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Select item 66091051.

Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model

Janeesh Plakkal Ayyappan, Kezia lizardo, Sean Wang, Edward Yurkow, Jyothi F Nagajyothi

Biomol Ther (Seoul) 2019 Jul; 27(4): 386–394. Published online 2019 Mar 13. doi: 10.4062/biomolther.2018.193

PMCID:: PMC6609105

Article PDF–6.8M

Select item 65807032.

Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo

Wi S. Lai, Deborah J. Stumpo, Melissa L. Wells, Artiom Gruzdev, Stephanie N. Hicks, Cindo O. Nicholson, Zhengfeng Yang, Roberta Faccio, Michael W. Webster, Lori A. Passmore, Perry J. Blackshear

Mol Cell Biol. 2019 Jul 1; 39(13): e00029-19. Prepublished online 2019 Apr 29. Published online 2019 Jun 13. doi: 10.1128/MCB.00029-19

PMCID:: PMC6580703

Article PDF–4.4M

Select item 65386843.

Delineating the role of eIF2α in retinal degeneration

Christopher R. Starr, Marina S. Gorbatyuk

Cell Death Dis. 2019 Jun; 10(6): 409. Published online 2019 May 28. doi: 10.1038/s41419-019-1641-y

PMCID:: PMC6538684

Article PDF–1.6M

Select item 63935414.

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice

Vruti Patel, Guillaume Bidault, Joseph E. Chambers, Stefania Carobbio, Angharad J. T. Everden, Concepción Garcés, Lucy E. Dalton, Fiona M. Gribble, Antonio Vidal-Puig, Stefan J. Marciniak

Sci Rep. 2019; 9: 2903. Published online 2019 Feb 27. doi: 10.1038/s41598-019-39562-y

PMCID:: PMC6393541

Article PDF–5.4M

Select item 62809905.

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

Yu-Chou Tseng, Samuel K. Kulp, I-Lu Lai, En-Chi Hsu, Wei A. He, David E. Frankhouser, Pearlly S. Yan, Xiaokui Mo, Mark Bloomston, Gregory B. Lesinski, Guido Marcucci, Denis C. Guttridge, Tanios Bekaii-Saab, Ching-Shih Chen

J Natl Cancer Inst. 2015 Dec; 107(12): djv274. Published online 2015 Oct 12. doi: 10.1093/jnci/djv274

PMCID:: PMC6280990

Article PDF–6.9M

Select item 61088356.

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

Agnieszka Krzyzosiak, Anna Sigurdardottir, Laura Luh, Marta Carrara, Indrajit Das, Kim Schneider, Anne Bertolotti

Cell. 2018 Aug 23; 174(5): 1216–1228.e19. doi: 10.1016/j.cell.2018.06.030

PMCID:: PMC6108835

Article

Select item 60635037.

The COPII cargo adapter SEC24C is essential for neuronal homeostasis

Bo Wang, Joung Hyuck Joo, Rebecca Mount, Brett J. W. Teubner, Alison Krenzer, Amber L. Ward, Viraj P. Ichhaporia, Elizabeth J. Adams, Rami Khoriaty, Samuel T. Peters, Shondra M. Pruett-Miller, Stanislav S. Zakharenko, David Ginsburg, Mondira Kundu

J Clin Invest. 2018 Aug 1; 128(8): 3319–3332. Published online 2018 Jun 25. doi: 10.1172/JCI98194

PMCID:: PMC6063503

Article PDF–26M

Select item 59883658.

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models

Chiara Lanzillotta, Antonella Tramutola, Shelby Meier, Frederick Schmitt, Eugenio Barone, Marzia Perluigi, Fabio Di Domenico, Jose F. Abisambra

J Alzheimers Dis. Author manuscript; available in PMC 2018 Jun 5.

Published in final edited form as: J Alzheimers Dis. 2018; 62(1): 347–359. doi: 10.3233/JAD-170617

PMCID:: PMC5988365

Article PDF–5.3M

Select item 56802979.

Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration

Mikako Yagi, Takeshi Uchiumi, Noriaki Sagata, Daiki Setoyama, Rie Amamoto, Yuichi Matsushima, Dongchon Kang

Sci Rep. 2017; 7: 15131. Published online 2017 Nov 9. doi: 10.1038/s41598-017-15414-5

PMCID:: PMC5680297

Article PDF–2.8M

Select item 548250810.

Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice

Masato Miyake, Masashi Kuroda, Hiroshi Kiyonari, Kenji Takehana, Satoshi Hisanaga, Masatoshi Morimoto, Jun Zhang, Miho Oyadomari, Hiroshi Sakaue, Seiichi Oyadomari

PLoS One. 2017; 12(6): e0179955. Published online 2017 Jun 23. doi: 10.1371/journal.pone.0179955

PMCID:: PMC5482508

Article PDF–4.6M

Select item 536863611.

Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo

Nils Blüthgen, Mirjam van Bentum, Barbara Merz, Dietmar Kuhl, Guido Hermey

Sci Rep. 2017; 7: 45101. Published online 2017 Mar 28. doi: 10.1038/srep45101

PMCID:: PMC5368636

Article PDF–2.3M

Select item 531960212.

NEURON-SPECIFIC SUMO KNOCKDOWN SUPPRESSES GLOBAL GENE EXPRESSION RESPONSE AND WORSENS FUNCTIONAL OUTCOME AFTER TRANSIENT FOREBRAIN ISCHEMIA IN MICE

LIN ZHANG, XIAOZHI LIU, HUAXIN SHENG, SHUAI LIU, YING LI, JULIA Q. ZHAO, DAVID S. WARNER, WULF PASCHEN, WEI YANG

Neuroscience. Author manuscript; available in PMC 2018 Feb 20.

Published in final edited form as: Neuroscience. 2017 Feb 20; 343: 190–212. Published online 2016 Dec 3. doi: 10.1016/j.neuroscience.2016.11.036

PMCID:: PMC5319602

Article PDF–1.7M

Select item 504256713.

Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response

Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-López, Maud Michelet, Benjamin Ducarouge, Alfredo Berzal-Herranz, Fabien Zoulim, Patrick Mehlen, Romain Parent

Cell Mol Gastroenterol Hepatol. 2016 May; 2(3): 281–301.e9. Published online 2016 Jan 9. doi: 10.1016/j.jcmgh.2015.12.011

PMCID:: PMC5042567

Article PDF–3.5M

Select item 481922514.

Identification of genes associated with the astrocyte-specific gene Gfap during astrocyte differentiation

Kenji Ito, Tsukasa Sanosaka, Katsuhide Igarashi, Maky Ideta-Otsuka, Akira Aizawa, Yuichi Uosaki, Azumi Noguchi, Hirokazu Arakawa, Kinichi Nakashima, Takumi Takizawa

Sci Rep. 2016; 6: 23903. Published online 2016 Apr 4. doi: 10.1038/srep23903

PMCID:: PMC4819225

Article PDF–1.7M

Select item 465368215.

Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response

Sara K. Young, Jeffrey A. Willy, Cheng Wu, Matthew S. Sachs, Ronald C. Wek

J Biol Chem. 2015 Nov 20; 290(47): 28257–28271. Published online 2015 Oct 7. doi: 10.1074/jbc.M115.693184

PMCID:: PMC4653682

Article PDF–3.1M

Select item 445413216.

p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo

Brendan D Stamper, Michael L Garcia, Duy Q Nguyen, Richard P Beyer, Theo K Bammler, Frederico M Farin, Terrance J Kavanagh, Sidney D Nelson

Gene Regul Syst Bio. 2015; 9: 1–14. Published online 2015 Jun 1. doi: 10.4137/GRSB.S25388

PMCID:: PMC4454132

Article PDF–1.4M

Select item 378133417.

Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network

Angela M. Arensdorf, Diane DeZwaan McCabe, Randal J. Kaufman, D. Thomas Rutkowski

Front Genet. 2013; 4: 188. Prepublished online 2013 Sep 2. Published online 2013 Sep 24. doi: 10.3389/fgene.2013.00188

PMCID:: PMC3781334

Article PDF–1.4M

Select item 373887718.

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor

Soetkin Versteyhe, Birgit Klaproth, Rehannah Borup, Jane Palsgaard, Maja Jensen, Steven G. Gray, Pierre De Meyts

Front Endocrinol (Lausanne) 2013; 4: 98. Prepublished online 2013 Mar 21. Published online 2013 Aug 9. doi: 10.3389/fendo.2013.00098

PMCID:: PMC3738877

Article PDF–869K

Select item 373773319.

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation

Franz Kratochvill, Christian Machacek, Claus Vogl, Florian Ebner, Vitaly Sedlyarov, Andreas R Gruber, Harald Hartweger, Raimund Vielnascher, Marina Karaghiosoff, Thomas Rülicke, Mathias Müller, Ivo Hofacker, Roland Lang, Pavel Kovarik

Mol Syst Biol. 2011; 7: 560. Published online 2011 Dec 20. doi: 10.1038/msb.2011.93