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Items: 1 to 20 of 57

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging
Mohammad Kasim Fatmi, Di Ren, Julia Fedorova, Linda Ines Zoungrana, Hao Wang, Kayla Davitt, Zehui Li, Migdalia Iglesias, Edward J. Lesnefsky, Meredith Krause‐Hauch, Ji Li
Aging Cell. 2023 Apr; 22(4): e13800. Published online 2023 Feb 16. doi: 10.1111/acel.13800
PMCID:
PMC10086528
ArticlePDF–7.0M
3.
Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
Themis Thoudam, Dipanjan Chanda, Jung Yi Lee, Min-Kyo Jung, Ibotombi Singh Sinam, Byung-Gyu Kim, Bo-Yoon Park, Woong Hee Kwon, Hyo-Jeong Kim, Myeongjin Kim, Chae Won Lim, Hoyul Lee, Yang Hoon Huh, Caroline A. Miller, Romil Saxena, Nicholas J. Skill, Nazmul Huda, Praveen Kusumanchi, Jing Ma, Zhihong Yang, Min-Ji Kim, Ji Young Mun, Robert A. Harris, Jae-Han Jeon, Suthat Liangpunsakul, In-Kyu Lee
Nat Commun. 2023; 14: 1703. Published online 2023 Mar 27. doi: 10.1038/s41467-023-37214-4
PMCID:
PMC10042999
ArticlePDF–12M
4.
Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue
Logan K. Townsend, Alyssa J. Weber, Pierre-Andre Barbeau, Graham P. Holloway, David C. Wright
Am J Physiol Cell Physiol. 2020 Jan 1; 318(1): C137–C149. Published online 2019 Nov 13. doi: 10.1152/ajpcell.00313.2019
PMCID:
PMC6985839
Article
5.
PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia
Fabrizio Pin, Leah J. Novinger, Joshua R. Huot, Robert A. Harris, Marion E. Couch, Thomas M. O’Connell, Andrea Bonetto
FASEB J. 2019 Jun; 33(6): 7778–7790. Published online 2019 Mar 20. doi: 10.1096/fj.201802799R
PMCID:
PMC6529344
Article
6.
PDK4 Augments ER–Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity
Themis Thoudam, Chae-Myeong Ha, Jaechan Leem, Dipanjan Chanda, Jong-Seok Park, Hyo-Jeong Kim, Jae-Han Jeon, Yeon-Kyung Choi, Suthat Liangpunsakul, Yang Hoon Huh, Tae-Hwan Kwon, Keun-Gyu Park, Robert A. Harris, Kyu-Sang Park, Hyun-Woo Rhee, In-Kyu Lee
Diabetes. 2019 Mar; 68(3): 571–586. Published online 2018 Dec 6. doi: 10.2337/db18-0363
PMCID:
PMC6385748
ArticlePDF–3.7M
7.
Loss of PDK4 switches the hepatic NF-κB/TNF pathway from pro-survival to pro-apoptosis
Jianguo Wu, Yulan Zhao, Young-Ki Park, Ji-Young Lee, Ling Gao, Jiajun Zhao, Li Wang
Hepatology. Author manuscript; available in PMC 2019 Sep 30.
Published in final edited form as: Hepatology. 2018 Sep; 68(3): 1111–1124. Published online 2018 May 20. doi: 10.1002/hep.29902
PMCID:
PMC6165716
ArticlePDF–3.6M
8.
Coenzyme A–mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice
Christopher Schafer, Zachary T. Young, Catherine A. Makarewich, Abdallah Elnwasany, Caroline Kinter, Michael Kinter, Luke I. Szweda
J Biol Chem. 2018 May 4; 293(18): 6915–6924. Published online 2018 Mar 14. doi: 10.1074/jbc.RA117.000268
PMCID:
PMC5936801
ArticlePDF–1.5M
9.
Pyruvate dehydrogenase kinase-4 contributes to the recirculation of gluconeogenic precursors during postexercise glycogen recovery
Eric A. F. Herbst, Rebecca E. K. MacPherson, Paul J. LeBlanc, Brian D. Roy, Nam Ho Jeoung, Robert A. Harris, Sandra J. Peters
Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15; 306(2): R102–R107. Published online 2013 Dec 4. doi: 10.1152/ajpregu.00150.2013
PMCID:
PMC3921314
Article
10.
Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart
Clair Crewe, Michael Kinter, Luke I. Szweda
PLoS One. 2013; 8(10): e77280. Published online 2013 Oct 7. doi: 10.1371/journal.pone.0077280
PMCID:
PMC3792029
ArticlePDF–1.3M
11.
Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high-saturated fat diet
Byounghoon Hwang, Pengfei Wu, Robert A. Harris
FEBS J. Author manuscript; available in PMC 2013 May 1.
Published in final edited form as: FEBS J. 2012 May; 279(10): 1883–1893. Published online 2012 Apr 4. doi: 10.1111/j.1742-4658.2012.08569.x
PMCID:
PMC3334477
ArticlePDF–3.0M
12.
Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice
Nam Ho Jeoung, Robert A. Harris
Am J Physiol Endocrinol Metab. 2008 Jul; 295(1): E46–E54. Published online 2008 Apr 22. doi: 10.1152/ajpendo.00536.2007
PMCID:
PMC2493588
Article
13.
Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily.
M Bowker-Kinley, K M Popov
Biochem J. 1999 Nov 15; 344(Pt 1): 47–53.
PMCID:
PMC1220612
SummaryPDF–280K
14.
Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Ibotombi Singh Sinam, Dipanjan Chanda, Themis Thoudam, Min‐Ji Kim, Byung‐Gyu Kim, Hyeon‐Ji Kang, Jung Yi Lee, Seung‐Hoon Baek, Shin‐Yoon Kim, Bum Jin Shim, Dongryeol Ryu, Jae‐Han Jeon, In‐Kyu Lee
J Cachexia Sarcopenia Muscle. 2022 Dec; 13(6): 3122–3136. Published online 2022 Oct 19. doi: 10.1002/jcsm.13100
Correction in:
J Cachexia Sarcopenia Muscle. 2023 Jun; 14(3): 1585.
Correction in:
J Cachexia Sarcopenia Muscle. 2023 Oct; 14(5): 2455.
PMCID:
PMC9745560
ArticlePDF–2.6M
15.
Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
Antonius Christianto, Takashi Baba, Fumiya Takahashi, Kai Inui, Miki Inoue, Mikita Suyama, Yusuke Ono, Yasuyuki Ohkawa, Ken-ichirou Morohashi
Commun Biol. 2021; 4: 1264. Published online 2021 Nov 4. doi: 10.1038/s42003-021-02790-y
PMCID:
PMC8569015
ArticlePDF–1.5M
16.
Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function
Nora Yucel, Yu Xin Wang, Thach Mai, Ermelinda Porpiglia, Peder J. Lund, Glenn Markov, Benjamin A. Garcia, Sean C. Bendall, Michael Angelo, Helen M. Blau
Cell Rep. Author manuscript; available in PMC 2019 Oct 11.
Published in final edited form as: Cell Rep. 2019 Jun 25; 27(13): 3939–3955.e6. doi: 10.1016/j.celrep.2019.05.092
PMCID:
PMC6788807
ArticlePDF–2.3M
17.
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis
Mithilesh Kumar Jha, Gyun Jee Song, Maan Gee Lee, Nam Ho Jeoung, Younghoon Go, Robert A. Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk
J Neurosci. 2015 Oct 21; 35(42): 14353–14369. doi: 10.1523/JNEUROSCI.1910-15.2015
PMCID:
PMC6605420
ArticlePDF–5.5M
18.
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, Keun-Gyu Park, Ajay Chawla, Jongsoon Lee, Robert A. Harris, In-Kyu Lee
Front Immunol. 2019; 10: 944. Published online 2019 May 7. doi: 10.3389/fimmu.2019.00944
PMCID:
PMC6514528
ArticlePDF–9.8M
19.
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells
A G Trinidad, N Whalley, R Rowlinson, O Delpuech, P Dudley, C Rooney, S E Critchlow
Oncogene. 2017 Nov 2; 36(44): 6164–6176. Published online 2017 Jul 10. doi: 10.1038/onc.2017.224
PMCID:
PMC5671936
ArticlePDF–3.5M
20.
Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
Sun Joo Lee, Ji Yun Jeong, Chang Joo Oh, Sungmi Park, Joon-Young Kim, Han-Jong Kim, Nam Doo Kim, Young-Keun Choi, Ji-Yeon Do, Younghoon Go, Chae-Myung Ha, Je-Yong Choi, Seung Huh, Nam Ho Jeoung, Ki-Up Lee, Hueng-Sik Choi, Yu Wang, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
Sci Rep. 2015; 5: 16577. Published online 2015 Nov 12. doi: 10.1038/srep16577
Correction in:
Sci Rep. 2016; 6: 18552.
PMCID:
PMC4642318
ArticlePDF–2.3M

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