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1.
Association of NUDT15 gene polymorphism with adverse reaction, treatment efficacy, and dose of 6-mercaptopurine in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis
Shan Du, Xuefei Huang, Xia He, Mian Mao, Min Chen, Rong Zhang, Huikai Shao, Ziyan Lv, Xinxia Liu, Junlan Chuan
Haematologica. 2024 Apr 1; 109(4): 1053–1068. Published online 2023 Oct 5. doi: 10.3324/haematol.2023.282761
PMCID:
PMC10985454
ArticlePDF–4.1M
2.
Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease
Shizuka Suzuki, Kan Uchiyama, Yutaro Motoi, Yuuki Yoshii, Yukari Inoue, Takahiro Kubota, Shunichi Odahara, Yuichiro Ohtaki, Shinichiro Takami, Zensho Ito, Nobuhiro Sato, Toshifumi Ohkusa, Shigeo Koido, Masayuki Saruta
BMC Gastroenterol. 2023; 23: 239. Published online 2023 Jul 15. doi: 10.1186/s12876-023-02881-6
PMCID:
PMC10350251
ArticlePDF–1.2M
3.
The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia
Mai-Lan Nguyen, Anh Vu Hoang, Bich Tram Duong, Nguyen The Nguyen Phung
HGG Adv. 2023 Apr 13; 4(2): 100183. Published online 2023 Feb 10. doi: 10.1016/j.xhgg.2023.100183
PMCID:
PMC9974434
ArticlePDF–1.6M
4.
Nudix hydrolase 15 (NUDT15) loss‐of‐function variants in an Australian inflammatory bowel disease population
Sadia Afrin, Lisa A. Simms, Anton Lord, Graham L. Radford‐Smith
Intern Med J. 2022 Nov; 52(11): 1971–1977. Published online 2022 Jun 8. doi: 10.1111/imj.15746
PMCID:
PMC9796699
ArticlePDF–979K
5.
Low NUDT15 expression levels due to bi-allelic NUDT15 variants and 6-mercaptopurine intolerance
Masanori Yoshida, Scott A Brown, Takaya Moriyama, Rina Nishii, Shin-ichi Tsujimoto, Yuji Yamada, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Tomoyuki Utano, Reiji Fukano, Ko Kudo, Kimiyoshi Sakaguchi, Yuki Arakawa, Katsuyoshi Koh, Masahiro Sekiguchi, Masahiro Sekimizu, Takako Miyamura, Hisashi Ishida, Takeshi Inukai, Daisuke Tomizawa, Nobutaka Kiyokawa, Motohiro Kato, Jun J Yang
Br J Haematol. Author manuscript; available in PMC 2023 Oct 1.
Published in final edited form as: Br J Haematol. 2022 Oct; 199(2): 270–276. Published online 2022 Jul 29. doi: 10.1111/bjh.18375
PMCID:
PMC9547862
ArticlePDF–390K
6.
A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T
Xiaoyun Lian, Yanwei Li, Lan Li, Kaicheng U, Wenxia Wang, Yinmin Shi, Jiying Ma, Huijuan Wang
Exp Biol Med (Maywood) 2021 Sep; 246(18): 1961–1967. Published online 2021 Jun 30. doi: 10.1177/15353702211026579
PMCID:
PMC8474986
ArticlePDF–572K
7.
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir
Rina Nishii, Takanori Mizuno, Daniel Rehling, Colton Smith, Brandi L. Clark, Xujie Zhao, Scott A. Brown, Brandon Smart, Takaya Moriyama, Yuji Yamada, Tatsuo Ichinohe, Makoto Onizuka, Yoshiko Atsuta, Lei Yang, Wenjian Yang, Paul G. Thomas, Pål Stenmark, Motohiro Kato, Jun J. Yang
Nat Commun. 2021; 12: 4181. Published online 2021 Jul 7. doi: 10.1038/s41467-021-24509-7
PMCID:
PMC8263746
ArticlePDF–1.4M
8.
DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes
Hee Young Ju, Ji Won Lee, Hee Won Cho, Ju Kyung Hyun, Youngeun Ma, Eun Sang Yi, Keon Hee Yoo, Ki Woong Sung, Rihwa Choi, Hong Hoe Koo, Soo-Youn Lee
PLoS One. 2021; 16(1): e0245667. Published online 2021 Jan 22. doi: 10.1371/journal.pone.0245667
PMCID:
PMC7822258
ArticlePDF–1.2M
9.
Determination of NUDT15 variants by targeted sequencing can identify compound heterozygosity in pediatric acute lymphoblastic leukemia patients
Chih-Hsiang Yu, Ya-Hsuan Chang, Der-Shiun Wang, Shiann-Tarng Jou, Chien-Yu Lin, Kai-Hsin Lin, Meng-Yao Lu, Lovely Raghav, Hsiu-Hao Chang, Kang-Hsi Wu, Shu-Wei Chou, Yu-Ling Ni, Dong-Tsamn Lin, Shu-Wha Lin, Hsuan-Yu Chen, Yung-Li Yang
Sci Rep. 2020; 10: 14400. Published online 2020 Sep 1. doi: 10.1038/s41598-020-71468-y
PMCID:
PMC7463237
ArticlePDF–1.5M
10.
Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil
Juliana Carla Gomes Rodrigues, Tatiane Piedade de Souza, Lucas Favacho Pastana, André Maurício Ribeiro dos Santos, Marianne Rodrigues Fernandes, Pablo Pinto, Alayde Vieira Wanderley, Sandro José de Souza, José Eduardo Kroll, Adenilson Leão Pereira, Leandro Magalhães, Laís Reis das Mercês, Amanda Ferreira Vidal, Tatiana Vinasco-Sandoval, Giovanna Chaves Cavalcante, João Farias Guerreiro, Paulo Pimentel de Assumpção, Ândrea Ribeiro-dos-Santos, Sidney Santos, Ney Pereira Carneiro dos Santos
PLoS One. 2020; 15(4): e0231651. Published online 2020 Apr 15. doi: 10.1371/journal.pone.0231651
PMCID:
PMC7159207
ArticlePDF–636K
11.
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity
Chase C. Suiter, Takaya Moriyama, Kenneth A. Matreyek, Wentao Yang, Emma Rose Scaletti, Rina Nishii, Wenjian Yang, Keito Hoshitsuki, Minu Singh, Amita Trehan, Chris Parish, Colton Smith, Lie Li, Deepa Bhojwani, Liz Y. P. Yuen, Chi-kong Li, Chak-ho Li, Yung-li Yang, Gareth J. Walker, James R. Goodhand, Nicholas A. Kennedy, Federico Antillon Klussmann, Smita Bhatia, Mary V. Relling, Motohiro Kato, Hiroki Hori, Prateek Bhatia, Tariq Ahmad, Allen E. J. Yeoh, Pål Stenmark, Douglas M. Fowler, Jun J. Yang
Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5394–5401. Published online 2020 Feb 24. doi: 10.1073/pnas.1915680117
PMCID:
PMC7071893
ArticlePDF–1.5M
12.
NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine
Nicholas C.K. Valerie, Anna Hagenkort, Brent D.G. Page, Geoffrey Masuyer, Daniel Rehling, Megan Carter, Luka Bevc, Patrick Herr, Evert Homan, Nina G. Sheppard, Pål Stenmark, Ann-Sofie Jemth, Thomas Helleday
Cancer Res. Author manuscript; available in PMC 2019 Nov 11.
Published in final edited form as: Cancer Res. 2016 Sep 15; 76(18): 5501–5511. Published online 2016 Aug 16. doi: 10.1158/0008-5472.CAN-16-0584
PMCID:
PMC6847052
ArticlePDF–2.1M
13.
The Nudix Hydrolase 15 (NUDT15) Gene Variants among Jordanian Arab Population
Yazun Bashir Jarrar, Maria Ghishan
Asian Pac J Cancer Prev. 2019; 20(3): 801–808. doi: 10.31557/APJCP.2019.20.3.801
PMCID:
PMC6825778
ArticlePDF–467K
14.
Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis
Ruili Wang, Baogang Liu, Jiapeng Li, Jiamin Xu, Xiaoling Wang, Zhigang Zhao, Libo Zhao
Drug Des Devel Ther. 2019; 13: 2729–2744. Published online 2019 Aug 5. doi: 10.2147/DDDT.S210512
PMCID:
PMC6689127
ArticlePDF–8.4M
15.
Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease
Gareth J. Walker, James W. Harrison, Graham A. Heap, Michiel D. Voskuil, Vibeke Andersen, Carl A. Anderson, Ashwin N. Ananthakrishnan, Jeffrey C. Barrett, Laurent Beaugerie, Claire M. Bewshea, Andy T. Cole, Fraser R. Cummings, Mark J. Daly, Pierre Ellul, Richard N. Fedorak, Eleonora A. M. Festen, Timothy H. Florin, Daniel R. Gaya, Jonas Halfvarson, Ailsa L. Hart, Neel M. Heerasing, Peter Hendy, Peter M. Irving, Samuel E. Jones, Jukka Koskela, James O. Lindsay, John C. Mansfield, Dermot McGovern, Miles Parkes, Richard C. G. Pollok, Subramaniam Ramakrishnan, David S. Rampton, Manuel A. Rivas, Richard K. Russell, Michael Schultz, Shaji Sebastian, Philippe Seksik, Abhey Singh, Kenji So, Harry Sokol, Kavitha Subramaniam, Anthony Todd, Vito Annese, Rinse K. Weersma, Ramnik Xavier, Rebecca Ward, Michael N. Weedon, James R. Goodhand, Nicholas A. Kennedy, Tariq Ahmad
JAMA. 2019 Feb 26; 321(8): 773–785. Published online 2019 Feb 26. doi: 10.1001/jama.2019.0709
Correction in:
JAMA. 2019 Apr 23; 321(16): 1636.
PMCID:
PMC6439872
Article
16.
Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms
Shinichi Tsujimoto, Tomoo Osumi, Meri Uchiyama, Ryota Shirai, Takaya Moriyama, Rina Nishii, Yuji Yamada, Ko Kudo, Masahiro Sekiguchi, Yuki Arakawa, Masanori Yoshida, Toru Uchiyama, Kiminori Terui, Shuichi Ito, Katsuyoshi Koh, Junko Takita, Etsuro Ito, Daisuke Tomizawa, Atsushi Manabe, Nobutaka Kiyokawa, Jun J Yang, Motohiro Kato
Leukemia. Author manuscript; available in PMC 2019 Jun 1.
Published in final edited form as: Leukemia. 2018 Dec; 32(12): 2710–2714. Published online 2018 Jul 2. doi: 10.1038/s41375-018-0190-1
PMCID:
PMC6289816
ArticlePDF–343K
17.
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study
Yoichi Kakuta, Yosuke Kawai, Daisuke Okamoto, Tetsuya Takagawa, Kentaro Ikeya, Hirotake Sakuraba, Atsushi Nishida, Shoko Nakagawa, Miki Miura, Takahiko Toyonaga, Kei Onodera, Masaru Shinozaki, Yoh Ishiguro, Shinta Mizuno, Masahiro Takahara, Shunichi Yanai, Ryota Hokari, Tomoo Nakagawa, Hiroshi Araki, Satoshi Motoya, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Katsuya Endo, Taku Kobayashi, Makoto Naganuma, Sakiko Hiraoka, Takayuki Matsumoto, Shiro Nakamura, Hiroshi Nakase, Tadakazu Hisamatsu, Makoto Sasaki, Hiroyuki Hanai, Akira Andoh, Masao Nagasaki, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune, Yasuo Suzuki, for the MENDEL study group
J Gastroenterol. 2018; 53(9): 1065–1078. Published online 2018 Jun 19. doi: 10.1007/s00535-018-1486-7
PMCID:
PMC6132901
ArticlePDF–1.0M
18.
NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia
Eun Sang Yi, Young Bae Choi, Rihwa Choi, Na Hee Lee, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Soo-Youn Lee, Hong Hoe Koo
Cancer Res Treat. 2018 Jul; 50(3): 872–882. Published online 2017 Sep 13. doi: 10.4143/crt.2017.283
PMCID:
PMC6056957
ArticlePDF–858K
19.
Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia
Yiping Zhu, Dandan Yin, Yali Su, Xuyang Xia, Takaya Moriyama, Rina Nishii, Fei Liao, Shouyue Zhang, Xia Guo, Qianqian Hou, Yuan Ai, Xueyan Zhou, Shuwen Sun, Duyu Zhang, Yan Zhang, Chao Lin, Yiqi Deng, Xiaoxi Lu, Yuelan Wang, Zhigui Ma, Heyao Wang, Bo Liu, Li Yang, Wei Zhang, Jun J. Yang, Yang Shu, Ju Gao, Heng Xu
Haematologica. 2018 Jul; 103(7): e293–e295. doi: 10.3324/haematol.2018.187658
PMCID:
PMC6029522
ArticlePDF–498K
20.
Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou, Yong Han
BMC Cancer. 2018; 18: 516. Published online 2018 May 2. doi: 10.1186/s12885-018-4398-2
PMCID:
PMC5932771
ArticlePDF–1.1M

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