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Select item 109553791.

Adrenal-Permissive Germline HSD3B1 Allele and Prostate Cancer Outcomes

Rana R. McKay, Tyler J. Nelson, Meghana S. Pagadala, Craig C. Teerlink, Anthony Gao, Alex K. Bryant, Fatai Y. Agiri, Kripa Guram, Reid F. Thompson, Kathryn M. Pridgen, Tyler M. Seibert, Kyung Min Lee, Hannah Carter, Julie A. Lynch, Richard L. Hauger, Brent S. Rose

JAMA Netw Open. 2024 Mar; 7(3): e242976. Published online 2024 Mar 20. doi: 10.1001/jamanetworkopen.2024.2976

PMCID:: PMC10955379

Article

Select item 106453862.

Intratumoral androgen biosynthesis associated with 3β-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer

Shinjini Ganguly, Zaeem Lone, Andrew Muskara, Jarrell Imamura, Aimalie Hardaway, Mona Patel, Mike Berk, Timothy D. Smile, Elai Davicioni, Kevin L. Stephans, Jay Ciezki, Christopher J. Weight, Shilpa Gupta, Chandana A. Reddy, Rahul D. Tendulkar, Abhishek A. Chakraborty, Eric A. Klein, Nima Sharifi, Omar Y. Mian

J Clin Invest. 2023 Nov 15; 133(22): e165718. Published online 2023 Nov 15. doi: 10.1172/JCI165718

PMCID:: PMC10645386

Article PDF–14M

Select item 101549393.

HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta

Alison Dickson, Eylan Yutuc, Catherine A. Thornton, James E. Dunford, Udo Oppermann, Yuqin Wang, William J. Griffiths

Open Biol. 2023 May; 13(5): 220313. Published online May 3, 2023. doi: 10.1098/rsob.220313

PMCID:: PMC10154939

Article PDF–3.5M

Select item 96546144.

HSD3B1 Expression Is Upregulated by Interleukin 4 in HT-29 Colon Cancer Cells via Multiple Signaling Pathways

Hsin-Mei Chen, Pei-Yu Hung, Chih-Hung Chen, Yu-Jhen Yu, Ming-Shan Syu, Meng-Chun Hu

Int J Mol Sci. 2022 Nov; 23(21): 13572. Published online 2022 Nov 5. doi: 10.3390/ijms232113572

PMCID:: PMC9654614

Article PDF–2.5M

Select item 94753545.

Association Between Adrenal-Restrictive HSD3B1 Inheritance and Hormone-Independent Subtypes of Endometrial and Breast Cancer

Jeffrey M McManus, Roberto Vargas, Peter S Bazeley, Fredrick R Schumacher, Nima Sharifi

JNCI Cancer Spectr. 2022 Oct; 6(5): pkac061. Published online 2022 Aug 10. doi: 10.1093/jncics/pkac061

PMCID:: PMC9475354

Article PDF–458K

Select item 93095366.

Role of single nucleotide polymorphisms of the HSD3B1 gene (rs6203 and rs33937873) in the prediction of prostate cancer risk

Yasmine M. Amrousy, Hesham Haffez, Doaa M. Abdou, Hanaa B. Atya

Mol Med Rep. 2022 Aug; 26(2): 271. Published online 2022 Jul 4. doi: 10.3892/mmr.2022.12787

PMCID:: PMC9309536

Article PDF–455K

Select item 91069017.

Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank

Jeffrey M. McManus, Navin Sabharwal, Peter Bazeley, Nima Sharifi

Eur J Endocrinol. Author manuscript; available in PMC 2023 May 12.

Published in final edited form as: Eur J Endocrinol. 2022 May 12; 187(1): 1–14. Published online 2022 May 12. doi: 10.1530/EJE-21-0996

PMCID:: PMC9106901

Article PDF–1.3M

Select item 85648988.

Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer

Megan L. Kruse, Mona Patel, Jeffrey McManus, Yoon-Mi Chung, Xiuxiu Li, Wei Wei, Peter S. Bazeley, Fumihiko Nakamura, Aimalie Hardaway, Erinn Downs, Sarat Chandarlapaty, Mathew Thomas, Halle C.F. Moore, George T. Budd, W.H. Wilson Tang, Stanley L. Hazen, Aaron Bernstein, Serena Nik-Zainal, Jame Abraham, Nima Sharifi

JCI Insight. 2021 Oct 22; 6(20): e150403. Published online 2021 Oct 22. doi: 10.1172/jci.insight.150403

PMCID:: PMC8564898

Article PDF–410K

Select item 76579629.

Germline HSD3B1 Genetics and Prostate Cancer Outcomes

Lewis Thomas, Nima Sharifi

Urology. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Urology. 2020 Nov; 145: 13–21. Published online 2020 Aug 28. doi: 10.1016/j.urology.2020.08.028

PMCID:: PMC7657962

Article PDF–494K

Select item 704283010.

HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer

Jason W. D. Hearn, Christopher J. Sweeney, Nima Almassi, Chad A. Reichard, Chandana A. Reddy, Hong Li, Brian Hobbs, David F. Jarrard, Yu-Hui Chen, Robert Dreicer, Jorge A. Garcia, Michael A. Carducci, Robert S. DiPaola, Nima Sharifi

JAMA Oncol. 2020 Apr; 6(4): e196496. Published online 2020 Feb 13. doi: 10.1001/jamaoncol.2019.6496

PMCID:: PMC7042830

Article

Select item 699501311.

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Joe Zein, Benjamin Gaston, Peter Bazeley, Mark D. DeBoer, Robert P. Igo, Jr, Eugene R. Bleecker, Deborah Meyers, Suzy Comhair, Nadzeya V. Marozkina, Calvin Cotton, Mona Patel, Mohammad Alyamani, Weiling Xu, William W. Busse, William J. Calhoun, Victor Ortega, Gregory A. Hawkins, Mario Castro, Kian Fan Chung, John V. Fahy, Anne M. Fitzpatrick, Elliot Israel, Nizar N. Jarjour, Bruce Levy, David T. Mauger, Wendy C. Moore, Patricia Noel, Stephen P. Peters, W. Gerald Teague, Sally E. Wenzel, Serpil C. Erzurum, Nima Sharifi

Proc Natl Acad Sci U S A. 2020 Jan 28; 117(4): 2187–2193. Published online 2020 Jan 13. doi: 10.1073/pnas.1918819117

PMCID:: PMC6995013

Article PDF–902K

Select item 673621512.

HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond

Navin Sabharwal, Nima Sharifi

Endocrinology. 2019 Sep; 160(9): 2180–2188. Published online 2019 Jul 4. doi: 10.1210/en.2019-00366

PMCID:: PMC6736215

Article

Select item 648461813.

Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone

Masaki Shiota, Shintaro Narita, Shusuke Akamatsu, Naohiro Fujimoto, Takayuki Sumiyoshi, Maki Fujiwara, Takeshi Uchiumi, Tomonori Habuchi, Osamu Ogawa, Masatoshi Eto

JAMA Netw Open. 2019 Feb; 2(2): e190115. Published online 2019 Feb 22. doi: 10.1001/jamanetworkopen.2019.0115

PMCID:: PMC6484618

Article

Select item 606349214.

HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer

Mohammad Alyamani, Hamid Emamekhoo, Sunho Park, Jennifer Taylor, Nima Almassi, Sunil Upadhyay, Allison Tyler, Michael P. Berk, Bo Hu, Tae Hyun Hwang, William Douglas Figg, Cody J. Peer, Caly Chien, Vadim S. Koshkin, Prateek Mendiratta, Petros Grivas, Brian Rini, Jorge Garcia, Richard J. Auchus, Nima Sharifi

J Clin Invest. 2018 Aug 1; 128(8): 3333–3340. Published online 2018 Jun 25. doi: 10.1172/JCI98319

PMCID:: PMC6063492

Article PDF–1.2M

Select item 593337715.

Association of HSD3B1 Genotype With Response to Androgen-Deprivation Therapy for Biochemical Recurrence After Radiotherapy for Localized Prostate Cancer

Jason W. D. Hearn, Wanling Xie, Mari Nakabayashi, Nima Almassi, Chad A. Reichard, Mark Pomerantz, Philip W. Kantoff, Nima Sharifi

JAMA Oncol. 2018 Apr; 4(4): 558–562. Published online 2017 Oct 12. doi: 10.1001/jamaoncol.2017.3164

PMCID:: PMC5933377

Article

Select item 593336116.

HSD3B1 and Response to a Nonsteroidal CYP17A1 Inhibitor in Castration-Resistant Prostate Cancer

Nima Almassi, Chad Reichard, Jianbo Li, Carly Russell, Jaselle Perry, Charles J. Ryan, Terence Friedlander, Nima Sharifi

JAMA Oncol. 2018 Apr; 4(4): 554–557. Published online 2017 Oct 12. doi: 10.1001/jamaoncol.2017.3159

PMCID:: PMC5933361

Article

Select item 548734317.

Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta

Tsai-Chun Lai, Hsiao-Fang Li, Yu-Shian Li, Pei-Yu Hung, Ming-Kwang Shyu, Meng-Chun Hu

Sci Rep. 2017; 7: 4271. Published online 2017 Jun 27. doi: 10.1038/s41598-017-04133-6

PMCID:: PMC5487343

Article PDF–1.7M

Select item 491213318.

Variant allele of HSD3B1 increases progression to castration-resistant prostate cancer

Gang Wu, Shengsong Huang, Kent L. Nastiuk, Jinliang Li, Jun Gu, Ming Wu, Qimin Zhang, Hanqing Lin, Denglong Wu

Prostate. Author manuscript; available in PMC 2016 Jun 17.

Published in final edited form as: Prostate. 2015 May; 75(7): 777–782. Published online 2015 Mar 1. doi: 10.1002/pros.22967

PMCID:: PMC4912133

Article PDF–920K

Select item 486416819.

Human 3β‐hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations

Toru Hanamura, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Yasuyo Shimojo, Takeshi Uehara, Takashi Suzuki, Shin‐ichi Hayashi, Ken‐ichi Ito

Cancer Med. 2016 Jul; 5(7): 1405–1415. Published online 2016 May 3. doi: 10.1002/cam4.708

PMCID:: PMC4864168

Article PDF–1.1M

Select item 393101220.

A gain of function mutation in DHT synthesis in castration-resistant prostate cancer

Kai-Hsiung Chang, Rui Li, Barbara Kuri, Yair Lotan, Claus G. Roehrborn, Jiayan Liu, Robert Vessella, Peter Nelson, Payal Kapur, Xiaofeng Guo, Hamid Mirzaei, Richard J. Auchus, Nima Sharifi

Cell. Author manuscript; available in PMC 2014 Aug 29.

Published in final edited form as: Cell. 2013 Aug 29; 154(5): 1074–1084. doi: 10.1016/j.cell.2013.07.029

PMCID:: PMC3931012

Article PDF–3.5M

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