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Select item 88501981.

Evolution of enhanced innate immune evasion by SARS-CoV-2

Lucy G. Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Ben Polacco, Adrian Pelin, Jyoti Batra, Matthew V. X. Whelan, Myra Hosmillo, Andrea Fossati, Roberta Ragazzini, Irwin Jungreis, Manisha Ummadi, Ajda Rojc, Jane Turner, Marie L. Bischof, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Joseph Hiatt, Romel Rosales, Briana L. McGovern, Aminu Jahun, Jacqueline M. Fabius, Kris White, Ian G. Goodfellow, Yasu Takeuchi, Paola Bonfanti, Kevan Shokat, Natalia Jura, Klim Verba, Mahdad Noursadeghi, Pedro Beltrao, Manolis Kellis, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Greg J. Towers, Nevan J. Krogan

Nature. 2022; 602(7897): 487–495. Published online 2021 Dec 23. doi: 10.1038/s41586-021-04352-y

Correction in:: Nature. 2022; 604(7905): E14.

PMCID:: PMC8850198

Article PDF–32M

Select item 84386902.

SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms

Seán I O’Donoghue, Andrea Schafferhans, Neblina Sikta, Christian Stolte, Sandeep Kaur, Bosco K Ho, Stuart Anderson, James B Procter, Christian Dallago, Nicola Bordin, Matt Adcock, Burkhard Rost

Mol Syst Biol. 2021 Sep; 17(9): e10079. Published online 2021 Sep 14. doi: 10.15252/msb.202010079

PMCID:: PMC8438690

Article PDF–2.1M

Select item 50264903.

Human mitochondrial import receptor Tom70 functions as a monomer

Anna C. Y. Fan, Lisandra M. Gava, Carlos H. I. Ramos, Jason C. Young

Biochem J. Author manuscript; available in PMC 2016 Sep 16.

Published in final edited form as: Biochem J. 2010 Aug 1; 429(3): 553–563. doi: 10.1042/BJ20091855

PMCID:: PMC5026490

Article PDF–1.1M

Select item 104919324.

The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis

Svenja Lenhard, Sarah Gerlich, Azkia Khan, Saskia Rödl, Jan-Eric Bökenkamp, Esra Peker, Christine Zarges, Janina Faust, Zuzana Storchova, Markus Räschle, Jan Riemer, Johannes M. Herrmann

J Cell Biol. 2023 Oct 2; 222(10): e202303002. Published online 2023 Sep 8. doi: 10.1083/jcb.202303002

PMCID:: PMC10491932

Article PDF–6.3M

Select item 91326815.

Binding of SARS-CoV-2 protein ORF9b to mitochondrial translocase TOM70 prevents its interaction with chaperone HSP90

Kehinde S. Ayinde, Glaucia M.S. Pinheiro, Carlos H.I. Ramos

Biochimie. 2022 Sep; 200: 99–106. Published online 2022 May 26. doi: 10.1016/j.biochi.2022.05.016

PMCID:: PMC9132681

Article PDF–1.9M

Select item 84305086.

Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90

Lukas Brandherm, Antonio Mario Kobaš, Mara Klöhn, Yannick Brüggemann, Stephanie Pfaender, Joachim Rassow, Sebastian Kreimendahl

Int J Mol Sci. 2021 Sep; 22(17): 9233. Published online 2021 Aug 26. doi: 10.3390/ijms22179233

PMCID:: PMC8430508

Article PDF–3.6M

Select item 84203667.

Relation between ORF8a and the mitochondrial protein TOM70 in SARS‐CoV‐2 infection

Milad Zandi, Saber Soltani

Acta Physiol (Oxf) 2021 Dec; 233(4): e13712. Published online 2021 Jul 14. doi: 10.1111/apha.13712

PMCID:: PMC8420366

Article PDF–79K

Select item 81218158.

Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

Xiaopan Gao, Kaixiang Zhu, Bo Qin, Vincent Olieric, Meitian Wang, Sheng Cui

Nat Commun. 2021; 12: 2843. Published online 2021 May 14. doi: 10.1038/s41467-021-23118-8

PMCID:: PMC8121815

Article PDF–5.5M

Select item 72687879.

De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment

Debdeep Dutta, Lauren C Briere, Oguz Kanca, Paul C Marcogliese, Melissa A Walker, Frances A High, Adeline Vanderver, Joel Krier, Nikkola Carmichael, Christine Callahan, Ryan J Taft, Cas Simons, Guy Helman, Undiagnosed Diseases Network, Michael F Wangler, Shinya Yamamoto, David A Sweetser, Hugo J Bellen

Hum Mol Genet. 2020 Jun 3; 29(9): 1568–1579. Published online 2020 Apr 30. doi: 10.1093/hmg/ddaa081

PMCID:: PMC7268787

Article PDF–1.2M

Select item 317318110.

Interaction between the Human Mitochondrial Import Receptors Tom20 and Tom70 in Vitro Suggests a Chaperone Displacement Mechanism

Anna C. Y. Fan, Guennadi Kozlov, Annabelle Hoegl, Richard C. Marcellus, Michael J. H. Wong, Kalle Gehring, Jason C. Young

J Biol Chem. 2011 Sep 16; 286(37): 32208–32219. Published online 2011 Jul 19. doi: 10.1074/jbc.M111.280446

PMCID:: PMC3173181

Article PDF–2.0M

Select item 945097311.

AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability

Martina Di Rienzo, Alessandra Romagnoli, Fabiola Ciccosanti, Giulia Refolo, Veronica Consalvi, Giuseppe Arena, Enza Maria Valente, Mauro Piacentini, Gian Maria Fimia

Autophagy. 2022; 18(8): 1752–1762. Published online 2021 Nov 19. doi: 10.1080/15548627.2021.1997052

PMCID:: PMC9450973

Article PDF–1.3M

Select item 738780812.

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

He-wei Jiang, Hai-nan Zhang, Qing-feng Meng, Jia Xie, Yang Li, Hong Chen, Yun-xiao Zheng, Xue-ning Wang, Huan Qi, Jing Zhang, Pei-Hui Wang, Ze-Guang Han, Sheng-ce Tao

Cell Mol Immunol. 2020 Sep; 17(9): 998–1000. Published online 2020 Jul 29. doi: 10.1038/s41423-020-0514-8

PMCID:: PMC7387808

Article PDF–1.0M

Select item 358938713.

Tom70 Is Essential for PINK1 Import into Mitochondria

Hiroki Kato, Qiping Lu, Doron Rapaport, Vera Kozjak-Pavlovic

PLoS One. 2013; 8(3): e58435. Published online 2013 Mar 5. doi: 10.1371/journal.pone.0058435

PMCID:: PMC3589387

Article PDF–667K

Select item 159317014.

An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway

Chiang-Hung Chou, Ru-Shuo Lee, Hsin-Fang Yang-Yen

Mol Biol Cell. 2006 Sep; 17(9): 3952–3963. doi: 10.1091/mbc.E06-04-0319

PMCID:: PMC1593170

Article PDF–2.4M

Select item 440341815.

Tom70 Mediates Sendai Virus-Induced Apoptosis on Mitochondria

Bo Wei, Ye Cui, Yuefeng Huang, Heng Liu, Lin Li, Mi Li, Kang-Cheng Ruan, Qin Zhou, Chen Wang

J Virol. 2015 Apr 1; 89(7): 3804–3818. Published online 2015 Jan 21. doi: 10.1128/JVI.02959-14

PMCID:: PMC4403418

Article PDF–4.2M

Select item 328827516.

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

Michael Lazarou, Seok Min Jin, Lesley A. Kane, Richard J. Youle

Dev Cell. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Dev Cell. 2012 Feb 14; 22(2): 320–333. Published online 2012 Jan 25. doi: 10.1016/j.devcel.2011.12.014

PMCID:: PMC3288275

Article PDF–3.4M

Select item 456377717.

Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10

G Bertolin, M Jacoupy, S Traver, R Ferrando-Miguel, T Saint Georges, K Grenier, H Ardila-Osorio, M-P Muriel, H Takahashi, A J Lees, C Gautier, D Guedin, F Coge, E A Fon, A Brice, O Corti

Cell Death Differ. 2015 Oct; 22(10): 1563–1576. Published online 2015 Jan 16. doi: 10.1038/cdd.2014.224

PMCID:: PMC4563777

Article PDF–5.1M

Select item 412330218.

Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy

Jun Li, Man Qi, Changming Li, Dan Shi, Dasheng Zhang, Duanyang Xie, Tianyou Yuan, Jing Feng, Yi Liu, Dandan Liang, Xinran Xu, Jinjin Chen, Liang Xu, Hong Zhang, Jiangchuan Ye, Fei Lv, Jian Huang, Luying Peng, Yi-Han Chen

Cell Res. 2014 Aug; 24(8): 977–993. Published online 2014 Jul 15. doi: 10.1038/cr.2014.94

PMCID:: PMC4123302

Article PDF–5.8M

Select item 266139419.

Interactions of S100A2 and S100A6 with the Tetratricopeptide Repeat Proteins, Hsp90/Hsp70-organizing Protein and Kinesin Light Chain

Seiko Shimamoto, Maki Takata, Masaaki Tokuda, Fumikazu Oohira, Hiroshi Tokumitsu, Ryoji Kobayashi

J Biol Chem. 2008 Oct 17; 283(42): 28246–28258. doi: 10.1074/jbc.M801473200

PMCID:: PMC2661394

Article PDF–879K

Select item 291026620.

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity

Hiroki Shiwaku, Natsue Yoshimura, Takuya Tamura, Masaki Sone, Soichi Ogishima, Kei Watase, Kazuhiko Tagawa, Hitoshi Okazawa

EMBO J. 2010 Jul 21; 29(14): 2446–2460. Published online 2010 Jun 8. doi: 10.1038/emboj.2010.116

PMCID:: PMC2910266

Article PDF–4.6M

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