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Select item 102359851.

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett

Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2220979120. Published online 2023 May 22. doi: 10.1073/pnas.2220979120

PMCID:: PMC10235985

Article PDF–8.3M

Select item 93810382.

Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla in mice

Taylor Follansbee, Dan Domocos, Eileen Nguyen, Amanda Nguyen, Aristea Bountouvas, Lauren Velasquez, Mirela Iodi Carstens, Keiko Takanami, Sarah E Ross, Earl Carstens

eLife. 2022; 11: e69626. Published online 2022 Aug 16. doi: 10.7554/eLife.69626

PMCID:: PMC9381038

Article PDF–6.0M

Select item 81725393.

Control of impulsivity by G_i-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex

Bastiaan van der Veen, Sampath K. T. Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M. Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam, Janet R. Nicholson, Birgit Liss, Wiebke Nissen, Anton Pekcec, Dennis Kätzel

Commun Biol. 2021; 4: 662. Published online 2021 Jun 2. doi: 10.1038/s42003-021-02188-w

PMCID:: PMC8172539

Article PDF–6.1M

Select item 67623114.

The NK1 Receptor Is Essential for the Full Expression of Noxious Inhibitory Controls in the Mouse

Hervé Bester, Carmen De Felipe, Stephen P. Hunt

J Neurosci. 2001 Feb 1; 21(3): 1039–1046. doi: 10.1523/JNEUROSCI.21-03-01039.2001

PMCID:: PMC6762311

Article PDF–270K

Select item 67406895.

Neurokinin-1 Receptor-Expressing Neurons in the Amygdala Modulate Morphine Reward and Anxiety Behaviors in the Mouse

Christopher A. Gadd, Patricia Murtra, Carmen De Felipe, Stephen P. Hunt

J Neurosci. 2003 Sep 10; 23(23): 8271–8280. doi: 10.1523/JNEUROSCI.23-23-08271.2003

PMCID:: PMC6740689

Article PDF–774K

Select item 63603566.

Mild Traumatic Brain Injury in Mice Beneficially Alters Lung NK1R and Structural Protein Expression to Enhance Survival after Pseudomonas aeruginosa Infection

Max Vaickus, Terry Hsieh, Ekaterina Kintsurashvili, Jiyoun Kim, Daniel Kirsch, George Kasotakis, Daniel G. Remick

Am J Pathol. 2019 Feb; 189(2): 295–307. doi: 10.1016/j.ajpath.2018.10.019

PMCID:: PMC6360356

Article

Select item 51138337.

Loss of neurokinin-1 receptor alters ocular surface homeostasis and promotes an early development of herpes stromal keratitis

Subhash Gaddipati, Pushpa Rao, Andrew David Jerome, Bala Bharathi Burugula, Norma P Gerard, Susmit Suvas

J Immunol. Author manuscript; available in PMC 2017 Nov 15.

Published in final edited form as: J Immunol. 2016 Nov 15; 197(10): 4021–4033. Published online 2016 Oct 17. doi: 10.4049/jimmunol.1600836

PMCID:: PMC5113833

Article PDF–3.7M

Select item 46830998.

Differences in the performance of NK1R−/− (‘knockout’) and wildtype mice in the 5‑Choice Continuous Performance Test

Ashley J. Porter, Katharine Pillidge, S. Clare Stanford, Jared W. Young

Behav Brain Res. 2016 Feb 1; 298(Pt B): 268–277. doi: 10.1016/j.bbr.2015.10.045

PMCID:: PMC4683099

Article

Select item 44747529.

A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch

Tasuku Akiyama, Tony Nguyen, Eric Curtis, Katsuko Nishida, Jahnavi Devireddy, Jeremy Delahanty, Mirela Iodi Carstens, E. Carstens

Pain. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Pain. 2015 Jul; 156(7): 1240–1246. doi: 10.1097/j.pain.0000000000000172

PMCID:: PMC4474752

Article PDF–767K

Select item 441548610.

A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R-/- mice

A J Porter, K Pillidge, Y C Tsai, J A Dudley, S P Hunt, S N Peirson, L A Brown, S C Stanford

Genes Brain Behav. 2015 Feb; 14(2): 189–199. Published online 2015 Feb 1. doi: 10.1111/gbb.12195

PMCID:: PMC4415486

Article PDF–1.3M

Select item 441438911.

The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene ‘knockout’ mice: Sex differences and implications for the treatment of attention deficit hyperactivity disorder

Ashley J. Porter, Katharine Pillidge, Ewelina M. Grabowska, S. Clare Stanford

Eur Neuropsychopharmacol. 2015 Apr; 25(4): 512–521. doi: 10.1016/j.euroneuro.2015.01.013

PMCID:: PMC4414389

Article

Select item 420994212.

The behavioural response of mice lacking NK₁ receptors to guanfacine resembles its clinical profile in treatment of ADHD

Katharine Pillidge, Ashley J Porter, Julia A Dudley, Yuan-Chen Tsai, David J Heal, S Clare Stanford

Br J Pharmacol. 2014 Oct; 171(20): 4785–4796. Published online 2014 Sep 26. doi: 10.1111/bph.12860

PMCID:: PMC4209942

Article PDF–798K

Select item 382322613.

Activation of neurokinin-1 receptors up-regulates substance P and neurokinin-1 receptor expression in murine pancreatic acinar cells

Yung-Hua Koh, Shabbir Moochhala, Madhav Bhatia

J Cell Mol Med. 2012 Jul; 16(7): 1582–1592. Published online 2012 Jun 28. doi: 10.1111/j.1582-4934.2011.01475.x

PMCID:: PMC3823226

Article PDF–321K

Select item 315460114.

Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice

Shannon Glaser, Eugenio Gaudio, Anastasia Renzi, Romina Mancinelli, Yoshiyuki Ueno, Julie Venter, Mellanie White, Shelley Kopriva, Valorie Chiasson, Sharon DeMorrow, Heather Francis, Fanyin Meng, Marco Marzioni, Antonio Franchitto, Domenico Alvaro, Scott Supowit, Donald J. DiPette, Paolo Onori, Gianfranco Alpini

Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2): G297–G305. Published online 2011 May 19. doi: 10.1152/ajpgi.00418.2010

PMCID:: PMC3154601

Article

Select item 311063715.

Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitis

Vinita S. Chauhan, John M. Kluttz, Kenneth L. Bost, Ian Marriott

J Immunol. Author manuscript; available in PMC 2012 Jun 15.

Published in final edited form as: J Immunol. 2011 Jun 15; 186(12): 7255–7263. Published online 2011 May 11. doi: 10.4049/jimmunol.1100721

PMCID:: PMC3110637

Article PDF–2.5M

Select item 304978616.

Performance Deficits of NK1 Receptor Knockout Mice in the 5-Choice Serial Reaction-Time Task: Effects of d-Amphetamine, Stress and Time of Day

Ting Carrie Yan, Julia A. Dudley, Ruth K. Weir, Ewelina M. Grabowska, Yolanda Peña-Oliver, Tamzin L. Ripley, Stephen P. Hunt, David N. Stephens, S. Clare Stanford

PLoS One. 2011; 6(3): e17586. Published online 2011 Mar 7. doi: 10.1371/journal.pone.0017586