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Select item 109621281.

NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells

Binghong Liu, Fei Song, Xiaoxia Zhou, Chan Wu, Huizhu Huang, Weiyin Wu, Gang Li, Yan Wang

J Cell Mol Med. 2024 Apr; 28(8): 1–11. Published online 2024 Mar 25. doi: 10.1111/jcmm.18233

PMCID:: PMC10962128

Article PDF–17M

Select item 103372842.

Genetic analysis of periventricular nodular heterotopia 7 caused by a novel NEDD4L missense mutation: Case and literature summary

Juan Liu, Jihong Hu, Yaqing Duan, Rong Qin, Chunguang Guo, Hongtao Zhou, Hua Liu, Chunlei Liu

Mol Genet Genomic Med. 2023 Jul; 11(7): e2169. Published online 2023 Mar 19. doi: 10.1002/mgg3.2169

PMCID:: PMC10337284

Article PDF–1.8M

Select item 101677413.

Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis

Shuang Li, Qinmao Ye, Jianxin Wei, Sarah J Taleb, Heather Wang, Yingze Zhang, Daniel J Kass, Jeffrey C Horowitz, Jing Zhao, Yutong Zhao

Transl Res. Author manuscript; available in PMC 2023 May 9.

Published in final edited form as: Transl Res. 2023 Mar; 253: 1–7. Published online 2022 Oct 17. doi: 10.1016/j.trsl.2022.10.002

PMCID:: PMC10167741

Article PDF–1.4M

Select item 91380474.

Down-regulated NEDD4L facilitates tumor progression through activating Notch signaling in lung adenocarcinoma

Liping Lin, Xuan Wu, Yuanxue Jiang, Caijiu Deng, Xi Luo, Jianjun Han, Jiazhu Hu, Xiaolong Cao

PeerJ. 2022; 10: e13402. Published online 2022 May 24. doi: 10.7717/peerj.13402

PMCID:: PMC9138047

Article PDF–6.3M

Select item 83198285.

Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis: A Multi-institutional Genome-Wide Association Study

Apostolos Gaitanidis, Haytham M. A. Kaafarani, Mathias A. Christensen, Kerry Breen, April Mendoza, Peter J. Fagenholz, George C. Velmahos, Maha R. Farhat

JAMA Surg. 2021 Oct; 156(10): 917–923. Published online 2021 Jul 28. doi: 10.1001/jamasurg.2021.3303

PMCID:: PMC8319828

Article

Select item 62260186.

A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling

Neil J. Grimsey, Rachan Narala, Cara C. Rada, Sohum Mehta, Bryan S. Stephens, Irina Kufareva, John Lapek, David J. Gonzalez, Tracy M. Handel, Jin Zhang, JoAnn Trejo

Cell Rep. Author manuscript; available in PMC 2018 Nov 9.

Published in final edited form as: Cell Rep. 2018 Sep 18; 24(12): 3312–3323.e5. doi: 10.1016/j.celrep.2018.08.061

PMCID:: PMC6226018

Article PDF–2.3M

Select item 50860937.

Mutations in the HECT domain of NEDD4L lead to AKT/mTOR pathway deregulation and cause periventricular nodular heterotopia

Loïc Broix, Hélène Jagline, Ekaterina Ivanova, Stéphane Schmucker, Nathalie Drouot, Jill Clayton-Smith, Alistair T. Pagnamenta, Kay.A. Metcalfe, Bertrand Isidor, Ulrike Walther Louvier, Annapurna Poduri, Jenny C. Taylor, Peggy Tilly, Karine Poirier, Yoann Saillour, Nicolas Lebrun, Tristan Stemmelen, Gabrielle Rudolf, Giuseppe Muraca, Benjamin Saintpierre, Adrienne Elmorjani, The Deciphering Developmental Disorders study, Martin Moïse, Nathalie Bednarek Weirauch, Renzo Guerrini, Anne Boland, Robert Olaso, Cecile Masson, Ratna Tripathy, David Keays, Cherif Beldjord, Laurent Nguyen, Juliette Godin, Usha Kini, Patrick Nischké, Jean-François Deleuze, Nadia Bahi-Buisson, Izabela Sumara, Maria-Victoria Hinckelmann, Jamel Chelly

Nat Genet. Author manuscript; available in PMC 2017 Apr 3.

Published in final edited form as: Nat Genet. 2016 Nov; 48(11): 1349–1358. Published online 2016 Oct 3. doi: 10.1038/ng.3676

PMCID:: PMC5086093

Article PDF–2.6M

Select item 40228408.

The phosphorylation of endogenous Nedd4-2 In Na⁺—absorbing human airway epithelial cells

Noor A.S. Ismail, Deborah L. Baines, Stuart M. Wilson

Eur J Pharmacol. 2014 Jun 5; 732(100): 32–42. doi: 10.1016/j.ejphar.2014.03.005

PMCID:: PMC4022840

Article

Select item 39196479.

Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma

Yusuke Kito, Juncheng Bai, Naoe Goto, Hiroshi Okubo, Yoshihiro Adachi, Tomoko Nagayama, Tamotsu Takeuchi

Int J Exp Pathol. 2014 Feb; 95(1): 24–28. Published online 2013 Oct 31. doi: 10.1111/iep.12051

PMCID:: PMC3919647

Article PDF–352K

Select item 384294610.

NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling

Jarred P. Tanksley, Xi Chen, Robert J. Coffey

PLoS One. 2013; 8(11): e81514. Published online 2013 Nov 28. doi: 10.1371/journal.pone.0081514

PMCID:: PMC3842946

Article PDF–688K

Select item 375653511.

Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics

Caitrin W. McDonough, Sarah E. Burbage, Julio D. Duarte, Yan Gong, Taimour Y. Langaee, Stephen T. Turner, John G. Gums, Arlene B. Chapman, Kent R. Bailey, Amber L. Beitelshees, Eric Boerwinkle, Carl J. Pepine, Rhonda M. Cooper-DeHoff, Julie A. Johnson

J Hypertens. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: J Hypertens. 2013 Apr; 31(4): 698–704. doi: 10.1097/HJH.0b013e32835e2a71

PMCID:: PMC3756535

Article PDF–765K

Select item 364569412.

A Functional Variant of NEDD4L Is Associated with Obesity and Related Phenotypes in a Han Population of Southern China

Yu-Lin Wang, Hui-Ying Liang, Yun-He Gao, Xue-Ji Wu, Xi Chen, Bing-Ying Pan, Xue-Xi Yang, Hua-Zhang Liu

Int J Mol Sci. 2013 Apr; 14(4): 7433–7444. Published online 2013 Apr 2. doi: 10.3390/ijms14047433

PMCID:: PMC3645694

Article PDF–204K

Select item 343412513.

Genome-Wide Association Study Identified CNP12587 Region Underlying Height Variation in Chinese Females

Yin-Ping Zhang, Fei-Yan Deng, Tie-Lin Yang, Feng Zhang, Xiang-Ding Chen, Hui Shen, Xue-Zheng Zhu, Qing Tian, Hong-Wen Deng

PLoS One. 2012; 7(9): e44292. Published online 2012 Sep 5. doi: 10.1371/journal.pone.0044292

PMCID:: PMC3434125

Article PDF–167K

Select item 281877514.

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

B Yang, S Kumar

Cell Death Differ. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Cell Death Differ. 2010 Jan; 17(1): 68. doi: 10.1038/cdd.2009.84

PMCID:: PMC2818775

Article PDF–331K

Select item 280149915.

Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study

Nanfang Li, Hongmei Wang, Jin Yang, Ling Zhou, Jing Hong, Yanying Guo, Wenli Luo, Jianhang Chang

BMC Med Genet. 2009; 10: 130. Published online 2009 Dec 9. doi: 10.1186/1471-2350-10-130

PMCID:: PMC2801499

Article PDF–242K

Select item 267898916.

A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain

Nicholas F Garrone, Bonnie L Blazer-Yost, Robert B Weiss, Jean-Marc Lalouel, Andreas Rohrwasser

BMC Cell Biol. 2009; 10: 26. Published online 2009 Apr 13. doi: 10.1186/1471-2121-10-26

PMCID:: PMC2678989

Article PDF–1.5M

Select item 242411017.

Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel

Nandita S Raikwar, Christie P. Thomas

Am J Physiol Renal Physiol. Author manuscript; available in PMC 2009 May 1.

Published in final edited form as: Am J Physiol Renal Physiol. 2008 May; 294(5): F1157–F1165. Published online 2008 Mar 5. doi: 10.1152/ajprenal.00339.2007

PMCID:: PMC2424110

Article PDF–2.2M

Select item 185599218.

Polymorphism in NEDD4L Is Associated with Increased Salt Sensitivity, Reduced Levels of P-renin and Increased Levels of Nt-proANP

Jonas Dahlberg, Lars-Olof Nilsson, Fredrik von Wowern, Olle Melander

PLoS One. 2007; 2(5): e432. Published online 2007 May 9. doi: 10.1371/journal.pone.0000432

PMCID:: PMC1855992

Article PDF–105K

Select item 1093355519.

NEDD4L intramolecular interactions regulate its auto and substrate Na_V1.5 ubiquitination

Katharine M. Wright, Sara Nathan, Hanjie Jiang, Wendy Xia, HyoJeon Kim, Nourdine Chakouri, Justin N. Nwafor, Lucile Fossier, Lakshmi Srinivasan, Zan Chen, Tatiana Boronina, Jeremy Post, Suman Paul, Robert N. Cole, Manu Ben-Johny, Philip A. Cole, Sandra B. Gabelli

J Biol Chem. 2024 Mar; 300(3): 105715. Published online 2024 Feb 2. doi: 10.1016/j.jbc.2024.105715

PMCID:: PMC10933555

Article PDF–5.1M

Select item 1042439820.

The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase

Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen, Ming-Hsien Chien

J Biomed Sci. 2023; 30: 68. Published online 2023 Aug 14. doi: 10.1186/s12929-023-00949-9

PMCID:: PMC10424398

Article PDF–6.4M

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