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Select item 107410961.

Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b⁺ Ly6G⁺ Cells and Increasing the Viral Load in the Cornea

Jing Feng, Lingling Yang, Lili Ran, Xia Qi, Xiaolei Wang, Yangyang Zhang, Zongzheng Zou, Ting Liu, Xiaochuan Wang, Yang Yu, Xiaodong Sun, Qingjun Zhou

Invest Ophthalmol Vis Sci. 2023 Dec; 64(15): 24. Published online 2023 Dec 20. doi: 10.1167/iovs.64.15.24

PMCID:: PMC10741096

Abstract Article PDF–4.0M

Select item 101069652.

Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice

D. Liskiewicz, Q. Zhang, C.S. Barthem, M. Jastroch, A. Liskiewicz, N. Khajavi, G. Grandl, C. Coupland, M. Kleinert, C. Garcia-Caceres, A. Novikoff, G. Maity, U. Boehm, M.H. Tschöp, T.D. Müller

Mol Metab. 2023 Jun; 72: 101714. Published online 2023 Mar 24. doi: 10.1016/j.molmet.2023.101714

PMCID:: PMC10106965

Abstract Article PDF–2.3M

Select item 100892463.

Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3

Chenyu Yang, Shanni Yamaki, Tyler Jung, Brian Kim, Ryan Huyhn, David D. McKemy

J Neurosci. 2023 Apr 12; 43(15): 2803–2814. doi: 10.1523/JNEUROSCI.2303-22.2023

PMCID:: PMC10089246

Abstract Article PDF–2.4M

Select item 100338854.

Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice

Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Fumiaki Oka, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Michiyasu Suzuki, Hideyuki Ishihara

Front Pharmacol. 2023; 14: 1138673. Published online 2023 Mar 9. doi: 10.3389/fphar.2023.1138673

PMCID:: PMC10033885

Abstract Article PDF–2.5M

Select item 98968685.

Effect of TRPM8 Functional Loss on Corneal Epithelial Wound Healing in Mice

Lili Ran, Jing Feng, Xia Qi, Ting Liu, Benxiang Qi, Kai Jiang, Zhenzhen Zhang, Yang Yu, Qingjun Zhou, Lixin Xie

Invest Ophthalmol Vis Sci. 2023 Jan; 64(1): 19. Published online 2023 Jan 24. doi: 10.1167/iovs.64.1.19

PMCID:: PMC9896868

Abstract Article PDF–18M

Select item 97845226.

Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression

Pablo Hernández-Ortego, Remedios Torres-Montero, Elvira de la Peña, Félix Viana, Jorge Fernández-Trillo

Int J Mol Sci. 2022 Dec; 23(24): 16164. Published online 2022 Dec 18. doi: 10.3390/ijms232416164

PMCID:: PMC9784522

Abstract Article PDF–4.2M

Select item 97581887.

TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

Xiaohua Lei, Qiang Liu, Wei Qin, Qing Tong, Zhenghao Li, Wendi Xu, Guoxing Liu, Jie Fu, Ju Zhang, Tao Kuang, Yaoli Shao, Chun Liu, Yu Fang, Zhenyu Cao, Likun Yan, Zhiqiang Liu, Siyuan Liu, Hirofumi Yamamoto, Masaki Mori, Xin M. Liang, Xundi Xu

Cell Death Dis. 2022 Dec; 13(12): 1050. Published online 2022 Dec 16. doi: 10.1038/s41419-022-05475-4

Correction in:: Cell Death Dis. 2023 Mar; 14(3): 204.

PMCID:: PMC9758188

Abstract Article PDF–4.2M

Select item 95880038.

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine

David Alarcón-Alarcón, David Cabañero, Jorge de Andrés-López, Magdalena Nikolaeva-Koleva, Simona Giorgi, Gregorio Fernández-Ballester, Asia Fernández-Carvajal, Antonio Ferrer-Montiel

Nat Commun. 2022; 13: 6304. Published online 2022 Oct 22. doi: 10.1038/s41467-022-33835-3

PMCID:: PMC9588003

Abstract Article PDF–1.9M

Select item 95198119.

Transient receptor potential melastatin 8 (TRPM8) is required for nitroglycerin and calcitonin gene-related peptide induced migraine-like pain behaviors in mice

Chao Wei, Brian Kim, David D. McKemy

Pain. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Pain. 2022 Dec 1; 163(12): 2380–2389. Published online 2022 Mar 29. doi: 10.1097/j.pain.0000000000002635

PMCID:: PMC9519811

Article PDF–1.6M

Select item 932735810.

Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol

Shiang-Suo Huang, Hsing-Hui Su, Szu-Yu Chien, Hsin-Yi Chung, Sih-Ting Luo, Yu-Ting Chu, Yi-Hsin Wang, Iona J. MacDonald, Hsun-Hua Lee, Yi-Hung Chen

J Neuroinflammation. 2022; 19: 192. Published online 2022 Jul 27. doi: 10.1186/s12974-022-02553-4

PMCID:: PMC9327358

Abstract Article PDF–6.6M

Select item 916678011.

Structures of a mammalian TRPM8 in closed state

Cheng Zhao, Yuan Xie, Lizhen Xu, Fan Ye, Ximing Xu, Wei Yang, Fan Yang, Jiangtao Guo

Nat Commun. 2022; 13: 3113. Published online 2022 Jun 3. doi: 10.1038/s41467-022-30919-y

PMCID:: PMC9166780

Abstract Article PDF–3.8M

Select item 896166812.

Trpm8 Expression in Human and Mouse Castration Resistant Prostate Adenocarcinoma Paves the Way for the Preclinical Development of TRPM8-Based Targeted Therapies

Sacha Genovesi, Riccardo Moro, Beatrice Vignoli, Dario De Felice, Marco Canossa, Rodolfo Montironi, Francesco Giuseppe Carbone, Mattia Barbareschi, Andrea Lunardi, Alessandro Alaimo

Biomolecules. 2022 Feb; 12(2): 193. Published online 2022 Jan 23. doi: 10.3390/biom12020193

PMCID:: PMC8961668

Abstract Article PDF–63M

Select item 887744813.

In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening

Nunzio Iraci, Carmine Ostacolo, Alicia Medina-Peris, Tania Ciaglia, Anton M. Novoselov, Andrea Altieri, David Cabañero, Asia Fernandez-Carvajal, Pietro Campiglia, Isabel Gomez-Monterrey, Alessia Bertamino, Alexander V. Kurkin

Int J Mol Sci. 2022 Feb; 23(4): 2070. Published online 2022 Feb 13. doi: 10.3390/ijms23042070

PMCID:: PMC8877448

Abstract Article PDF–4.0M

Select item 859613214.

Rational Design of a Modality‐Specific Inhibitor of TRPM8 Channel against Oxaliplatin‐Induced Cold Allodynia

Aerziguli Aierken, Ya‐Kai Xie, Wenqi Dong, Abuliken Apaer, Jia‐Jia Lin, Zihan Zhao, Shilong Yang, Zhen‐Zhong Xu, Fan Yang

Adv Sci (Weinh) 2021 Nov; 8(22): 2101717. Published online 2021 Oct 17. doi: 10.1002/advs.202101717

PMCID:: PMC8596132

Abstract Article PDF–6.4M

Select item 851722215.

Suppressive Effects of Transient Receptor Potential Melastatin 8 Agonist on Epileptiform Discharges and Epileptic Seizures

Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Takao Inoue, Yuichi Fujiyama, Kohei Haji, Yuichi Maruta, Hideyuki Ishihara, Michiyasu Suzuki

Front Pharmacol. 2021; 12: 766782. Published online 2021 Oct 1. doi: 10.3389/fphar.2021.766782

PMCID:: PMC8517222

Abstract Article PDF–1.5M

Select item 851369716.

Constitutive Phosphorylation as a Key Regulator of TRPM8 Channel Function

Bastián Rivera, Claudio Moreno, Boris Lavanderos, Ji Yeon Hwang, Jorge Fernández-Trillo, Kang-Sik Park, Patricio Orio, Félix Viana, Rodolfo Madrid, María Pertusa

J Neurosci. 2021 Oct 13; 41(41): 8475–8493. doi: 10.1523/JNEUROSCI.0345-21.2021

PMCID:: PMC8513697

Abstract Article PDF–6.1M

Select item 823328317.

Mapping the expression of transient receptor potential channels across murine placental development

Katrien De Clercq, Vicente Pérez-García, Rieta Van Bree, Federica Pollastro, Karen Peeraer, Thomas Voets, Joris Vriens

Cell Mol Life Sci. 2021 Jun; 78(11): 4993–5014. Published online 2021 Apr 21. doi: 10.1007/s00018-021-03837-3

PMCID:: PMC8233283

Abstract Article PDF–4.1M

Select item 817749018.

TRPM8 modulates temperature regulation in a sex-dependent manner without affecting cold-induced bone loss

Adriana Lelis Carvalho, Annika Treyball, Daniel J. Brooks, Samantha Costa, Ryan J. Neilson, Michaela R. Reagan, Mary L. Bouxsein, Katherine J. Motyl

PLoS One. 2021; 16(6): e0231060. Published online 2021 Jun 4. doi: 10.1371/journal.pone.0231060

PMCID:: PMC8177490

Abstract Article PDF–3.9M

Select item 804810419.

Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

Mark A. Landy, Megan Goyal, Katherine M. Casey, Chen Liu, Helen C. Lai

Cell Rep. Author manuscript; available in PMC 2021 Apr 15.

Published in final edited form as: Cell Rep. 2021 Mar 30; 34(13): 108913. doi: 10.1016/j.celrep.2021.108913

PMCID:: PMC8048104

Abstract Article PDF–1.5M

Select item 799751520.

Odontoblast TRPC5 channels signal cold pain in teeth

Laura Bernal, Pamela Sotelo-Hitschfeld, Christine König, Viktor Sinica, Amanda Wyatt, Zoltan Winter, Alexander Hein, Filip Touska, Susanne Reinhardt, Aaron Tragl, Ricardo Kusuda, Philipp Wartenberg, Allen Sclaroff, John D. Pfeifer, Fabien Ectors, Andreas Dahl, Marc Freichel, Viktorie Vlachova, Sebastian Brauchi, Carolina Roza, Ulrich Boehm, David E. Clapham, Jochen K. Lennerz, Katharina Zimmermann

Sci Adv. 2021 Mar; 7(13): eabf5567. Published online 2021 Mar 26. doi: 10.1126/sciadv.abf5567