelaziz Hussein, Shengchun Feng, Yiming Fu, Junfeng Wang, Shuyi Liang, Canjun Zhu, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Yongliang Zhang, Lin Zhang, Gang Shu, Qingyan Jiang, Songbo Wang

Mol Metab. 2023 Jul; 73: 101747. Published online 2023 Jun 4. doi: 10.1016/j.molmet.2023.101747

PMCID:: PMC10293773

Abstract Article PDF–4.0M

Select item 102906776.

Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21

Marlou Klein Hazebroek, Rutger Laterveer, Maria Kutschke, Vida Ramšak Marčeta, Clarissa S. Barthem, Susanne Keipert

Sci Rep. 2023; 13: 10288. Published online 2023 Jun 24. doi: 10.1038/s41598-023-37264-0

PMCID:: PMC10290677

Abstract Article PDF–1.7M

Select item 102901507.

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Anna Park, Kwang-eun Kim, Isaac Park, Sang Heon Lee, Kun-Young Park, Minkyo Jung, Xiaoxu Li, Maroun Bou Sleiman, Su Jeong Lee, Dae-Soo Kim, Jaehoon Kim, Dae-Sik Lim, Eui-Jeon Woo, Eun Woo Lee, Baek Soo Han, Kyoung-Jin Oh, Sang Chul Lee, Johan Auwerx, Ji Young Mun, Hyun-Woo Rhee, Won Kon Kim, Kwang-Hee Bae, Jae Myoung Suh

Nat Commun. 2023; 14: 3746. Published online 2023 Jun 23. doi: 10.1038/s41467-023-39106-z

PMCID:: PMC10290150

Abstract Article PDF–1.7M

Select item 102182478.

Temperature-Dependent Effects of Eicosapentaenoic Acid (EPA) on Browning of Subcutaneous Adipose Tissue in UCP1 Knockout Male Mice

Yujiao Zu, Mandana Pahlavani, Latha Ramalingam, Shasika Jayarathne, Jose Andrade, Shane Scoggin, William T. Festuccia, Nishan S. Kalupahana, Naima Moustaid-Moussa

Int J Mol Sci. 2023 May; 24(10): 8708. Published online 2023 May 13. doi: 10.3390/ijms24108708

PMCID:: PMC10218247

Abstract Article PDF–3.4M

Select item 99682979.

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Eun-Ji Park, Hyun-Soo Kim, Do-Hyoung Lee, Su-Min Kim, Joon-Sup Yoon, Ji-Min Lee, Se Jin Im, Ho Lee, Min-Woo Lee, Chang-Woo Lee

Nat Commun. 2023; 14: 1097. Published online 2023 Feb 25. doi: 10.1038/s41467-023-36836-y

PMCID:: PMC9968297

Abstract Article PDF–4.4M

Select item 993217710.

Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT

Kyung-Mi Choi, Christopher Y. Ko, Sung-Min An, Seung-Hee Cho, Douglas J. Rowland, Jung Hak Kim, Anna Fasoli, Abhijit J. Chaudhari, Donald M. Bers, John C. Yoon

Mol Metab. 2023 Mar; 69: 101679. Published online 2023 Jan 25. doi: 10.1016/j.molmet.2023.101679

PMCID:: PMC9932177

Abstract Article PDF–3.0M

Select item 991706111.

Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer’s Disease-Related Pathologies

Cha-Gyun Jung, Hitoshi Yamashita, Reiko Kato, Chunyu Zhou, Hiroaki Matsushita, Tamaki Takeuchi, Mona Abdelhamid, Yuxin Chen, Makoto Michikawa

Int J Mol Sci. 2023 Feb; 24(3): 2741. Published online 2023 Feb 1. doi: 10.3390/ijms24032741

PMCID:: PMC9917061

Abstract Article PDF–5.0M

Select item 977285512.

Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle

Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley

Redox Biol. 2023 Feb; 59: 102574. Published online 2022 Dec 6. doi: 10.1016/j.redox.2022.102574

PMCID:: PMC9772855

Abstract Article PDF–2.9M

Select item 970658213.

SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex

Huanming Shen, Ting He, Shuai Wang, Lingfeng Hou, Yixin Wei, Yunjia Liu, Chunli Mo, Zehang Zhao, WeiXin You, Huiling Guo, Boan Li

Theranostics. 2022; 12(18): 7699–7716. Published online 2022 Nov 7. doi: 10.7150/thno.77102

PMCID:: PMC9706582

Abstract Article PDF–2.5M

Select item 964667514.

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Ambre M. Bertholet, Andrew M. Natale, Paola Bisignano, Junji Suzuki, Andriy Fedorenko, James Hamilton, Tatiana Brustovetsky, Lawrence Kazak, Ryan Garrity, Edward T. Chouchani, Nickolay Brustovetsky, Michael Grabe, Yuriy Kirichok

Nature. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nature. 2022 Jun; 606(7912): 180–187. Published online 2022 May 25. doi: 10.1038/s41586-022-04747-5

PMCID:: PMC9646675

Abstract Article PDF–2.9M

Select item 954644815.

Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner

Spyridon Sideromenos, Anna Gundacker, Maria Nikou, Raimund Oberle, Orsolya Horvath, Peter Stoehrmann, Timo Partonen, Daniela D. Pollak

J Neurosci. 2022 Oct 5; 42(40): 7659–7672. doi: 10.1523/JNEUROSCI.2509-21.2022

PMCID:: PMC9546448

Abstract Article PDF–2.1M

Select item 945249616.

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Yusuke Adachi, Kazutaka Ueda, Seitaro Nomura, Kaoru Ito, Manami Katoh, Mikako Katagiri, Shintaro Yamada, Masaki Hashimoto, Bowen Zhai, Genri Numata, Akira Otani, Munetoshi Hinata, Yuta Hiraike, Hironori Waki, Norifumi Takeda, Hiroyuki Morita, Tetsuo Ushiku, Toshimasa Yamauchi, Eiki Takimoto, Issei Komuro

Nat Commun. 2022; 13: 5117. Published online 2022 Sep 7. doi: 10.1038/s41467-022-32658-6