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Select item 78567381.

Helicobacter pylori-induced gastric cancer is orchestrated by MRCKβ-mediated Siah2 phosphorylation

Pragyesh Dixit, Shrikant B. Kokate, Indrajit Poirah, Debashish Chakraborty, Duane T. Smoot, Hassan Ashktorab, Niranjan Rout, Shivaram P. Singh, Asima Bhattacharyya

J Biomed Sci. 2021; 28: 12. Published online 2021 Feb 3. doi: 10.1186/s12929-021-00710-0

PMCID:: PMC7856738

Article PDF–2.7M

Select item 75496362.

The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108

Mathieu Unbekandt, Sergio Lilla, Sara Zanivan, Michael F. Olson

Small GTPases. 2020; 11(6): 451–460. Published online 2019 Jan 22. doi: 10.1080/21541248.2018.1564472

PMCID:: PMC7549636

Article PDF–2.7M

Select item 61429173.

DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies

Olivera Story Jovanova, Ivana Nedeljkovic, Derek Spieler, Rosie M. Walker, Chunyu Liu, Michelle Luciano, Jan Bressler, Jennifer Brody, Amanda J. Drake, Kathryn L. Evans, Rahul Gondalia, Sonja Kunze, Brigitte Kuhnel, Jari Lahti, Rozenn N. Lemaitre, Riccardo E. Marioni, Brenton Swenson, Jayandra Jung Himali, Hongsheng Wu, Yun Li, Allan F. McRae, Tom C. Russ, James Stewart, Zhiying Wang, Guosheng Zhang, Karl-Heinz Ladwig, Andre G. Uitterlinden, Xiuqing Guo, Annette Peters, Katri Räikkönen, John M. Starr, Melanie Waldenberger, Naomi R. Wray, Eric A. Whitsel, Nona Sotoodehnia, Sudha Seshadri, David J. Porteous, Joyce van Meurs, Thomas H. Mosley, Andrew M. McIntosh, Michael M. Mendelson, Daniel Levy, Lifang Hou, Johan G. Eriksson, Myriam Fornage, Ian J. Deary, Andrea Baccarelli, Henning Tiemeier, Najaf Amin

JAMA Psychiatry. 2018 Sep; 75(9): 949–959. Published online 2018 Jul 11. doi: 10.1001/jamapsychiatry.2018.1725

Correction in:: JAMA Psychiatry. 2018 Nov; 75(11): 1206.

PMCID:: PMC6142917

Article

Select item 31768124.

Co-Crystal Structures of Inhibitors with MRCKβ, a Key Regulator of Tumor Cell Invasion

Timo Heikkila, Edward Wheatley, Diane Crighton, Ewald Schroder, Alexandra Boakes, Sarah J. Kaye, Mokdad Mezna, Leon Pang, Mathew Rushbrooke, Andrew Turnbull, Michael F. Olson

PLoS One. 2011; 6(9): e24825. Published online 2011 Sep 20. doi: 10.1371/journal.pone.0024825

PMCID:: PMC3176812

Article PDF–1.7M

Select item 28772525.

Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients

Yeon Joo Kim, Nayoung Kim, Min-Kyung Lee, Hyo-Jin Choi, Han Joo Baek, Chang-Hoon Nam

Exp Mol Med. 2010 May 31; 42(5): 319–326. Published online 2010 Feb 22. doi: 10.3858/emm.2010.42.5.030

PMCID:: PMC2877252

Article PDF–581K

Select item 24476376.

Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/β

Sung Hee Choi, Gabriella Czifra, Noemi Kedei, Nancy E. Lewin, Jozsef Lazar, Yongmei Pu, Victor E. Marquez, Peter M. Blumberg

J Biol Chem. 2008 Apr 18; 283(16): 10543–10549. doi: 10.1074/jbc.M707463200

PMCID:: PMC2447637

Article PDF–460K

Select item 33505767.

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

Brian J. O’Roak, Laura Vives, Santhosh Girirajan, Emre Karakoc, Nik Krumm, Bradley P. Coe, Roie Levy, Arthur Ko, Choli Lee, Joshua D. Smith, Emily H. Turner, Ian B. Stanaway, Benjamin Vernot, Maika Malig, Carl Baker, Beau Reilly, Joshua M. Akey, Elhanan Borenstein, Mark J. Rieder, Deborah A. Nickerson, Raphael Bernier, Jay Shendure, Evan E. Eichler

Nature. Author manuscript; available in PMC 2012 Nov 10.

Published in final edited form as: Nature. 2012 May 10; 485(7397): 246–250. Published online 2012 Apr 4. doi: 10.1038/nature10989

PMCID:: PMC3350576

Article PDF–480K

Select item 30419508.

Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration

Lin Huo, Wenyu Wen, Rui Wang, Chuen Kam, Jun Xia, Wei Feng, Mingjie Zhang

EMBO J. 2011 Feb 16; 30(4): 665–678. Published online 2011 Jan 14. doi: 10.1038/emboj.2010.353

PMCID:: PMC3041950

Article PDF–3.5M

Select item 57489779.

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion

Paolo Armando Gagliardi, Desiana Somale, Alberto Puliafito, Giulia Chiaverina, Laura di Blasio, Michele Oneto, Paolo Bianchini, Federico Bussolino, Luca Primo

J Cell Biol. 2018 Jan 2; 217(1): 231–249. doi: 10.1083/jcb.201703044

PMCID:: PMC5748977

Article PDF–4.1M

Select item 12146510.

Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization

Thomas Leung, Xiang-Qun Chen, Ivan Tan, Edward Manser, Louis Lim

Mol Cell Biol. 1998 Jan; 18(1): 130–140. doi: 10.1128/mcb.18.1.130

PMCID:: PMC121465

Article PDF–1.7M

Select item 550170111.

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

Ryan KC Yuen, Daniele Merico, Matt Bookman, Jennifer L Howe, Bhooma Thiruvahindrapuram, Rohan V Patel, Joe Whitney, Nicole Deflaux, Jonathan Bingham, Zhuozhi Wang, Giovanna Pellecchia, Janet A Buchanan, Susan Walker, Christian R Marshall, Mohammed Uddin, Mehdi Zarrei, Eric Deneault, Lia D’Abate, Ada JS Chan, Stephanie Koyanagi, Tara Paton, Sergio L Pereira, Ny Hoang, Worrawat Engchuan, Edward J Higginbotham, Karen Ho, Sylvia Lamoureux, Weili Li, Jeffrey R MacDonald, Thomas Nalpathamkalam, Wilson WL Sung, Fiona J Tsoi, John Wei, Lizhen Xu, Anne-Marie Tasse, Emily Kirby, William Van Etten, Simon Twigger, Wendy Roberts, Irene Drmic, Sanne Jilderda, Bonnie MacKinnon Modi, Barbara Kellam, Michael Szego, Cheryl Cytrynbaum, Rosanna Weksberg, Lonnie Zwaigenbaum, Marc Woodbury-Smith, Jessica Brian, Lili Senman, Alana Iaboni, Krissy Doyle-Thomas, Ann Thompson, Christina Chrysler, Jonathan Leef, Tal Savion-Lemieux, Isabel M Smith, Xudong Liu, Rob Nicolson, Vicki Seifer, Angie Fedele, Edwin H Cook, Stephen Dager, Annette Estes, Louise Gallagher, Beth A Malow, Jeremy R Parr, Sarah J Spence, Jacob Vorstman, Brendan J Frey, James T Robinson, Lisa J Strug, Bridget A Fernandez, Mayada Elsabbagh, Melissa T Carter, Joachim Hallmayer, Bartha M Knoppers, Evdokia Anagnostou, Peter Szatmari, Robert H Ring, David Glazer, Mathew T Pletcher, Stephen W Scherer

Nat Neurosci. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Nat Neurosci. 2017 Apr; 20(4): 602–611. Published online 2017 Mar 6. doi: 10.1038/nn.4524

PMCID:: PMC5501701

Article PDF–1.3M

Select item 325981512.

PAK Is Regulated by PI3K, PIX, CDC42, and PP2Cα and Mediates Focal Adhesion Turnover in the Hyperosmotic Stress-induced p38 Pathway

Perry M. Chan, Louis Lim, Edward Manser

J Biol Chem. 2008 Sep 5; 283(36): 24949–24961. doi: 10.1074/jbc.M801728200

PMCID:: PMC3259815

Article PDF–1.0M

Select item 370730513.

Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells

J-Y Chuang, S-A Wang, W-B Yang, H-C Yang, C-Y Hung, T-P Su, W-C Chang, J-J Hung

Oncogene. Author manuscript; available in PMC 2013 Jul 10.

Published in final edited form as: Oncogene. 2012 Nov 22; 31(47): 4946–4959. Published online 2012 Jan 23. doi: 10.1038/onc.2011.649

PMCID:: PMC3707305

Article PDF–6.7M

Select item 373297114.

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation

Emilie A. Bard-Chapeau, Jayantha Gunaratne, Pankaj Kumar, Belinda Q. Chua, Julius Muller, Frederic A. Bard, Walter Blackstock, Neal G. Copeland, Nancy A. Jenkins

Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31): E2885–E2894. Published online 2013 Jul 15. doi: 10.1073/pnas.1309310110

PMCID:: PMC3732971

Article PDF–1.9M

Select item 694423815.

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion

Antoine Méant, Beichen Gao, Geneviève Lavoie, Sami Nourreddine, Flora Jung, Léo Aubert, Joseph Tcherkezian, Anne-Claude Gingras, Philippe P. Roux

Mol Cell Proteomics. 2020 Jan; 19(1): 50–64. Published online 2019 Nov 2. doi: 10.1074/mcp.RA119.001811

PMCID:: PMC6944238

Article PDF–5.7M

Select item 122409116.

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

Mercedes Pozuelo Rubio, Kathryn M Geraghty, Barry H C Wong, Nicola T Wood, David G Campbell, Nick Morrice, Carol Mackintosh

Biochem J. 2004 Apr 15; 379(Pt 2): 395–408. doi: 10.1042/BJ20031797

PMCID:: PMC1224091

Summary PDF–323K

Select item 796299417.

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy

Yanke Chen, Ting Jiang, Hongyi Zhang, Xingchun Gou, Cong Han, Jianhui Wang, Ann T. Chen, Jun Ma, Jun Liu, Zeming Chen, Xintao Jing, Hong Lei, Zhenzhen Wang, Youmei Bao, Mehdi Baqri, Yong Zhu, Ranjit S. Bindra, James E. Hansen, Jun Dou, Chen Huang, Jiangbing Zhou

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1276–1285. Published online 2020 Oct 1. doi: 10.1038/s41556-020-00586-6

PMCID:: PMC7962994

Article PDF–5.5M

Select item 397730518.

RSPO–LGR4 functions via IQGAP1 to potentiate Wnt signaling

Kendra S. Carmon, Xing Gong, Jing Yi, Anthony Thomas, Qingyun Liu

Proc Natl Acad Sci U S A. 2014 Apr 1; 111(13): E1221–E1229. Published online 2014 Mar 17. doi: 10.1073/pnas.1323106111

PMCID:: PMC3977305

Article PDF–1.7M

Select item 461025719.

Systematic VCP-UBXD Adaptor Network Proteomics Identifies a Role for UBXN10 in Regulating Ciliogenesis

Malavika Raman, Mikhail Sergeev, Maija Garnaas, John R. Lydeard, Edward L. Huttlin, Wolfram Goessling, Jagesh V. Shah, J. Wade Harper

Nat Cell Biol. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Cell Biol. 2015 Oct; 17(10): 1356–1369. Published online 2015 Sep 21. doi: 10.1038/ncb3238

Correction in:: Nat Cell Biol. 2016 Mar; 18(3): 347.

PMCID:: PMC4610257

Article PDF–4.5M

Select item 660120820.

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18

Manal Alsulami, Nayla Munawar, Eugene Dillon, Giorgio Oliviero, Kieran Wynne, Mona Alsolami, Catherine Moss, Peadar Ó Gaora, Fergal O'Meara, David Cotter, Gerard Cagney

Mol Cell Proteomics. 2019 Jul; 18(7): 1428–1436. Published online 2019 May 10. doi: 10.1074/mcp.RA119.001518

PMCID:: PMC6601208

Article PDF–1.8M

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