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Select item 103111111.

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE^−/− mice

Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qin

Clin Sci (Lond) 2023 Jun; 137(12): 979–993. Published online 2023 Jun 28. doi: 10.1042/CS20230031

PMCID:: PMC10311111

Article PDF–3.9M

Select item 101731912.

ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Zongli Zhang, Yue Yuan, Lin Hu, Jian Tang, Zhongji Meng, Longjun Dai, Yujiu Gao, Shinan Ma, Xiaoli Wang, Yahong Yuan, Qiufang Zhang, Weibin Cai, Xuzhi Ruan, Xingrong Guo

J Adv Res. 2023 May; 47: 41–56. Published online 2022 Aug 27. doi: 10.1016/j.jare.2022.08.006

PMCID:: PMC10173191

Article PDF–8.2M

Select item 94046963.

ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo

Front Endocrinol (Lausanne) 2022; 13: 927763. Published online 2022 Aug 11. doi: 10.3389/fendo.2022.927763

PMCID:: PMC9404696

Article PDF–46M

Select item 84666414.

Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment

Hossein Arefanian, Irina Al-Khairi, Nermeen Abu Khalaf, Preethi Cherian, Sina Kavalakatt, Dhanya Madhu, Aditi Mathur, Mohamed G. Qaddoumi, Fahd Al-Mulla, Jehad Abubaker, Mohamed Abu-Farha

Lipids Health Dis. 2021; 20: 117. Published online 2021 Sep 26. doi: 10.1186/s12944-021-01547-0

PMCID:: PMC8466641

Article PDF–3.2M

Select item 82157835.

Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells

Yu Bai, Qiang Du, Le Zhang, Ling Li, Nana Wang, Bo Wu, Ping Li, Ling Li

Front Endocrinol (Lausanne) 2021; 12: 635321. Published online 2021 Jun 8. doi: 10.3389/fendo.2021.635321

PMCID:: PMC8215783

Article PDF–1.7M

Select item 75264406.

ANGPTL8 has both endocrine and autocrine effects on substrate utilization

Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs

JCI Insight. 2020 Sep 3; 5(17): e138777. Published online 2020 Sep 3. doi: 10.1172/jci.insight.138777

PMCID:: PMC7526440

Article PDF–14M

Select item 66846157.

Angptl8 mediates food-driven resetting of hepatic circadian clock in mice

Siyu Chen, Mengyang Feng, Shiyao Zhang, Zhewen Dong, Yifan Wang, Wenxiang Zhang, Chang Liu

Nat Commun. 2019; 10: 3518. Published online 2019 Aug 6. doi: 10.1038/s41467-019-11513-1

PMCID:: PMC6684615

Article PDF–3.6M

Select item 54608328.

ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice

Viktoria Gusarova, Serena Banfi, Corey A. Alexa-Braun, Lisa M. Shihanian, Ivory J. Mintah, Joseph S. Lee, Yurong Xin, Qi Su, Vishal Kamat, Jonathan C. Cohen, Helen H. Hobbs, Brian Zambrowicz, George D. Yancopoulos, Andrew J. Murphy, Jesper Gromada

Endocrinology. 2017 May 1; 158(5): 1252–1259. Published online 2017 Feb 15. doi: 10.1210/en.2016-1894

PMCID:: PMC5460832

Article

Select item 44730789.

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

Aaron R. Cox, Carol J. Lam, Claire W. Bonnyman, Julia Chavez, Jacqueline S. Rios, Jake A. Kushner

Diabetologia. 2015; 58(7): 1523–1531. Published online 2015 Apr 28. doi: 10.1007/s00125-015-3590-z

PMCID:: PMC4473078

Article PDF–938K

Select item 929396410.

ANGPTL8 is a negative regulator in pathological cardiac hypertrophy

Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang

Cell Death Dis. 2022 Jul; 13(7): 621. Published online 2022 Jul 18. doi: 10.1038/s41419-022-05029-8

PMCID:: PMC9293964

Article PDF–8.3M

Select item 845605511.

Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8

Kelli L. Sylvers-Davie, Ashley Segura-Roman, Alicia M. Salvi, Kylie J. Schache, Brandon S.J. Davies

J Lipid Res. 2021; 62: 100112. Published online 2021 Aug 27. doi: 10.1016/j.jlr.2021.100112

PMCID:: PMC8456055

Article PDF–2.1M

Select item 674725212.

Loss of Glycine N-Methyltransferase Associates with Angiopoietin-Like Protein 8 Expression in High Fat-Diet-Fed Mice

Jian-Wei Huang, Chao-Ju Chen, Chia-Hung Yen, Yi-Ming Arthur Chen, Yu-Peng Liu

Int J Mol Sci. 2019 Sep; 20(17): 4223. Published online 2019 Aug 29. doi: 10.3390/ijms20174223

PMCID:: PMC6747252

Article PDF–1.3M

Select item 564160413.

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

Xun Chi, Emily C. Britt, Hannah W. Shows, Alexander J. Hjelmaas, Shwetha K. Shetty, Emily M. Cushing, Wendy Li, Alex Dou, Ren Zhang, Brandon S.J. Davies

Mol Metab. 2017 Oct; 6(10): 1137–1149. Published online 2017 Jun 29. doi: 10.1016/j.molmet.2017.06.014

PMCID:: PMC5641604

Article PDF–1.8M

Select item 482074314.

Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies

Yong-ho Lee, Sang-Guk Lee, Chan Joo Lee, Soo Hyun Kim, Young-Mi Song, Mi Ra Yoon, Byung Hun Jeon, Jae Hyuk Lee, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong-Soo Cha

Sci Rep. 2016; 6: 24013. Published online 2016 Apr 5. doi: 10.1038/srep24013

PMCID:: PMC4820743

Article PDF–1.4M

Select item 396450115.

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

Yang Jiao, John Le Lay, Ming Yu, Ali Naji, Klaus H. Kaestner

Diabetes. 2014 Apr; 63(4): 1283–1288. Published online 2014 Mar 13. doi: 10.2337/db13-1435

PMCID:: PMC3964501

Article PDF–1.4M

Select item 379173416.

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

Yan Wang, Fabiana Quagliarini, Viktoria Gusarova, Jesper Gromada, David M. Valenzuela, Jonathan C. Cohen, Helen H. Hobbs

Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40): 16109–16114. Published online 2013 Sep 16. doi: 10.1073/pnas.1315292110

PMCID:: PMC3791734

Article PDF–877K

Select item 424304017.

ANGPTL8 (Betatrophin) Does Not Control Pancreatic Beta Cell Expansion

Viktoria Gusarova, Corey A. Alexa, Erqian Na, Panayiotis E. Stevis, Yurong Xin, Susan Bonner-Weir, Jonathan C. Cohen, Helen H. Hobbs, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada

Cell. Author manuscript; available in PMC 2015 Oct 23.

Published in final edited form as: Cell. 2014 Oct 23; 159(3): 691–696. doi: 10.1016/j.cell.2014.09.027

PMCID:: PMC4243040

Article PDF–1.1M

Select item 342312018.

Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism

Gang Ren, Ji Young Kim, Cynthia M. Smas

Am J Physiol Endocrinol Metab. 2012 Aug 1; 303(3): E334–E351. Published online 2012 May 8. doi: 10.1152/ajpendo.00084.2012

PMCID:: PMC3423120

Article

Select item 1036312019.

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis

Dan-Pei Li, Li Huang, Ran-Ran Kan, Xiao-Yu Meng, Shu-Yun Wang, Hua-Jie Zou, Ya-Ming Guo, Pei-Qiong Luo, Li-Meng Pan, Yu-Xi Xiang, Bei-Bei Mao, Yu-Yu Xie, Zhi-Han Wang, Min Yang, Rui He, Yan Yang, Zhe-Long Liu, Jun-Hui Xie, De-Lin Ma, Ben-Ping Zhang, Shi-Ying Shao, Xi Chen, Si-Miao Xu, Wen-Tao He, Wen-Jun Li, Yong Chen, Xue-Feng Yu

Nat Commun. 2023; 14: 4436. Published online 2023 Jul 22. doi: 10.1038/s41467-023-40183-3