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Items: 1 to 20 of 29

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes
Qinwen Ge, Zhenyu Shi, Kai-ao Zou, Jun Ying, Jiali Chen, Wenhua Yuan, Weidong Wang, Luwei Xiao, Xia Lin, Di Chen, Xin-Hua Feng, Ping-er Wang, Peijian Tong, Hongting Jin
JCI Insight. 2023 Feb 8; 8(3): e166688. Published online 2023 Feb 8. doi: 10.1172/jci.insight.166688
PMCID:
PMC9926971
ArticlePDF–3.8M
3.
De novo synthesis of protein phosphatase 1A, magnesium dependent, alpha isoform (PPM1A) during oocyte maturation
Dana Chuderland, Zeev Dvashi, Ruth Kaplan-Kraicer, Daniella Ben-Meir, Ruth Shalgi, Sara Lavi
Cell Mol Biol Lett. 2012 Sep; 17(3): 433–445. Published online 2012 Jun 5. doi: 10.2478/s11658-012-0022-7
PMCID:
PMC6275799
SummaryPDF–350K
4.
PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1
Weiwen Xiang, Qian Zhang, Xia Lin, Shiying Wu, Yao Zhou, Fansen Meng, Yunyun Fan, Tao Shen, Mu Xiao, Zongping Xia, Jian Zou, Xin-Hua Feng, Pinglong Xu
Sci Adv. 2016 Jul; 2(7): e1501889. Published online 2016 Jul 1. doi: 10.1126/sciadv.1501889
PMCID:
PMC4942338
ArticlePDF–1.2M
5.
The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration
Ruyuan Zhou, Qirou Wu, Mengqiu Wang, Seema Irani, Xiao Li, Qian Zhang, Fansen Meng, Shengduo Liu, Fei Zhang, Liming Wu, Xia Lin, Xiaojian Wang, Jian Zou, Hai Song, Jun Qin, Tingbo Liang, Xin-Hua Feng, Yan Jessie Zhang, Pinglong Xu
PLoS Biol. 2021 Feb; 19(2): e3001122. Published online 2021 Feb 25. doi: 10.1371/journal.pbio.3001122
PMCID:
PMC7978383
ArticlePDF–5.0M
6.
Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis
Beomgu Lee, You Seon Song, Christopher Rhodes, Tae Sik Goh, Jong Seong Roh, Hoim Jeong, Jisu Park, Han-Na Lee, Seung-Geun Lee, Soohyun Kim, Mingyo Kim, Sang-Il Lee, Dong Hyun Sohn, William H. Robinson
Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Feb 12.
Published in final edited form as: Biochem Biophys Res Commun. 2020 Feb 12; 522(3): 731–735. Published online 2019 Nov 30. doi: 10.1016/j.bbrc.2019.11.112
PMCID:
PMC7218691
ArticlePDF–1005K
7.
Delayed Re-epithelialization in Ppm1a Gene-deficient Mice Is Mediated by Enhanced Activation of Smad2
Xue Yang, Yan Teng, Ning Hou, Xiongwei Fan, Xuan Cheng, Jun Li, Lijuan Wang, Youliang Wang, Xiushan Wu, Xiao Yang
J Biol Chem. 2011 Dec 9; 286(49): 42267–42273. Published online 2011 Oct 11. doi: 10.1074/jbc.M111.292284
PMCID:
PMC3234921
ArticlePDF–1.5M
8.
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273
Keon Woo Khim, Sun Sil Choi, Hyun-Jun Jang, Yo Han Lee, Eujin Lee, Ji-Min Hyun, Hye-Jin Eom, Sora Yoon, Jeong-Won Choi, Tae-Eun Park, Dougu Nam, Jang Hyun Choi
Cells. 2020 Feb; 9(2): 343. Published online 2020 Feb 2. doi: 10.3390/cells9020343
PMCID:
PMC7072254
ArticlePDF–3.0M
9.
PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
Zexing Li, Ge Liu, Liwei Sun, Yan Teng, Xuejiang Guo, Jianhang Jia, Jiahao Sha, Xiao Yang, Dahua Chen, Qinmiao Sun
PLoS Pathog. 2015 Mar; 11(3): e1004783. Published online 2015 Mar 27. doi: 10.1371/journal.ppat.1004783
PMCID:
PMC4376777
ArticlePDF–5.7M
10.
PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3
Fangyan Dai, Tao Shen, Zhaoyong Li, Xia Lin, Xin-Hua Feng
EMBO Rep. 2011 Nov; 12(11): 1175–1181. Published online 2011 Sep 30. doi: 10.1038/embor.2011.174
Correction in:
EMBO Rep. 2011 Nov; 12(11): 1204.
PMCID:
PMC3207100
ArticlePDF–875K
11.
Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a
Naomasa Kakiya, Takashi Saito, Per Nilsson, Yukio Matsuba, Satoshi Tsubuki, Nobuyuki Takei, Hiroyuki Nawa, Takaomi C. Saido
J Biol Chem. 2012 Aug 24; 287(35): 29362–29372. Published online 2012 Jul 5. doi: 10.1074/jbc.M112.340372
PMCID:
PMC3436156
ArticlePDF–3.0M
12.
C-terminal Domain (CTD) Small Phosphatase-like 2 Modulates the Canonical Bone Morphogenetic Protein (BMP) Signaling and Mesenchymal Differentiation via Smad Dephosphorylation
Yulan Zhao, Mu Xiao, Baoguo Sun, Zhengmao Zhang, Tao Shen, Xueyan Duan, Paul Borchyung Yu, Xin-Hua Feng, Xia Lin
J Biol Chem. 2014 Sep 19; 289(38): 26441–26450. Published online 2014 Aug 6. doi: 10.1074/jbc.M114.568964
PMCID:
PMC4176200
ArticlePDF–2.1M
13.
Inhibition of TGF-β Signaling at the Nuclear Envelope: Characterization of Interactions between MAN1, Smad2 and 3, and PPM1A
Benjamin Bourgeois, Bernard Gilquin, Carine Tellier-Lebègue, Cecilia Östlund, Wei Wu, Javier Pérez, Perla El Hage, François Lallemand, Howard J. Worman, Sophie Zinn-Justin
Sci Signal. Author manuscript; available in PMC 2013 Dec 18.
Published in final edited form as: Sci Signal. 2013 Jun 18; 6(280): 10.1126/scisignal.2003411. Published online 2013 Jun 18. doi: 10.1126/scisignal.2003411
PMCID:
PMC3843637
ArticlePDF–4.0M
14.
Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression
Rohan Samarakoon, Subhanir S. Chitnis, Stephen P. Higgins, Craig E. Higgins, Joan C. Krepinsky, Paul J. Higgins
PLoS One. 2011; 6(7): e22896. Published online 2011 Jul 28. doi: 10.1371/journal.pone.0022896
PMCID:
PMC3145778
ArticlePDF–2.3M
15.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase
Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong
EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500
PMCID:
PMC5341520
ArticlePDF–1.1M
16.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
ArticlePDF–1.4M
17.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
ArticlePDF–3.0M
18.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
ArticlePDF–5.7M
19.
BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System
Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran
PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086
PMCID:
PMC1413568
ArticlePDF–99K
20.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
ArticlePDF–2.0M

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