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Select item 48134601.

Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age

Jeff P. Gorski, Nichole T. Huffman, Julian Vallejo, Leticia Brotto, Sridar V. Chittur, Anne Breggia, Amber Stern, Jian Huang, Chenglin Mo, Nabil G. Seidah, Lynda Bonewald, Marco Brotto

J Biol Chem. 2016 Feb 26; 291(9): 4308–4322. Published online 2015 Dec 30. doi: 10.1074/jbc.M115.686626

PMCID:: PMC4813460

Article PDF–2.9M

Select item 31907292.

Site-1 Protease Is Essential to Growth Plate Maintenance and Is a Critical Regulator of Chondrocyte Hypertrophic Differentiation in Postnatal Mice

Debabrata Patra, Elizabeth DeLassus, Shinya Hayashi, Linda J. Sandell

J Biol Chem. 2011 Aug 19; 286(33): 29227–29240. Published online 2011 Jun 7. doi: 10.1074/jbc.M110.208686

PMCID:: PMC3190729

Article PDF–20M

Select item 30581473.

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell specific manner

Daniel L. Popkin, John R. Teijaro, Brian M. Sullivan, Shuzo Urata, Sophie Rutschmann, Juan Carlos de la Torre, Stefan Kunz, Bruce Beutler, Michael Oldstone

Cell Host Microbe. Author manuscript; available in PMC 2012 Mar 17.

Published in final edited form as: Cell Host Microbe. 2011 Mar 17; 9(3): 212–222. doi: 10.1016/j.chom.2011.02.006

PMCID:: PMC3058147

Article PDF–1.9M

Select item 30234794.

Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization

Jeff P. Gorski, Nichole T. Huffman, Sridar Chittur, Ronald J. Midura, Claudine Black, Julie Oxford, Nabil G. Seidah

J Biol Chem. 2011 Jan 21; 286(3): 1836–1849. Published online 2010 Nov 12. doi: 10.1074/jbc.M110.151647

PMCID:: PMC3023479

Article PDF–3.4M

Select item 28241835.

Potential Role of Proprotein Convertase SKI-1 in the Mineralization of Primary Bone

Jeff P. Gorski, Nichole T. Huffman, Chaoying Cui, Ellen P. Henderson, Ronald J. Midura, Nabil G. Seidah

Cells Tissues Organs. 2008 Dec; 189(1-4): 25–32. Published online 2008 Aug 26. doi: 10.1159/000151723

PMCID:: PMC2824183

Article PDF–180K

Select item 73280006.

Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations

Debabrata Patra, Joongho Kim, Qiang Zhang, Eric Tycksen, Linda J. Sandell

Biol Open. 2020 Jun 15; 9(6): bio052993. Published online 2020 Jun 23. doi: 10.1242/bio.052993

PMCID:: PMC7328000

Article PDF–15M

Select item 45140037.

Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control

Sarah Klünder, Jörg Heeren, Sandra Markmann, René Santer, Thomas Braulke, Sandra Pohl

J Lipid Res. 2015 Aug; 56(8): 1625–1632. doi: 10.1194/jlr.M060756

PMCID:: PMC4514003

Article PDF–908K

Select item 33374788.

Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice

Sophie Rutschmann, Karine Crozat, Xiaohong Li, Xin Du, Jeffrey C. Hanselman, Alana A. Shigeoka, Katharina Brandl, Daniel L. Popkin, Dianne B. McKay, Yu Xia, Eva Marie Y. Moresco, Bruce Beutler

G3 (Bethesda) 2012 Apr; 2(4): 499–504. Published online 2012 Apr 1. doi: 10.1534/g3.112.002196

PMCID:: PMC3337478

Article PDF–1.0M

Select item 26512979.

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

Katharina Brandl, Sophie Rutschmann, Xiaohong Li, Xin Du, Nengming Xiao, Bernd Schnabl, David A. Brenner, Bruce Beutler

Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9): 3300–3305. Published online 2009 Feb 6. doi: 10.1073/pnas.0813036106

PMCID:: PMC2651297

Article PDF–1.2M

Select item 6108810.

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

Jian Yang, Joseph L. Goldstein, Robert E. Hammer, Young-Ah Moon, Michael S. Brown, Jay D. Horton

Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24): 13607–13612. doi: 10.1073/pnas.201524598

PMCID:: PMC61088

Article PDF–233K

Select item 1054468011.

Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51

Muhammad G. Mousa, Lahari Vuppaladhadiam, Meredith O. Kelly, Terri Pietka, Shelby Ek, Karen C. Shen, Gretchen A. Meyer, Brian N. Finck, Rita T. Brookheart

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112336. Published online 2023 Mar 31. doi: 10.1016/j.celrep.2023.112336

PMCID:: PMC10544680

Article PDF–1.3M

Select item 991283912.

Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages

Yinglan Cheng, Ichiro Manabe, Sumio Hayakawa, Yusuke Endo, Yumiko Oishi

Front Immunol. 2023; 14: 1009973. Published online 2023 Jan 27. doi: 10.3389/fimmu.2023.1009973

PMCID:: PMC9912839

Article PDF–8.2M

Select item 648371613.

Site-1 protease–derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability

Fei Wang, Chuanming Xu, Renfei Luo, Kexin Peng, Nirupama Ramkumar, Shiying Xie, Xiaohan Lu, Long Zhao, Chang-Jiang Zuo, Donald E. Kohan, Tianxin Yang

JCI Insight. 2019 Apr 4; 4(7): e124174. Published online 2019 Apr 4. doi: 10.1172/jci.insight.124174

PMCID:: PMC6483716

Article PDF–4.3M

Select item 836420014.

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization

Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xi’e Wang, Junyu Xiao, Chih-chen Wang, Lei Wang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2100133118. Published online 2021 Aug 4. doi: 10.1073/pnas.2100133118

PMCID:: PMC8364200

Article PDF–2.5M

Select item 1546115.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

Nabil G. Seidah, Seyed J. Mowla, Josée Hamelin, Aida M. Mamarbachi, Suzanne Benjannet, Barry B. Touré, Ajoy Basak, Jon Scott Munzer, Jadwiga Marcinkiewicz, Mei Zhong, Jean-Christophe Barale, Claude Lazure, Richard A. Murphy, Michel Chrétien, Mieczyslaw Marcinkiewicz

Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4): 1321–1326. doi: 10.1073/pnas.96.4.1321