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Select item 108949711.

Tyro3 promotes the maturation of glutamatergic synapses

Sheng Miao, Lawrence Fourgeaud, Patrick G. Burrola, Shani Stern, Yuhan Zhang, Kaisa E. Happonen, Sammy Weiser Novak, Fred H. Gage, Greg Lemke

Front Neurosci. 2024; 18: 1327423. Published online 2024 Feb 12. doi: 10.3389/fnins.2024.1327423

PMCID:: PMC10894971

Article PDF–2.7M

Select item 66978152.

Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma

Jason P. Wong, Timothy J. Stuhlmiller, Louise C. Giffin, Carolina Lin, Rachele Bigi, Jichen Zhao, Weihe Zhang, Ariana G. Bravo Cruz, Steven I. Park, H. Shelton Earp, Dirk P. Dittmer, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, Blossom Damania

Proc Natl Acad Sci U S A. 2019 Aug 13; 116(33): 16541–16550. Published online 2019 Jul 25. doi: 10.1073/pnas.1903991116

PMCID:: PMC6697815

Article PDF–2.5M

Select item 55535593.

Tyro3 Carboxyl Terminal Region Confers Stability and Contains the Autophosphorylation Sites

Hanshuang Shao, Douglas Lauffenburger, Alan Wells

Biochem Biophys Res Commun. Author manuscript; available in PMC 2018 Aug 26.

Published in final edited form as: Biochem Biophys Res Commun. 2017 Aug 26; 490(3): 1074–1079. Published online 2017 Jun 28. doi: 10.1016/j.bbrc.2017.06.168

PMCID:: PMC5553559

Article PDF–723K

Select item 33725374.

Involvement of Receptor Tyrosine Kinase Tyro3 in Amyloidogenic APP Processing and β-Amyloid Deposition in Alzheimer's Disease Models

Yan Zheng, Qi Wang, Bing Xiao, Qingjun Lu, Yizheng Wang, Xiaomin Wang

PLoS One. 2012; 7(6): e39035. Published online 2012 Jun 11. doi: 10.1371/journal.pone.0039035

PMCID:: PMC3372537

Article PDF–3.5M

Select item 98700755.

TYRO3 agonist as therapy for glomerular disease

Fang Zhong, Hong Cai, Jia Fu, Zeguo Sun, Zhengzhe Li, David Bauman, Lois Wang, Bhaskar Das, Kyung Lee, John Cijiang He

JCI Insight. 2023 Jan 10; 8(1): e165207. Published online 2023 Jan 10. doi: 10.1172/jci.insight.165207

PMCID:: PMC9870075

Article PDF–13M

Select item 97448756.

Regulation of bone homeostasis by MERTK and TYRO3

Janik Engelmann, Jennifer Zarrer, Victoria Gensch, Kristoffer Riecken, Nikolaus Berenbrok, The Vinh Luu, Antonia Beitzen-Heineke, Maria Elena Vargas-Delgado, Klaus Pantel, Carsten Bokemeyer, Somasekhar Bhamidipati, Ihab S. Darwish, Esteban Masuda, Tal Burstyn-Cohen, Emily J. Alberto, Sourav Ghosh, Carla Rothlin, Eric Hesse, Hanna Taipaleenmäki, Isabel Ben-Batalla, Sonja Loges

Nat Commun. 2022; 13: 7689. Published online 2022 Dec 12. doi: 10.1038/s41467-022-33938-x

PMCID:: PMC9744875

Article PDF–3.8M

Select item 82625017.

TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

Zhou Jiang, Seung-Oe Lim, Meisi Yan, Jennifer L. Hsu, Jun Yao, Yongkun Wei, Shih-Shin Chang, Hirohito Yamaguchi, Heng-Huan Lee, Baozhen Ke, Jung-Mao Hsu, Li-Chuan Chan, Gabriel N. Hortobagyi, Liuqing Yang, Chunru Lin, Dihua Yu, Mien-Chie Hung

J Clin Invest. 2021 Apr 15; 131(8): e139434. Published online 2021 Apr 15. doi: 10.1172/JCI139434

PMCID:: PMC8262501

Article PDF–5.5M

Select item 32076778.

Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse

Charlotte Lindfors, Ida A. K. Nilsson, Pablo M. Garcia-Roves, Aamir R. Zuberi, Mohsen Karimi, Leah Rae Donahue, Derry C. Roopenian, Jan Mulder, Mathias Uhlén, Tomas J. Ekström, Muriel T. Davisson, Tomas G. M. Hökfelt, Martin Schalling, Jeanette E. Johansen

Proc Natl Acad Sci U S A. 2011 Nov 1; 108(44): 18108–18113. Published online 2011 Oct 24. doi: 10.1073/pnas.1114863108

PMCID:: PMC3207677

Article PDF–656K

Select item 31240839.

Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice

Angela Pierce, Mei Xu, Brian Bliesner, Zhilin Liu, JoAnne Richards, Stuart Tobet, Margaret E. Wierman

Mol Cell Endocrinol. Author manuscript; available in PMC 2012 Jun 6.

Published in final edited form as: Mol Cell Endocrinol. 2011 Jun 6; 339(1-2): 151–158. Published online 2011 Apr 22. doi: 10.1016/j.mce.2011.04.007

PMCID:: PMC3124083

Article PDF–620K

Select item 1039892110.

Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis

Liang Gao, Chao He, Aizhen Yang, Haibin Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu

Cell Commun Signal. 2023; 21: 195. Published online 2023 Aug 3. doi: 10.1186/s12964-023-01133-0

Correction in:: Cell Commun Signal. 2023; 21: 225.

PMCID:: PMC10398921

Article PDF–3.1M

Select item 943308911.

Tissue-specific modifier alleles determine Mertk loss-of-function traits

Yemsratch T Akalu, Maria E Mercau, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh

eLife. 2022; 11: e80530. Published online 2022 Aug 15. doi: 10.7554/eLife.80530

PMCID:: PMC9433089

Article PDF–3.0M

Select item 630294812.

Tyro3 is a podocyte protective factor in glomerular disease

Fang Zhong, Zhaohong Chen, Liwen Zhang, Yifan Xie, Viji Nair, Wenjun Ju, Matthias Kretzler, Robert G. Nelson, Zhengzhe Li, Hongyu Chen, Yongjun Wang, Aihua Zhang, Kyung Lee, Zhihong Liu, John Cijiang He

JCI Insight. 2018 Nov 15; 3(22): e123482. Published online 2018 Nov 15. doi: 10.1172/jci.insight.123482

PMCID:: PMC6302948

Article PDF–23M

Select item 619369613.

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis

Claire E. J. Waterborg, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Fons A. J. van de Loo

PLoS One. 2018; 13(10): e0205902. Published online 2018 Oct 18. doi: 10.1371/journal.pone.0205902

PMCID:: PMC6193696

Article PDF–3.6M

Select item 548584314.

TAM receptors are not required for Zika virus infection in mice

Andrew K. Hastings, Laura J. Yockey, Brett W. Jagger, Jesse Hwang, Ryuta Uraki, Hallie F. Gaitsch, Lindsay A. Parnell, Bin Cao, Indira Mysorekar, Carla V. Rothlin, Erol Fikrig, Michael S. Diamond, Akiko Iwasaki

Cell Rep. Author manuscript; available in PMC 2017 Jun 27.

Published in final edited form as: Cell Rep. 2017 Apr 18; 19(3): 558–568. doi: 10.1016/j.celrep.2017.03.058

PMCID:: PMC5485843

Article PDF–1.0M

Select item 545116315.

The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation

Dennis Y. Kim, Joanna Yu, Ryan K. Mui, Rieko Niibori, Hamza Bin Taufique, Rukhsana Aslam, John W. Semple, Sabine P. Cordes

Dis Model Mech. 2017 May 1; 10(5): 581–595. doi: 10.1242/dmm.027433

PMCID:: PMC5451163

Article

Select item 467438916.

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

Jonathan J. Miner, Brian P. Daniels, Bimmi Shrestha, Jose L. Proenca-Modena, Erin D. Lew, Helen M. Lazear, Matthew J. Gorman, Greg Lemke, Robyn S. Klein, Michael S. Diamond

Nat Med. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Nat Med. 2015 Dec; 21(12): 1464–1472. Published online 2015 Nov 2. doi: 10.1038/nm.3974