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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 91255682.

Overexpression of Constitutively Active PKG-I Protects Female, But Not Male Mice From Diet-Induced Obesity

Dejan M. Nikolic, Yanzhang Li, Shu Liu, Shuxia Wang

Obesity (Silver Spring) Author manuscript; available in PMC 2022 May 23.

Published in final edited form as: Obesity (Silver Spring). 2011 Apr; 19(4): 784–791. Published online 2010 Oct 7. doi: 10.1038/oby.2010.223

PMCID:: PMC9125568

Article PDF–1.4M

Select item 72530253.

Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing

Nadine Schall, Julian J. Garcia, Hema Kalyanaraman, Shyamsundar Pal China, Jenna J. Lee, Robert L. Sah, Alexander Pfeifer, Renate B. Pilz

JCI Insight. 2020 May 7; 5(9): e135355. Published online 2020 May 7. doi: 10.1172/jci.insight.135355

PMCID:: PMC7253025

Article PDF–34M

Select item 69180624.

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling

Martin Feelisch, Takaaki Akaike, Kayleigh Griffiths, Tomoaki Ida, Oleksandra Prysyazhna, Joanna J Goodwin, Nicholas D Gollop, Bernadette O Fernandez, Magdalena Minnion, Miriam M Cortese-Krott, Alessandra Borgognone, Rosie M Hayes, Philip Eaton, Michael P Frenneaux, Melanie Madhani

Cardiovasc Res. 2020 Jan 1; 116(1): 51–62. Published online 2019 Aug 1. doi: 10.1093/cvr/cvz202

PMCID:: PMC6918062

Article PDF–1.2M

Select item 68939795.

cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice

Maria Shvedova, Maxim M Litvak, Jesse D Roberts, Jr., Dai Fukumura, Tomoaki Suzuki, İkbal Şencan, Ge Li, Paula Reventun, Emmanuel S Buys, Hyung-Hwan Kim, Sava Sakadžić, Cenk Ayata, Paul L Huang, Robert Feil, Dmitriy N Atochin

J Cereb Blood Flow Metab. 2019 Dec; 39(12): 2379–2391. Published online 2019 Aug 18. doi: 10.1177/0271678X19870583

PMCID:: PMC6893979

Article PDF–1.0M

Select item 66846046.

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B₁₂ analog

Gerburg K. Schwaerzer, Hema Kalyanaraman, Darren E. Casteel, Nancy D. Dalton, Yusu Gu, Seunghoe Lee, Shunhui Zhuang, Nisreen Wahwah, Jan M. Schilling, Hemal H. Patel, Qian Zhang, Ayako Makino, Dianna M. Milewicz, Kirk L. Peterson, Gerry R. Boss, Renate B. Pilz

Nat Commun. 2019; 10: 3533. Published online 2019 Aug 6. doi: 10.1038/s41467-019-11389-1

PMCID:: PMC6684604

Article PDF–2.9M

Select item 61661007.

S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling

Alexandre Dumoulin, Alina Dagane, Gunnar Dittmar, Fritz G. Rathjen

Front Mol Neurosci. 2018; 11: 345. Published online 2018 Sep 24. doi: 10.3389/fnmol.2018.00345

PMCID:: PMC6166100

Article PDF–4.3M

Select item 61137338.

Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion

Hitoshi Uchida, Shinji Matsumura, Tayo Katano, Masahiko Watanabe, Jens Schlossmann, Seiji Ito

Mol Pain. 2018; 14: 1744806918796409. Published online 2018 Aug 28. doi: 10.1177/1744806918796409

PMCID:: PMC6113733

Article PDF–1.9M

Select item 54372339.

The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

Hema Kalyanaraman, Shunhui Zhuang, Renate B. Pilz, Darren E. Casteel

J Biol Chem. 2017 May 19; 292(20): 8262–8268. Published online 2017 Mar 30. doi: 10.1074/jbc.C117.787358

PMCID:: PMC5437233

Article PDF–1.0M

Select item 540947210.

NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function

Alok K. Sharma, Gabriel Birrane, Clemens Anklin, Alan C. Rigby, Seth L. Alper

J Biol Chem. 2017 Apr 28; 292(17): 7052–7065. Published online 2017 Mar 9. doi: 10.1074/jbc.M117.781260

PMCID:: PMC5409472

Article PDF–2.7M

Select item 539461811.

Cyclic GMP-dependent protein kinase-I localized in nociceptors modulates nociceptive cortical neuronal activity and pain hypersensitivity

Vijayan Gangadharan, Xu Wang, Ceng Luo

Mol Pain. 2017; 13: 1744806917701743. Published online 2017 Apr 5. doi: 10.1177/1744806917701743

PMCID:: PMC5394618

Article PDF–1.7M

Select item 515437612.

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca²⁺ sparks and BK channels

Kaivan Khavandi, Rachael A. Baylie, Sarah A. Sugden, Majid Ahmed, Viktoria Csato, Philip Eaton, David C. Hill-Eubanks, Adrian D. Bonev, Mark T. Nelson, Adam S. Greenstein

Sci Signal. Author manuscript; available in PMC 2017 Apr 11.

Published in final edited form as: Sci Signal. 2016 Oct 11; 9(449): ra100. Published online 2016 Oct 11. doi: 10.1126/scisignal.aaf6625

PMCID:: PMC5154376

Article PDF–1.3M

Select item 501613913.

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation

Oleksandra Prysyazhna, Joseph Robert Burgoyne, Jenna Scotcher, Steven Grover, David Kass, Philip Eaton

J Biol Chem. 2016 Aug 12; 291(33): 17427–17436. Published online 2016 Jun 24. doi: 10.1074/jbc.M116.724070

PMCID:: PMC5016139

Article PDF–1.8M

Select item 493834014.

Iron deficiency anemia in cyclic GMP kinase knockout mice

Elisabeth Angermeier, Katrin Domes, Robert Lukowski, Jens Schlossmann, Birgit Rathkolb, Martin Hraběde Angelis, Franz Hofmann

Haematologica. 2016 Feb; 101(2): e48–e51. doi: 10.3324/haematol.2015.137026

PMCID:: PMC4938340

Article PDF–682K

Select item 449776015.

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart

Taishi Nakamura, Mark J. Ranek, Dong I. Lee, Virginia Shalkey Hahn, Choel Kim, Philip Eaton, David A. Kass

J Clin Invest. 2015 Jun 1; 125(6): 2468–2472. Published online 2015 May 4. doi: 10.1172/JCI80275

PMCID:: PMC4497760

Article PDF–2.3M

Select item 418703616.

PKG-1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension

Ramaswamy Ramchandran, Aarti Raghavan, David Geenen, Miranda Sun, Laura Bach, Qiwei Yang, J. Usha Raj

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1; 307(7): L537–L544. Published online 2014 Aug 15. doi: 10.1152/ajplung.00093.2014

PMCID:: PMC4187036

Article

Select item 401067917.

Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis

Wenpeng Cui, Hasiyeti Maimaitiyiming, Xinyu Qi, Heather Norman, Qi Zhou, Xiaojun Wang, Jian Fu, Shuxia Wang

Am J Physiol Renal Physiol. 2014 May 1; 306(9): F996–F1007. Published online 2014 Feb 26. doi: 10.1152/ajprenal.00657.2013

PMCID:: PMC4010679

Article

Select item 392022318.

Dehydroepiandrosterone promotes pulmonary artery relaxation by NADPH oxidation-elicited subunit dimerization of protein kinase G 1α

Dhara Patel, Sharath Kandhi, Melissa Kelly, Boon Hwa Neo, Michael S. Wolin

Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15; 306(4): L383–L391. Published online 2013 Dec 27. doi: 10.1152/ajplung.00301.2013

PMCID:: PMC3920223

Article

Select item 380529419.

Mutation of the Protein Kinase I Alpha Leucine Zipper Domain Produces Hypertension and Progressive Left Ventricular Hypertrophy: A Novel Mouse Model of Age-Dependent Hypertensive Heart Disease

Robert M. Blanton, Eiki Takimoto, Mark Aronovitz, Robrecht Thoonen, David A. Kass, Richard H. Karas, Michael E. Mendelsohn

J Gerontol A Biol Sci Med Sci. 2013 Nov; 68(11): 1351–1355. Published online 2013 May 8. doi: 10.1093/gerona/glt042

PMCID:: PMC3805294

Article PDF–8.6M

Select item 376128920.

Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function

Hasiyeti Maimaitiyiming, Yanzhang Li, Wenpeng Cui, Xiaopeng Tong, Heather Norman, Xinyu Qi, Shuxia Wang

Am J Physiol Renal Physiol. 2013 Sep 15; 305(6): F881–F890. Published online 2013 Jul 3. doi: 10.1152/ajprenal.00192.2013

PMCID:: PMC3761289

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