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Select item 84085931.

PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

Emily Maguire, Georgina E Menzies, Thomas Phillips, Michael Sasner, Harriet M Williams, Magdalena A Czubala, Neil Evans, Emma L Cope, Rebecca Sims, Gareth R Howell, Emyr Lloyd‐Evans, Julie Williams, Nicholas D Allen, Philip R Taylor

EMBO J. 2021 Sep 1; 40(17): e105603. Published online 2021 Jul 13. doi: 10.15252/embj.2020105603

PMCID:: PMC8408593

Article PDF–3.1M

Select item 63598632.

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting

Alzheimers Res Ther. 2019; 11: 16. Published online 2019 Feb 2. doi: 10.1186/s13195-019-0469-0

PMCID:: PMC6359863

Article PDF–2.1M

Select item 47883553.

A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma

Jennifer Gossmann, Manfred Stolte, Michael Lohoff, Philipp Yu, Roland Moll, Florian Finkernagel, Holger Garn, Cornelia Brendel, Alwina Bittner, Andreas Neubauer, Minh Q. Huynh

PLoS One. 2016; 11(3): e0150411. Published online 2016 Mar 11. doi: 10.1371/journal.pone.0150411

PMCID:: PMC4788355

Article PDF–5.2M

Select item 47807024.

Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice

Hirotake Ichise, Taeko Ichise, Nobuaki Yoshida

PLoS One. 2016; 11(3): e0150521. Published online 2016 Mar 7. doi: 10.1371/journal.pone.0150521

PMCID:: PMC4780702

Article PDF–25M

Select item 38371105.

Targeted Inhibition of Phospholipase C γ2 Adaptor Function Blocks Osteoclastogenesis and Protects from Pathological Osteolysis

Corinne Decker, Pamela Hesker, Kaihua Zhang, Roberta Faccio

J Biol Chem. 2013 Nov 22; 288(47): 33634–33641. Published online 2013 Sep 30. doi: 10.1074/jbc.M113.477281

PMCID:: PMC3837110

Article PDF–1.8M

Select item 19521646.

Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing

Li Bai, Yuhong Chen, Yinghong He, Xuezhi Dai, Xueyan Lin, Renren Wen, Demin Wang

Mol Cell Biol. 2007 Sep; 27(17): 5957–5967. Published online 2007 Jun 25. doi: 10.1128/MCB.02273-06

PMCID:: PMC1952164

Article PDF–1.0M

Select item 16985237.

Essential Role of Phospholipase Cγ2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis

Renren Wen, Yuhong Chen, Li Bai, Guoping Fu, James Schuman, Xuezhi Dai, Hu Zeng, Chunying Yang, Robert P. Stephan, John L. Cleveland, Demin Wang

Mol Cell Biol. 2006 Dec; 26(24): 9364–9376. Published online 2006 Oct 9. doi: 10.1128/MCB.00839-06

PMCID:: PMC1698523

Article PDF–1.0M

Select item 88577838.

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease

Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Evan J. Messenger, Brad T. Casali, Miguel Moutinho, Yunlong Liu, Adrian L. Oblak, Bruce T. Lamb, Gary E. Landreth, Stephanie J. Bissel, Kwangsik Nho

Genome Med. 2022; 14: 17. Published online 2022 Feb 18. doi: 10.1186/s13073-022-01022-0

PMCID:: PMC8857783

Article PDF–3.0M

Select item 74884849.

The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions

Mari Takalo, Rebekka Wittrahm, Benedikt Wefers, Samira Parhizkar, Kimmo Jokivarsi, Teemu Kuulasmaa, Petra Mäkinen, Henna Martiskainen, Wolfgang Wurst, Xianyuan Xiang, Mikael Marttinen, Pekka Poutiainen, Annakaisa Haapasalo, Mikko Hiltunen, Christian Haass

Mol Neurodegener. 2020; 15: 52. Published online 2020 Sep 11. doi: 10.1186/s13024-020-00402-7

PMCID:: PMC7488484

Article PDF–4.6M

Select item 436882210.

Restoration of Responsiveness of Phospholipase Cγ2-Deficient Platelets by Enforced Expression of Phospholipase Cγ1

Yongwei Zheng, Tamara Adams, Huiying Zhi, Mei Yu, Renren Wen, Peter J. Newman, Demin Wang, Debra K. Newman

PLoS One. 2015; 10(3): e0119739. Published online 2015 Mar 20. doi: 10.1371/journal.pone.0119739

PMCID:: PMC4368822

Article PDF–1.4M

Select item 402054211.

Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLC γ2-PKC and MAPK Pathways

Ting-Lin Yen, Wan-Jung Lu, Li-Ming Lien, Philip Aloysius Thomas, Tzu-Yin Lee, Hou-Chang Chiu, Joen-Rong Sheu, Kuan-Hung Lin

Biomed Res Int. 2014; 2014: 728019. Published online 2014 Apr 29. doi: 10.1155/2014/728019

PMCID:: PMC4020542

Article PDF–2.4M

Select item 313886612.

CD8+ T cells Regulate Bone Tumor Burden Independent of Osteoclast Resorption

Kaihua Zhang, Seokho Kim, Viviana Cremasco, Angela C. Hirbe, Deborah V. Novack, Katherine Weilbaecher, Roberta Faccio

Cancer Res. Author manuscript; available in PMC 2012 Jul 15.

Published in final edited form as: Cancer Res. 2011 Jul 15; 71(14): 4799–4808. Published online 2011 May 20. doi: 10.1158/0008-5472.CAN-10-3922

Correction in:: volume 72 on page 568

PMCID:: PMC3138866

Article PDF–3.7M

Select item 275571413.

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

Katy L. Everett, Tom D. Bunney, Youngdae Yoon, Fernando Rodrigues-Lima, Richard Harris, Paul C. Driscoll, Koichiro Abe, Helmut Fuchs, Martin Hrabé de Angelis, Philipp Yu, Wohnwa Cho, Matilda Katan

J Biol Chem. 2009 Aug 21; 284(34): 23083–23093. Published online 2009 Jun 16. doi: 10.1074/jbc.M109.019265

PMCID:: PMC2755714

Article PDF–1.9M

Select item 269948814.

Foxo3−/− mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution

Rochelle M. Hinman, Whitney A. Nichols, Tracy M. Diaz, Teresa D. Gallardo, Diego H. Castrillon, Anne B. Satterthwaite

Int Immunol. 2009 Jul; 21(7): 831–842. Published online 2009 Jun 5. doi: 10.1093/intimm/dxp049

PMCID:: PMC2699488

Article PDF–823K

Select item 257088315.

Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis

Yabing Chen, Xiaohong Wang, Lie Di, Guoping Fu, Yuhong Chen, Li Bai, Jianzhong Liu, Xu Feng, Jay M. McDonald, Sue Michalek, Yinghong He, Mei Yu, Yang-Xin Fu, Renren Wen, Hui Wu, Demin Wang

J Biol Chem. 2008 Oct 24; 283(43): 29593–29601. doi: 10.1074/jbc.M802493200

PMCID:: PMC2570883

Article PDF–629K

Select item 219417816.

Coupling Between B Cell Receptor and Phospholipase C-γ2 Is Essential for Mature B Cell Development

Masaki Hikida, Sachiko Johmura, Ari Hashimoto, Mayuko Takezaki, Tomohiro Kurosaki

J Exp Med. 2003 Aug 18; 198(4): 581–589. doi: 10.1084/jem.20030280

PMCID:: PMC2194178

Article PDF–307K

Select item 219416017.

Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling

Masatsugu Oh-hora, Sachiko Johmura, Ari Hashimoto, Masaki Hikida, Tomohiro Kurosaki

J Exp Med. 2003 Dec 15; 198(12): 1841–1851. doi: 10.1084/jem.20031547

PMCID:: PMC2194160

Article PDF–336K

Select item 40787018.

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

James L. Clements, Jong Ran Lee, Barbara Gross, Baoli Yang, John D. Olson, Alexander Sandra, Stephen P. Watson, Steven R. Lentz, Gary A. Koretzky

J Clin Invest. 1999 Jan 1; 103(1): 19–25. doi: 10.1172/JCI5317

PMCID:: PMC407870

Article PDF–492K

Select item 13988819.

Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex

Shiann-Tarng Jou, Nick Carpino, Yutaka Takahashi, Roland Piekorz, Jyh-Rong Chao, Neena Carpino, Demin Wang, James N. Ihle

Mol Cell Biol. 2002 Dec; 22(24): 8580–8591. doi: 10.1128/MCB.22.24.8580-8591.2002

PMCID:: PMC139888

Article PDF–756K

Select item 568413120.

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang

Nat Commun. 2017; 8: 1457. Published online 2017 Nov 13. doi: 10.1038/s41467-017-01388-5