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Select item 83220581.

The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth

Tong Zhou, Yong-Hua Sang, Shang Cai, Chun Xu, Min-hua Shi

Cell Death Dis. 2021 Aug; 12(8): 751. Published online 2021 Jul 29. doi: 10.1038/s41419-021-04039-2

PMCID:: PMC8322058

Article PDF–5.0M

Select item 78930702.

POLRMT mutations impair mitochondrial transcription causing neurological disease

Monika Oláhová, Bradley Peter, Zsolt Szilagyi, Hector Diaz-Maldonado, Meenakshi Singh, Ewen W. Sommerville, Emma L. Blakely, Jack J. Collier, Emily Hoberg, Viktor Stránecký, Hana Hartmannová, Anthony J. Bleyer, Kim L. McBride, Sasigarn A. Bowden, Zuzana Korandová, Alena Pecinová, Hans-Hilger Ropers, Kimia Kahrizi, Hossein Najmabadi, Mark A. Tarnopolsky, Lauren I. Brady, K. Nicole Weaver, Carlos E. Prada, Katrin Õunap, Monica H. Wojcik, Sander Pajusalu, Safoora B. Syeda, Lynn Pais, Elicia A. Estrella, Christine C. Bruels, Louis M. Kunkel, Peter B. Kang, Penelope E. Bonnen, Tomáš Mráček, Stanislav Kmoch, Gráinne S. Gorman, Maria Falkenberg, Claes M. Gustafsson, Robert W. Taylor

Nat Commun. 2021; 12: 1135. Published online 2021 Feb 18. doi: 10.1038/s41467-021-21279-0

PMCID:: PMC7893070

Article PDF–2.0M

Select item 50275083.

Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity

Benedict G. Tan, Frederick C. Wellesley, Nigel J. Savery, Mark D. Szczelkun

Nucleic Acids Res. 2016 Sep 19; 44(16): 7817–7829. Published online 2016 Jul 19. doi: 10.1093/nar/gkw648

PMCID:: PMC5027508

Article PDF–9.1M

Select item 47419254.

Targeting mitochondrial RNA polymerase in acute myeloid leukemia

Fernando N. Bralha, Sanduni U. Liyanage, Rose Hurren, Xiaoming Wang, Meong Hi Son, Thomas A. Fung, Francine B. Chingcuanco, Aveline Y. W. Tung, Ana C. Andreazza, Pamela Psarianos, Aaron D. Schimmer, Leonardo Salmena, Rebecca R. Laposa

Oncotarget. 2015 Nov 10; 6(35): 37216–37228. Published online 2015 Oct 15. doi: 10.18632/oncotarget.6129

PMCID:: PMC4741925

Article PDF–5.8M

Select item 43218155.

Structure of human mitochondrial RNA polymerase elongation complex

Kathrin Schwinghammer, Alan C.M. Cheung, Yaroslav I. Morozov, Karen Agaronyan, Dmitry Temiakov, Patrick Cramer

Nat Struct Mol Biol. Author manuscript; available in PMC 2015 Feb 9.

Published in final edited form as: Nat Struct Mol Biol. 2013 Nov; 20(11): 1298–1303. Published online 2013 Oct 6. doi: 10.1038/nsmb.2683

PMCID:: PMC4321815

Article PDF–2.7M

Select item 39733266.

A novel intermediate in transcription initiation by human mitochondrial RNA polymerase

Yaroslav I. Morozov, Karen Agaronyan, Alan C. M. Cheung, Michael Anikin, Patrick Cramer, Dmitry Temiakov

Nucleic Acids Res. 2014 Apr; 42(6): 3884–3893. Published online 2014 Jan 6. doi: 10.1093/nar/gkt1356

PMCID:: PMC3973326

Article PDF–2.4M

Select item 36982227.

Human Mitochondrial RNA Polymerase: Evaluation of the Single-Nucleotide-Addition Cycle on Synthetic RNA/DNA Scaffolds

Eric D. Smidansky, Jamie J. Arnold, Shelley L. Reynolds, Craig E. Cameron

Biochemistry. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Biochemistry. 2011 Jun 7; 50(22): 5016–5032. Published online 2011 May 12. doi: 10.1021/bi200350d

Correction in:: volume 50 on page 5969

PMCID:: PMC3698222

Article PDF–2.7M

Select item 31431688.

Transcription of Muscle Actin Genes by a Nuclear Form of Mitochondrial RNA Polymerase

Yu-Ling Lee, Chun-Hui Chiao, Ming-Ta Hsu

PLoS One. 2011; 6(7): e22583. Published online 2011 Jul 25. doi: 10.1371/journal.pone.0022583

PMCID:: PMC3143168

Article PDF–1.6M

Select item 25162549.

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

Sjoerd Wanrooij, Javier Miralles Fusté, Géraldine Farge, Yonghong Shi, Claes M. Gustafsson, Maria Falkenberg

Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32): 11122–11127. Published online 2008 Aug 6. doi: 10.1073/pnas.0805399105

PMCID:: PMC2516254

Article PDF–1004K

Select item 135216510.

Transcription of mammalian mRNAs by a novel nuclear RNA polymerase of mitochondrial origin

Julia E. Kravchenko, Igor B. Rogozin, Eugene V. Koonin, Peter M. Chumakov

Nature. Author manuscript; available in PMC 2006 Jan 27.

Published in final edited form as: Nature. 2005 Aug 4; 436(7051): 735–739. doi: 10.1038/nature03848

PMCID:: PMC1352165

Article PDF–635K

Select item 669875311.

Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria

Anna V Kotrys, Dominik Cysewski, Sylwia D Czarnomska, Zbigniew Pietras, Lukasz S Borowski, Andrzej Dziembowski, Roman J Szczesny

Nucleic Acids Res. 2019 Aug 22; 47(14): 7502–7517. Published online 2019 Jun 21. doi: 10.1093/nar/gkz542

PMCID:: PMC6698753

Article PDF–7.1M

Select item 470541612.

Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import

Jessica Nouws, Arvind V. Goswami, Megan Bestwick, Beverly Jo McCann, Yulia V. Surovtseva, Gerald S. Shadel

J Biol Chem. 2016 Jan 8; 291(2): 989–997. Published online 2015 Nov 19. doi: 10.1074/jbc.M115.689299

PMCID:: PMC4705416

Article PDF–1.4M

Select item 397332113.

Organization of the human mitochondrial transcription initiation complex

Elena Yakubovskaya, Kip E. Guja, Edward T. Eng, Woo Suk Choi, Edison Mejia, Dmitri Beglov, Mark Lukin, Dima Kozakov, Miguel Garcia-Diaz

Nucleic Acids Res. 2014 Apr; 42(6): 4100–4112. Published online 2014 Jan 9. doi: 10.1093/nar/gkt1360

PMCID:: PMC3973321

Article PDF–5.5M

Select item 357581614.

Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis

Yulia V. Surovtseva, Gerald S. Shadel

Nucleic Acids Res. 2013 Feb; 41(4): 2479–2488. Published online 2013 Jan 7. doi: 10.1093/nar/gks1447

PMCID:: PMC3575816

Article PDF–5.8M

Select item 659006115.

Structural basis of mitochondrial transcription initiation

Hauke S. Hillen, Yaroslav I. Morozov, Azadeh Sarfallah, Dmitry Temiakov, Patrick Cramer

Cell. Author manuscript; available in PMC 2019 Jun 24.

Published in final edited form as: Cell. 2017 Nov 16; 171(5): 1072–1081.e10. doi: 10.1016/j.cell.2017.10.036

PMCID:: PMC6590061

Article PDF–4.6M

Select item 260604616.

Human Mitochondrial Ribosomal Protein MRPL12 Interacts Directly with Mitochondrial RNA Polymerase to Modulate Mitochondrial Gene Expression

Zhibo Wang, Justin Cotney, Gerald S. Shadel

J Biol Chem. Author manuscript; available in PMC 2008 Dec 22.

Published in final edited form as: J Biol Chem. 2007 Apr 27; 282(17): 12610–12618. Published online 2007 Mar 2. doi: 10.1074/jbc.M700461200

PMCID:: PMC2606046

Article PDF–575K

Select item 16632517.

Human Mitochondrial Transcription Factor B1 Interacts with the C-Terminal Activation Region of h-mtTFA and Stimulates Transcription Independently of Its RNA Methyltransferase Activity

Vicki McCulloch, Gerald S. Shadel

Mol Cell Biol. 2003 Aug; 23(16): 5816–5824. doi: 10.1128/MCB.23.16.5816-5824.2003

PMCID:: PMC166325

Article PDF–269K

Select item 320770218.

Mitochondrial Ribosomal Protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription

Yulia V. Surovtseva, Timothy E. Shutt, Justin Cotney, Huseyin Cimen, Sophia Y. Chen, Emine C. Koc, Gerald S. Shadel

Proc Natl Acad Sci U S A. 2011 Nov 1; 108(44): 17921-17926. Published online 2011 Oct 14. doi: 10.1073/pnas.1108852108

PMCID:: PMC3207702

Article PDF–897K

Select item 310539619.

TEFM (c17orf42) is necessary for transcription of human mtDNA

Michal Minczuk, Jiuya He, Anna M. Duch, Thijs J. Ettema, Aleksander Chlebowski, Karol Dzionek, Leo G. J. Nijtmans, Martijn A. Huynen, Ian J. Holt

Nucleic Acids Res. 2011 May; 39(10): 4284–4299. Published online 2011 Jan 27. doi: 10.1093/nar/gkq1224

PMCID:: PMC3105396

Article PDF–6.7M

Select item 53305120.

The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells

Martina Gaspari, Maria Falkenberg, Nils-Göran Larsson, Claes M Gustafsson

EMBO J. 2004 Nov 24; 23(23): 4606–4614. Published online 2004 Nov 4. doi: 10.1038/sj.emboj.7600465

PMCID:: PMC533051

Article PDF–216K

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