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Select item 105423291.

Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain

Alejandro Orrico-Sanchez, Bruno P. Guiard, Stella Manta, Jacques Callebert, Jean-Marie Launay, Franck Louis, Antoine Paccard, Carole Gruszczynski, Catalina Betancur, Vincent Vialou, Sophie Gautron

Transl Psychiatry. 2023; 13: 302. Published online 2023 Sep 29. doi: 10.1038/s41398-023-02596-y

PMCID:: PMC10542329

Article PDF–3.2M

Select item 103805672.

Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin

Anna Hucke, Rita Schröter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli

Int J Mol Sci. 2023 Jul; 24(14): 11486. Published online 2023 Jul 14. doi: 10.3390/ijms241411486

PMCID:: PMC10380567

Article PDF–3.5M

Select item 79171853.

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2^−/− Mice

Bridget L. Morse, Lisa Hong Chen, John T. Catlow, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren

Front Pharmacol. 2021; 12: 631793. Published online 2021 Feb 15. doi: 10.3389/fphar.2021.631793

PMCID:: PMC7917185

Article PDF–1.7M

Select item 74562534.

Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice

Kevin M. Huang, Alix F. Leblanc, Muhammad Erfan Uddin, Ji Young Kim, Mingqing Chen, Eric D. Eisenmann, Alice A. Gibson, Yang Li, Kristen W. Hong, Duncan DiGiacomo, Sherry H. Xia, Paola Alberti, Alessia Chiorazzi, Stephen N. Housley, Timothy C. Cope, Jason A. Sprowl, Jing Wang, Charles L. Loprinzi, Anne Noonan, Maryam B. Lustberg, Guido Cavaletti, Navjot Pabla, Shuiying Hu, Alex Sparreboom

J Clin Invest. 2020 Sep 1; 130(9): 4601–4606. Published online 2020 Jul 27. doi: 10.1172/JCI136796

PMCID:: PMC7456253

Article PDF–2.5M

Select item 44133205.

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

Navjotsingh Pabla, Alice A. Gibson, Mike Buege, Su Sien Ong, Lie Li, Shuiying Hu, Guoqing Du, Jason A. Sprowl, Aksana Vasilyeva, Laura J. Janke, Eberhard Schlatter, Taosheng Chen, Giuliano Ciarimboli, Alex Sparreboom

Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16): 5231–5236. Published online 2015 Apr 6. doi: 10.1073/pnas.1424313112

PMCID:: PMC4413320

Article PDF–1.1M

Select item 37040386.

Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2

Jason A. Sprowl, Giuliano Ciarimboli, Cynthia S. Lancaster, Hugh Giovinazzo, Alice A. Gibson, Guoqing Du, Laura J. Janke, Guido Cavaletti, Anthony F. Shields, Alex Sparreboom

Proc Natl Acad Sci U S A. 2013 Jul 2; 110(27): 11199–11204. Published online 2013 Jun 17. doi: 10.1073/pnas.1305321110

PMCID:: PMC3704038

Article PDF–1.1M

Select item 31606257.

Major contribution of tubular secretion to creatinine clearance in mice

Christoph Eisner, Robert Faulhaber-Walter, Yaohui Wang, Asada Leelahavanichkul, Peter S.T. Yuen, Diane Mizel, Robert A. Star, Josephine P. Briggs, Mark Levine, Jurgen Schnermann

Kidney Int. Author manuscript; available in PMC 2011 Aug 24.

Published in final edited form as: Kidney Int. 2010 Mar; 77(6): 519–526. Published online 2009 Dec 23. doi: 10.1038/ki.2009.501

PMCID:: PMC3160625

Article PDF–1.6M

Select item 28321408.

Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions

Giuliano Ciarimboli, Dirk Deuster, Arne Knief, Michael Sperling, Michael Holtkamp, Bayram Edemir, Hermann Pavenstädt, Claudia Lanvers-Kaminsky, Antoinette am Zehnhoff-Dinnesen, Alfred H. Schinkel, Hermann Koepsell, Heribert Jürgens, Eberhard Schlatter

Am J Pathol. 2010 Mar; 176(3): 1169–1180. doi: 10.2353/ajpath.2010.090610

PMCID:: PMC2832140

Article PDF–1018K

Select item 14683989.

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Wolfgang Kummer, Silke Wiegand, Sibel Akinci, Ignatz Wessler, Alfred H Schinkel, Jürgen Wess, Hermann Koepsell, Rainer V Haberberger, Katrin S Lips

Respir Res. 2006; 7(1): 65. Published online 2006 Apr 12. doi: 10.1186/1465-9921-7-65

PMCID:: PMC1468398

Article PDF–2.7M

Select item 20762610.

Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations

Johan W. Jonker, Els Wagenaar, Sven van Eijl, Alfred H. Schinkel

Mol Cell Biol. 2003 Nov; 23(21): 7902–7908. doi: 10.1128/MCB.23.21.7902-7908.2003

PMCID:: PMC207626

Article PDF–174K

Select item 779258511.

Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families

Matthias Gorecki, Simon F. Müller, Regina Leidolf, Joachim Geyer

Int J Mol Sci. 2021 Jan; 22(1): 22. Published online 2020 Dec 22. doi: 10.3390/ijms22010022

PMCID:: PMC7792585

Article PDF–845K

Select item 479936212.

A phosphotyrosine switch regulates organic cation transporters

Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Shuiying Hu, Guoqing Du, Wenwei Lin, Lie Li, Shashank Bharill, Rachel A. Ness, Adrian Stecula, Steven M. Offer, Robert B. Diasio, Anne T. Nies, Matthias Schwab, Guido Cavaletti, Eberhard Schlatter, Giuliano Ciarimboli, Jan H. M. Schellens, Ehud Y. Isacoff, Andrej Sali, Taosheng Chen, Sharyn D. Baker, Alex Sparreboom, Navjotsingh Pabla

Nat Commun. 2016; 7: 10880. Published online 2016 Mar 16. doi: 10.1038/ncomms10880

PMCID:: PMC4799362

Article PDF–1.0M

Select item 274686613.

Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity

Kelly K. Filipski, Ron H. Mathijssen, Torben S. Mikkelsen, Alfred H. Schinkel, Alex Sparreboom

Clin Pharmacol Ther. Author manuscript; available in PMC 2009 Oct 1.

Published in final edited form as: Clin Pharmacol Ther. 2009 Oct; 86(4): 396–402. Published online 2009 Jul 22. doi: 10.1038/clpt.2009.139

PMCID:: PMC2746866

Article PDF–1.5M

Select item 16561114.

Imprinted silencing of Slc22a2 and Slc22a3 does not need transcriptional overlap between Igf2r and Air

Frank Sleutels, Grace Tjon, Thomas Ludwig, Denise P. Barlow

EMBO J. 2003 Jul 15; 22(14): 3696–3704. doi: 10.1093/emboj/cdg341

PMCID:: PMC165611

Article PDF–235K

Select item 124008015.

Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements

Florian M. Pauler, Stefan H. Stricker, Katarzyna E. Warczok, Denise P. Barlow

Genome Res. 2005 Oct; 15(10): 1379–1387. doi: 10.1101/gr.3783805

PMCID:: PMC1240080

Article PDF–804K

Select item 31277916.

Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes

Ronald Zwart, Frank Sleutels, Anton Wutz, Alfred H. Schinkel, Denise P. Barlow

Genes Dev. 2001 Sep 15; 15(18): 2361–2366. doi: 10.1101/gad.206201

PMCID:: PMC312779

Article PDF–151K

Select item 441045517.

Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation

Chelsea Marcho, Ariana Bevilacqua, Kimberly D Tremblay, Jesse Mager

Epigenetics Chromatin. 2015; 8: 10. Published online 2015 Mar 14. doi: 10.1186/s13072-015-0003-y

PMCID:: PMC4410455

Article PDF–1.7M

Select item 308194818.

EXTRA-EMBRYONIC-SPECIFIC IMPRINTED EXPRESSION IS RESTRICTED TO DEFINED LINEAGES IN THE POST-IMPLANTATION EMBRYO

Quanah J. Hudson, Christine I.M. Seidl, Tomasz M. Kulinski, Ru Huang, Katarzyna E. Warczok, Romana Bittner, Marisa S. Bartolomei, Denise P. Barlow

Dev Biol. Author manuscript; available in PMC 2012 May 15.

Published in final edited form as: Dev Biol. 2011 May 15; 353(2): 420–431. Published online 2011 Feb 24. doi: 10.1016/j.ydbio.2011.02.017

PMCID:: PMC3081948

Article PDF–2.1M

Select item 445477719.

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern

Tomasz M. Kulinski, M. Rita T. Casari, Philipp M. Guenzl, Daniel Wenzel, Daniel Andergassen, Anastasiya Hladik, Paul Datlinger, Matthias Farlik, H. -Christian Theussl, Josef M. Penninger, Sylvia Knapp, Christoph Bock, Denise P. Barlow, Quanah J. Hudson

Dev Biol. 2015 Jun 15; 402(2): 291–305. doi: 10.1016/j.ydbio.2015.04.010