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Select item 102390681.

Genetic deletion of skeletal muscle iPLA₂γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism

Sung Ho Moon, Beverly Gibson Dilthey, Shaoping Guan, Harold F. Sims, Sara K. Pittman, Amy L. Keith, Christopher M. Jenkins, Conrad C. Weihl, Richard W. Gross

iScience. 2023 Jun 16; 26(6): 106895. Published online 2023 May 18. doi: 10.1016/j.isci.2023.106895

PMCID:: PMC10239068

Abstract Article PDF–6.4M

Select item 68381782.

Genetic Ablation of Calcium-independent Phospholipase A₂γ Exacerbates Glomerular Injury in Adriamycin Nephrosis in Mice

Hanan Elimam, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Andrey V. Cybulsky

Sci Rep. 2019; 9: 16229. Published online 2019 Nov 7. doi: 10.1038/s41598-019-52834-x

PMCID:: PMC6838178

Abstract Article PDF–3.6M

Select item 50167013.

Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A₂γ (iPLA₂γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size

Sung Ho Moon, David J. Mancuso, Harold F. Sims, Xinping Liu, Annie L. Nguyen, Kui Yang, Shaoping Guan, Beverly Gibson Dilthey, Christopher M. Jenkins, Carla J. Weinheimer, Attila Kovacs, Dana Abendschein, Richard W. Gross

J Biol Chem. 2016 Sep 9; 291(37): 19687–19700. Published online 2016 Jul 23. doi: 10.1074/jbc.M116.740597

PMCID:: PMC5016701

Abstract Article PDF–873K

Select item 29802834.

Genetic Ablation of Calcium-independent Phospholipase A₂γ Leads to Alterations in Mitochondrial Lipid Metabolism and Function Resulting in a Deficient Mitochondrial Bioenergetic Phenotype

David J. Mancuso, Harold F. Sims, Xianlin Han, Christopher M. Jenkins, Shao Ping Guan, Kui Yang, Sung Ho Moon, Terri Pietka, Nada A. Abumrad, Paul H. Schlesinger, Richard W. Gross

J Biol Chem. Author manuscript; available in PMC 2010 Nov 12.

Published in final edited form as: J Biol Chem. 2007 Nov 30; 282(48): 34611–34622. Published online 2007 Oct 8. doi: 10.1074/jbc.M707795200

PMCID:: PMC2980283

Abstract Article PDF–2.0M

Select item 29367545.

Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca²⁺-independent phospholipase A₂γ-deficient mice

Emiko Yoda, Keiko Hachisu, Yoshitaka Taketomi, Kotomi Yoshida, Masanori Nakamura, Kazutaka Ikeda, Ryo Taguchi, Yoshihito Nakatani, Hiroshi Kuwata, Makoto Murakami, Ichiro Kudo, Shuntaro Hara

J Lipid Res. 2010 Oct; 51(10): 3003–3015. doi: 10.1194/jlr.M008060

PMCID:: PMC2936754

Abstract Article PDF–1.3M

Select item 29176206.

Inhibition of Ca²⁺-Independent Phospholipase A₂ Results in Insufficient Insulin Secretion and Impaired Glucose Tolerance

Keying Song, Xu Zhang, Chunying Zhao, Natasha T. Ang, Zhongmin Alex Ma

Mol Endocrinol. Author manuscript; available in PMC 2010 Aug 8.

Published in final edited form as: Mol Endocrinol. 2005 Feb; 19(2): 504–515. Published online 2004 Oct 7. doi: 10.1210/me.2004-0169

PMCID:: PMC2917620

Abstract Article PDF–1015K

Select item 28865247.

Mice deficient in Group VIB phospholipase A₂ (iPLA₂γ) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet

Haowei Song, Mary Wohltmann, Shunzhong Bao, Jack H. Ladenson, Clay F. Semenkovich, John Turk

Am J Physiol Endocrinol Metab. 2010 Jun; 298(6): E1097–E1114. Published online 2010 Feb 23. doi: 10.1152/ajpendo.00780.2009

PMCID:: PMC2886524

Abstract Article

Select item 27909948.

Genetic Ablation of Calcium-independent Phospholipase A₂γ Leads to Alterations in Hippocampal Cardiolipin Content and Molecular Species Distribution, Mitochondrial Degeneration, Autophagy, and Cognitive Dysfunction

David J. Mancuso, Paul Kotzbauer, David F. Wozniak, Harold F. Sims, Christopher M. Jenkins, Shaoping Guan, Xianlin Han, Kui Yang, Gang Sun, Ibrahim Malik, Sara Conyers, Karen G. Green, Robert E. Schmidt, Richard W. Gross

J Biol Chem. 2009 Dec 18; 284(51): 35632–35644. Published online 2009 Oct 19. doi: 10.1074/jbc.M109.055194

PMCID:: PMC2790994

Abstract Article PDF–3.4M

Select item 54815729.

The phospholipase iPLA₂γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling

Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Maoyin Li, Harold F. Sims, Shaoping Guan, Richard W. Gross

J Biol Chem. 2017 Jun 23; 292(25): 10672–10684. Published online 2017 Apr 25. doi: 10.1074/jbc.M117.783068

PMCID:: PMC5481572

Abstract Article PDF–2.7M

Select item 507331510.

SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy

Kwang-Youn Kim, Hyun-Jun Jang, Yong Ryul Yang, Kwang-Il Park, JeongKon Seo, Il-Woo Shin, Tae-Il Jeon, Soon-cheol Ahn, Pann-Ghill Suh, Timothy F. Osborne, Young-Kyo Seo

Sci Rep. 2016; 6: 35732. Published online 2016 Oct 21. doi: 10.1038/srep35732

Correction in:: Sci Rep. 2016; 6: 37794.

PMCID:: PMC5073315

Abstract Article PDF–2.8M

Select item 493817111.

Genetic Ablation of Calcium-independent Phospholipase A₂γ Induces Glomerular Injury in Mice

Hanan Elimam, Joan Papillon, Daniel R. Kaufman, Julie Guillemette, Lamine Aoudjit, Richard W. Gross, Tomoko Takano, Andrey V. Cybulsky

J Biol Chem. 2016 Jul 8; 291(28): 14468–14482. Published online 2016 May 12. doi: 10.1074/jbc.M115.696781

PMCID:: PMC4938171

Abstract Article PDF–3.8M

Select item 431704612.

Calcium-independent Phospholipase A₂γ Enhances Activation of the ATF6 Transcription Factor during Endoplasmic Reticulum Stress

Hanan Elimam, Joan Papillon, Tomoko Takano, Andrey V. Cybulsky

J Biol Chem. 2015 Jan 30; 290(5): 3009–3020. Published online 2014 Dec 9. doi: 10.1074/jbc.M114.592261

PMCID:: PMC4317046

Abstract Article PDF–1.6M

Select item 419690213.

Group VIB Calcium-Independent Phospholipase A₂ (iPLA₂γ) Regulates Platelet Activation, Hemostasis and Thrombosis in Mice

Emiko Yoda, Kohmi Rai, Mai Ogawa, Yuki Takakura, Hiroshi Kuwata, Hidenori Suzuki, Yoshihito Nakatani, Makoto Murakami, Shuntaro Hara

PLoS One. 2014; 9(10): e109409. Published online 2014 Oct 14. doi: 10.1371/journal.pone.0109409

PMCID:: PMC4196902

Abstract Article PDF–1.2M

Select item 369761114.

The Absence of Myocardial Calcium-Independent Phospholipase A₂γ Results in Impaired Prostaglandin E₂ Production and Decreased Survival in Mice with Acute Trypanosoma cruzi Infection

Janhavi Sharma, Christopher S. Eickhoff, Daniel F. Hoft, David A. Ford, Richard W. Gross, Jane McHowat

Infect Immun. 2013 Jul; 81(7): 2278–2287. doi: 10.1128/IAI.00497-12

PMCID:: PMC3697611

Abstract Article PDF–1.0M

Select item 343618515.

Genetic Ablation of Calcium-independent Phospholipase A₂γ (iPLA₂γ) Attenuates Calcium-induced Opening of the Mitochondrial Permeability Transition Pore and Resultant Cytochrome c Release

Sung Ho Moon, Christopher M. Jenkins, Michael A. Kiebish, Harold F. Sims, David J. Mancuso, Richard W. Gross

J Biol Chem. 2012 Aug 24; 287(35): 29837–29850. Published online 2012 Jul 9. doi: 10.1074/jbc.M112.373654

PMCID:: PMC3436185

Abstract Article PDF–3.8M

Select item 334023116.

Activation of Mitochondrial Calcium-independent Phospholipase A₂γ (iPLA₂γ) by Divalent Cations Mediating Arachidonate Release and Production of Downstream Eicosanoids

Sung Ho Moon, Christopher M. Jenkins, Xinping Liu, Shaoping Guan, David J. Mancuso, Richard W. Gross

J Biol Chem. 2012 Apr 27; 287(18): 14880–14895. Published online 2012 Mar 2. doi: 10.1074/jbc.M111.336776

PMCID:: PMC3340231

Abstract Article PDF–2.6M

Select item 297857817.

Genetic Ablation of Calcium-independent Phospholipase A₂γ Prevents Obesity and Insulin Resistance during High Fat Feeding by Mitochondrial Uncoupling and Increased Adipocyte Fatty Acid Oxidation

David J. Mancuso, Harold F. Sims, Kui Yang, Michael A. Kiebish, Xiong Su, Christopher M. Jenkins, Shaoping Guan, Sung Ho Moon, Terri Pietka, Fatiha Nassir, Timothy Schappe, Kristin Moore, Xianlin Han, Nada A. Abumrad, Richard W. Gross

J Biol Chem. 2010 Nov 19; 285(47): 36495–36510. Published online 2010 Sep 3. doi: 10.1074/jbc.M110.115766

PMCID:: PMC2978578

Abstract Article PDF–4.8M

Select item 717052218.

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA₂γ knockout

Xinping Liu, Harold F. Sims, Christopher M. Jenkins, Shaoping Guan, Beverly G. Dilthey, Richard W. Gross

J Biol Chem. 2020 Apr 17; 295(16): 5307–5320. Published online 2020 Mar 11. doi: 10.1074/jbc.RA119.012296

PMCID:: PMC7170522

Abstract Article PDF–3.1M

Select item 307462919.

Activation of group VI phospholipase A₂ isoforms in cardiac endothelial cells

Janhavi Sharma, John Turk, David J. Mancuso, Harold F. Sims, Richard W. Gross, Jane McHowat

Am J Physiol Cell Physiol. 2011 Apr; 300(4): C872–C879. Published online 2011 Jan 12. doi: 10.1152/ajpcell.00289.2010

PMCID:: PMC3074629

Abstract Article

Select item 729503320.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

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