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Select item 99284241.

An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

Fernanda M Bosada, Karel van Duijvenboden, Alexandra E Giovou, Mathilde R Rivaud, Jae-Sun Uhm, Arie O Verkerk, Bastiaan J Boukens, Vincent M Christoffels

eLife. 2023; 12: e80317. Published online 2023 Jan 30. doi: 10.7554/eLife.80317

PMCID:: PMC9928424

Article PDF–6.6M

Select item 95609992.

The Transcription Factor Tbx5 Regulates Direction-Selective Retinal Ganglion Cell Development and Image Stabilization

Timour Al-Khindi, Michael Sherman, Takashi Kodama, Preethi Gopal, Zhiwei Pan, James Kiraly, Hao Zhang, Loyal A. Goff, Sascha du Lac, Alex L. Kolodkin

Curr Biol. Author manuscript; available in PMC 2023 Oct 10.

Published in final edited form as: Curr Biol. 2022 Oct 10; 32(19): 4286–4298.e5. Published online 2022 Aug 22. doi: 10.1016/j.cub.2022.07.064

PMCID:: PMC9560999

Article PDF–1.2M

Select item 57450773.

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

Xinan H Yang, Rangarajan D Nadadur, Catharina RE Hilvering, Valerio Bianchi, Michael Werner, Stefan R Mazurek, Margaret Gadek, Kaitlyn M Shen, Joseph Aaron Goldman, Leonid Tyan, Jenna Bekeny, Johnathon M Hall, Nutishia Lee, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Kenneth D Poss, Christopher R Weber, Wouter de Laat, Alexander J Ruthenburg, Ivan P Moskowitz

eLife. 2017; 6: e31683. Published online 2017 Dec 27. doi: 10.7554/eLife.31683

PMCID:: PMC5745077

Article PDF–4.5M

Select item 94525194.

devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data

Francisco X. Galdos, Sidra Xu, William R. Goodyer, Lauren Duan, Yuhsin V. Huang, Soah Lee, Han Zhu, Carissa Lee, Nicholas Wei, Daniel Lee, Sean M. Wu

Nat Commun. 2022; 13: 5271. Published online 2022 Sep 7. doi: 10.1038/s41467-022-33045-x

PMCID:: PMC9452519

Article PDF–10M

Select item 82626355.

Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control

Franziska S Rathjens, Alica Blenkle, Lavanya M Iyer, Anke Renger, Fahima Syeda, Claudia Noack, Andreas Jungmann, Matthias Dewenter, Karl Toischer, Ali El-Armouche, Oliver J Müller, Larissa Fabritz, Wolfram-Hubertus Zimmermann, Laura C Zelarayan, Maria-Patapia Zafeiriou

Cardiovasc Res. 2021 Jul 1; 117(8): 1908–1922. Published online 2020 Aug 10. doi: 10.1093/cvr/cvaa239

PMCID:: PMC8262635

Article PDF–1.6M

Select item 71121736.

TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway

Nariaki Miyao, Yukiko Hata, Hironori Izumi, Ryo Nagaoka, Yuko Oku, Ichiro Takasaki, Taisuke Ishikawa, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Tomoyuki Yoshida, Hideyuki Hasegawa, Naomasa Makita, Naoki Nishida, Hisashi Mori, Fukiko Ichida, Keiichi Hirono

PLoS One. 2020; 15(4): e0227393. Published online 2020 Apr 1. doi: 10.1371/journal.pone.0227393

PMCID:: PMC7112173

Article PDF–2.0M

Select item 60347017.

Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development

Thomas J. Cunningham, Joseph J. Lancman, Marie Berenguer, P. Duc Si Dong, Gregg Duester

Cell Rep. Author manuscript; available in PMC 2018 Jul 6.

Published in final edited form as: Cell Rep. 2018 Jun 12; 23(11): 3146–3151. doi: 10.1016/j.celrep.2018.05.052

PMCID:: PMC6034701

Article PDF–952K

Select item 52665948.

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm

Rangarajan D. Nadadur, Michael T. Broman, Bastiaan Boukens, Stefan R. Mazurek, Xinan Yang, Malou van den Boogaard, Jenna Bekeny, Margaret Gadek, Tarsha Ward, Min Zhang, Yun Qiao, James F. Martin, Christine E. Seidman, Jon Seidman, Vincent Christoffels, Igor R. Efimov, Elizabeth M. McNally, Christopher R. Weber, Ivan P. Moskowitz

Sci Transl Med. Author manuscript; available in PMC 2017 Jan 25.

Published in final edited form as: Sci Transl Med. 2016 Aug 31; 8(354): 354ra115. doi: 10.1126/scitranslmed.aaf4891

PMCID:: PMC5266594

Article PDF–1.6M

Select item 43581109.

Novel Exons in the Tbx5 Gene Locus Generate Protein Isoforms with Distinct Expression Domains and Function

Abir Yamak, Romain O. Georges, Massomeh Sheikh-Hassani, Martin Morin, Hiba Komati, Mona Nemer

J Biol Chem. 2015 Mar 13; 290(11): 6844–6856. Published online 2015 Jan 25. doi: 10.1074/jbc.M114.634451

PMCID:: PMC4358110

Article PDF–5.6M

Select item 316368010.

Synergistic Activation of Cardiac Genes by Myocardin and Tbx5

Chunbo Wang, Dongsun Cao, Qing Wang, Da-Zhi Wang

PLoS One. 2011; 6(8): e24242. Published online 2011 Aug 29. doi: 10.1371/journal.pone.0024242

PMCID:: PMC3163680

Article PDF–826K

Select item 886022311.

Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction

Antoinette F. van Ouwerkerk, Fernanda M. Bosada, Karel van Duijvenboden, Arjan C. Houweling, Koen T. Scholman, Vincent Wakker, Cornelis P. Allaart, Jae-Sun Uhm, Inge B. Mathijssen, Ton Baartscheer, Alex V. Postma, Phil Barnett, Arie O. Verkerk, Bastiaan J. Boukens, Vincent M. Christoffels

Circulation. 2022 Feb 22; 145(8): 606–619. Published online 2022 Feb 3. doi: 10.1161/CIRCULATIONAHA.121.054347

PMCID:: PMC8860223

Article PDF–2.2M

Select item 832857712.

Transcriptional Patterning of the Ventricular Cardiac Conduction System

Ozanna Burnicka-Turek, Michael T. Broman, Jeffrey D. Steimle, Bastiaan J. Boukens, Nataliya B. Petrenko, Kohta Ikegami, Rangarajan D. Nadadur, Yun Qiao, David E. Arnolds, Xinan H. Yang, Vickas V. Patel, Marcelo A. Nobrega, Igor R. Efimov, Ivan P. Moskowitz

Circ Res. Author manuscript; available in PMC 2021 Aug 2.

Published in final edited form as: Circ Res. 2020 Jul 17; 127(3): e94–e106. Published online 2020 Apr 15. doi: 10.1161/CIRCRESAHA.118.314460

PMCID:: PMC8328577

Article PDF–2.2M

Select item 476969313.

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis

Luis Luna-Zurita, Christian U. Stirnimann, Sebastian Glatt, Bogac L. Kaynak, Sean Thomas, Florence Baudin, Md Abul Hassan Samee, Daniel He, Eric M. Small, Maria Mileikovsky, Andras Nagy, Alisha K. Holloway, Katherine S. Pollard, Christoph W. Müller, Benoit G. Bruneau

Cell. Author manuscript; available in PMC 2017 Feb 25.

Published in final edited form as: Cell. 2016 Feb 25; 164(5): 999–1014. Published online 2016 Feb 11. doi: 10.1016/j.cell.2016.01.004

PMCID:: PMC4769693

Article PDF–2.7M

Select item 459873614.

Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors

Fang Bai, Chae Ho Lim, Jingyue Jia, Katherine Santostefano, Chelsey Simmons, Hideko Kasahara, Weihui Wu, Naohiro Terada, Shouguang Jin

Sci Rep. 2015; 5: 15014. Published online 2015 Oct 9. doi: 10.1038/srep15014

PMCID:: PMC4598736

Article PDF–2.7M

Select item 451494315.

The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model

Renita C. Polk, Peter Gergics, Jeffrey D. Steimle, Huiqing Li, Ivan P. Moskowitz, Sally A. Camper, Roger H. Reeves

BMC Dev Biol. 2015; 15: 30. Published online 2015 Jul 25. doi: 10.1186/s12861-015-0080-y

PMCID:: PMC4514943

Article PDF–1.9M

Select item 427335416.

Regulatory modulation of the T-box gene Tbx5 links development, evolution, and adaptation of the sternum

Sorrel R. B. Bickley, Malcolm P. O. Logan

Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50): 17917–17922. Published online 2014 Dec 2. doi: 10.1073/pnas.1409913111

PMCID:: PMC4273354

Article PDF–1.5M

Select item 338682517.

TBX5 drives Scn5a expression to regulate cardiac conduction system function

David E. Arnolds, Fang Liu, John P. Fahrenbach, Gene H. Kim, Kurt J. Schillinger, Scott Smemo, Elizabeth M. McNally, Marcelo A. Nobrega, Vickas V. Patel, Ivan P. Moskowitz

J Clin Invest. 2012 Jul 2; 122(7): 2509–2518. Published online 2012 Jun 25. doi: 10.1172/JCI62617

PMCID:: PMC3386825

Article PDF–4.4M

Select item 279985718.

Tbx4/5 gene duplication and the origin of vertebrate paired appendages

Carolina Minguillon, Jeremy J. Gibson-Brown, Malcolm P. Logan

Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51): 21726–21730. Published online 2009 Dec 7. doi: 10.1073/pnas.0910153106

PMCID:: PMC2799857

Article PDF–1.7M

Select item 242313719.

Distinct Expression and Function of Alternatively Spliced Tbx5 Isoforms in Cell Growth and Differentiation

Romain Georges, Georges Nemer, Martin Morin, Chantal Lefebvre, Mona Nemer

Mol Cell Biol. 2008 Jun; 28(12): 4052–4067. Published online 2008 Apr 7. doi: 10.1128/MCB.02100-07

PMCID:: PMC2423137

Article PDF–2.1M

Select item 642856920.

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

Wenli Dai, Brigitte Laforest, Leonid Tyan, Kaitlyn M Shen, Rangarajan D Nadadur, Francisco J Alvarado, Stefan R Mazurek, Sonja Lazarevic, Margaret Gadek, Yitang Wang, Ye Li, Hector H Valdivia, Le Shen, Michael T Broman, Ivan P Moskowitz, Christopher R Weber

eLife. 2019; 8: e41814. Published online 2019 Mar 21. doi: 10.7554/eLife.41814

PMCID:: PMC6428569

Article PDF–9.4M

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