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Select item 108044461.

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

Hideko Isozaki, Ramin Sakhtemani, Ammal Abbasi, Naveed Nikpour, Marcello Stanzione, Sunwoo Oh, Adam Langenbucher, Susanna Monroe, Wenjia Su, Heidie Frisco Cabanos, Faria M. Siddiqui, Nicole Phan, Pégah Jalili, Daria Timonina, Samantha Bilton, Maria Gomez-Caraballo, Hannah L. Archibald, Varuna Nangia, Kristin Dionne, Amanda Riley, Matthew Lawlor, Mandeep Kaur Banwait, Rosemary G. Cobb, Lee Zou, Nicholas J. Dyson, Christopher J. Ott, Cyril Benes, Gad Getz, Chang S. Chan, Alice T. Shaw, Justin F. Gainor, Jessica J. Lin, Lecia V. Sequist, Zofia Piotrowska, Beow Y. Yeap, Jeffrey A. Engelman, Jake June-Koo Lee, Yosef E. Maruvka, Rémi Buisson, Michael S. Lawrence, Aaron N. Hata

Nature. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: Nature. 2023 Aug; 620(7973): 393–401. Published online 2023 Jul 5. doi: 10.1038/s41586-023-06303-1

PMCID:: PMC10804446

Abstract Article PDF–5.7M

Select item 104575832.

Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage

Chloe Wick, Seyed Arad Moghadasi, Jordan T. Becker, Elisa Fanunza, Sunwoo Oh, Elodie Bournique, Rémi Buisson, Reuben S. Harris

J Biol Chem. 2023 Sep; 299(9): 105073. Published online 2023 Jul 19. doi: 10.1016/j.jbc.2023.105073

PMCID:: PMC10457583

Abstract Article PDF–2.0M

Select item 102946563.

Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression

Lilian Göttig, Christina Weiß, Miona Stubbe, Lisa Hanrieder, Samuel Hofmann, Alessandro Grodziecki, Daniela Stadler, Arnaud Carpentier, Ulrike Protzer, Sabrina Schreiner

mBio. 2023 May-Jun; 14(3): e03478-22. Published online 2023 May 8. doi: 10.1128/mbio.03478-22

PMCID:: PMC10294656

Abstract Article PDF–5.7M

Select item 102535834.

DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo

Jordan A. Naumann, Prokopios P. Argyris, Michael A. Carpenter, Harshita B. Gupta, Yanjun Chen, Nuri A. Temiz, Yufan Zhou, Cameron Durfee, Joshua Proehl, Brenda L. Koniar, Silvestro G. Conticello, David A. Largaespada, William L. Brown, Hideki Aihara, Rachel I. Vogel, Reuben S. Harris

Int J Mol Sci. 2023 Jun; 24(11): 9305. Published online 2023 May 26. doi: 10.3390/ijms24119305

PMCID:: PMC10253583

Abstract Article PDF–13M

Select item 99499405.

The base-editing enzyme APOBEC3A catalyzes cytosine deamination in RNA with low proficiency and high selectivity

Aleksia Barka, Kiara N. Berríos, Peter Bailer, Emily K. Schutsky, Tong Wang, Rahul M. Kohli

ACS Chem Biol. Author manuscript; available in PMC 2023 Mar 18.

Published in final edited form as: ACS Chem Biol. 2022 Mar 18; 17(3): 629–636. Published online 2022 Mar 9. doi: 10.1021/acschembio.1c00919

PMCID:: PMC9949940

Abstract Article PDF–1.1M

Select item 98811296.

Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome

Yoshihiro Nakata, Hirotaka Ode, Mai Kubota, Takaaki Kasahara, Kazuhiro Matsuoka, Atsuko Sugimoto, Mayumi Imahashi, Yoshiyuki Yokomaku, Yasumasa Iwatani

Nucleic Acids Res. 2023 Jan 25; 51(2): 783–795. Published online 2023 Jan 5. doi: 10.1093/nar/gkac1238

PMCID:: PMC9881129

Abstract Article PDF–2.1M

Select item 94852127.

Differences in integration frequencies and APOBEC3 profiles of five high-risk HPV types adheres to phylogeny

Alexander Hesselberg Løvestad, Adina Repesa, Jean-Marc Costanzi, Sonja Lagström, Irene Kraus Christiansen, Trine B. Rounge, Ole Herman Ambur

Tumour Virus Res. 2022 Dec; 14: 200247. Published online 2022 Sep 11. doi: 10.1016/j.tvr.2022.200247

PMCID:: PMC9485212

Abstract Article PDF–2.3M

Select item 92830078.

Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers

Rachel A. DeWeerd, Eszter Németh, Ádám Póti, Nataliya Petryk, Chun-Long Chen, Olivier Hyrien, Dávid Szüts, Abby M. Green

Cell Rep. Author manuscript; available in PMC 2022 Jul 14.

Published in final edited form as: Cell Rep. 2022 Mar 22; 38(12): 110555. doi: 10.1016/j.celrep.2022.110555

PMCID:: PMC9283007

Abstract Article PDF–2.2M

Select item 91718129.

APOBEC3A regulates transcription from interferon-stimulated response elements

Manabu Taura, John A. Frank, Takehiro Takahashi, Yong Kong, Eriko Kudo, Eric Song, Maria Tokuyama, Akiko Iwasaki

Proc Natl Acad Sci U S A. 2022 May 17; 119(20): e2011665119. Published online 2022 May 12. doi: 10.1073/pnas.2011665119

PMCID:: PMC9171812

Abstract Article PDF–1.1M

Select item 881984310.

Two different kinds of interaction modes of deaminase APOBEC3A with single‐stranded DNA in solution detected by nuclear magnetic resonance

Yaping Liu, Wenxian Lan, Chunxi Wang, Chunyang Cao

Protein Sci. 2022 Feb; 31(2): 443–453. Published online 2021 Nov 26. doi: 10.1002/pro.4242

PMCID:: PMC8819843

Abstract Article PDF–2.6M

Select item 856812911.

Comprehensive Analyses Identify APOBEC3A as a Genomic Instability-Associated Immune Prognostic Biomarker in Ovarian Cancer

Fangfang Xu, Tingwei Liu, Zhuonan Zhou, Chang Zou, Shaohua Xu

Front Immunol. 2021; 12: 749369. Published online 2021 Oct 21. doi: 10.3389/fimmu.2021.749369

PMCID:: PMC8568129

Abstract Article PDF–4.5M

Select item 854609812.

Single-stranded DNA binding proteins influence APOBEC3A substrate preference

Amber L. Brown, Christopher D. Collins, Secily Thompson, Margo Coxon, Tony M. Mertz, Steven A. Roberts

Sci Rep. 2021; 11: 21008. Published online 2021 Oct 25. doi: 10.1038/s41598-021-00435-y

PMCID:: PMC8546098

Abstract Article PDF–1.3M

Select item 842422013.

Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network

Vincent Caval, Rodolphe Suspène, Pierre Khalfi, Julien Gaillard, Grégory Caignard, Damien Vitour, Philippe Roingeard, Jean-Pierre Vartanian, Simon Wain-Hobson

J Biol Chem. 2021 Sep; 297(3): 101081. Published online 2021 Aug 14. doi: 10.1016/j.jbc.2021.101081

PMCID:: PMC8424220

Abstract Article PDF–1.7M

Select item 841902514.

Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner

Kailiang Zhao, Qiang Zhang, Sheryl Flanagan, Xueting Lang, Long Jiang, Leslie A. Parsels, Joshua D. Parsels, Weiping Zou, Theodore S. Lawrence, Rémi Buisson, Michael D. Green, Meredith A. Morgan

Mol Cancer Res. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Mol Cancer Res. 2021 Sep; 19(9): 1571–1582. Published online 2021 May 27. doi: 10.1158/1541-7786.MCR-21-0219

PMCID:: PMC8419025

Abstract Article PDF–2.1M

Select item 836360715.

Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

Sunwoo Oh, Elodie Bournique, Danae Bowen, Pégah Jalili, Ambrocio Sanchez, Ian Ward, Alexandra Dananberg, Lavanya Manjunath, Genevieve P. Tran, Bert L. Semler, John Maciejowski, Marcus Seldin, Rémi Buisson

Nat Commun. 2021; 12: 4917. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25203-4

PMCID:: PMC8363607

Abstract Article PDF–2.7M

Select item 811578016.

Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection

Maxwell Shapiro, Laurie T. Krug, Thomas MacCarthy

PLoS Pathog. 2021 Apr; 17(4): e1009560. Published online 2021 Apr 30. doi: 10.1371/journal.ppat.1009560

PMCID:: PMC8115780

Abstract Article PDF–1.4M

Select item 795373617.

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Emily K. Law, Rena Levin-Klein, Matthew C. Jarvis, Hyoung Kim, Prokopios P. Argyris, Michael A. Carpenter, Gabriel J. Starrett, Nuri A. Temiz, Lindsay K. Larson, Cameron Durfee, Michael B. Burns, Rachel I. Vogel, Spyridon Stavrou, Alexya N. Aguilera, Sandra Wagner, David A. Largaespada, Timothy K. Starr, Susan R. Ross, Reuben S. Harris

J Exp Med. 2020 Dec 7; 217(12): e20200261. Published online 2020 Sep 1. doi: 10.1084/jem.20200261

PMCID:: PMC7953736

Abstract Article PDF–5.2M

Select item 795260218.

An extended APOBEC3A mutation signature in cancer

Adam Langenbucher, Danae Bowen, Ramin Sakhtemani, Elodie Bournique, Jillian F. Wise, Lee Zou, Ashok S. Bhagwat, Rémi Buisson, Michael S. Lawrence

Nat Commun. 2021; 12: 1602. Published online 2021 Mar 11. doi: 10.1038/s41467-021-21891-0

PMCID:: PMC7952602

Abstract Article PDF–1.9M

Select item 791308019.

Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Željko Antić, Stefan H. Lelieveld, Cédric G. van der Ham, Edwin Sonneveld, Peter M. Hoogerbrugge, Roland P. Kuiper

Genes (Basel) 2021 Feb; 12(2): 214. Published online 2021 Feb 2. doi: 10.3390/genes12020214

PMCID:: PMC7913080

Abstract Article PDF–1.4M

Select item 764368120.

Genomic, transcriptomic, and viral integration profiles associated with recurrent/metastatic progression in high‐risk human papillomavirus cervical carcinomas

Jing Jing Liu, Jung Yoon Ho, Jung Eum Lee, Soo Young Hur, Jinseon Yoo, Kyu Ryung Kim, Daeun Ryu, Tae Min Kim, Youn Jin Choi

Cancer Med. 2020 Nov; 9(21): 8243–8257. Published online 2020 Oct 5. doi: 10.1002/cam4.3426

PMCID:: PMC7643681

Abstract Article PDF–1.6M

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