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Select item 100262511.

Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation

Marc R Benoit, Mabintou Darboe, Brati Das, Yingying Ge, John Zhou, Annie Yao, Wanxia He, Riqiang Yan, Xiangyou Hu

Hum Mol Genet. 2023 Apr 1; 32(7): 1193–1207. Published online 2022 Nov 12. doi: 10.1093/hmg/ddac282

PMCID:: PMC10026251

Article PDF–2.1M

Select item 99424142.

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler

Mol Neurodegener. 2023; 18: 13. Published online 2023 Feb 21. doi: 10.1186/s13024-023-00596-6

PMCID:: PMC9942414

Article PDF–2.3M

Select item 99054733.

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup

Sci Rep. 2023; 13: 2216. Published online 2023 Feb 7. doi: 10.1038/s41598-023-28846-z

PMCID:: PMC9905473

Article PDF–3.1M

Select item 92995354.

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

Neeraj Singh, Brati Das, John Zhou, Xiangyou Hu, Riqiang Yan

Sci Adv. 2022 Jul; 8(29): eabo3610. Published online 2022 Jul 20. doi: 10.1126/sciadv.abo3610

PMCID:: PMC9299535

Article PDF–5.5M

Select item 87600505.

BACE1 controls synaptic function through modulating release of synaptic vesicles

Brati Das, Neeraj Singh, Annie Y. Yao, John Zhou, Wanxia He, Xiangyou Hu, Riqiang Yan

Mol Psychiatry. 2021; 26(11): 6394–6410. Published online 2021 Jun 22. doi: 10.1038/s41380-021-01166-2

PMCID:: PMC8760050

Article PDF–4.3M

Select item 66503616.

The Alzheimer’s disease-associated protein BACE1 modulates T cell activation and Th17 function

Gerard Hernandez Mir, Itay Raphael, Shankar Revu, Catherine H Poholek, Lyndsay Avery, William F Hawse, Lawrence P Kane, Mandy J McGeachy

J Immunol. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: J Immunol. 2019 Aug 1; 203(3): 665–675. Published online 2019 Jun 17. doi: 10.4049/jimmunol.1800363

PMCID:: PMC6650361

Article PDF–2.2M

Select item 66423357.

Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice

Yong-Gang Fan, Tian Guo, Xiao-Ran Han, Jun-Lin Liu, Yu-Ting Cai, Han Xue, Xue-Shi Huang, Yan-Chun Li, Zhan-You Wang, Chuang Guo

EBioMedicine. 2019 Jul; 45: 393–407. Published online 2019 Jul 11. doi: 10.1016/j.ebiom.2019.07.014

PMCID:: PMC6642335

Article PDF–6.6M

Select item 63634298.

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

Divna Lazic, Abhay P. Sagare, Angeliki M. Nikolakopoulou, John H. Griffin, Robert Vassar, Berislav V. Zlokovic

J Exp Med. 2019 Feb 4; 216(2): 279–293. doi: 10.1084/jem.20181035

PMCID:: PMC6363429

Article PDF–2.7M

Select item 60739819.

BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice

Zena K. Chatila, Eunhee Kim, Clara Berlé, Enjana Bylykbashi, Alexander Rompala, Mary K. Oram, Drew Gupta, Sang Su Kwak, Young Hye Kim, Doo Yeon Kim, Se Hoon Choi, Rudolph E. Tanzi

eNeuro. 2018 Jul-Aug; 5(4): ENEURO.0067-18.2018. Prepublished online 2018 Jul 30. Published online 2018 Aug 3. doi: 10.1523/ENEURO.0067-18.2018

PMCID:: PMC6073981

Article PDF–1.9M

Select item 607254510.

Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome

Julia Herber, Jasenka Njavro, Regina Feederle, Ute Schepers, Ulrike C. Müller, Stefan Bräse, Stephan A. Müller, Stefan F. Lichtenthaler

Mol Cell Proteomics. 2018 Aug; 17(8): 1487–1501. Published online 2018 Apr 30. doi: 10.1074/mcp.RA118.000608

PMCID:: PMC6072545

Article PDF–1.0M

Select item 554571311.

Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice

Z A Cordner, K L K Tamashiro

Transl Psychiatry. 2016 Jul; 6(7): e854. Published online 2016 Jul 12. doi: 10.1038/tp.2016.127

PMCID:: PMC5545713

Article PDF–2.6M

Select item 551111212.

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

Hailong Hou, Qingyuan Fan, Wanxia He, Hoonkyo Suh, Xiangyou Hu, Riqiang Yan

Stem Cell Reports. 2017 Jul 11; 9(1): 217–230. Published online 2017 Jun 29. doi: 10.1016/j.stemcr.2017.05.030

PMCID:: PMC5511112

Article PDF–5.8M

Select item 535716913.

BACE1 regulates the proliferation and cellular functions of Schwann cells

Xiangyou Hu, Hailong Hou, Chinthasagar Bastian, Wanxia He, Shupeng Qiu, Yingying Ge, Xinhua Yin, Grahame J. Kidd, Sylvain Brunet, Bruce D. Trapp, Selva Baltan, Riqiang Yan

Glia. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Glia. 2017 May; 65(5): 712–726. Published online 2017 Feb 13. doi: 10.1002/glia.23122

PMCID:: PMC5357169

Article PDF–3.8M

Select item 494712514.

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

Katherine R. Sadleir, Patty C. Kandalepas, Virginie Buggia-Prévot, Daniel A. Nicholson, Gopal Thinakaran, Robert Vassar

Acta Neuropathol. 2016; 132: 235–256. Published online 2016 Mar 18. doi: 10.1007/s00401-016-1558-9

PMCID:: PMC4947125

Article PDF–6.0M

Select item 492969615.

BACE-1 is expressed in the blood–brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease

Kavi Devraj, Slobodan Poznanovic, Christoph Spahn, Gerhard Schwall, Patrick N Harter, Michel Mittelbronn, Katia Antoniello, Paolo Paganetti, Andreas Muhs, Mike Heilemann, Richard A Hawkins, André Schrattenholz, Stefan Liebner

J Cereb Blood Flow Metab. 2016 Jul; 36(7): 1281–1294. Published online 2015 Oct 13. doi: 10.1177/0271678X15606463

PMCID:: PMC4929696

Article PDF–1.6M

Select item 488765416.

Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice

Gang Luo, Hongxia Xu, Yinuo Huang, Dapeng Mo, Ligang Song, Baixue Jia, Bo Wang, Zhanqiang Jin, Zhongrong Miao

Biomed Res Int. 2016; 2016: 8380618. Published online 2016 May 18. doi: 10.1155/2016/8380618

PMCID:: PMC4887654

Article PDF–2.2M

Select item 481641217.

Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice

R. E. K. MacPherson, P. Baumeister, W. T. Peppler, D. C. Wright, J. P. Little

J Appl Physiol (1985) 2015 Nov 15; 119(10): 1097–1104. Published online 2015 Sep 24. doi: 10.1152/japplphysiol.00299.2015

PMCID:: PMC4816412

Article

Select item 477391918.

Partial BACE1 Reduction in a Down Syndrome Mouse Model blocks Alzheimer-related Endosomal Anomalies and Cholinergic Neurodegeneration: Role of APP-CTF

Ying Jiang, Andrew Rigoglioso, Corrinne M. Peterhoff, Monika Pawlik, Yutaka Sato, Cynthia Bleiwas, Philip Stavrides, John F. Smiley, Stephen D. Ginsberg, Paul M. Mathews, Efrat Levy, Ralph A. Nixon

Neurobiol Aging. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Neurobiol Aging. 2016 Mar; 39: 90–98. Published online 2015 Dec 2. doi: 10.1016/j.neurobiolaging.2015.11.013

PMCID:: PMC4773919

Article PDF–834K

Select item 459713619.

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

Bastian Dislich, Felix Wohlrab, Teresa Bachhuber, Stephan A. Müller, Peer-Hendrik Kuhn, Sebastian Hogl, Melanie Meyer-Luehmann, Stefan F. Lichtenthaler

Mol Cell Proteomics. 2015 Oct; 14(10): 2550–2563. Published online 2015 Jul 2. doi: 10.1074/mcp.M114.041533