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Items: 1 to 20 of 65

1.
Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport
Olivia J Rickman, Emma Guignard, Thomas Chabanon, Giovanni Bertoldi, Muriel Auberson, Edith Hummler
Life Sci Alliance. 2024 Mar; 7(3): e202302304. Published online 2024 Jan 3. doi: 10.26508/lsa.202302304
PMCID:
PMC10765116
ArticlePDF–4.2M
2.
TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection
Kristin Metzdorf, Henning Jacobsen, Marina C. Greweling-Pils, Markus Hoffmann, Tatjana Lüddecke, Felicitas Miller, Lars Melcher, Amy M. Kempf, Inga Nehlmeier, Dunja Bruder, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Luka Čičin-Šain
Viruses. 2023 Feb; 15(2): 271. Published online 2023 Jan 18. doi: 10.3390/v15020271
PMCID:
PMC9961888
ArticlePDF–2.6M
3.
Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions
Xingxing Li, Liuqing He, Jianhua Luo, Yangling Zheng, Yao Zhou, Danyang Li, Yuanyuan Zhang, Zhenrui Pan, Yanyan Li, Liang Tao
Nat Commun. 2022; 13: 4331. Published online 2022 Jul 26. doi: 10.1038/s41467-022-31994-x
PMCID:
PMC9321280
ArticlePDF–1.9M
4.
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2
Thao Vo, Kshitiz Paudel, Ishita Choudhary, Sonika Patial, Yogesh Saini
Sci Rep. 2022; 12: 1357. Published online 2022 Jan 25. doi: 10.1038/s41598-022-04906-8
PMCID:
PMC8789794
ArticlePDF–3.8M
5.
Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells
Dorothea Bestle, Hannah Limburg, Diana Kruhl, Anne Harbig, David A. Stein, Hong Moulton, Mikhail Matrosovich, Elsayed M. Abdelwhab, Jürgen Stech, Eva Böttcher-Friebertshäuser
J Virol. 2021 Oct; 95(20): e00906-21. Prepublished online 2021 Jul 28. Published online 2021 Sep 27. doi: 10.1128/JVI.00906-21
PMCID:
PMC8475512
ArticlePDF–4.1M
6.
H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
Ruth Lydia Olga Lambertz, Ingo Gerhauser, Inga Nehlmeier, Sabine Gärtner, Michael Winkler, Sarah Rebecca Leist, Heike Kollmus, Stefan Pöhlmann, Klaus Schughart
Virol J. 2020; 17: 56. Published online 2020 Apr 22. doi: 10.1186/s12985-020-01323-z
PMCID:
PMC7178614
ArticlePDF–1.6M
7.
Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
Ruth L. O. Lambertz, Jan Pippel, Ingo Gerhauser, Heike Kollmus, Darisuren Anhlan, Eike R. Hrincius, Joern Krausze, Nora Kühn, Klaus Schughart
J Gen Virol. 2018 Sep; 99(9): 1187–1198. Published online 2018 Aug 6. doi: 10.1099/jgv.0.001128
PMCID:
PMC6230768
ArticlePDF–4.6M
8.
TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus
Kouji Sakai, Yasushi Ami, Noriko Nakajima, Katsuhiro Nakajima, Minori Kitazawa, Masaki Anraku, Ikuyo Takayama, Natthanan Sangsriratanakul, Miyuki Komura, Yuko Sato, Hideki Asanuma, Emi Takashita, Katsuhiro Komase, Kazuaki Takehara, Masato Tashiro, Hideki Hasegawa, Takato Odagiri, Makoto Takeda
Sci Rep. 2016; 6: 29430. Published online 2016 Jul 8. doi: 10.1038/srep29430
PMCID:
PMC4937385
ArticlePDF–2.1M
9.
A Mutant H3N2 Influenza Virus Uses an Alternative Activation Mechanism in TMPRSS2 Knockout Mice by Loss of an Oligosaccharide in the Hemagglutinin Stalk Region
Kouji Sakai, Tsuyoshi Sekizuka, Yasushi Ami, Noriko Nakajima, Minori Kitazawa, Yuko Sato, Katsuhiro Nakajima, Masaki Anraku, Toru Kubota, Katsuhiro Komase, Kazuaki Takehara, Hideki Hasegawa, Takato Odagiri, Masato Tashiro, Makoto Kuroda, Makoto Takeda
J Virol. 2015 May 1; 89(9): 5154–5158. Published online 2015 Feb 11. doi: 10.1128/JVI.00124-15
PMCID:
PMC4403495
ArticlePDF–1.1M
10.
The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses
Kouji Sakai, Yasushi Ami, Maino Tahara, Toru Kubota, Masaki Anraku, Masako Abe, Noriko Nakajima, Tsuyoshi Sekizuka, Kazuya Shirato, Yuriko Suzaki, Akira Ainai, Yuichiro Nakatsu, Kazuhiko Kanou, Kazuya Nakamura, Tadaki Suzuki, Katsuhiro Komase, Eri Nobusawa, Katsumi Maenaka, Makoto Kuroda, Hideki Hasegawa, Yoshihiro Kawaoka, Masato Tashiro, Makoto Takeda
J Virol. 2014 May; 88(10): 5608–5616. doi: 10.1128/JVI.03677-13
PMCID:
PMC4019123
ArticlePDF–3.0M
11.
TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice
Carolin Tarnow, Géraldine Engels, Annika Arendt, Folker Schwalm, Hanna Sediri, Annette Preuss, Peter S. Nelson, Wolfgang Garten, Hans-Dieter Klenk, Gülsah Gabriel, Eva Böttcher-Friebertshäuser
J Virol. 2014 May; 88(9): 4744–4751. doi: 10.1128/JVI.03799-13
PMCID:
PMC3993819
ArticlePDF–1.9M
12.
Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice
Bastian Hatesuer, Stephanie Bertram, Nora Mehnert, Mahmoud M. Bahgat, Peter S. Nelson, Stefan Pöhlman, Klaus Schughart
PLoS Pathog. 2013 Dec; 9(12): e1003774. Published online 2013 Dec 5. doi: 10.1371/journal.ppat.1003774
Correction in:
PLoS Pathog. 2014 Sep; 10(9): e1004435.
PMCID:
PMC3857797
ArticlePDF–5.3M
13.
Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion
Yong-Biao Ma, Jian-Wen Qiao, Xiao Hu
Exp Biol Med (Maywood) 2023 Jan; 248(2): 91–105. Published online 2022 Nov 20. doi: 10.1177/15353702221134111
PMCID:
PMC10041054
ArticlePDF–7.0M
14.
Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways
Naoko Iwata-Yoshikawa, Masatoshi Kakizaki, Nozomi Shiwa-Sudo, Takashi Okura, Maino Tahara, Shuetsu Fukushi, Ken Maeda, Miyuki Kawase, Hideki Asanuma, Yuriko Tomita, Ikuyo Takayama, Shutoku Matsuyama, Kazuya Shirato, Tadaki Suzuki, Noriyo Nagata, Makoto Takeda
Nat Commun. 2022; 13: 6100. Published online 2022 Oct 15. doi: 10.1038/s41467-022-33911-8
PMCID:
PMC9568946
ArticlePDF–1.9M
15.
Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury
Susan Bengs, Alexia Rossi, Martina Haberecker, Nidaa Mikail, Alexander Meisel, Ahmed Haider, Muriel Grämer, Angela Portmann, Atanas Todorov, Christof Schönenberger, Caroline E. Gebhard, Gabriela M. Kuster, Vera Regitz-Zagrosek, Catherine Gebhard
Sci Rep. 2021; 11: 23993. Published online 2021 Dec 14. doi: 10.1038/s41598-021-03181-3
PMCID:
PMC8671541
ArticlePDF–4.5M
16.
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
Young Joo Sun, Gabriel Velez, Dylan E. Parsons, Kun Li, Miguel E. Ortiz, Shaunik Sharma, Paul B. McCray, Jr., Alexander G. Bassuk, Vinit B. Mahajan
J Clin Invest. 2021 May 17; 131(10): e147973. Published online 2021 May 17. doi: 10.1172/JCI147973
PMCID:
PMC8121520
ArticlePDF–5.1M
17.
Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung
Tomoya Sagawa, Takahiro Tsujikawa, Akiko Honda, Natsuko Miyasaka, Michitaka Tanaka, Takashi Kida, Koichi Hasegawa, Tomoaki Okuda, Yutaka Kawahito, Hirohisa Takano
Environ Res. 2021 Apr; 195: 110722. Published online 2021 Jan 7. doi: 10.1016/j.envres.2021.110722
PMCID:
PMC7789825
ArticlePDF–10M
18.
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium
Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Nicholas M. Negretti, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols, Lior Z. Braunstein, Alice Hackett, Michael Koval, Susan H. Guttentag, Timothy S. Blackwell, Steven A. Webber, Nicholas E. Banovich, Vanderbilt COVID-19 Consortium Cohort, Human Cell Atlas Biological Network, Jonathan A. Kropski, Jennifer M.S. Sucre
J Clin Invest. 2021 Jan 4; 131(1): e140766. Published online 2021 Jan 4. doi: 10.1172/JCI140766
PMCID:
PMC7773394
ArticlePDF–7.2M
19.
Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice
Min Yee, E. David Cohen, Jeannie Haak, Andrew M. Dylag, Michael A. O’Reilly
Sci Rep. 2020; 10: 22401. Published online 2020 Dec 28. doi: 10.1038/s41598-020-79595-2
PMCID:
PMC7769981
ArticlePDF–6.3M
20.
Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19
Dylan C. Sarver, G. William Wong
Biochem Biophys Res Commun. 2021 Jan 29; 538: 92–96. Published online 2020 Nov 2. doi: 10.1016/j.bbrc.2020.10.066
PMCID:
PMC7605802
ArticlePDF–816K

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