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Select item 54129771.

Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells

Vidisha Raje, Marta Derecka, Marc Cantwell, Jeremy Meier, Karol Szczepanek, Jennifer D. Sisler, Birgit Strobl, Ana Gamero, Thurl E. Harris, Andrew C. Larner

Endocrinology. 2017 Jan 1; 158(1): 148–157. Published online 2016 Nov 1. doi: 10.1210/en.2015-2048

PMCID:: PMC5412977

Article

Select item 43963802.

Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

Kenichi Izumi, Keiichiro Mine, Yoshitaka Inoue, Miho Teshima, Shuichiro Ogawa, Yuji Kai, Toshinobu Kurafuji, Kanako Hirakawa, Daiki Miyakawa, Haruka Ikeda, Akari Inada, Manami Hara, Hisakata Yamada, Koichi Akashi, Yoshiyuki Niho, Keisuke Ina, Takashi Kobayashi, Yasunobu Yoshikai, Keizo Anzai, Teruo Yamashita, Hiroko Minagawa, Shuji Fujimoto, Hironori Kurisaki, Kazuya Shimoda, Hitoshi Katsuta, Seiho Nagafuchi

Nat Commun. 2015 Apr 7; 6: 6748. Published online 2015 Apr 7. doi: 10.1038/ncomms7748

PMCID:: PMC4396380

Article PDF–1.6M

Select item 41275193.

Role of Tyk-2 in Th9 and Th17 cells in allergic asthma

Caroline Übel, Anna Graser, Sonja Koch, Ralf J. Rieker, Hans A. Lehr, Mathias Müller, Susetta Finotto

Sci Rep. 2014; 4: 5865. Published online 2014 Aug 11. doi: 10.1038/srep05865

PMCID:: PMC4127519

Article PDF–995K

Select item 34789774.

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St John Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart, Kevin Woller, Robert V Talanian

BMC Struct Biol. 2012; 12: 22. Published online 2012 Sep 20. doi: 10.1186/1472-6807-12-22

PMCID:: PMC3478977

Article PDF–2.3M

Select item 33775895.

TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo

Michaela Prchal-Murphy, Christian Semper, Caroline Lassnig, Barbara Wallner, Christian Gausterer, Ingeborg Teppner-Klymiuk, Julianna Kobolak, Simone Müller, Thomas Kolbe, Marina Karaghiosoff, Andras Dinnyés, Thomas Rülicke, Nicole R. Leitner, Birgit Strobl, Mathias Müller

PLoS One. 2012; 7(6): e39141. Published online 2012 Jun 18. doi: 10.1371/journal.pone.0039141

PMCID:: PMC3377589

Article PDF–929K

Select item 31738196.

The Role of Tyk2 in Regulation of Breast Cancer Growth

Qifang Zhang, Jamie L. Sturgill, Maciej Kmieciak, Karol Szczepanek, Marta Derecka, Catherine Koebel, Laura J. Graham, Yun Dai, Shuang Chen, Steven Grant, Joanna Cichy, Kazuya Shimoda, Ana Gamero, Masoud Manjili, Harry Bear, Daniel Conrad, Andrew C. Larner

J Interferon Cytokine Res. 2011 Sep; 31(9): 671–677. doi: 10.1089/jir.2011.0023

PMCID:: PMC3173819

Article PDF–527K

Select item 28642437.

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Claus Vogl, Thomas Flatt, Bernd Fuhrmann, Elisabeth Hofmann, Barbara Wallner, Rita Stiefvater, Pavel Kovarik, Birgit Strobl, Mathias Müller

BMC Genomics. 2010; 11: 199. Published online 2010 Mar 25. doi: 10.1186/1471-2164-11-199

PMCID:: PMC2864243

Article PDF–1.1M

Select item 5292828.

TYK2 is a key regulator of the surveillance of B lymphoid tumors

Dagmar Stoiber, Boris Kovacic, Christian Schuster, Carola Schellack, Marina Karaghiosoff, Rita Kreibich, Eva Weisz, Michaela Artwohl, Olaf C. Kleine, Mathias Muller, Sabina Baumgartner-Parzer, Jacques Ghysdael, Michael Freissmuth, Veronika Sexl

J Clin Invest. 2004 Dec 1; 114(11): 1650–1658. doi: 10.1172/JCI22315

PMCID:: PMC529282

Article PDF–825K

Select item 2088039.

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

Michael H. Shaw, Victor Boyartchuk, Sandy Wong, Marina Karaghiosoff, Josiane Ragimbeau, Sandra Pellegrini, Mathias Muller, William F. Dietrich, George S. Yap

Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20): 11594–11599. Published online 2003 Sep 18. doi: 10.1073/pnas.1930781100

PMCID:: PMC208803

Article PDF–428K

Select item 951900610.

Tyk2 is a tumor suppressor in colorectal cancer

Stefan Moritsch, Bernadette Mödl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Müller, Birgit Strobl, Robert Eferl

Oncoimmunology. 2022; 11(1): 2127271. Published online 2022 Sep 26. doi: 10.1080/2162402X.2022.2127271

PMCID:: PMC9519006

Article PDF–26M

Select item 635569611.

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets

Jacquelyn A. Gorman, Christian Hundhausen, Mackenzie Kinsman, Tanvi Arkatkar, Eric J. Allenspach, Courtnee Clough, Samuel E. West, Kerri Thomas, Ahmet Eken, Socheath Khim, Malika Hale, Mohamed Oukka, Shaun W. Jackson, Karen Cerosaletti, Jane H. Buckner, David J. Rawlings

Front Immunol. 2019; 10: 44. Published online 2019 Jan 25. doi: 10.3389/fimmu.2019.00044

PMCID:: PMC6355696

Article PDF–2.9M

Select item 573783512.

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Calliope A. Dendrou, Adrian Cortes, Lydia Shipman, Hayley G. Evans, Kathrine E. Attfield, Luke Jostins, Thomas Barber, Gurman Kaur, Subita Balaram Kuttikkatte, Oliver A. Leach, Christiane Desel, Soren L. Faergeman, Jane Cheeseman, Matt J. Neville, Stephen Sawcer, Alastair Compston, Adam R. Johnson, Christine Everett, John I. Bell, Fredrik Karpe, Mark Ultsch, Charles Eigenbrot, Gil McVean, Lars Fugger

Sci Transl Med. Author manuscript; available in PMC 2017 Dec 20.

Published in final edited form as: Sci Transl Med. 2016 Nov 2; 8(363): 363ra149. doi: 10.1126/scitranslmed.aag1974

PMCID:: PMC5737835

Article PDF–2.4M

Select item 463556413.

Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

Eva Hainzl, Silvia Stockinger, Isabella Rauch, Susanne Heider, David Berry, Caroline Lassnig, Clarissa Schwab, Felix Rosebrock, Gabriel Milinovich, Michaela Schlederer, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Lukas Kenner, Xiaonan Han, Thomas Decker, Birgit Strobl, Mathias Müller

J Immunol. 2015 Nov 15; 195(10): 5011–5024. Published online 2015 Oct 2. doi: 10.4049/jimmunol.1402565

PMCID:: PMC4635564

Article PDF–2.4M

Select item 322501314.

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)

Tom Grunert, Nicole R. Leitner, Martina Marchetti-Deschmann, Ingrid Miller, Barbara Wallner, Marta Radwan, Claus Vogl, Thomas Kolbe, Dagmar Kratky, Manfred Gemeiner, Günter Allmaier, Mathias Müller, Birgit Strobl

J Proteomics. 2011 Nov 18; 74(12): 2866–2880. doi: 10.1016/j.jprot.2011.07.006

PMCID:: PMC3225013

Article

Select item 300862815.

A Single Nucleotide Polymorphism in Tyk2 Controls Susceptibility to Experimental Allergic Encephalomyelitis

Karen M. Spach, Rajkumar Noubade, Ben McElvany, William F. Hickey, Elizabeth P. Blankenhorn, Cory Teuscher

J Immunol. Author manuscript; available in PMC 2010 Dec 22.

Published in final edited form as: J Immunol. 2009 Jun 15; 182(12): 7776–7783. doi: 10.4049/jimmunol.0900142

PMCID:: PMC3008628

Article PDF–609K

Select item 281891716.

Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair

Allan J. Bieber, Kanitta Suwansrinon, Jason Kerkvliet, Weidong Zhang, Larry R. Pease, Moses Rodriguez

Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2): 792–797. Published online 2009 Dec 22. doi: 10.1073/pnas.0906589107

PMCID:: PMC2818917

Article PDF–517K

Select item 163676617.

Tyk2 Tyrosine Kinase Expression Is Required for the Maintenance of Mitochondrial Respiration in Primary Pro-B Lymphocytes

Ramesh Potla, Thomas Koeck, Joanna Wegrzyn, Srujana Cherukuri, Kazuya Shimoda, Darren P. Baker, Janice Wolfman, Sarah M. Planchon, Christine Esposito, Brian Hoit, Jozef Dulak, Alan Wolfman, Dennis Stuehr, Andrew C. Larner

Mol Cell Biol. 2006 Nov; 26(22): 8562–8571. Published online 2006 Sep 18. doi: 10.1128/MCB.00497-06

PMCID:: PMC1636766

Article PDF–310K

Select item 710892718.

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis

Eric Gracey, Dominika Hromadová, Melissa Lim, Zoya Qaiyum, Michael Zeng, Yuchen Yao, Archita Srinath, Yuriy Baglaenko, Natalia Yeremenko, William Westlin, Craig Masse, Mathias Müller, Birgit Strobl, Wenyan Miao, Robert D. Inman

J Clin Invest. 2020 Apr 1; 130(4): 1863–1878. Published online 2020 Mar 9. doi: 10.1172/JCI126567

PMCID:: PMC7108927

Article PDF–11M

Select item 668974319.

Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation

Kartiga Natarajan, Velmurugan Meganathan, Courtney Mitchell, Vijay Boggaram

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317(1): L127–L140. Published online 2019 May 1. doi: 10.1152/ajplung.00448.2018

Correction in:: Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1; 317(2): L303.

PMCID:: PMC6689743

Article

Select item 639808320.

NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity

Natalija Simonović, Agnieszka Witalisz-Siepracka, Katrin Meissl, Caroline Lassnig, Ursula Reichart, Thomas Kolbe, Matthias Farlik, Christoph Bock, Veronika Sexl, Mathias Müller, Birgit Strobl

J Immunol. 2019 Mar 15; 202(6): 1724–1734. Published online 2019 Feb 4. doi: 10.4049/jimmunol.1701649

PMCID:: PMC6398083

Article PDF–1.5M

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