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Select item 109405441.

A Bcl11b^N797K variant isolated from an immunodeficient patient inhibits early thymocyte development in mice

Kazuaki Matsumoto, Kazuki Okuyama, Tom Sidwell, Motoi Yamashita, Takaho Endo, Naoko Satoh-Takayama, Hiroshi Ohno, Tomohiro Morio, Ellen V. Rothenberg, Ichiro Taniuchi

Front Immunol. 2024; 15: 1363704. Published online 2024 Mar 1. doi: 10.3389/fimmu.2024.1363704

PMCID:: PMC10940544

Article PDF–5.1M

Select item 107835272.

The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene

Elise Vickridge, Camila C F Faraco, Fanny Lo, Hedyeh Rahimian, Zi Yang Liu, Payman S Tehrani, Billel Djerir, Zubaidah M Ramdzan, Lam Leduy, Alexandre Maréchal, Anne-Claude Gingras, Alain Nepveu

Nucleic Acids Res. 2024 Jan 11; 52(1): 223–242. Published online 2023 Nov 13. doi: 10.1093/nar/gkad1037

PMCID:: PMC10783527

Article PDF–2.3M

Select item 96646383.

Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau, Anke K. Bergmann

Clin Epigenetics. 2022; 14: 148. Published online 2022 Nov 14. doi: 10.1186/s13148-022-01362-z

Correction in:: Clin Epigenetics. 2023; 15: 3.

PMCID:: PMC9664638

Article PDF–1.6M

Select item 86491744.

Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage

Lindsey E. Montefiori, Charles G. Mullighan

Best Pract Res Clin Haematol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Best Pract Res Clin Haematol. 2021 Dec; 34(4): 101329. Published online 2021 Oct 23. doi: 10.1016/j.beha.2021.101329

PMCID:: PMC8649174

Article PDF–1.0M

Select item 86011525.

Human cytomegalovirus expands a CD8⁺ T cell population with loss of BCL11B expression and gain of NK cell identity

Rosa Sottile, M. Kazim Panjwani, Colleen M. Lau, Anthony F. Daniyan, Kento Tanaka, Juliet N. Barker, Renier J. Brentjens, Joseph C. Sun, Jean-Benoit Le Luduec, Katharine C. Hsu

Sci Immunol. Author manuscript; available in PMC 2022 Mar 24.

Published in final edited form as: Sci Immunol. 2021 Sep 24; 6(63): eabe6968. Published online 2021 Sep 24. doi: 10.1126/sciimmunol.abe6968

PMCID:: PMC8601152

Article PDF–3.4M

Select item 85633956.

Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous stem cell leukemia

Lindsey E. Montefiori, Sonja Bendig, Zhaohui Gu, Xiaolong Chen, Petri Pölönen, Xiaotu Ma, Alex Murison, Andy Zeng, Laura Garcia-Prat, Kirsten Dickerson, Ilaria Iacobucci, Sherif Abdelhamed, Ryan Hiltenbrand, Paul E. Mead, Cyrus M. Mehr, Beisi Xu, Zhongshan Cheng, Ti-Cheng Chang, Tamara Westover, Jing Ma, Anna Stengel, Shunsuke Kimura, Chunxu Qu, Marcus B. Valentine, Marissa Rashkovan, Selina Luger, Mark R. Litzow, Jacob M. Rowe, Monique L. den Boer, Victoria Wang, Jun Yin, Steven M. Kornblau, Stephen P. Hunger, Mignon L. Loh, Ching-Hon Pui, Wenjian Yang, Kristine R. Crews, Kathryn G. Roberts, Jun J. Yang, Mary V. Relling, William E. Evans, Wendy Stock, Elisabeth M. Paietta, Adolfo A. Ferrando, Jinghui Zhang, Wolfgang Kern, Torsten Haferlach, Gang Wu, John E. Dick, Jeffery M. Klco, Claudia Haferlach, Charles G. Mullighan

Cancer Discov. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: Cancer Discov. 2021 Nov; 11(11): 2846–2867. Published online 2021 Jun 8. doi: 10.1158/2159-8290.CD-21-0145

PMCID:: PMC8563395

Article PDF–3.2M

Select item 85136707.

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Danika Di Giacomo, Roberta La Starza, Paolo Gorello, Fabrizia Pellanera, Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Pierini, Christine J. Harrison, Silvia Arniani, Martina Moretti, Nicoletta Testoni, Giovanna De Santis, Giovanni Roti, Caterina Matteucci, Renato Bassan, Peter Vandenberghe, Stein Aerts, Jan Cools, Beat Bornhauser, Jean-Pierre Bourquin, Rocco Piazza, Cristina Mecucci

Blood. 2021 Sep 2; 138(9): 773–784. Prepublished online 2021 Apr 19. doi: 10.1182/blood.2020010510

PMCID:: PMC8513670

Article

Select item 67397398.

CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease

Marija Fjodorova, Morgane Louessard, Zongze Li, Daniel C. De La Fuente, Emma Dyke, Simon P. Brooks, Anselme L. Perrier, Meng Li

Stem Cell Reports. 2019 Sep 10; 13(3): 448–457. Published online 2019 Aug 22. doi: 10.1016/j.stemcr.2019.07.015

PMCID:: PMC6739739

Article PDF–4.0M

Select item 67322789.

A De Novo heterozygous frameshift mutation identified in BCL11B causes neurodevelopmental disorder by whole exome sequencing

Fengchang Qiao, Chen Wang, Chunyu Luo, Yan Wang, Binbin Shao, Jianxin Tan, Ping Hu, Zhengfeng Xu

Mol Genet Genomic Med. 2019 Sep; 7(9): e897. Published online 2019 Jul 25. doi: 10.1002/mgg3.897

PMCID:: PMC6732278

Article PDF–717K

Select item 615505310.

Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus

Tsuyoshi Hachiya, Akira Narita, Hideki Ohmomo, Yoichi Sutoh, Shohei Komaki, Kozo Tanno, Mamoru Satoh, Kiyomi Sakata, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Masayuki Yamamoto, Makoto Sasaki, Atsushi Hozawa, Atsushi Shimizu

Sci Rep. 2018; 8: 14162. Published online 2018 Sep 21. doi: 10.1038/s41598-018-32074-1

PMCID:: PMC6155053

Article PDF–2.6M

Select item 591853011.

BCL11B Drives Human Mammary Stem Cell Self-Renewal In Vitro by Inhibiting Basal Differentiation

Daniel H. Miller, Dexter X. Jin, Ethan S. Sokol, Janel R. Cabrera, Daphne A. Superville, Rebecca A. Gorelov, Charlotte Kuperwasser, Piyush B. Gupta

Stem Cell Reports. 2018 Mar 13; 10(3): 1131–1145. Published online 2018 Mar 1. doi: 10.1016/j.stemcr.2018.01.036

PMCID:: PMC5918530

Article PDF–3.6M

Select item 580968512.

The N-Terminal CCHC Zinc Finger Motif Mediates Homodimerization of Transcription Factor BCL11B

Piotr Grabarczyk, Passorn Winkler, Martin Delin, Praveen K. Sappa, Sander Bekeschus, Petra Hildebrandt, Grzegorz K. Przybylski, Uwe Völker, Elke Hammer, Christian A. Schmidt

Mol Cell Biol. 2018 Mar 1; 38(5): e00368-17. Prepublished online 2017 Dec 4. Published online 2018 Feb 12. doi: 10.1128/MCB.00368-17

PMCID:: PMC5809685

Article PDF–3.8M

Select item 559932613.

VL Ha, A Luong, F Li, D Casero, J Malvar, YM Kim, R Bhatia, GM Crooks, C Parekh

Leukemia. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Leukemia. 2017 Nov; 31(11): 2503–2514. Published online 2017 Feb 24. doi: 10.1038/leu.2017.70

PMCID:: PMC5599326

Article PDF–1.0M

Select item 491174514.

Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4⁺ T-Cell Activation

Marion Dubuissez, Ingrid Loison, Sonia Paget, Han Vorng, Saliha Ait-Yahia, Olivier Rohr, Anne Tsicopoulos, Dominique Leprince

Mol Cell Biol. 2016 Jul 1; 36(13): 1881–1898. Prepublished online 2016 May 9. Published online 2016 Jun 15. doi: 10.1128/MCB.00062-16

PMCID:: PMC4911745

Article PDF–4.7M

Select item 422362615.

Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients

Isabelle Bartram, Nicola Gökbuget, Cornelia Schlee, Sandra Heesch, Lars Fransecky, Stefan Schwartz, Reingard Stuhlmann, Kerstin Schäfer-Eckhart, Michael Starck, Albrecht Reichle, Dieter Hoelzer, Claudia D Baldus, Martin Neumann

J Hematol Oncol. 2014; 7: 51. Published online 2014 Jul 15. doi: 10.1186/s13045-014-0051-y

PMCID:: PMC4223626

Article PDF–1.3M

Select item 413539316.

The multifaceted roles of Bcl11b in thymic and peripheral T cells - impact on immune diseases

Dorina Avram, Danielle Califano

J Immunol. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: J Immunol. 2014 Sep 1; 193(5): 2059–2065. doi: 10.4049/jimmunol.1400930

PMCID:: PMC4135393

Article PDF–358K

Select item 400811117.

Integrated genome-wide genotyping and gene expression profiling reveals BCL11B as a putative oncogene in acute myeloid leukemia with 14q32 aberrations

Saman Abbas, Mathijs A. Sanders, Annelieke Zeilemaker, Wendy M.C. Geertsma-Kleinekoort, Jasper E. Koenders, Francois G. Kavelaars, Zabiollah G. Abbas, Souad Mahamoud, Isabel W.T. Chu, Remco Hoogenboezem, Justine K. Peeters, Ellen van Drunen, Janneke van Galen, H. Berna Beverloo, Bob Löwenberg, Peter J.M. Valk

Haematologica. 2014 May; 99(5): 848–857. doi: 10.3324/haematol.2013.095604

PMCID:: PMC4008111

Article PDF–11M

Select item 355933718.

Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma

Nobuyuki Kurosawa, Rika Fujimoto, Tatsuhiko Ozawa, Takahiro Itoyama, Naoki Sadamori, Masaharu Isobe

PLoS One. 2013; 8(1): e55147. Published online 2013 Jan 30. doi: 10.1371/journal.pone.0055147

PMCID:: PMC3559337

Article PDF–809K

Select item 336524619.

Role of the transcription factor Bcl11b in development and lymphomagenesis

Ryo KOMINAMI

Proc Jpn Acad Ser B Phys Biol Sci. 2012 Mar 9; 88(3): 72–87. doi: 10.2183/pjab.88.72

PMCID:: PMC3365246

Article PDF–432K

Select item 328839220.

Common Genetic Variation in the 3-BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk The AortaGen Consortium

Gary F. Mitchell, Germaine C. Verwoert, Kirill V. Tarasov, Aaron Isaacs, Albert V. Smith, Yasmin, Ernst R. Rietzschel, Toshiko Tanaka, Yongmei Liu, Afshin Parsa, Samer S. Najjar, Kevin M. O’Shaughnessy, Sigurdur Sigurdsson, Marc L. De Buyzere, Martin G. Larson, Mark P.S. Sie, Jeanette S. Andrews, Wendy S. Post, Francesco U.S. Mattace-Raso, Carmel M. McEniery, Gudny Eiriksdottir, Patrick Segers, Ramachandran S. Vasan, Marie Josee E. van Rijn, Timothy D. Howard, Patrick F. McArdle, Abbas Dehghan, Elizabeth Jewell, Stephen J. Newhouse, Sofie Bekaert, Naomi M. Hamburg, Anne B. Newman, Albert Hofman, Angelo Scuteri, Dirk De Bacquer, Mohammad Arfan Ikram, Bruce Psaty, Christian Fuchsberger, Matthias Olden, Louise V. Wain, Paul Elliott, Nicholas L. Smith, Janine F. Felix, Jeanette Erdmann, Joseph A. Vita, Kim Sutton-Tyrrell, Eric J.G. Sijbrands, Serena Sanna, Lenore J. Launer, Tim De Meyer, Andrew D. Johnson, Anna F.C. Schut, David M. Herrington, Fernando Rivadeneira, Manuela Uda, Ian B. Wilkinson, Thor Aspelund, Thierry C. Gillebert, Luc Van Bortel, Emelia J. Benjamin, Ben A. Oostra, Jingzhong Ding, Quince Gibson, André G. Uitterlinden, Gonçalo R. Abecasis, John R. Cockcroft, Vilmundur Gudnason, Guy G. De Backer, Luigi Ferrucci, Tamara B. Harris, Alan R. Shuldiner, Cornelia M. van Duijn, Daniel Levy, Edward G. Lakatta, Jacqueline C.M. Witteman

Circ Cardiovasc Genet. Author manuscript; available in PMC 2013 Feb 1.

Published in final edited form as: Circ Cardiovasc Genet. 2012 Feb 1; 5(1): 81–90. Published online 2011 Nov 8. doi: 10.1161/CIRCGENETICS.111.959817

PMCID:: PMC3288392

Article PDF–792K

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