PMC Links for Gene (Select 230908) - PMC

Result Filters

Links from Gene

Items: 1 to 20 of 213

<< First< Prev

Page of 11

Select item 109467061.

TDP‐43 pathology and functional deficits in wild‐type and ALS/FTD mutant cyclin F mouse models

Annika van Hummel, Miheer Sabale, Magdalena Przybyla, Julia van der Hoven, Gabriella Chan, Astrid F. Feiten, Roger S. Chung, Lars M. Ittner, Yazi D. Ke

Neuropathol Appl Neurobiol. 2023 Apr; 49(2): e12902. Published online 2023 Apr 10. doi: 10.1111/nan.12902

PMCID:: PMC10946706

Article PDF–6.7M

Select item 105671152.

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

Julie C Necarsulmer, Jeremy M Simon, Baggio A Evangelista, Youjun Chen, Xu Tian, Sara Nafees, Ariana B Marquez, Huijun Jiang, Ping Wang, Deepa Ajit, Viktoriya D Nikolova, Kathryn M Harper, J Ashley Ezzell, Feng-Chang Lin, Adriana S Beltran, Sheryl S Moy, Todd J Cohen

eLife. 2023; 12: RP85921. Published online 2023 Oct 11. doi: 10.7554/eLife.85921

PMCID:: PMC10567115

Article PDF–13M

Select item 104638843.

Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse

George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser, Sarah E. Stabenfeldt

Acta Neuropathol Commun. 2023; 11: 137. Published online 2023 Aug 22. doi: 10.1186/s40478-023-01625-7

PMCID:: PMC10463884

Article PDF–3.7M

Select item 101837354.

TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord

Ryan A Milstead, Christopher D Link, Zuoshang Xu, Charles A Hoeffer

Cereb Cortex. 2023 May 15; 33(10): 5808–5816. Published online 2022 Nov 28. doi: 10.1093/cercor/bhac461

PMCID:: PMC10183735

Article PDF–2.0M

Select item 99453255.

TDP-43 drives synaptic and cognitive deterioration following traumatic brain injury

Fei Gao, Mei Hu, Jian Zhang, Jack Hashem, Chu Chen

Acta Neuropathol. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Acta Neuropathol. 2022 Aug; 144(2): 187–210. Published online 2022 Jun 17. doi: 10.1007/s00401-022-02449-w

PMCID:: PMC9945325

Article PDF–3.8M

Select item 98402056.

Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice

Alicia Dubinski, Myriam Gagné, Sarah Peyrard, David Gordon, Kevin Talbot, Christine Vande Velde

Hum Mol Genet. 2023 Jan 15; 32(2): 319–332. Published online 2022 Aug 22. doi: 10.1093/hmg/ddac206

PMCID:: PMC9840205

Article PDF–2.0M

Select item 97620627.

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes

Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley J. Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P. Ling, Juan C. Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar, Tong Li

Mol Neurodegener. 2022; 17: 83. Published online 2022 Dec 17. doi: 10.1186/s13024-022-00589-x

PMCID:: PMC9762062

Article PDF–6.5M

Select item 96837248.

TDP-43 safeguards the embryo genome from L1 retrotransposition

Ten D. Li, Kensaku Murano, Tomohiro Kitano, Youjia Guo, Lumi Negishi, Haruhiko Siomi

Sci Adv. 2022 Nov; 8(47): eabq3806. Published online 2022 Nov 23. doi: 10.1126/sciadv.abq3806

PMCID:: PMC9683724

Article PDF–1.4M

Select item 94400509.

Importance of the Q/N-rich segment for protein stability of endogenous mouse TDP-43

Toshiya Sato, Kanako Oda, Seiko Sakai, Rika Kato, Saori Yamamori, Makoto Itakura, Yoshio Kodera, Masatoyo Nishizawa, Toshikuni Sasaoka, Osamu Onodera, Minesuke Yokoyama

Sci Rep. 2022; 12: 14923. Published online 2022 Sep 2. doi: 10.1038/s41598-022-19153-0

PMCID:: PMC9440050

Article PDF–1.7M

Select item 910727310.

Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis

Seong Kwon Hur, Mandana Hunter, Myrna A. Dominique, Madona Farag, Dejania Cotton-Samuel, Tahiyana Khan, John Q. Trojanowski, Krista J. Spiller, Virginia M.-Y. Lee

Acta Neuropathol Commun. 2022; 10: 75. Published online 2022 May 14. doi: 10.1186/s40478-022-01373-0

PMCID:: PMC9107273

Article PDF–1.7M

Select item 906649511.

Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

Miriam Pacetti, Laura De Conti, Luciano E. Marasco, Maurizio Romano, Mohammad M. Rashid, Martina Nubiè, Francisco E. Baralle, Marco Baralle

Dis Model Mech. 2022 Apr 1; 15(4): dmm049032. Published online 2022 Apr 29. doi: 10.1242/dmm.049032

PMCID:: PMC9066495

Article

Select item 891716312.

Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD⁺ balance as a therapeutic strategy

Mukesh Gautam, Aksu Gunay, Navdeep S. Chandel, P. Hande Ozdinler

Sci Rep. 2022; 12: 4287. Published online 2022 Mar 11. doi: 10.1038/s41598-022-08068-5

PMCID:: PMC8917163

Article PDF–5.9M

Select item 862144013.

Differential Expression Patterns of TDP-43 in Single Moderate versus Repetitive Mild Traumatic Brain Injury in Mice

Tamara Janković, Petra Dolenec, Jelena Rajič Bumber, Nika Gržeta, Jasna Kriz, Gordana Župan, Kristina Pilipović

Int J Mol Sci. 2021 Nov; 22(22): 12211. Published online 2021 Nov 11. doi: 10.3390/ijms222212211

PMCID:: PMC8621440

Article PDF–5.2M

Select item 856959214.

Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice

Kaitlyn M. Campbell, Yiding Xu, Chintan Patel, Jeremy M. Rayl, Helena D. Zomer, Hari Prasad Osuru, Michael Pratt, Patcharin Pramoonjago, Madeline Timken, Lyndzi M. Miller, Abigail Ralph, Kathryn M. Storey, Yiheng Peng, Jenny Drnevich, Clotilde Lagier-Tourenne, Philip C. Wong, Huanyu Qiao, Prabhakara P. Reddi

J Biol Chem. 2021 Nov; 297(5): 101231. Published online 2021 Sep 29. doi: 10.1016/j.jbc.2021.101231

PMCID:: PMC8569592

Article PDF–5.5M

Select item 840446615.

Translational regulation in the brain by TDP-43 phase separation

Ju Gao, Luwen Wang, Xiaojia Ren, Justin R. Dunn, Ariele Peters, Masaru Miyagi, Hisashi Fujioka, Fangli Zhao, Candice Askwith, Jingjing Liang, Xinglong Wang

J Cell Biol. 2021 Oct 4; 220(10): e202101019. Published online 2021 Aug 24. doi: 10.1083/jcb.202101019

PMCID:: PMC8404466

Article PDF–7.7M

Select item 778754716.

Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice

Pichet Termsarasab, Thananan Thammongkolchai, Ju Gao, Luwen Wang, Jingjing Liang, Xinglong Wang

Exp Biol Med (Maywood) 2020 Nov; 245(17): 1584–1593. Published online 2020 Mar 25. doi: 10.1177/1535370220914253

PMCID:: PMC7787547

Article PDF–1.6M

Select item 764577817.

Female sex mitigates motor and behavioural phenotypes in TDP-43^Q331K knock-in mice

Jodie Watkins, Anshua Ghosh, Amy F. A. Keerie, James J. P. Alix, Richard J. Mead, Jemeen Sreedharan

Sci Rep. 2020; 10: 19220. Published online 2020 Nov 5. doi: 10.1038/s41598-020-76070-w

Correction in:: Sci Rep. 2021; 11: 11058.

PMCID:: PMC7645778

Article PDF–1.8M

Select item 751949618.

TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model

Frank Zamudio, Anjanet R. Loon, Shayna Smeltzer, Khawla Benyamine, Nanda K. Navalpur Shanmugam, Nicholas J. F. Stewart, Daniel C. Lee, Kevin Nash, Maj-Linda B. Selenica

J Neuroinflammation. 2020; 17: 283. Published online 2020 Sep 26. doi: 10.1186/s12974-020-01952-9

PMCID:: PMC7519496

Article PDF–8.2M

Select item 737980319.

Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Michael Briese, Lena Saal-Bauernschubert, Patrick Lüningschrör, Mehri Moradi, Benjamin Dombert, Verena Surrey, Silke Appenzeller, Chunchu Deng, Sibylle Jablonka, Michael Sendtner

Acta Neuropathol Commun. 2020; 8: 116. Published online 2020 Jul 24. doi: 10.1186/s40478-020-00987-6

PMCID:: PMC7379803

Article PDF–7.8M

Select item 736717620.

DeepCLIP: predicting the effect of mutations on protein–RNA binding with deep learning

Alexander Gulliver Bjørnholt Grønning, Thomas Koed Doktor, Simon Jonas Larsen, Ulrika Simone Spangsberg Petersen, Lise Lolle Holm, Gitte Hoffmann Bruun, Michael Birkerod Hansen, Anne-Mette Hartung, Jan Baumbach, Brage Storstein Andresen

Nucleic Acids Res. 2020 Jul 27; 48(13): 7099–7118. Published online 2020 Jun 19. doi: 10.1093/nar/gkaa530