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Items: 1 to 20 of 119

1.
Titin force in muscle cells alters lattice order, thick and thin filament protein formation
Anthony L. Hessel, Weikang Ma, Nicole Mazara, Paige E. Rice, Devin Nissen, Henry Gong, Michel Kuehn, Thomas Irving, Wolfgang A. Linke
Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48): e2209441119. Published online 2022 Nov 21. doi: 10.1073/pnas.2209441119
PMCID:
PMC9860331
ArticlePDF–2.9M
2.
Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions
Colleen Kelly, Nicola Pace, Matthew Gage, Mark Pfuhl
J Mol Biol. Author manuscript; available in PMC 2022 Oct 10.
Published in final edited form as: J Mol Biol. 2021 Jun 25; 433(13): 166977. Published online 2021 Mar 31. doi: 10.1016/j.jmb.2021.166977
PMCID:
PMC9550216
ArticlePDF–1.1M
3.
Transcriptomic profiles of muscular dystrophy with myositis (mdm) in extensor digitorum longus, psoas, and soleus muscles from mice
Pabodha Hettige, Uzma Tahir, Kiisa C. Nishikawa, Matthew J. Gage
BMC Genomics. 2022; 23: 657. Published online 2022 Sep 17. doi: 10.1186/s12864-022-08873-2
PMCID:
PMC9482285
ArticlePDF–6.5M
4.
Shortening the thick filament by partial deletion of titin’s C-zone alters cardiac function by reducing the operating sarcomere length range
Mei Methawasin, Gerrie P. Farman, Shawtaroh Granzier-Nakajima, Joshua Strom, Balazs Kiss, John E Smith, III, Henk Granzier
J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2022 Apr; 165: 103–114. Published online 2022 Jan 11. doi: 10.1016/j.yjmcc.2022.01.002
PMCID:
PMC8940690
ArticlePDF–2.0M
5.
Depletion of m6A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin
Siyun Gao, Haifeng Sun, Kejing Chen, Xueying Gu, Hongyu Chen, Liudan Jiang, Lei Chen, Shengqi Zhang, Yi Liu, Dan Shi, Dandan Liang, Liang Xu, Jian Yang, Yanjiao Ruan, Hao Chen, Bin Shen, Honghui Ma, Yi‐Han Chen
J Cell Mol Med. 2021 Dec; 25(23): 10879–10891. Published online 2021 Oct 30. doi: 10.1111/jcmm.16955
PMCID:
PMC8642692
ArticlePDF–1.8M
6.
Titin M-line insertion sequence 7 is required for proper cardiac function in mice
Ariane Biquand, Simone Spinozzi, Paola Tonino, Jérémie Cosette, Joshua Strom, Zaher Elbeck, Ralph Knöll, Henk Granzier, William Lostal, Isabelle Richard
J Cell Sci. 2021 Sep 15; 134(18): jcs258684. Published online 2021 Sep 17. doi: 10.1242/jcs.258684
PMCID:
PMC8466004
Article
7.
Non-cross Bridge Viscoelastic Elements Contribute to Muscle Force and Work During Stretch-Shortening Cycles: Evidence From Whole Muscles and Permeabilized Fibers
Anthony L. Hessel, Jenna A. Monroy, Kiisa C. Nishikawa
Front Physiol. 2021; 12: 648019. Published online 2021 Mar 29. doi: 10.3389/fphys.2021.648019
PMCID:
PMC8039322
ArticlePDF–3.7M
8.
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant
He Jiang, Charlotte Hooper, Matthew Kelly, Violetta Steeples, Jillian N. Simon, Julia Beglov, Amar J. Azad, Lisa Leinhos, Pauline Bennett, Elisabeth Ehler, Jacinta I. Kalisch-Smith, Duncan B. Sparrow, Roman Fischer, Raphael Heilig, Henrik Isackson, Mehroz Ehsan, Giannino Patone, Norbert Huebner, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Basic Res Cardiol. 2021; 116(1): 14. Published online 2021 Feb 26. doi: 10.1007/s00395-021-00853-z
PMCID:
PMC7910237
ArticlePDF–1.7M
9.
Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle
Yong Li, Anthony L Hessel, Andreas Unger, David Ing, Jannik Recker, Franziska Koser, Johanna K Freundt, Wolfgang A Linke
eLife. 2020; 9: e64107. Published online 2020 Dec 24. doi: 10.7554/eLife.64107
PMCID:
PMC7781594
ArticlePDF–7.1M
10.
Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)
Christine M. Loescher, Martin Breitkreuz, Yong Li, Alexander Nickel, Andreas Unger, Alexander Dietl, Andreas Schmidt, Belal A. Mohamed, Sebastian Kötter, Joachim P. Schmitt, Marcus Krüger, Martina Krüger, Karl Toischer, Christoph Maack, Lars I. Leichert, Nazha Hamdani, Wolfgang A. Linke
Proc Natl Acad Sci U S A. 2020 Sep 29; 117(39): 24545–24556. Published online 2020 Sep 14. doi: 10.1073/pnas.2004900117
PMCID:
PMC7533878
ArticlePDF–2.3M
11.
Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt
Nat Commun. 2020; 11: 3133. Published online 2020 Jun 19. doi: 10.1038/s41467-020-16929-8
PMCID:
PMC7305127
ArticlePDF–5.1M
12.
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
Jaime Andrés Rivas-Pardo, Yong Li, Zsolt Mártonfalvi, Rafael Tapia-Rojo, Andreas Unger, Ángel Fernández-Trasancos, Elías Herrero-Galán, Diana Velázquez-Carreras, Julio M. Fernández, Wolfgang A. Linke, Jorge Alegre-Cebollada
Nat Commun. 2020; 11: 2060. Published online 2020 Apr 28. doi: 10.1038/s41467-020-15465-9
PMCID:
PMC7189229
ArticlePDF–4.3M
13.
Resolving titin’s lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes
Franziska Rudolph, Judith Hüttemeister, Katharina da Silva Lopes, René Jüttner, Lily Yu, Nora Bergmann, Dhana Friedrich, Stephan Preibisch, Eva Wagner, Stephan E. Lehnart, Carol C. Gregorio, Michael Gotthardt
Proc Natl Acad Sci U S A. 2019 Dec 10; 116(50): 25126–25136. Published online 2019 Nov 22. doi: 10.1073/pnas.1904385116
PMCID:
PMC6911189
ArticlePDF–3.7M
14.
Fine mapping titin’s C-zone: matching cardiac myosin-binding protein C stripes with titin’s super-repeats.
Paola Tonino, Balazs Kiss, Jochen Gohlke, John E. Smith, III, Henk Granzier
J Mol Cell Cardiol. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2019 Aug; 133: 47–56. Published online 2019 May 31. doi: 10.1016/j.yjmcc.2019.05.026
PMCID:
PMC6639027
ArticlePDF–754K
15.
Genetic Variants Associated With Cancer Therapy–Induced Cardiomyopathy
Pablo Garcia-Pavia, Yuri Kim, Maria Alejandra Restrepo-Cordoba, Ida G. Lunde, Hiroko Wakimoto, Amanda M. Smith, Christopher N. Toepfer, Kelly Getz, Joshua Gorham, Parth Patel, Kaoru Ito, Jonathan A. Willcox, Zoltan Arany, Jian Li, Anjali T. Owens, Risha Govind, Beatriz Nuñez, Erica Mazaika, Antoni Bayes-Genis, Roddy Walsh, Brian Finkelman, Josep Lupon, Nicola Whiffin, Isabel Serrano, William Midwinter, Alicja Wilk, Alfredo Bardaji, Nathan Ingold, Rachel Buchan, Upasana Tayal, Domingo A. Pascual-Figal, Antonio de Marvao, Mian Ahmad, Jose Manuel Garcia-Pinilla, Antonis Pantazis, Fernando Dominguez, A. John Baksi, Declan P. O’Regan, Stuart D. Rosen, Sanjay K. Prasad, Enrique Lara-Pezzi, Mariano Provencio, Alexander R. Lyon, Luis Alonso-Pulpon, Stuart A. Cook, Steven R. DePalma, Paul J.R. Barton, Richard Aplenc, Jonathan G. Seidman, Bonnie Ky, James S. Ware, Christine E. Seidman
Circulation. 2019 Jul 2; 140(1): 31–41. Published online 2019 Apr 16. doi: 10.1161/CIRCULATIONAHA.118.037934
PMCID:
PMC6613726
ArticlePDF–337K
16.
Deleting full length titin versus the titin M-band region leads to differential mechanosignaling and cardiac phenotypes.
Michael H. Radke, Christopher Polack, Mei Methawasin, Claudia Fink, Henk L. Granzier, Michael Gotthardt
Circulation. Author manuscript; available in PMC 2020 Apr 9.
Published in final edited form as: Circulation. 2019 Apr 9; 139(15): 1813–1827. doi: 10.1161/CIRCULATIONAHA.118.037588
PMCID:
PMC6453709
ArticlePDF–2.9M
17.
Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance
Rebecca E. Slater, Joshua G. Strom, Mei Methawasin, Martin Liss, Michael Gotthardt, Nancy Sweitzer, Henk L. Granzier
J Gen Physiol. 2019 Jan 7; 151(1): 42–52. doi: 10.1085/jgp.201812259
PMCID:
PMC6314384
ArticlePDF–1.4M
18.
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy
Ambjorn Brynnel, Yaeren Hernandez, Balazs Kiss, Johan Lindqvist, Maya Adler, Justin Kolb, Robbert van der Pijl, Jochen Gohlke, Joshua Strom, John Smith, Coen Ottenheijm, Henk L Granzier
eLife. 2018; 7: e40532. Published online 2018 Dec 19. doi: 10.7554/eLife.40532
PMCID:
PMC6300359
ArticlePDF–3.7M
19.
The giant protein titin regulates the length of the striated muscle thick filament
Paola Tonino, Balazs Kiss, Josh Strom, Mei Methawasin, John E. Smith, III, Justin Kolb, Siegfried Labeit, Henk Granzier
Nat Commun. 2017; 8: 1041. Published online 2017 Oct 19. doi: 10.1038/s41467-017-01144-9
PMCID:
PMC5648799
ArticlePDF–1.2M
20.
Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model
Qifeng Zhou, Scott Kesteven, Jianxin Wu, Parwez Aidery, Meinrad Gawaz, Michael Gramlich, Michael P. Feneley, Richard P. Harvey
Biomed Res Int. 2015; 2015: 163564. Published online 2015 Oct 4. doi: 10.1155/2015/163564
PMCID:
PMC4609346
ArticlePDF–1.9M

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