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Items: 1 to 20 of 57

1.
Defining blood-induced microglia functions in neurodegeneration through multiomic profiling
Andrew S. Mendiola, Zhaoqi Yan, Karuna Dixit, Jeffrey R. Johnson, Mehdi Bouhaddou, Anke Meyer-Franke, Min-Gyoung Shin, Yu Yong, Ayushi Agrawal, Eilidh MacDonald, Gayathri Muthukumar, Clairice Pearce, Nikhita Arun, Belinda Cabriga, Rosa Meza-Acevedo, Maria del Pilar S. Alzamora, Scott S. Zamvil, Alexander R. Pico, Jae Kyu Ryu, Nevan J. Krogan, Katerina Akassoglou
Nat Immunol. 2023; 24(7): 1173–1187. Published online 2023 Jun 8. doi: 10.1038/s41590-023-01522-0
PMCID:
PMC10307624
AbstractArticlePDF–18M
2.
Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome
Salome M. Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Jürgen Brinckmann, Ulrich auf dem Keller, Sabine Werner, Mattia R. Bordoli
Cell Mol Life Sci. 2023 Apr; 80(4): 89. Published online 2023 Mar 15. doi: 10.1007/s00018-023-04735-6
PMCID:
PMC10017657
AbstractArticlePDF–5.2M
3.
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection
Oscar Negrón, Woosuk S. Hur, Joni Prasad, David S. Paul, Sarah E. Rowe, Jay L. Degen, Sara R. Abrahams, Silvio Antoniak, Brian P. Conlon, Wolfgang Bergmeier, Magnus Hӧӧk, Matthew J. Flick
PLoS Pathog. 2022 Jan; 18(1): e1010227. Published online 2022 Jan 18. doi: 10.1371/journal.ppat.1010227
PMCID:
PMC8797238
AbstractArticlePDF–2.8M
4.
Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi
Cédric Duval, Adomas Baranauskas, Tímea Feller, Majid Ali, Lih T. Cheah, Nadira Y. Yuldasheva, Stephen R. Baker, Helen R. McPherson, Zaher Raslan, Marc A. Bailey, Richard M. Cubbon, Simon D. Connell, Ramzi A. Ajjan, Helen Philippou, Khalid M. Naseem, Victoria C. Ridger, Robert A. S. Ariëns
Proc Natl Acad Sci U S A. 2021 Jul 6; 118(27): e2103226118. Published online 2021 Jun 28. doi: 10.1073/pnas.2103226118
PMCID:
PMC8271579
AbstractArticlePDF–2.1M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Klf14 is an imprinted transcription factor that regulates placental growth
Erik Koppes, Ben Shaffer, Elena Sadovsky, Katherine Himes, Yaacov Barak, Yoel Sadovsky, J. Richard Chaillet
Placenta. Author manuscript; available in PMC 2020 Dec 31.
Published in final edited form as: Placenta. 2019 Dec; 88: 61–67. Published online 2019 Sep 27. doi: 10.1016/j.placenta.2019.09.013
PMCID:
PMC7774094
AbstractArticlePDF–834K
7.
The plasminogen receptor, Plg-RKT, plays a role in inflammation and fibrinolysis during cutaneous wound healing in mice
Lina Ny, Robert J. Parmer, Yue Shen, Sandra Holmberg, Nagyung Baik, Assar Bäckman, Jessica Broden, Malgorzata Wilczynska, Tor Ny, Lindsey A. Miles
Cell Death Dis. 2020 Dec; 11(12): 1054. Published online 2020 Dec 12. doi: 10.1038/s41419-020-03230-1
PMCID:
PMC7733490
AbstractArticlePDF–3.0M
8.
Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation
Lakmali Munasinghage Silva, Andrew Gary Lum, Collin Tran, Molly W. Shaw, Zhen Gao, Matthew J. Flick, Niki M. Moutsopoulos, Thomas H. Bugge, Eric S. Mullins
Blood. 2019 Jul 18; 134(3): 291–303. Prepublished online 2019 May 17. doi: 10.1182/blood.2018874859
PMCID:
PMC6639982
AbstractArticle
9.
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model
Mario Merlini, Victoria A. Rafalski, Pamela Rios E. Coronado, T. Michael Gill, Maya Ellisman, Gayathri Muthukumar, Keshav S. Subramanian, Jae Kyu Ryu, Catriona A. Syme, Dimitrios Davalos, William W. Seeley, Lennart Mucke, Robert B. Nelson, Katerina Akassoglou
Neuron. Author manuscript; available in PMC 2020 Mar 20.
Published in final edited form as: Neuron. 2019 Mar 20; 101(6): 1099–1108.e6. Published online 2019 Feb 5. doi: 10.1016/j.neuron.2019.01.014
PMCID:
PMC6602536
AbstractArticlePDF–2.6M
10.
Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b
Cameron T. Landers, Hui-Ying Tung, J. Morgan Knight, Matthew C. Madison, Yifan Wu, Zhimin Zeng, Paul C. Porter, Antony Rodriguez, Matthew J. Flick, Farrah Kheradmand, David B. Corry
J Biol Chem. 2019 May 31; 294(22): 8834–8847. Published online 2019 Apr 16. doi: 10.1074/jbc.RA118.006724
PMCID:
PMC6552423
AbstractArticlePDF–2.7M
11.
The Plasminogen Receptor, Plg-RKT, is Essential for Mammary Lobuloalveolar Development and Lactation
Lindsey A. Miles, Nagyung Baik, Hongdong Bai, Helen P. Makarenkova, William B. Kiosses, Stan Krajewski, Francis J. Castellino, Alex Valenzuela, Nissi M. Varki, Barbara M. Mueller, Robert J. Parmer
J Thromb Haemost. Author manuscript; available in PMC 2019 May 1.
Published in final edited form as: J Thromb Haemost. 2018 May; 16(5): 919–932. Published online 2018 Apr 1. doi: 10.1111/jth.13988
PMCID:
PMC5965281
AbstractArticlePDF–2.7M
12.
Thrombin promotes diet-induced obesity through fibrin-driven inflammation
Anna K. Kopec, Sara R. Abrahams, Sherry Thornton, Joseph S. Palumbo, Eric S. Mullins, Senad Divanovic, Hartmut Weiler, A. Phillip Owens, III, Nigel Mackman, Ashley Goss, Joanne van Ryn, James P. Luyendyk, Matthew J. Flick
J Clin Invest. 2017 Aug 1; 127(8): 3152–3166. Published online 2017 Jul 24. doi: 10.1172/JCI92744
PMCID:
PMC5531415
AbstractArticlePDF–2.6M
13.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
14.
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression
Alexandra Naba, Karl R. Clauser, D. R. Mani, Steven A. Carr, Richard O. Hynes
Sci Rep. 2017; 7: 40495. Published online 2017 Jan 10. doi: 10.1038/srep40495
PMCID:
PMC5223159
AbstractArticlePDF–2.3M
15.
The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits
James R. Byrnes, Clare Wilson, Anthony M. Boutelle, Chase B. Brandner, Matthew J. Flick, Helen Philippou, Alisa S. Wolberg
Blood. 2016 Oct 13; 128(15): 1969–1978. Prepublished online 2016 Aug 25. doi: 10.1182/blood-2016-04-712323
PMCID:
PMC5064719
AbstractArticle
16.
Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism
Nikita Joshi, Anna K. Kopec, Jessica L. Ray, Holly Cline-Fedewa, Atta Nawabi, Timothy Schmitt, Rance Nault, Timothy R. Zacharewski, Cheryl E. Rockwell, Matthew J. Flick, James P. Luyendyk
Blood. 2016 Jun 2; 127(22): 2751–2762. Prepublished online 2016 Feb 26. doi: 10.1182/blood-2015-09-670703
PMCID:
PMC4891955
AbstractArticle
17.
CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
Patrick L. Crosswhite, Joanna J. Podsiadlowska, Carol D. Curtis, Siqi Gao, Lijun Xia, R. Sathish Srinivasan, Courtney T. Griffin
J Clin Invest. 2016 Jun 1; 126(6): 2254–2266. Published online 2016 May 3. doi: 10.1172/JCI84652
PMCID:
PMC4887170
AbstractArticlePDF–6.9M
18.
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice
N. Joshi, A. K. Kopec, K. M. O’Brien, K. L. Towery, H. Cline-Fedewa, K.J. Williams, B. L. Copple, M. J. Flick, J. P. Luyendyk
J Thromb Haemost. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: J Thromb Haemost. 2015 Jan; 13(1): 57–71. Published online 2014 Dec 11. doi: 10.1111/jth.12770
PMCID:
PMC4487795
AbstractArticlePDF–2.8M
19.
Fibrin Accumulation Secondary to Loss of Plasmin-Mediated Fibrinolysis Drives Inflammatory Osteoporosis in Mice
Heather A. Cole, Tetsuro Ohba, Jeffry S. Nyman, Haro Hirotaka, Justin M. M. Cates, Matthew J. Flick, Jay L. Degen, Jonathan G. Schoenecker
Arthritis Rheumatol. Author manuscript; available in PMC 2015 Aug 1.
Published in final edited form as: Arthritis Rheumatol. 2014 Aug; 66(8): 2222–2233. doi: 10.1002/art.38639
PMCID:
PMC4474376
AbstractArticlePDF–1.0M
20.
Fibrin, γ’-fibrinogen, and trans-clot pressure gradient control hemostatic clot growth during human blood flow over a collagen/tissue factor wound
Ryan W. Muthard, John D. Welsh, Lawrence F. Brass, Scott L. Diamond
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3): 645–654. Published online 2015 Jan 22. doi: 10.1161/ATVBAHA.114.305054
PMCID:
PMC4344417
AbstractArticlePDF–2.7M

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