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Items: 1 to 20 of 86

1.
The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
Lena H Nguyen, Youfen Xu, Maanasi Nair, Angelique Bordey
eLife. 2024; 12: RP91010. Published online 2024 Feb 27. doi: 10.7554/eLife.91010
PMCID:
PMC10942629
AbstractArticlePDF–5.5M
2.
Rheb1 is required for limb growth through regulating chondrogenesis in growth plate
Yuwei Zhang, Jiaxin Wen, Ruijun Lai, Jiahuan Zhang, Kai Li, Yue Zhang, Anling Liu, Xiaochun Bai
Cell Tissue Res. 2024; 395(3): 261–269. Published online 2024 Jan 23. doi: 10.1007/s00441-024-03861-2
PMCID:
PMC10904423
AbstractArticlePDF–7.1M
3.
Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction
Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker
Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120
PMCID:
PMC10589673
AbstractArticlePDF–6.8M
4.
Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation
Wanchun Yang, Dejiang Pang, Mina Chen, Chongyangzi Du, Lanlan Jia, Luoling Wang, Yunling He, Wanxiang Jiang, Liping Luo, Zongyan Yu, Mengqian Mao, Qiuyun Yuan, Ping Tang, Xiaoqiang Xia, Yiyuan Cui, Bo Jing, Alexander Platero, Yanhui Liu, Yuquan Wei, Paul F. Worley, Bo Xiao
Dev Cell. Author manuscript; available in PMC 2022 May 12.
Published in final edited form as: Dev Cell. 2021 Mar 22; 56(6): 811–825.e6. Published online 2021 Mar 15. doi: 10.1016/j.devcel.2021.02.022
PMCID:
PMC9096910
AbstractArticlePDF–2.5M
5.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
6.
Rapamycin Promotes the Expansion of Myeloid Cells by Increasing G-CSF Expression in Mesenchymal Stem Cells
Minghao Li, Yanjie Lan, Juan Gao, Shengnan Yuan, Shuaibing Hou, Tengxiao Guo, Fei Zhao, Yuxia Wang, Weiping Yuan, Xiaomin Wang
Front Cell Dev Biol. 2022; 10: 779159. Published online 2022 Mar 17. doi: 10.3389/fcell.2022.779159
PMCID:
PMC8969869
AbstractArticlePDF–3.1M
7.
Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver
Chongyangzi Du, Wanchun Yang, Zongyan Yu, Qiuyun Yuan, Dejiang Pang, Ping Tang, Wanxiang Jiang, Mina Chen, Bo Xiao
Front Cell Dev Biol. 2022; 10: 808140. Published online 2022 Mar 16. doi: 10.3389/fcell.2022.808140
PMCID:
PMC8965806
AbstractArticlePDF–2.5M
8.
GATOR2 complex–mediated amino acid signaling regulates brain myelination
Zongyan Yu, Zhiwen Yang, Guoru Ren, Yingjie Wang, Xiang Luo, Feiyan Zhu, Shouyang Yu, Lanlan Jia, Mina Chen, Paul F. Worley, Bo Xiao
Proc Natl Acad Sci U S A. 2022 Jan 18; 119(3): e2110917119. Published online 2022 Jan 12. doi: 10.1073/pnas.2110917119
PMCID:
PMC8784133
AbstractArticlePDF–3.3M
9.
Altered White Matter and microRNA Expression in a Murine Model Related to Williams Syndrome Suggests That miR-34b/c Affects Brain Development via Ptpru and Dcx Modulation
Meitar Grad, Ariel Nir, Gilad Levy, Sari Schokoroy Trangle, Guy Shapira, Noam Shomron, Yaniv Assaf, Boaz Barak
Cells. 2022 Jan; 11(1): 158. Published online 2022 Jan 4. doi: 10.3390/cells11010158
PMCID:
PMC8750756
AbstractArticlePDF–24M
10.
HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading
Liqun Xu, Lijun Zhang, Xiaoyan Zhang, Gaozhi Li, Yixuan Wang, Jingjing Dong, Honghui Wang, Zebing Hu, Xinsheng Cao, Shu Zhang, Fei Shi
Int J Mol Sci. 2021 Oct; 22(19): 10527. Published online 2021 Sep 29. doi: 10.3390/ijms221910527
PMCID:
PMC8508889
AbstractArticlePDF–3.8M
11.
GPR84 Is Essential for the Taste of Medium Chain Saturated Fatty Acids
Yan Liu, Han Xu, Naima Dahir, Ashley Calder, Fangjun Lin, Timothy A. Gilbertson
J Neurosci. 2021 Jun 16; 41(24): 5219–5228. doi: 10.1523/JNEUROSCI.2530-20.2021
PMCID:
PMC8211552
AbstractArticlePDF–773K
12.
Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells
Juan Gao, Shuaibing Hou, Shengnan Yuan, Yuxia Wang, Yanan Gao, Xiaolu Sun, Weili Wang, Yajing Chu, Yuan Zhou, Xiaoming Feng, Hongbo R. Luo, Tao Cheng, Jun Shi, Weiping Yuan, Xiaomin Wang
Front Cell Dev Biol. 2021; 9: 650599. Published online 2021 May 27. doi: 10.3389/fcell.2021.650599
PMCID:
PMC8191467
AbstractArticlePDF–3.4M
13.
RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity
Martina Proietti Onori, Linda M. C. Koene, Carmen B. Schäfer, Mark Nellist, Marcel de Brito van Velze, Zhenyu Gao, Ype Elgersma, Geeske M. van Woerden
PLoS Biol. 2021 May; 19(5): e3001279. Published online 2021 May 26. doi: 10.1371/journal.pbio.3001279
PMCID:
PMC8186814
AbstractArticlePDF–5.0M
14.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
15.
Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain
Xiaqing Ma, Wenjie Du, Wenying Wang, Limin Luo, Min Huang, Haiyan Wang, Raozhou Lin, Zhongping Li, Haibo Shi, Tifei Yuan, Wei Jiang, Paul F. Worley, Tao Xu
Cell Death Dis. 2020 Sep; 11(9): 747. Published online 2020 Sep 12. doi: 10.1038/s41419-020-02966-0
PMCID:
PMC7487067
AbstractArticlePDF–1.8M
16.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
17.
Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment
Anaelle A Dumas, Nicola Pomella, Gabriel Rosser, Loredana Guglielmi, Claire Vinel, Thomas O Millner, Jeremy Rees, Natasha Aley, Denise Sheer, Jun Wei, Anantha Marisetty, Amy B Heimberger, Robert L Bowman, Sebastian Brandner, Johanna A Joyce, Silvia Marino
EMBO J. 2020 Aug 3; 39(15): e103790. Published online 2020 Jun 22. doi: 10.15252/embj.2019103790
PMCID:
PMC7396846
AbstractArticlePDF–2.7M
18.
Rheb1-independent Activation of mTORC1 in Mammary Tumors Occurs Through Activating Mutations in mTOR
Bin Xiao, Dongmei Zuo, Alison Hirukawa, Robert D. Cardiff, Richard Lamb, Nahum Sonenberg, William J. Muller
Cell Rep. Author manuscript; available in PMC 2020 Jun 9.
Published in final edited form as: Cell Rep. 2020 Apr 28; 31(4): 107571. doi: 10.1016/j.celrep.2020.107571
PMCID:
PMC7281837
AbstractArticlePDF–3.0M
19.
Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway
Wen Meng, Xiuci Liang, Ting Xiao, Jing Wang, Jie Wen, Hairong Luo, Jianhui Teng, Yanquan Fei, Qinghai Zhang, Bilian Liu, Fang Hu, Juli Bai, Meilian Liu, Zhiguang Zhou, Feng Liu
J Mol Cell Biol. 2019 Sep; 11(9): 781–790. Published online 2019 Jul 22. doi: 10.1093/jmcb/mjz056
PMCID:
PMC6821354
AbstractArticlePDF–19M
20.
Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model
Linda M. C. Koene, Saskia E. van Grondelle, Martina Proietti Onori, Ilse Wallaard, Nathalie H. R. M. Kooijman, Annabel van Oort, Jadwiga Schreiber, Ype Elgersma
Ann Clin Transl Neurol. 2019 Jul; 6(7): 1273–1291. Published online 2019 Jun 24. doi: 10.1002/acn3.50829
PMCID:
PMC6649373
AbstractArticlePDF–2.6M

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