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Select item 77904151.

Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

Passley Hargrove-Grimes, Anupam K. Mondal, Jessica Gumerson, Jacob Nellissery, Angel M. Aponte, Linn Gieser, Haohua Qian, Robert N. Fariss, Juan S. Bonifacino, Tiansen Li, Anand Swaroop

PLoS Genet. 2020 Dec; 16(12): e1009259. Published online 2020 Dec 23. doi: 10.1371/journal.pgen.1009259

PMCID:: PMC7790415

Article PDF–4.4M

Select item 36976202.

Regulation of Rab5 Function during Phagocytosis of Live Pseudomonas aeruginosa in Macrophages

Sushmita Mustafi, Nathalie Rivero, Joan C. Olson, Philip D. Stahl, M. Alejandro Barbieri

Infect Immun. 2013 Jul; 81(7): 2426–2436. doi: 10.1128/IAI.00387-13

PMCID:: PMC3697620

Article PDF–1.1M

Select item 42452263.

RABEX-5 Is Upregulated and Plays an Oncogenic Role in Gastric Cancer Development by Activating the VEGF Signaling Pathway

Shuang Wang, Aixia Lu, Xiangming Chen, Lin Wei, Jiqiang Ding

PLoS One. 2014; 9(11): e113891. Published online 2014 Nov 26. doi: 10.1371/journal.pone.0113891

PMCID:: PMC4245226

Article PDF–12M

Select item 41385794.

Rab5 Activity Regulates GLUT4 Sorting Into Insulin-Responsive and Non-Insulin-Responsive Endosomal Compartments: A Potential Mechanism for Development of Insulin Resistance

Kandice L. Tessneer, Robert M. Jackson, Beth A. Griesel, Ann Louise Olson

Endocrinology. 2014 Sep; 155(9): 3315–3328. Published online 2014 Jun 16. doi: 10.1210/en.2013-2148

PMCID:: PMC4138579

Article

Select item 36172845.

Rabex-5 Protein Regulates Dendritic Localization of Small GTPase Rab17 and Neurite Morphogenesis in Hippocampal Neurons

Yasunori Mori, Takahide Matsui, Mitsunori Fukuda

J Biol Chem. 2013 Apr 5; 288(14): 9835–9847. Published online 2013 Feb 19. doi: 10.1074/jbc.M112.427591

PMCID:: PMC3617284

Article PDF–3.1M

Select item 28219166.

Delayed Onset of Positive Feedback Activation of Rab5 by Rabex-5 and Rabaptin-5 in Endocytosis

Huaiping Zhu, Hong Qian, Guangpu Li

PLoS One. 2010; 5(2): e9226. Published online 2010 Feb 16. doi: 10.1371/journal.pone.0009226

PMCID:: PMC2821916

Article PDF–709K

Select item 50358837.

Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production

David Millrine, Mami Tei, Yohannes Gemechu, Tadamitsu Kishimoto

Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): 10625–10630. Published online 2016 Sep 6. doi: 10.1073/pnas.1611751113

PMCID:: PMC5035883

Article PDF–1020K

Select item 49441588.

AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway

Ermes Candiello, Manuel Kratzke, Dirk Wenzel, Dan Cassel, Peter Schu

Sci Rep. 2016; 6: 29950. Published online 2016 Jul 14. doi: 10.1038/srep29950

PMCID:: PMC4944158

Article PDF–1.4M

Select item 36273999.

Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated ß1/ß2-integrin trafficking

E. Taniguchi Ishikawa, K.H. Chang, R. Nayak, H.A Olsson, A. Ficker, S.K. Dunn, M. Madhu, A. Sengupta, J.A. Whitsett, H.L. Grimes, J.A. Cancelas

Nat Commun. Author manuscript; available in PMC 2013 Oct 3.

Published in final edited form as: Nat Commun. 2013; 4: 1660. doi: 10.1038/ncomms2645

PMCID:: PMC3627399

Article PDF–1.1M

Select item 277710210.

Rabex-5 Is a Rab22 Effector and Mediates a Rab22-Rab5 Signaling Cascade in Endocytosis

Huaiping Zhu, Zhimin Liang, Guangpu Li

Mol Biol Cell. 2009 Nov 15; 20(22): 4720–4729. doi: 10.1091/mbc.E09-06-0453

PMCID:: PMC2777102

Article PDF–1.4M

Select item 141384511.

RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells

Janet Kalesnikoff, Eon J. Rios, Ching-Cheng Chen, Susumu Nakae, Brian A. Zabel, Eugene C. Butcher, Mindy Tsai, See-Ying Tam, Stephen J. Galli

Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8): 2659–2664. Published online 2006 Feb 21. doi: 10.1073/pnas.0511191103

PMCID:: PMC1413845

Article PDF–450K

Select item 512767912.

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis

Thomas Marichal, Nicolas Gaudenzio, Sophie El Abbas, Riccardo Sibilano, Oliwia Zurek, Philipp Starkl, Laurent L. Reber, Dimitri Pirottin, Jinah Kim, Pierre Chambon, Axel Roers, Nadine Antoine, Yuko Kawakami, Toshiaki Kawakami, Fabrice Bureau, See-Ying Tam, Mindy Tsai, Stephen J. Galli

J Clin Invest. 2016 Dec 1; 126(12): 4497–4515. Published online 2016 Nov 7. doi: 10.1172/JCI86359

PMCID:: PMC5127679

Article PDF–6.9M

Select item 346331013.

Rabex-5 Protein Regulates the Endocytic Trafficking Pathway of Ubiquitinated Neural Cell Adhesion Molecule L1

Yoshikatsu Aikawa

J Biol Chem. 2012 Sep 21; 287(39): 32312–32323. Published online 2012 Jul 30. doi: 10.1074/jbc.M112.374322

PMCID:: PMC3463310

Article PDF–2.6M

Select item 117053914.

Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion.

H Gournier, H Stenmark, V Rybin, R Lippé, M Zerial

EMBO J. 1998 Apr 1; 17(7): 1930–1940. doi: 10.1093/emboj/17.7.1930

PMCID:: PMC1170539

Summary PDF–511K

Select item 296679915.

Thymic Stromal Lymphopoietin Contributes to Myeloid Hyperplasia and Increased Immunoglobulins, But Not Epidermal Hyperplasia, in RabGEF1-Deficient Mice

Mindy Tsai, Ching-Cheng Chen, Kaori Mukai, Chang Ho Song, Lucas J. Thompson, Steven F. Ziegler, See-Ying Tam, Stephen J. Galli

Am J Pathol. 2010 Nov; 177(5): 2411–2420. doi: 10.2353/ajpath.2010.100181

PMCID:: PMC2966799

Article PDF–1.4M

Select item 189083616.

Roles of RabGEF1/Rabex-5 domains in regulating FcϵRI surface expression and FcϵRI-dependent responses in mast cells

Janet Kalesnikoff, Eon J. Rios, Ching-Cheng Chen, M. Alejandro Barbieri, Mindy Tsai, See-Ying Tam, Stephen J. Galli

Blood. 2007 Jun 15; 109(12): 5308–5317. Prepublished online 2007 Mar 6. doi: 10.1182/blood-2007-01-067363

PMCID:: PMC1890836

Article

Select item 513489317.

Variants of Rab GTPase-effector binding protein-2 cause variation in the collateral circulation and severity of stroke

Jennifer L. Lucitti, Robert Sealock, Brian K. Buckley, Hua Zhang, Lin Xiao, Andrew C. Dudley, James E. Faber

Stroke. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Stroke. 2016 Dec; 47(12): 3022–3031. Published online 2016 Nov 3. doi: 10.1161/STROKEAHA.116.014160

PMCID:: PMC5134893

Article PDF–1.0M

Select item 122122018.

RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.

S Traver, C Bidot, N Spassky, T Baltauss, M F De Tand, J L Thomas, B Zalc, I Janoueix-Lerosey, J D Gunzburg

Biochem J. 2000 Aug 15; 350(Pt 1): 19–29.

PMCID:: PMC1221220

Summary PDF–289K

Select item 169887719.

Redundant functions of RIM1α and RIM2α in Ca²⁺-triggered neurotransmitter release

Susanne Schoch, Tobias Mittelstaedt, Pascal S Kaeser, Daniel Padgett, Nicole Feldmann, Vivien Chevaleyre, Pablo E Castillo, Robert E Hammer, Weiping Han, Frank Schmitz, Weichun Lin, Thomas C Südhof

EMBO J. 2006 Dec 13; 25(24): 5852–5863. Published online 2006 Nov 23. doi: 10.1038/sj.emboj.7601425

PMCID:: PMC1698877

Article PDF–477K

Select item 578004120.

Endosomal Rab cycles regulate Parkin-mediated mitophagy

Koji Yamano, Chunxin Wang, Shireen A Sarraf, Christian Münch, Reika Kikuchi, Nobuo N Noda, Yohei Hizukuri, Masato T Kanemaki, Wade Harper, Keiji Tanaka, Noriyuki Matsuda, Richard J Youle

eLife. 2018; 7: e31326. Published online 2018 Jan 23. doi: 10.7554/eLife.31326