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Select item 105115061.

Critical requirement of SOS1 for tumor development and microenvironment modulation in KRAS^G12D-driven lung adenocarcinoma

Fernando C. Baltanás, Rósula García-Navas, Pablo Rodríguez-Ramos, Nuria Calzada, Cristina Cuesta, Javier Borrajo, Rocío Fuentes-Mateos, Andrea Olarte-San Juan, Nerea Vidaña, Esther Castellano, Eugenio Santos

Nat Commun. 2023; 14: 5856. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41583-1

PMCID:: PMC10511506

Article PDF–4.3M

Select item 94060652.

Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia

Carmela Gómez, Rósula Garcia-Navas, Fernando C. Baltanás, Rocío Fuentes-Mateos, Alberto Fernández-Medarde, Nuria Calzada, Eugenio Santos

Cancers (Basel) 2022 Aug; 14(16): 3893. Published online 2022 Aug 11. doi: 10.3390/cancers14163893

PMCID:: PMC9406065

Article PDF–3.6M

Select item 82342573.

SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology

Fernando C. Baltanás, Rósula García-Navas, Eugenio Santos

Int J Mol Sci. 2021 Jun; 22(12): 6613. Published online 2021 Jun 21. doi: 10.3390/ijms22126613

PMCID:: PMC8234257

Article PDF–643K

Select item 45361554.

Absence of both Sos-1 and Sos-2 in peripheral CD4⁺ T cells leads to PI3K pathway activation and defects in migration

Geoffrey Guittard, Robert L Kortum, Lakshmi Balagopalan, Nicolas Çuburu, Phan Nguyen, Connie L Sommers, Lawrence E Samelson

Eur J Immunol. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: Eur J Immunol. 2015 Aug; 45(8): 2389–2395. Published online 2015 Jun 5. doi: 10.1002/eji.201445226

PMCID:: PMC4536155

Article PDF–1.1M

Select item 41385745.

ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis

Hyun Jung Jun, Jeremy Roy, Tegan B. Smith, Levi B. Wood, Keara Lane, Steve Woolfenden, Diana Punko, Roderick T. Bronson, Kevin M. Haigis, Sylvie Breton, Al Charest

Endocrinology. 2014 Sep; 155(9): 3661–3673. Published online 2014 Jun 27. doi: 10.1210/en.2014-1341

PMCID:: PMC4138574

Article

Select item 40215596.

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1

Yingying Qu, Qin Chen, Xueping Lai, Changhong Zhu, Cheng Chen, Xian Zhao, Rong Deng, Ming Xu, Haihua Yuan, Yanli Wang, Jianxiu Yu, Jian Huang

Mol Cancer. 2014; 13: 95. Published online 2014 Apr 29. doi: 10.1186/1476-4598-13-95

PMCID:: PMC4021559

Article PDF–1.5M

Select item 38706767.

Regulation of Son of sevenless by the membrane-actin linker protein ezrin

Katja J. Geißler, M. Juliane Jung, Lars Björn Riecken, Tobias Sperka, Yan Cui, Stephan Schacke, Ulrike Merkel, Robby Markwart, Ignacio Rubio, Manuel E. Than, Constanze Breithaupt, Sebastian Peuker, Reinhard Seifert, Ulrich Benjamin Kaupp, Peter Herrlich, Helen Morrison

Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51): 20587–20592. Published online 2013 Dec 2. doi: 10.1073/pnas.1222078110

PMCID:: PMC3870676

Article PDF–1.7M

Select item 22867298.

Directed discovery of bivalent peptide ligands to an SH3 domain

Monique R. Ferguson, Xiuzhen Fan, Munia Mukherjee, Jinquan Luo, Raza Khan, Josephine C. Ferreon, Vincent J. Hilser, Robert E. Shope, Robert O. Fox

Protein Sci. 2004 Mar; 13(3): 626–632. doi: 10.1110/ps.03470504

PMCID:: PMC2286729

Article PDF–320K

Select item 98398449.

PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1

Qian‐Zhi Ni, Bing Zhu, Yan Ji, Qian‐Wen Zheng, Xin Liang, Ning Ma, Hao Jiang, Feng‐Kun Zhang, Yu‐Rong Shang, Yi‐Kang Wang, Sheng Xu, Er‐Bin Zhang, Yan‐Mei Yuan, Tian‐Wei Chen, Fen‐Fen Yin, Hui‐Jun Cao, Jing‐Yi Huang, Ji Xia, Xu‐Fen Ding, Xiao‐Song Qiu, Kai Ding, Chao Song, Wen‐Tao Zhou, Meng Wu, Kang Wang, Rui Lui, Qiu Lin, Wei Chen, Zhi‐Gang Li, Shu‐Qun Cheng, Xiao‐Fan Wang, Dong Xie, Jing‐Jing Li

Adv Sci (Weinh) 2023 Jan; 10(2): 2202448. Published online 2022 Dec 1. doi: 10.1002/advs.202202448

PMCID:: PMC9839844

Article PDF–5.7M

Select item 629387010.

Unique dependence on Sos1 in Kras^G12D-induced leukemogenesis

Xiaona You, Guangyao Kong, Erik A. Ranheim, David Yang, Yun Zhou, Jing Zhang

Blood. 2018 Dec 13; 132(24): 2575–2579. Prepublished online 2018 Oct 30. doi: 10.1182/blood-2018-09-874107

PMCID:: PMC6293870

Article

Select item 606675311.

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis

Pilar Liceras-Boillos, David Jimeno, Rósula García-Navas, L. Francisco Lorenzo-Martín, Mauricio Menacho-Marquez, Carmen Segrelles, Carmela Gómez, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M. Paramio, Xosé R. Bustelo, Fernando C. Baltanás, Eugenio Santos

Mol Cell Biol. 2018 Aug 15; 38(16): e00049-18. Prepublished online 2018 May 29. Published online 2018 Jul 30. doi: 10.1128/MCB.00049-18

PMCID:: PMC6066753

Article PDF–7.8M

Select item 341618012.

Deconstructing Ras Signaling in the Thymus

Robert L. Kortum, Connie L. Sommers, John M. Pinski, Clayton P. Alexander, Robert K. Merrill, Wenmei Li, Paul E. Love, Lawrence E. Samelson

Mol Cell Biol. 2012 Jul; 32(14): 2748–2759. doi: 10.1128/MCB.00317-12

PMCID:: PMC3416180

Article PDF–3.1M

Select item 23257013.

The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.

K H Nielsen, A G Papageorge, W C Vass, B M Willumsen, D R Lowy

Mol Cell Biol. 1997 Dec; 17(12): 7132–7138. doi: 10.1128/mcb.17.12.7132

PMCID:: PMC232570

Summary PDF–532K

Select item 23197414.

A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.

M Sakaue, D Bowtell, M Kasuga

Mol Cell Biol. 1995 Jan; 15(1): 379–388. doi: 10.1128/mcb.15.1.379

PMCID:: PMC231974

Summary PDF–486K

Select item 4953115.

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

D Bowtell, P Fu, M Simon, P Senior

Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14): 6511–6515. doi: 10.1073/pnas.89.14.6511

PMCID:: PMC49531

Summary Page Browse PDF–2.6M

Select item 1058326516.

LACK OF EMBRYONIC HOMOZYGOUS OR ADULT HETEROZYGOUS LYMPHATIC PHENOTYPES FOR A Sos1 MUTATION AND LACK OF LYMPHATIC EMBRYONIC PHENOTYPES FOR A HOMOZYGOUS Cx47 MUTATION IN MICE

X. Geng, L. Chen, R.S. Srinivasan, R.J. Kylat, M.H. Witte, R.P. Erickson

Lymphology. Author manuscript; available in PMC 2023 Oct 18.

Published in final edited form as: Lymphology. 2022; 55(3): 129–134.

PMCID:: PMC10583265

Article PDF–1.5M

Select item 425956717.

The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from its Guanine Nucleotide Exchange Activity In Vivo

Robert L. Kortum, Lakshmi Balagopalan, Clayton P. Alexander, Julie Garcia, John M. Pinski, Robert K. Merrill, Phan H. Nguyen, Wenmei Li, Isha Agarwal, Itoro O. Akpan, Connie L. Sommers, Lawrence E. Samelson

Sci Signal. Author manuscript; available in PMC 2014 Dec 8.

Published in final edited form as: Sci Signal. 2013 Nov 12; 6(301): ra99. Published online 2013 Nov 12. doi: 10.1126/scisignal.2004494

PMCID:: PMC4259567

Article PDF–2.3M

Select item 345947918.

Signaling to Cardiac Hypertrophy: Insights from Human and Mouse RASopathies

Valentina Sala, Simona Gallo, Christian Leo, Stefano Gatti, Bruce D Gelb, Tiziana Crepaldi

Mol Med. 2012; 18(1): 938–947. Published online 2012 May 4. doi: 10.2119/molmed.2011.00512

PMCID:: PMC3459479

Article PDF–604K

Select item 314574419.

Targeted Sos1 deletion reveals its critical role in early T-cell development

Robert L. Kortum, Connie L. Sommers, Clayton P. Alexander, John M. Pinski, Wenmei Li, Alex Grinberg, Jan Lee, Paul E. Love, Lawrence E. Samelson

Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30): 12407–12412. Published online 2011 Jul 11. doi: 10.1073/pnas.1104295108

PMCID:: PMC3145744

Article PDF–979K

Select item 734034320.

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

Jesse E. Jun, Kayla R. Kulhanek, Hang Chen, Arup Chakraborty, Jeroen P. Roose

Sci Signal. Author manuscript; available in PMC 2020 Jul 7.

Published in final edited form as: Sci Signal. 2019 Jul 23; 12(591): eaao0736. Published online 2019 Jul 23. doi: 10.1126/scisignal.aao0736

PMCID:: PMC7340343

Article PDF–2.4M

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