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Select item 104174241.

DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway

Akhona Vava, Juliano D. Paccez, Yihong Wang, Xuesong Gu, Manoj K. Bhasin, Michael Myers, Nelson C. Soares, Towia A. Libermann, Luiz F. Zerbini

Cells. 2023 Aug; 12(15): 1973. Published online 2023 Jul 31. doi: 10.3390/cells12151973

PMCID:: PMC10417424

Article PDF–3.1M

Select item 81591602.

Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M

Ho Shin Kim, Jared T. Hammill, Daniel C. Scott, Yizhe Chen, Amy L. Rice, William Pistel, Bhuvanesh Singh, Brenda A. Schulman, R. Kiplin Guy

J Med Chem. 2021 May 13; 64(9): 5850–5862. Published online 2021 May 4. doi: 10.1021/acs.jmedchem.1c00035

PMCID:: PMC8159160

Article PDF–2.6M

Select item 78447703.

MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1)

Jing Xiao, Guang Li, Jingyu Zhou, Shalong Wang, Dongcai Liu, Guoshun Shu, Jianping Zhou, Feng Ren

Oncol Res. 2018; 26(4): 593–604. Published online 2018 May 7. doi: 10.3727/096504017X14920318811712

PMCID:: PMC7844770

Article PDF–13M

Select item 59141764.

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation

Jared T. Hammill, Deepak Bhasin, Daniel C. Scott, Jaeki Min, Yizhe Chen, Yan Lu, Lei Yang, Ho Shin Kim, Michele C. Connelly, Courtney Hammill, Gloria Holbrook, Cynthia Jeffries, Bhuvanesh Singh, Brenda A. Schulman, R. Kiplin Guy

J Med Chem. Author manuscript; available in PMC 2019 Apr 12.

Published in final edited form as: J Med Chem. 2018 Apr 12; 61(7): 2694–2706. Published online 2018 Mar 26. doi: 10.1021/acs.jmedchem.7b01282

PMCID:: PMC5914176

Article PDF–912K

Select item 56583595.

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

Haibin Zhou, Jianfeng Lu, Liu Liu, Denzil Bernard, Chao-Yie Yang, Ester Fernandez-Salas, Krishnapriya Chinnaswamy, Stephanie Layton, Jeanne Stuckey, Qing Yu, Weihua Zhou, Zhenqiang Pan, Yi Sun, Shaomeng Wang

Nat Commun. 2017; 8: 1150. Published online 2017 Oct 27. doi: 10.1038/s41467-017-01243-7

PMCID:: PMC5658359

Article PDF–3.1M

Select item 56529606.

MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1

Yu Shuang, Chao Li, Xuan Zhou, Yongwang Huang, Lun Zhang

Oncol Rep. 2017 Oct; 38(4): 2155–2165. Published online 2017 Aug 3. doi: 10.3892/or.2017.5875

PMCID:: PMC5652960

Article PDF–1.4M

Select item 31908057.

Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1

Kenneth Wu, Hua Yan, Lei Fang, Xinjiang Wang, Cathie Pfleger, Xuejun Jiang, Lan Huang, Zhen-Qiang Pan

J Biol Chem. 2011 Sep 30; 286(39): 34060–34070. Published online 2011 Aug 3. doi: 10.1074/jbc.M111.273045

PMCID:: PMC3190805

Article PDF–1.6M

Select item 58988158.

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation

Jared T. Hammill, Daniel C. Scott, Jaeki Min, Michele C. Connelly, Gloria Holbrook, Fangyi Zhu, Amy Matheny, Lei Yang, Bhuvanesh Singh, Brenda A. Schulman, R. Kiplin Guy

J Med Chem. Author manuscript; available in PMC 2019 Apr 12.

Published in final edited form as: J Med Chem. 2018 Apr 12; 61(7): 2680–2693. Published online 2018 Mar 26. doi: 10.1021/acs.jmedchem.7b01277

PMCID:: PMC5898815

Article PDF–975K

Select item 30604849.

SCCRO (DCUN1D1) Promotes Nuclear Translocation and Assembly of the Neddylation E3 Complex

Guochang Huang, Andrew J. Kaufman, Y. Ramanathan, Bhuvanesh Singh

J Biol Chem. 2011 Mar 25; 286(12): 10297–10304. Published online 2011 Jan 19. doi: 10.1074/jbc.M110.203729

PMCID:: PMC3060484

Article PDF–1.7M

Select item 476037410.

Regulation of glucose metabolism by p62/SQSTM1 through HIF1α

Ke Chen, Jin Zeng, Haibing Xiao, Chunhua Huang, Junhui Hu, Weimin Yao, Gan Yu, Wei Xiao, Hua Xu, Zhangqun Ye

J Cell Sci. 2016 Feb 15; 129(4): 817–830. doi: 10.1242/jcs.178756

PMCID:: PMC4760374

Article

Select item 541974311.

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

Kate E Coleman, Miklós Békés, Jessica R Chapman, Sarah B Crist, Mathew JK Jones, Beatrix M Ueberheide, Tony T Huang

eLife. 2017; 6: e24325. Published online 2017 May 5. doi: 10.7554/eLife.24325

PMCID:: PMC5419743

Article PDF–2.3M

Select item 426387612.

SCCRO3 (DCUN1D3) Antagonizes the Neddylation and Oncogenic Activity of SCCRO (DCUN1D1)

Guochang Huang, Cameron Stock, Claire C. Bommeljé, Víola B. Weeda, Kushyup Shah, Sarina Bains, Elizabeth Buss, Manish Shaha, Willi Rechler, Suresh Y. Ramanathan, Bhuvanesh Singh

J Biol Chem. 2014 Dec 12; 289(50): 34728–34742. Published online 2014 Oct 27. doi: 10.1074/jbc.M114.585505

PMCID:: PMC4263876

Article PDF–2.7M

Select item 321401013.

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

Daniel C. Scott, Julie K. Monda, Eric J. Bennett, J. Wade Harper, Brenda A. Schulman

Science. Author manuscript; available in PMC 2012 May 4.

Published in final edited form as: Science. 2011 Nov 4; 334(6056): 674–678. Published online 2011 Sep 22. doi: 10.1126/science.1209307

PMCID:: PMC3214010

Article PDF–3.3M

Select item 419171614.

Oncogenic function of SCCRO5/DCUN1D5 Requires its Neddylation E3 Activity and Nuclear Localization

Claire C. Bommeljé, Víola B. Weeda, Guochang Huang, Kushyup Shah, Sarina Bains, Elizabeth Buss, Manish Shaha, Mithat Gönen, Ronald Ghossein, Y. Ramanathan, Bhuvanesh Singh

Clin Cancer Res. Author manuscript; available in PMC 2014 Oct 9.

Published in final edited form as: Clin Cancer Res. 2014 Jan 15; 20(2): 372–381. Published online 2013 Nov 5. doi: 10.1158/1078-0432.CCR-13-1252

PMCID:: PMC4191716

Article PDF–1.1M

Select item 362424815.

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase

Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, Michael Ohh

Mol Cell Biol. 2013 Apr; 33(8): 1621–1631. doi: 10.1128/MCB.01342-12

PMCID:: PMC3624248

Article PDF–1.9M

Select item 428173316.

The Ubiquitin-associated (UBA) Domain of SCCRO/DCUN1D1 Protein Serves as a Feedback Regulator of Biochemical and Oncogenic Activity

Guochang Huang, Christopher W. Towe, Lydia Choi, Yoshihiro Yonekawa, Claire C. Bommeljé, Sarina Bains, Willi Rechler, Bing Hao, Yegnanarayana Ramanathan, Bhuvanesh Singh

J Biol Chem. 2015 Jan 2; 290(1): 296–309. Published online 2014 Nov 19. doi: 10.1074/jbc.M114.560169

PMCID:: PMC4281733

Article PDF–3.5M

Select item 378621217.

Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes

Julie K. Monda, Daniel C. Scott, Darcie J. Miller, John Lydeard, David King, J. Wade Harper, Eric J. Bennett, Brenda A. Schulman

Structure. Author manuscript; available in PMC 2013 Sep 30.

Published in final edited form as: Structure. 2013 Jan 8; 21(1): 42–53. Published online 2012 Nov 29. doi: 10.1016/j.str.2012.10.013

PMCID:: PMC3786212

Article PDF–4.8M

Select item 271832918.

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes

Nathalie Meyer-Schaller, Yang-Chieh Chou, Izabela Sumara, Dale D. O. Martin, Thimo Kurz, Nadja Katheder, Kay Hofmann, Luc G. Berthiaume, Frank Sicheri, Matthias Peter

Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30): 12365–12370. Published online 2009 Jul 14. doi: 10.1073/pnas.0812528106

PMCID:: PMC2718329

Article PDF–1.3M

Select item 583651219.

Cand1-mediated adaptive exchange mechanism enables variation in F-box protein expression

Xing Liu, Justin M. Reitsma, Jennifer L. Mamrosh, Yaru Zhang, Ronny Straube, Raymond J. Deshaies

Mol Cell. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Mol Cell. 2018 Mar 1; 69(5): 773–786.e6. doi: 10.1016/j.molcel.2018.01.038

PMCID:: PMC5836512

Article PDF–2.7M

Select item 681835320.

Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions

Weili Kong, Tsuyoshi Hayashi, Guillaume Fiches, Qikai Xu, Mamie Z. Li, Jianwen Que, Shuai Liu, Wei Zhang, Jun Qi, Netty Santoso, Stephen J. Elledge, Jian Zhu

Genomics Proteomics Bioinformatics. 2019 Jun; 17(3): 319–331. Published online 2019 Sep 5. doi: 10.1016/j.gpb.2018.12.010