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Items: 1 to 20 of 72

1.
Functional characterization of lysosomal interaction of Akt with VRK2
Noriyuki Hirata, Futoshi Suizu, Mami Matsuda-Lennikov, Tsutomu Tanaka, Tatsuma Edamura, Satoko Ishigaki, Thoria Donia, Pathrapol Lithanatudom, Chikashi Obuse, Toshihiko Iwanaga, Masayuki Noguchi
Oncogene. 2018; 37(40): 5367–5386. Published online 2018 Jun 5. doi: 10.1038/s41388-018-0330-0
PMCID:
PMC6172193
ArticlePDF–6.9M
2.
Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
Hoyoung Sohn, Borah Kim, Keun Hyang Kim, Min-Kyoung Kim, Tai Kiu Choi, Sang-Hyuk Lee
PLoS One. 2014; 9(7): e103519. Published online 2014 Jul 31. doi: 10.1371/journal.pone.0103519
PMCID:
PMC4117506
ArticlePDF–253K
3.
Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
Marta Vázquez-Cedeira, Iria Barcia-Sanjurjo, Marta Sanz-García, Ramiro Barcia, Pedro A. Lazo
PLoS One. 2011; 6(8): e23235. Published online 2011 Aug 4. doi: 10.1371/journal.pone.0023235
PMCID:
PMC3150407
ArticlePDF–900K
4.
Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice
Mei-Yu Yin, Lei Guo, Li-Juan Zhao, Chen Zhang, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li, Chuang Wang, Hong Chang
BMC Med. 2023; 21: 256. Published online 2023 Jul 14. doi: 10.1186/s12916-023-02945-0
PMCID:
PMC10349461
ArticlePDF–2.3M
5.
VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn
JCI Insight. 2022 Oct 10; 7(19): e158755. Published online 2022 Oct 10. doi: 10.1172/jci.insight.158755
PMCID:
PMC9675470
ArticlePDF–15M
6.
VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer
Jionghuang Chen, Kexiong Qiao, Chaolei Zhang, Xinyang Zhou, Qian Du, Yuezhen Deng, Liping Cao
Int J Biol Sci. 2022; 18(3): 1288–1302. Published online 2022 Jan 9. doi: 10.7150/ijbs.66313
PMCID:
PMC8771851
ArticlePDF–2.4M
7.
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
Rafael M. Couñago, Charles K. Allerston, Pavel Savitsky, Hatylas Azevedo, Paulo H. Godoi, Carrow I. Wells, Alessandra Mascarello, Fernando H. de Souza Gama, Katlin B. Massirer, William J. Zuercher, Cristiano R. W. Guimarães, Opher Gileadi
Sci Rep. 2017; 7: 7501. Published online 2017 Aug 8. doi: 10.1038/s41598-017-07755-y
PMCID:
PMC5548783
ArticlePDF–4.6M
8.
Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2
Annabel T. Olson, Amber B. Rico, Zhigang Wang, Gustavo Delhon, Matthew S. Wiebe
J Virol. 2017 Aug 1; 91(15): e00635-17. Prepublished online 2017 May 17. Published online 2017 Jul 12. doi: 10.1128/JVI.00635-17
PMCID:
PMC5512240
ArticlePDF–2.2M
9.
Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci
Samuel E. Jones, Jessica Tyrrell, Andrew R. Wood, Robin N. Beaumont, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F. Wilson, Fabiola Del Greco, Andrew A. Hicks, Chol Shin, Chang-Ho Yun, Seung Ku Lee, Andres Metspalu, Enda M. Byrne, Philip R. Gehrman, Henning Tiemeier, Karla V. Allebrandt, Rachel M. Freathy, Anna Murray, David A. Hinds, Timothy M. Frayling, Michael N. Weedon
PLoS Genet. 2016 Aug; 12(8): e1006125. Published online 2016 Aug 5. doi: 10.1371/journal.pgen.1006125
PMCID:
PMC4975467
ArticlePDF–2.3M
10.
Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study
Laura del Puerto-Nevado, Juan Pablo Marin-Arango, Maria Jesus Fernandez-Aceñero, David Arroyo-Manzano, Javier Martinez-Useros, Aurea Borrero-Palacios, Maria Rodriguez-Remirez, Arancha Cebrian, Teresa Gomez del Pulgar, Marlid Cruz-Ramos, Cristina Carames, Begoña Lopez-Botet, Jesús Garcia-Foncillas
BMC Cancer. 2016; 16: 519. Published online 2016 Jul 25. doi: 10.1186/s12885-016-2574-9
PMCID:
PMC4960836
ArticlePDF–953K
11.
Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression
D M Monsalve, T Merced, I F Fernández, S Blanco, M Vázquez-Cedeira, P A Lazo
Cell Death Dis. 2013 Feb; 4(2): e513. Published online 2013 Feb 28. doi: 10.1038/cddis.2013.40
PMCID:
PMC3734818
ArticlePDF–1.4M
12.
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
Stacy Steinberg, Simone de Jong, Ole A. Andreassen, Thomas Werge, Anders D. Børglum, Ole Mors, Preben B. Mortensen, Omar Gustafsson, Javier Costas, Olli P. H. Pietiläinen, Ditte Demontis, Sergi Papiol, Johanna Huttenlocher, Manuel Mattheisen, René Breuer, Evangelos Vassos, Ina Giegling, Gillian Fraser, Nicholas Walker, Annamari Tuulio-Henriksson, Jaana Suvisaari, Jouko Lönnqvist, Tiina Paunio, Ingrid Agartz, Ingrid Melle, Srdjan Djurovic, Eric Strengman, Gesche Jürgens, Birte Glenthøj, Lars Terenius, David M. Hougaard, Torben Ørntoft, Carsten Wiuf, Michael Didriksen, Mads V. Hollegaard, Merete Nordentoft, Ruud van Winkel, Gunter Kenis, Lilia Abramova, Vasily Kaleda, Manuel Arrojo, Julio Sanjuán, Celso Arango, Swetlana Sperling, Moritz Rossner, Michele Ribolsi, Valentina Magni, Alberto Siracusano, Claus Christiansen, Lambertus A. Kiemeney, Jan Veldink, Leonard van den Berg, Andres Ingason, Pierandrea Muglia, Robin Murray, Markus M. Nöthen, Engilbert Sigurdsson, Hannes Petursson, Unnur Thorsteinsdottir, Augustine Kong, I. Alex Rubino, Marc De Hert, János M. Réthelyi, István Bitter, Erik G. Jönsson, Vera Golimbet, Angel Carracedo, Hannelore Ehrenreich, Nick Craddock, Michael J. Owen, Michael C. O'Donovan, Mirella Ruggeri, Sarah Tosato, Leena Peltonen, Roel A. Ophoff, David A. Collier, David St Clair, Marcella Rietschel, Sven Cichon, Hreinn Stefansson, Dan Rujescu, Kari Stefansson, Irish Schizophrenia Genomics Consortium, GROUP, Wellcome Trust Case Control Consortium 2
Hum Mol Genet. 2011 Oct 15; 20(20): 4076–4081. Published online 2011 Jul 26. doi: 10.1093/hmg/ddr325
PMCID:
PMC3298077
ArticlePDF–103K
13.
Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
Eric D. Scheeff, Jeyanthy Eswaran, Gabor Bunkoczi, Stefan Knapp, Gerard Manning
Structure. 2009 Jan 14; 17(1): 128–138. doi: 10.1016/j.str.2008.10.018
PMCID:
PMC2639636
Article
14.
The Vaccinia-related Kinases Phosphorylate the N′ Terminus of BAF, Regulating Its Interaction with DNA and Its Retention in the Nucleus
R. Jeremy Nichols, Matthew S. Wiebe, Paula Traktman
Mol Biol Cell. 2006 May; 17(5): 2451–2464. doi: 10.1091/mbc.E05-12-1179
PMCID:
PMC1446082
ArticlePDF–574K
15.
Glycogen synthase kinase 3β suppresses polyglutamine aggregation by inhibiting Vaccinia-related kinase 2 activity
Eunju Lee, Hye Guk Ryu, Sangjune Kim, Dohyun Lee, Young-Hun Jeong, Kyong-Tai Kim
Sci Rep. 2016; 6: 29097. Published online 2016 Jul 5. doi: 10.1038/srep29097
PMCID:
PMC4932512
ArticlePDF–1.6M
16.
Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2
Marta Vázquez-Cedeira, Pedro A. Lazo
J Biol Chem. 2012 Dec 14; 287(51): 42739–42750. Published online 2012 Oct 26. doi: 10.1074/jbc.M112.404285
PMCID:
PMC3522273
ArticlePDF–969K
17.
VRK2 Inhibits Mitogen-Activated Protein Kinase Signaling and Inversely Correlates with ErbB2 in Human Breast Cancer
Isabel F. Fernández, Sandra Blanco, José Lozano, Pedro A. Lazo
Mol Cell Biol. 2010 Oct; 30(19): 4687–4697. Published online 2010 Aug 2. doi: 10.1128/MCB.01581-09
PMCID:
PMC2950518
ArticlePDF–2.1M
18.
Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
Marta Sanz-García, Inmaculada López-Sánchez, Pedro A. Lazo
Mol Cell Proteomics. 2008 Nov; 7(11): 2199–2214. doi: 10.1074/mcp.M700586-MCP200
PMCID:
PMC2577208
ArticlePDF–1.1M
19.
The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53
Alberto Valbuena, Sandra Blanco, Francisco M. Vega, Pedro A. Lazo
PLoS One. 2008; 3(7): e2649. Published online 2008 Jul 9. doi: 10.1371/journal.pone.0002649
PMCID:
PMC2441436
ArticlePDF–702K
20.
Vaccinia-Related Kinase 2 Mediates Accumulation of Polyglutamine Aggregates via Negative Regulation of the Chaperonin TRiC
Sangjune Kim, Do-Young Park, Dohyun Lee, Wanil Kim, Young-Hun Jeong, Juhyun Lee, Sung-Kee Chung, Hyunjung Ha, Bo-Hwa Choi, Kyong-Tai Kim
Mol Cell Biol. 2014 Feb; 34(4): 643–652. doi: 10.1128/MCB.00756-13
PMCID:
PMC3911496
ArticlePDF–1.7M

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