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Select item 106737371.

Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α

Takuma Hotani, Kanako Nakagawa, Tomohito Tsukamoto, Hiroyuki Mizuguchi, Fuminori Sakurai

Inflammation. 2023; 46(6): 2332–2342. Published online 2023 Aug 24. doi: 10.1007/s10753-023-01881-8

PMCID:: PMC10673737

Article PDF–1.1M

Select item 86883292.

Protein Kinase RNA-activated Controls Mitotic Progression and Determines Paclitaxel Chemosensitivity through B-cell lymphoma 2 in Ovarian Cancer

Ling Yin, Yongji Zeng, Renya Zeng, Yuanhong Chen, Tian-Li Wang, Kerry J. Rodabaugh, Fang Yu, Amarnath Natarajan, Adam R. Karpf, Jixin Dong

Oncogene. Author manuscript; available in PMC 2022 May 19.

Published in final edited form as: Oncogene. 2021 Dec; 40(50): 6772–6785. Published online 2021 Nov 19. doi: 10.1038/s41388-021-02117-5

PMCID:: PMC8688329

Article PDF–3.6M

Select item 83102913.

The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus

Hector Moreno, Stefan Kunz

Viruses. 2021 Jul; 13(7): 1313. Published online 2021 Jul 7. doi: 10.3390/v13071313

PMCID:: PMC8310291

Article PDF–1.6M

Select item 80942694.

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

Anindita Bose, François Mouton‐Liger, Claire Paquet, Pierre Mazot, Marc Vigny, Françoise Gray, Jacques Hugon

Brain Pathol. 2011 Mar; 21(2): 189–200. Published online 2010 Oct 3. doi: 10.1111/j.1750-3639.2010.00437.x

PMCID:: PMC8094269

Article PDF–1.0M

Select item 80805645.

PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs

Teresa Cesaro, Yohei Hayashi, Fabian Borghese, Didier Vertommen, Fanny Wavreil, Thomas Michiels

Sci Rep. 2021; 11: 9188. Published online 2021 Apr 28. doi: 10.1038/s41598-021-88610-z

PMCID:: PMC8080564

Article PDF–2.3M

Select item 79867436.

EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia

Demy J. S. Kuipers, Wim Mandemakers, Chin‐Song Lu, Simone Olgiati, Guido J. Breedveld, Christina Fevga, Vera Tadic, Miryam Carecchio, Bradley Osterman, Lena Sagi‐Dain, Yah‐Huei Wu‐Chou, Chiung C. Chen, Hsiu‐Chen Chang, Shey‐Lin Wu, Tu‐Hsueh Yeh, Yi‐Hsin Weng, Antonio E. Elia, Celeste Panteghini, Nicolas Marotta, Martje G. Pauly, Andrea A. Kühn, Jens Volkmann, Baiba Lace, Inge A. Meijer, Krishna Kandaswamy, Marialuisa Quadri, Barbara Garavaglia, Katja Lohmann, Peter Bauer, Niccolò E. Mencacci, Steven J. Lubbe, Christine Klein, Aida M. Bertoli‐Avella, Vincenzo Bonifati

Ann Neurol. 2021 Mar; 89(3): 485–497. Published online 2020 Dec 15. doi: 10.1002/ana.25973

PMCID:: PMC7986743

Article PDF–2.2M

Select item 66159997.

Structural basis of protein kinase R autophosphorylation

Christopher B. Mayo, Heidi Erlandsen, David J. Mouser, Aaron G. Feinstein, Victoria L. Robinson, Eric R. May, James L. Cole

Biochemistry. Author manuscript; available in PMC 2020 Jul 9.

Published in final edited form as: Biochemistry. 2019 Jul 9; 58(27): 2967–2977. Published online 2019 Jun 27. doi: 10.1021/acs.biochem.9b00161

PMCID:: PMC6615999

Article PDF–2.1M

Select item 66123958.

Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1

Yan Tang, Guang Shi, JungWoo Yang, Wang Zheng, Jingfeng Tang, Xing-Zhen Chen, Jianzheng Yang, Zuocheng Wang

Biomed Res Int. 2019; 2019: 5320747. Published online 2019 Jun 23. doi: 10.1155/2019/5320747

PMCID:: PMC6612395

Article PDF–1.3M

Select item 65161799.

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions

Marion Tible, François Mouton Liger, Julien Schmitt, Albert Giralt, Karim Farid, Sylvie Thomasseau, Sarah Gourmaud, Claire Paquet, Laure Rondi Reig, Eliane Meurs, Jean‐Antoine Girault, Jacques Hugon

Aging Cell. 2019 Jun; 18(3): e12887. Published online 2019 Mar 1. doi: 10.1111/acel.12887

PMCID:: PMC6516179

Article PDF–1.5M

Select item 646700410.

The search for a PKR code—differential regulation of protein kinase R activity by diverse RNA and protein regulators

Charles Bou-Nader, Jackson M. Gordon, Frances E. Henderson, Jinwei Zhang

RNA. 2019 May; 25(5): 539–556. doi: 10.1261/rna.070169.118

PMCID:: PMC6467004

Article PDF–4.2M

Select item 638644011.

Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation

Yusuke Imai, Osamu Yoshida, Takao Watanabe, Atsushi Yukimoto, Yohei Koizumi, Yoshio Ikeda, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa

PLoS One. 2019; 14(2): e0212589. Published online 2019 Feb 22. doi: 10.1371/journal.pone.0212589

PMCID:: PMC6386440

Article PDF–1.5M

Select item 635431912.

Protein Kinase R Is Constitutively Expressed in the Human Pancreas

Alexander Jonsson, Erik Yngve, Marie Karlsson, Sofie Ingvast, Oskar Skog, Olle Korsgren

J Histochem Cytochem. 2019 Feb; 67(2): 99–105. Published online 2018 Sep 28. doi: 10.1369/0022155418802838

PMCID:: PMC6354319

Article PDF–1.1M

Select item 582740913.

Antagonism of the Protein Kinase R Pathway in Human Cells by Rhesus Cytomegalovirus

Stephanie J. Child, Sarah E. Hickson, Avraham Bayer, Daniel Malouli, Klaus Früh, Adam P. Geballe

J Virol. 2018 Mar 15; 92(6): e01793-17. Prepublished online 2017 Dec 20. Published online 2018 Feb 26. doi: 10.1128/JVI.01793-17

PMCID:: PMC5827409

Article PDF–2.0M

Select item 562549414.

Highly Pathogenic New World Arenavirus Infection Activates the Pattern Recognition Receptor Protein Kinase R without Attenuating Virus Replication in Human Cells

Cheng Huang, Olga A. Kolokoltsova, Elizabeth J. Mateer, Takaaki Koma, Slobodan Paessler

J Virol. 2017 Oct 15; 91(20): e01090-17. Prepublished online 2017 Aug 9. Published online 2017 Sep 27. doi: 10.1128/JVI.01090-17

PMCID:: PMC5625494

Article PDF–1.7M

Select item 548742915.

dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication

Yu-Hsiu Chang, Kean Seng Lau, Rei-Lin Kuo, Jim-Tong Horng

Front Cell Infect Microbiol. 2017; 7: 284. Published online 2017 Jun 28. doi: 10.3389/fcimb.2017.00284

PMCID:: PMC5487429

Article PDF–1.9M

Select item 534505216.

Auto-phosphorylation Represses Protein Kinase R Activity

Die Wang, Nicole A. de Weerd, Belinda Willard, Galina Polekhina, Bryan R. G. Williams, Anthony J. Sadler

Sci Rep. 2017; 7: 44340. Published online 2017 Mar 10. doi: 10.1038/srep44340

PMCID:: PMC5345052

Article PDF–4.8M

Select item 513337517.

Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner

In Soo Oh, Kathrin Textoris-Taube, Pil Soo Sung, Wonseok Kang, Xenia Gorny, Thilo Kähne, Seon-Hui Hong, Young Joon Choi, Clemens Cammann, Michael Naumann, Jong Hoon Kim, Su-Hyung Park, Ook Joon Yoo, Peter M Kloetzel, Ulrike Seifert, Eui-Cheol Shin

Exp Mol Med. 2016 Nov; 48(11): e270. Published online 2016 Nov 11. doi: 10.1038/emm.2016.98

PMCID:: PMC5133375

Article PDF–2.1M

Select item 512238518.

Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance

Chuncheng Hao, Ruping Shao, Uma Raju, Bingliang Fang, Stephen G. Swisher, Apar Pataer

Oncotarget. 2016 Jun 21; 7(25): 38235–38242. Published online 2016 May 18. doi: 10.18632/oncotarget.9428

PMCID:: PMC5122385

Article PDF–2.5M

Select item 499921419.

Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production

Shin Hashimoto, Soh Yamamoto, Noriko Ogasawara, Toyotaka Sato, Keisuke Yamamoto, Hiroshi Katoh, Toru Kubota, Tsukasa Shiraishi, Takashi Kojima, Tetsuo Himi, Hiroyuki Tsutsumi, Shin-ichi Yokota

PLoS One. 2016; 11(8): e0161793. Published online 2016 Aug 25. doi: 10.1371/journal.pone.0161793

PMCID:: PMC4999214

Article PDF–11M

Select item 464177520.

Regulation of PKR by RNA: Formation of active and inactive dimers

Bushra Husain, Stephen Hesler, James L. Cole

Biochemistry. Author manuscript; available in PMC 2016 Nov 10.

Published in final edited form as: Biochemistry. 2015 Nov 10; 54(44): 6663–6672. Published online 2015 Oct 26. doi: 10.1021/acs.biochem.5b01046

PMCID:: PMC4641775

Article PDF–1.0M

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