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Items: 1 to 20 of 36

1.
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling
Carolina Magdalen Greco, Marlene Cervantes, Jean-Michel Fustin, Kakeru Ito, Nicholas Ceglia, Muntaha Samad, Jiejun Shi, Kevin Brian Koronowski, Ignasi Forne, Suman Ranjit, Jonathan Gaucher, Kenichiro Kinouchi, Rika Kojima, Enrico Gratton, Wei Li, Pierre Baldi, Axel Imhof, Hitoshi Okamura, Paolo Sassone-Corsi
Sci Adv. 2020 Dec; 6(51): eabc5629. Published online 2020 Dec 16. doi: 10.1126/sciadv.abc5629
PMCID:
PMC7744083
AbstractArticlePDF–4.5M
2.
Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma
Igor P. Pogribny, Kostiantyn Dreval, Iryna Kindrat, Stepan Melnyk, Leandro Jimenez, Aline de Conti, Volodymyr Tryndyak, Marta Pogribna, Juliana Festa Ortega, S. Jill James, Ivan Rusyn, Frederick A. Beland
FASEB J. 2018 Mar; 32(3): 1591–1601. Published online 2017 Nov 10. doi: 10.1096/fj.201700866R
PMCID:
PMC6137451
AbstractArticle
3.
Crystallization of mouse S-adenosyl-l-homocysteine hydrolase
Masaaki Ishihara, Yoshio Kusakabe, Tsuyoshi Ohsumichi, Nobutada Tanaka, Masayuki Nakanishi, Yukio Kitade, Kazuo T. Nakamura
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1; 66(Pt 3): 313–315. Published online 2010 Feb 24. doi: 10.1107/S1744309110000771
PMCID:
PMC2833045
AbstractArticlePDF–142K
4.
Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells
Paula Boczki, Marco Colombo, Juliane Weiner, Inka Rapöhn, Martin Lacher, Wieland Kiess, Martha Hanschkow, Antje Körner, Kathrin Landgraf
Adipocyte. 2024; 13(1): 2290218. Published online 2023 Dec 8. doi: 10.1080/21623945.2023.2290218
PMCID:
PMC10732623
AbstractArticlePDF–2.3M
5.
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch, Owen J. Sansom
Nat Metab. 2023; 5(8): 1303–1318. Published online 2023 Aug 14. doi: 10.1038/s42255-023-00857-0
PMCID:
PMC10447251
AbstractArticlePDF–17M
6.
S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation
Maria Elena Fernandez-Sanchez, Thomas Gonatopoulos-Pournatzis, Gavin Preston, Margaret A. Lawlor, Victoria H. Cowling
Mol Cell Biol. 2009 Dec; 29(23): 6182–6191. Published online 2009 Oct 5. doi: 10.1128/MCB.00973-09
PMCID:
PMC2786700
AbstractArticlePDF–1.9M
7.
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene.
M W Miller, D M Duhl, B M Winkes, F Arredondo-Vega, P J Saxon, G L Wolff, C J Epstein, M S Hershfield, G S Barsh
EMBO J. 1994 Apr 15; 13(8): 1806–1816. doi: 10.1002/j.1460-2075.1994.tb06449.x
PMCID:
PMC395020
SummaryPage BrowsePDF–3.1M
8.
DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
Ji Cao, Xiaobing Chen, Li Jiang, Bin Lu, Meng Yuan, Difeng Zhu, Hong Zhu, Qiaojun He, Bo Yang, Meidan Ying
Nat Commun. 2020; 11: 1251. Published online 2020 Mar 6. doi: 10.1038/s41467-020-15109-y
PMCID:
PMC7060199
AbstractArticlePDF–2.6M
9.
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
Jichun Zhou, Lihua Yang, Tianyu Zhong, Martin Mueller, Yi Men, Na Zhang, Juanke Xie, Karolyn Giang, Hunter Chung, Xueguang Sun, Lingeng Lu, Gordon G Carmichael, Hugh S Taylor, Yingqun Huang
Nat Commun. 2015; 6: 10221. Published online 2015 Dec 21. doi: 10.1038/ncomms10221
PMCID:
PMC4703905
AbstractArticlePDF–2.0M
10.
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1α
Siming Li, Erland Arning, Chang Liu, Victor Vitvitsky, Carlos Hernandez, Ruma Banerjee, Teodoro Bottiglieri, Jiandie D. Lin
Am J Physiol Endocrinol Metab. 2009 Mar; 296(3): E543–E548. Published online 2009 Jan 21. doi: 10.1152/ajpendo.90719.2008
PMCID:
PMC2660144
AbstractArticle
11.
Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2−/y mice
Traci L. Pawlowski, Silvia Heringer-Walther, Chun-Huai Cheng, John G. Archie, Chin-Fu Chen, Thomas Walther, Anand K. Srivastava
Genomics. Author manuscript; available in PMC 2011 Aug 31.
Published in final edited form as: Genomics. 2009 Sep; 94(3): 188–195. Published online 2009 Jun 6. doi: 10.1016/j.ygeno.2009.05.011
PMCID:
PMC3164574
AbstractArticlePDF–2.0M
12.
Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia
Teresa Partearroyo, Silvia Murillo-Cuesta, Néstor Vallecillo, Jose M. Bermúdez-Muñoz, Lourdes Rodríguez-de la Rosa, Giacomo Mandruzzato, Adelaida M. Celaya, Steven H. Zeisel, María A. Pajares, Gregorio Varela-Moreiras, Isabel Varela-Nieto
FASEB J. 2019 May; 33(5): 5942–5956. Published online 2019 Feb 12. doi: 10.1096/fj.201801533R
PMCID:
PMC6463923
AbstractArticle
13.
IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss
Adelaida M. Celaya, Lourdes Rodríguez-de la Rosa, Jose M. Bermúdez-Muñoz, José M. Zubeldia, Carlos Romá-Mateo, Carlos Avendaño, Federico V. Pallardó, Isabel Varela-Nieto
Cells. 2021 Jul; 10(7): 1686. Published online 2021 Jul 3. doi: 10.3390/cells10071686
PMCID:
PMC8304185
AbstractArticlePDF–7.1M
14.
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers
NPJ Syst Biol Appl. 2021; 7: 25. Published online 2021 May 28. doi: 10.1038/s41540-021-00184-8
PMCID:
PMC8163790
AbstractArticlePDF–6.9M
15.
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
M Mehrabian, P Z Wen, J Fisler, R C Davis, A J Lusis
J Clin Invest. 1998 Jun 1; 101(11): 2485–2496. doi: 10.1172/JCI1748
PMCID:
PMC508838
SummaryPDF–1.0M
16.
Liver and brain differential expression of one-carbon metabolism genes during ontogenesis
Apolline Imbard, Leslie Schwendimann, Sophie Lebon, Pierre Gressens, Henk J. Blom, Jean-François Benoist
Sci Rep. 2021; 11: 21132. Published online 2021 Oct 26. doi: 10.1038/s41598-021-00311-9
PMCID:
PMC8548596
AbstractArticlePDF–1.3M
17.
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism
Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell
iScience. 2020 May 22; 23(5): 101132. Published online 2020 May 1. doi: 10.1016/j.isci.2020.101132
PMCID:
PMC7236060
AbstractArticlePDF–6.1M
18.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
19.
Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Dyna I. Shirasaki, Erin R. Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H. Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A. Loo, X. William Yang
Neuron. Author manuscript; available in PMC 2013 Jul 12.
Published in final edited form as: Neuron. 2012 Jul 12; 75(1): 41–57. doi: 10.1016/j.neuron.2012.05.024
PMCID:
PMC3432264
AbstractArticlePDF–4.9M
20.
Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells
Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch
Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262
PMCID:
PMC6244183
AbstractArticlePDF–753K

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