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Select item 89860731.

Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway

Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S. Kanwar

JCI Insight. 2022 Mar 22; 7(6): e155487. Published online 2022 Mar 22. doi: 10.1172/jci.insight.155487

PMCID:: PMC8986073

Article PDF–4.4M

Select item 88970162.

Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis

Xiaoping Zheng, Fei Deng, Isha Sharma, Yashpal S. Kanwar

Am J Physiol Renal Physiol. 2022 Mar 1; 322(3): F344–F359. Published online 2022 Feb 1. doi: 10.1152/ajprenal.00460.2021

PMCID:: PMC8897016

Article

Select item 68191053.

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

Fei Deng, Isha Sharma, Yingbo Dai, Ming Yang, Yashpal S. Kanwar

J Clin Invest. 2019 Nov 1; 129(11): 5033–5049. Published online 2019 Oct 14. doi: 10.1172/JCI129903

PMCID:: PMC6819105

Article PDF–41M

Select item 44468754.

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

Ming Zhan, Irtaza M. Usman, Lin Sun, Yashpal S. Kanwar

J Am Soc Nephrol. 2015 Jun; 26(6): 1304–1321. Published online 2014 Sep 30. doi: 10.1681/ASN.2014050457

PMCID:: PMC4446875

Article

Select item 36708395.

Kidney Specific Protein-Positive Cells Derived from Embryonic Stem Cells Reproduce Tubular Structures In Vitro and Differentiate into Renal Tubular Cells

Ryuji Morizane, Toshiaki Monkawa, Shizuka Fujii, Shintaro Yamaguchi, Koichiro Homma, Yumi Matsuzaki, Hideyuki Okano, Hiroshi Itoh

PLoS One. 2013; 8(6): e64843. Published online 2013 Jun 3. doi: 10.1371/journal.pone.0064843

PMCID:: PMC3670839

Article PDF–18M

Select item 22429146.

Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase

Peter M. Brown, Tom T. Caradoc-Davies, James M. Dickson, Garth J. S. Cooper, Kerry M. Loomes, Edward N. Baker

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1; 62(Pt 8): 811–813. Published online 2006 Jul 25. doi: 10.1107/S1744309106028144

PMCID:: PMC2242914

Article PDF–301K

Select item 54077287.

Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI

Rajesh K. Dutta, Vinay K. Kondeti, Isha Sharma, Navdeep S. Chandel, Susan E. Quaggin, Yashpal S. Kanwar

J Am Soc Nephrol. 2017 May; 28(5): 1421–1436. Published online 2016 Nov 28. doi: 10.1681/ASN.2016070744

PMCID:: PMC5407728

Article

Select item 28868168.

Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis

Ping Xie, Lin Sun, Peter J. Oates, Satish K. Srivastava, Yashpal S. Kanwar

Am J Physiol Renal Physiol. 2010 Jun; 298(6): F1393–F1404. Published online 2010 Mar 24. doi: 10.1152/ajprenal.00137.2010

PMCID:: PMC2886816

Article

Select item 13124169.

Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience

Baibaswata Nayak, Ping Xie, Shigeru Akagi, Qiwei Yang, Lin Sun, Jun Wada, Arun Thakur, Farhad R. Danesh, Sumant S. Chugh, Yashpal S. Kanwar

Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50): 17952–17957. Published online 2005 Dec 5. doi: 10.1073/pnas.0509089102

PMCID:: PMC1312416

Article PDF–561K

Select item 639737110.

Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress

Tatsuya Tominaga, Isha Sharma, Yui Fujita, Toshio Doi, Aryana K. Wallner, Yashpal S. Kanwar

Am J Physiol Renal Physiol. 2019 Feb 1; 316(2): F301–F315. Published online 2018 Dec 12. doi: 10.1152/ajprenal.00534.2018

PMCID:: PMC6397371

Article

Select item 539768111.

High Glucose–Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy

Isha Sharma, Rajesh K. Dutta, Neel K. Singh, Yashpal S. Kanwar

Am J Pathol. 2017 Apr; 187(4): 724–739. doi: 10.1016/j.ajpath.2016.12.011

PMCID:: PMC5397681

Article PDF–4.0M

Select item 471422012.

Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES

Tatsuya Tominaga, Rajesh K. Dutta, Darukeshwara Joladarashi, Toshio Doi, Janardan K. Reddy, Yashpal S. Kanwar

J Biol Chem. 2016 Jan 15; 291(3): 1348–1367. Published online 2015 Nov 17. doi: 10.1074/jbc.M115.698191

PMCID:: PMC4714220

Article PDF–11M

Select item 2761813.

Identification of a renal-specific oxido-reductase in newborn diabetic mice

Qiwei Yang, Bharat Dixit, Jun Wada, Yufeng Tian, Elisabeth I. Wallner, Satish K. Srivastva, Yashpal S. Kanwar

Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18): 9896–9901. Published online 2000 Aug 15. doi: 10.1073/pnas.160266197

PMCID:: PMC27618

Article PDF–378K

Select item 724329414.

Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes

Isha Sharma, Fei Deng, Yingjun Liao, Yashpal S. Kanwar

Diabetes. 2020 Jun; 69(6): 1248–1263. Published online 2020 Mar 13. doi: 10.2337/db19-0935

PMCID:: PMC7243294

Article PDF–6.7M

Select item 122223115.

myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol.

R J Arner, K S Prabhu, J T Thompson, G R Hildenbrandt, A D Liken, C C Reddy

Biochem J. 2001 Dec 1; 360(Pt 2): 313–320. doi: 10.1042/0264-6021:3600313

PMCID:: PMC1222231

Summary PDF–208K

Select item 162277416.

Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism

Peter M. Brown, Tom T. Caradoc-Davies, James M. J. Dickson, Garth J. S. Cooper, Kerry M. Loomes, Edward N. Baker

Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41): 15032–15037. Published online 2006 Sep 29. doi: 10.1073/pnas.0605143103

PMCID:: PMC1622774

Article PDF–2.0M

Select item 307093717.

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition

Jing Chen, Collin Melton, Nayoung Suh, Jeong Su Oh, Kathleen Horner, Fang Xie, Claudio Sette, Robert Blelloch, Marco Conti

Genes Dev. 2011 Apr; 25(7): 755–766. doi: 10.1101/gad.2028911

PMCID:: PMC3070937

Article PDF–965K

Select item 30876318.

GenePaint.org: an atlas of gene expression patterns in the mouse embryo

Axel Visel, Christina Thaller, Gregor Eichele

Nucleic Acids Res. 2004 Jan 1; 32(Database issue): D552–D556. doi: 10.1093/nar/gkh029

PMCID:: PMC308763

Article PDF–253K

Select item 1683319.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Article PDF–847K

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163