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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 43157412.

Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress

Ying Xu, Jianchun Pan, Jiao Sun, Lianshu Ding, Lina Ruan, Miranda Reed, Xuefeng Yu, Jonathan Klabni, Dan Lin, Jianxin Li, Ling Chen, Chong Zhang, Hanting Zhang, James M. O’Donnell

Neurobiol Aging. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Neurobiol Aging. 2015 Feb; 36(2): 955–970. Published online 2014 Aug 30. doi: 10.1016/j.neurobiolaging.2014.08.028

PMCID:: PMC4315741

Article PDF–1.3M

Select item 34914733.

Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity

Fei Hu, Jing Ren, Ju-en Zhang, Weixin Zhong, Minmin Luo

Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43): 17681–17686. Published online 2012 Oct 8. doi: 10.1073/pnas.1209185109

PMCID:: PMC3491473

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Select item 41975684.

Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages

Otgonchimeg Rentsendorj, Franco R. D'Alessio, David B. Pearse

J Leukoc Biol. 2014 Nov; 96(5): 907–915. doi: 10.1189/jlb.3A0314-152R

PMCID:: PMC4197568

Article

Select item 34685265.

Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP

Monika Thumova, Vladimir Pech, Otto Froehlich, Diana Agazatian, Xiaonan Wang, Jill W. Verlander, Young Hee Kim, Susan M. Wall

Am J Physiol Renal Physiol. 2012 Sep 15; 303(6): F812–F820. Published online 2012 Jul 18. doi: 10.1152/ajprenal.00577.2011

PMCID:: PMC3468526

Article

Select item 31546286.

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury

Otgonchimeg Rentsendorj, Mahendra Damarla, Neil R. Aggarwal, Ji-Young Choi, Laura Johnston, Franco R. D'Alessio, Michael T. Crow, David B. Pearse

Am J Physiol Lung Cell Mol Physiol. 2011 Aug; 301(2): L161–L170. Published online 2011 May 13. doi: 10.1152/ajplung.00073.2011

PMCID:: PMC3154628

Article

Select item 27579807.

Dual Acylation of PDE2A Splice Variant 3: TARGETING TO SYNAPTIC MEMBRANES

Corina Russwurm, Georg Zoidl, Doris Koesling, Michael Russwurm

J Biol Chem. 2009 Sep 18; 284(38): 25782–25790. Published online 2009 Jul 24. doi: 10.1074/jbc.M109.017194

PMCID:: PMC2757980

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Select item 26047958.

Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

Eric P. Schmidt, Mahendra Damarla, Otgonchimeg Rentsendorj, Laura E. Servinsky, Bing Zhu, Aigul Moldobaeva, Alfredo Gonzalez, Paul M. Hassoun, David B. Pearse

Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6): L1056–L1065. Published online 2008 Oct 10. doi: 10.1152/ajplung.90329.2008

PMCID:: PMC2604795

Article

Select item 81257279.

Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kämmerer

Int J Mol Sci. 2021 May; 22(9): 4816. Published online 2021 May 1. doi: 10.3390/ijms22094816

PMCID:: PMC8125727

Article PDF–3.7M

Select item 13062110.

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

Sergio E. Martinez, Albert Y. Wu, Natalie A. Glavas, Xiao-Bo Tang, Stewart Turley, Wim G. J. Hol, Joseph A. Beavo

Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 13260–13265. Published online 2002 Sep 23. doi: 10.1073/pnas.192374899

PMCID:: PMC130621

Article PDF–1007K

Select item 274672711.

Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species

Diane T. Stephenson, Tim M. Coskran, Margaret B. Wilhelms, Wendy O. Adamowicz, Michele M. O'Donnell, Kathleen B. Muravnick, Frank S. Menniti, Robin J. Kleiman, Daniel Morton

J Histochem Cytochem. 2009 Oct; 57(10): 933–949. doi: 10.1369/jhc.2009.953471

PMCID:: PMC2746727

Article PDF–4.3M

Select item 542376712.

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

Stefania Monterisi, Miguel J Lobo, Craig Livie, John C Castle, Michael Weinberger, George Baillie, Nicoletta C Surdo, Nshunge Musheshe, Alessandra Stangherlin, Eyal Gottlieb, Rory Maizels, Mario Bortolozzi, Massimo Micaroni, Manuela Zaccolo

eLife. 2017; 6: e21374. Published online 2017 May 2. doi: 10.7554/eLife.21374

PMCID:: PMC5423767

Article PDF–4.1M

Select item 316240213.

A Phosphodiesterase 2A Isoform Localized to Mitochondria Regulates Respiration

Rebeca Acin-Perez, Michael Russwurm, Kathrin Günnewig, Melanie Gertz, Georg Zoidl, Lavoisier Ramos, Jochen Buck, Lonny R. Levin, Joachim Rassow, Giovanni Manfredi, Clemens Steegborn

J Biol Chem. 2011 Sep 2; 286(35): 30423–30432. Published online 2011 Jul 1. doi: 10.1074/jbc.M111.266379

PMCID:: PMC3162402

Article PDF–2.4M

Select item 727176614.

FGF20-expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Growth of Underlying Turbinates to Optimize Epithelial Surface Area

Lu M. Yang, Sung-Ho Huh, David M. Ornitz

Dev Cell. Author manuscript; available in PMC 2020 Jun 4.

Published in final edited form as: Dev Cell. 2018 Sep 10; 46(5): 564–580.e5. Published online 2018 Aug 9. doi: 10.1016/j.devcel.2018.07.010

PMCID:: PMC7271766

Article PDF–1.8M

Select item 120157915.

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

Jeff S. Isenberg, Lisa A. Ridnour, Elizabeth M. Perruccio, Michael G. Espey, David A. Wink, David D. Roberts

Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37): 13141–13146. Published online 2005 Sep 6. doi: 10.1073/pnas.0502977102

PMCID:: PMC1201579

Article PDF–546K

Select item 613159016.

P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb

Martina Pyrski, Mahbuba Tusty, Eugenia Eckstein, Livio Oboti, Diego J. Rodriguez-Gil, Charles A. Greer, Frank Zufall

Front Cell Neurosci. 2018; 12: 295. Published online 2018 Sep 4. doi: 10.3389/fncel.2018.00295

PMCID:: PMC6131590

Article PDF–4.2M

Select item 721545017.

PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis

Federica Barbagallo, Valentina Rotilio, Maria Rita Assenza, Salvatore Aguanno, Tiziana Orsini, Sabrina Putti, Andrea M. Isidori, Andrea Lenzi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Int J Mol Sci. 2020 Apr; 21(8): 2902. Published online 2020 Apr 21. doi: 10.3390/ijms21082902

PMCID:: PMC7215450

Article PDF–3.3M

Select item 1089115418.

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress

Silvia Cardarelli, Martina Biglietto, Tiziana Orsini, Valentina Fustaino, Lucia Monaco, Ana Gabriela de Oliveira do Rêgo, Francesca Liccardo, Silvia Masciarelli, Francesco Fazi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Cell Death Dis. 2024 Feb; 15(2): 169. Published online 2024 Feb 23. doi: 10.1038/s41419-024-06549-1

PMCID:: PMC10891154

Article PDF–2.6M

Select item 309571819.

Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip

R Machold, C Klein, G Fishell

Gene Expr Patterns. Author manuscript; available in PMC 2012 Jun 1.

Published in final edited form as: Gene Expr Patterns. 2011 JUN-JUL; 11(5-6): 349–359. Published online 2011 Apr 2. doi: 10.1016/j.gep.2011.03.007

PMCID:: PMC3095718

Article PDF–4.5M

Select item 757883320.

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy

Miguel J. Lobo, Laia Reverte-Salisa, Ying-Chi Chao, Andreas Koschinski, Frank Gesellchen, Gunasekaran Subramaniam, He Jiang, Samuel Pace, Natasha Larcom, Ester Paolocci, Alexander Pfeifer, Sara Zanivan, Manuela Zaccolo

Commun Biol. 2020; 3: 596. Published online 2020 Oct 21. doi: 10.1038/s42003-020-01311-7

PMCID:: PMC7578833

Article PDF–4.3M

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