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Select item 100623601.

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

Molly O’Reilly, Laura C Sommerfeld, C O’Shea, S Broadway-Stringer, S Andaleeb, J S Reyat, S N Kabir, D Stastny, A Malinova, D Delbue, L Fortmueller, K Gehmlich, D Pavlovic, B V Skryabin, A P Holmes, P Kirchhof, L Fabritz

Europace. 2023 Mar; 25(3): 1152–1161. Published online 2022 Dec 12. doi: 10.1093/europace/euac218

PMCID:: PMC10062360

Article PDF–4.5M

Select item 80053772.

Phospho-ablation of cardiac sodium channel Na_v1.5 mitigates susceptibility to atrial fibrillation and improves glucose homeostasis under conditions of diet-induced obesity

Revati S. Dewal, Amara Greer-Short, Cemantha Lane, Shinsuke Nirengi, Pedro Acosta Manzano, Diego Hernández-Saavedra, Katherine R. Wright, Drew Nassal, Lisa A. Baer, Peter J. Mohler, Thomas J. Hund, Kristin I. Stanford

Int J Obes (Lond) 2021; 45(4): 795–807. Published online 2021 Jan 26. doi: 10.1038/s41366-021-00742-4

PMCID:: PMC8005377

Article PDF–1.1M

Select item 76546583.

Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice

Martina Comelli, Marianna Meo, Daniel O. Cervantes, Emanuele Pizzo, Aaron Plosker, Peter J. Mohler, Thomas J. Hund, Jason T. Jacobson, Olivier Meste, Marcello Rota

Am J Physiol Heart Circ Physiol. 2020 Oct 1; 319(4): H893–H905. Published online 2020 Sep 4. doi: 10.1152/ajpheart.00379.2020

PMCID:: PMC7654658

Article

Select item 68255294.

SCN5A Variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells

Laura L. Daniel, Tao Yang, Brett Kroncke, Lynn Hall, Dina Stroud, Dan M. Roden

Heart Rhythm. Author manuscript; available in PMC 2020 Nov 1.

Published in final edited form as: Heart Rhythm. 2019 Nov; 16(11): 1676–1685. Published online 2019 May 21. doi: 10.1016/j.hrthm.2019.05.017

PMCID:: PMC6825529

Article PDF–1.4M

Select item 67666185.

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome

Malcolm Finlay, Justine Bhar-Amato, Keat-Eng Ng, Diogo Santos, Michele Orini, Vishal Vyas, Peter Taggart, Andrew A. Grace, Christopher L.-H. Huang, Pier D. Lambiase, Andrew Tinker

Am J Physiol Cell Physiol. 2019 Sep 1; 317(3): C576–C583. Published online 2019 Jul 10. doi: 10.1152/ajpcell.00028.2019

PMCID:: PMC6766618

Article

Select item 64048816.

CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

Paul D. Pang, Katherina M. Alsina, Shuyi Cao, Amrita B. Koushik, Xander H.T. Wehrens, Thomas A. Cooper

J Am Heart Assoc. 2018 Oct 2; 7(19): e010393. Published online 2018 Sep 28. doi: 10.1161/JAHA.118.010393

PMCID:: PMC6404881

Article PDF–1.1M

Select item 62309057.

CaMKII-dependent late Na⁺ current increases electrical dispersion and arrhythmia in ischemia-reperfusion

Taylor Howard, Amara Greer-Short, Tony Satroplus, Nehal Patel, Drew Nassal, Peter J. Mohler, Thomas J. Hund

Am J Physiol Heart Circ Physiol. 2018 Oct 1; 315(4): H794–H801. Published online 2018 Jun 22. doi: 10.1152/ajpheart.00197.2018

PMCID:: PMC6230905

Article

Select item 59159488.

Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome

Allen Kelly, Simona Salerno, Adam Connolly, Martin Bishop, Flavien Charpentier, Tomas Stølen, Godfrey L Smith

Cardiovasc Res. 2018 Apr 1; 114(5): 724–736. Published online 2017 Dec 18. doi: 10.1093/cvr/cvx244

PMCID:: PMC5915948

Article PDF–1.5M

Select item 55939189.

The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3

Karan R. Chadda, Shiraz Ahmad, Haseeb Valli, Ingrid den Uijl, Ali BAK Al-Hadithi, Samantha C. Salvage, Andrew A. Grace, Christopher L.-H. Huang, Kamalan Jeevaratnam

Sci Rep. 2017; 7: 11070. Published online 2017 Sep 11. doi: 10.1038/s41598-017-11210-3

PMCID:: PMC5593918

Article PDF–2.1M

Select item 470154910.

Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice

Elaine Wan, Jeffrey Abrams, Richard L. Weinberg, Alexander N. Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John P. Morrow, Hasan Garan, Steven O. Marx

J Clin Invest. 2016 Jan 4; 126(1): 112–122. Published online 2015 Nov 23. doi: 10.1172/JCI84669

PMCID:: PMC4701549

Article PDF–2.5M

Select item 454540611.

Intracellular Calcium Attenuates Late Current Conducted by Mutant Human Cardiac Sodium Channels

Franck Potet, Thomas M. Beckermann, Jennifer D. Kunic, Alfred L. George, Jr.

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Aug; 8(4): 933–941. Published online 2015 May 28. doi: 10.1161/CIRCEP.115.002760

PMCID:: PMC4545406

Article PDF–1.3M

Select item 445435112.

Altered Na⁺ Channels Promote Pause-Induced Spontaneous Diastolic Activity in Long QT Syndrome Type 3 Myocytes

Sandra Fredj, Nicolas Lindegger, Kevin J. Sampson, Peter Carmeliet, Robert S. Kass

Circ Res. Author manuscript; available in PMC 2015 Jun 3.

Published in final edited form as: Circ Res. 2006 Nov 24; 99(11): 1225–1232. Published online 2006 Nov 2. doi: 10.1161/01.RES.0000251305.25604.b0

PMCID:: PMC4454351

Article PDF–1.9M

Select item 426969813.

Light phase-restricted feeding slows basal heart rate to exaggerate the type-3 long QT syndrome phenotype in mice

Elizabeth A. Schroder, Don E. Burgess, Cody L. Manning, Yihua Zhao, Arthur J. Moss, Abhijit Patwardhan, Claude S. Elayi, Karyn A. Esser, Brian P. Delisle

Am J Physiol Heart Circ Physiol. 2014 Dec 15; 307(12): H1777–H1785. Published online 2014 Oct 24. doi: 10.1152/ajpheart.00341.2014

PMCID:: PMC4269698

Article

Select item 415940414.

Dynamics of sodium channel Na_v 1.5 expression in astrocytes in mouse models of multiple sclerosis

Laura W. Pappalardo, Shujun Liu, Joel A. Black, Stephen G. Waxman

Neuroreport. Author manuscript; available in PMC 2015 Oct 22.

Published in final edited form as: Neuroreport. 2014 Oct 22; 25(15): 1208–1215. doi: 10.1097/WNR.0000000000000249

PMCID:: PMC4159404

Article PDF–764K

Select item 404220015.

Measurement and interpretation of electrocardiographic QT intervals in murine hearts

Yanmin Zhang, JingJing Wu, James H. King, Christopher L.-H. Huang, James A. Fraser

Am J Physiol Heart Circ Physiol. 2014 Jun 1; 306(11): H1553–H1557. Published online 2014 Apr 4. doi: 10.1152/ajpheart.00459.2013

PMCID:: PMC4042200

Article

Select item 377911016.

Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a^+/− hearts

Gareth D K Matthews, Laila Guzadhur, Ian N Sabir, Andrew A Grace, Christopher L-H Huang

J Physiol. 2013 Sep 1; 591(Pt 17): 4167–4188. Published online 2013 Jul 8. doi: 10.1113/jphysiol.2013.254938

PMCID:: PMC3779110

Article PDF–1.2M

Select item 359555417.

Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy

Man Liu, Lianzhi Gu, Matthew S. Sulkin, Hong Liu, Euy-Myoung Jeong, Ian Greener, An Xie, Igor R. Efimov, Samuel C. Dudley, Jr.

J Mol Cell Cardiol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: J Mol Cell Cardiol. 2013 Jan; 54: 25–34. Published online 2012 Nov 1. doi: 10.1016/j.yjmcc.2012.10.011

PMCID:: PMC3595554

Article PDF–2.6M

Select item 339079218.

Reduced Na⁺ and higher K⁺ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice

Claire A. Martin, Urszula Siedlecka, Kristin Kemmerich, Jason Lawrence, James Cartledge, Laila Guzadhur, Nicola Brice, Andrew A. Grace, Christof Schwiening, Cesare M. Terracciano, Christopher L.-H. Huang

Open Biol. 2012 Jun; 2(6): 120072. doi: 10.1098/rsob.120072

PMCID:: PMC3390792

Article PDF–1.3M

Select item 333078919.

Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome

Jingjing Wu, Yanmin Zhang, Xinzhao Zhang, Longxian Cheng, Wim J. Lammers, Andrew A. Grace, James A. Fraser, Henggui Zhang, Christopher L. -H. Huang, Ming Lei

Am J Physiol Heart Circ Physiol. 2012 Apr 1; 302(7): H1510–H1523. Published online 2012 Jan 27. doi: 10.1152/ajpheart.00357.2011

PMCID:: PMC3330789

Article

Select item 313538320.

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel

Thomas C. Atack, Dina Myers Stroud, Hiroshi Watanabe, Tao Yang, Lynn Hall, Susan B. Hipkens, John S. Lowe, Brenda Leake, Mark A. Magnuson, Ping Yang, Dan M. Roden

Circ Res. Author manuscript; available in PMC 2012 Jun 24.

Published in final edited form as: Circ Res. 2011 Jun 24; 109(1): 38–46. Published online 2011 May 12. doi: 10.1161/CIRCRESAHA.110.235630