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Select item 101548221.

Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell‐derived neural crest cells

Kyosuke Mukae, Hisanori Takenobu, Yuki Endo, Masayuki Haruta, Tianyuan Shi, Shunpei Satoh, Miki Ohira, Michinori Funato, Junya Toguchida, Kenji Osafune, Tatsutoshi Nakahata, Hiroaki Kanda, Takehiko Kamijo

Cancer Sci. 2023 May; 114(5): 1898–1911. Published online 2023 Feb 3. doi: 10.1111/cas.15730

PMCID:: PMC10154822

Article PDF–13M

Select item 65452492.

Down-Regulation of MYCN Protein by CX-5461 Leads to Neuroblastoma Tumor Growth Suppression

Jordan S. Taylor, Jasmine Zeki, Kimberly Ornell, Jeannine Coburn, Hiroyuki Shimada, Naohiko Ikegaki, Bill Chiu

J Pediatr Surg. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: J Pediatr Surg. 2019 Jun; 54(6): 1192–1197. Published online 2019 Feb 28. doi: 10.1016/j.jpedsurg.2019.02.028

PMCID:: PMC6545249

Article PDF–553K

Select item 55822123.

MYCN induces neuroblastoma in primary neural crest cells

R R Olsen, J H Otero, J García-López, K Wallace, D Finkelstein, J E Rehg, Z Yin, Y-D Wang, K W Freeman

Oncogene. 2017 Aug 31; 36(35): 5075–5082. Published online 2017 May 1. doi: 10.1038/onc.2017.128

PMCID:: PMC5582212

Article PDF–3.4M

Select item 45193184.

Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis

Bret C. Mobley, Minjae Kwon, Bradley R. Kraemer, F. Edward Hickman, Jingbo Qiao, Dai H. Chung, Bruce D. Carter

PLoS One. 2015; 10(7): e0133897. Published online 2015 Jul 29. doi: 10.1371/journal.pone.0133897

PMCID:: PMC4519318

Article PDF–3.1M

Select item 43650145.

Molecular and In Vivo Characterization of Cancer-Propagating Cells Derived from MYCN-Dependent Medulloblastoma

Zai Ahmad, Lukasz Jasnos, Veronica Gil, Louise Howell, Albert Hallsworth, Kevin Petrie, Tomoyuki Sawado, Louis Chesler

PLoS One. 2015; 10(3): e0119834. Published online 2015 Mar 18. doi: 10.1371/journal.pone.0119834

PMCID:: PMC4365014

Article PDF–1.2M

Select item 35059856.

Inducible and reversible regulation of endogenous gene in mouse

Ruilin Sun, Kai Zhao, Ruling Shen, Lei Cai, Xingyu Yang, Ying Kuang, Jifang Mao, Fang Huang, Zhugang Wang, Jian Fei

Nucleic Acids Res. 2012 Nov; 40(21): e166. Published online 2012 Aug 8. doi: 10.1093/nar/gks738

PMCID:: PMC3505985

Article PDF–16M

Select item 26737107.

Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes

Brian Cox, Thomas Kislinger, Dennis A Wigle, Anitha Kannan, Kevin Brown, Tadashi Okubo, Brigid Hogan, Igor Jurisica, Brendan Frey, Janet Rossant, Andrew Emili

Mol Syst Biol. 2007; 3: 109. Published online 2007 May 8. doi: 10.1038/msb4100151

PMCID:: PMC2673710

Article PDF–545K

Select item 21152498.

N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization

J Cell Biol. 1988 Oct 1; 107(4): 1325–1335. doi: 10.1083/jcb.107.4.1325

PMCID:: PMC2115249

Summary PDF–3.9M

Select item 11669309.

Nucleotide sequence of the coding region of the mouse N-myc gene.

Y Taya, S Mizusawa, S Nishimura

EMBO J. 1986 Jun; 5(6): 1215–1219. doi: 10.1002/j.1460-2075.1986.tb04349.x

PMCID:: PMC1166930

Summary Page Browse PDF–875K

Select item 40092310.

IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.

R Dildrop, A Ma, K Zimmerman, E Hsu, A Tesfaye, R DePinho, F W Alt

EMBO J. 1989 Apr; 8(4): 1121–1128. doi: 10.1002/j.1460-2075.1989.tb03482.x

PMCID:: PMC400923

Summary Page Browse PDF–1.8M

Select item 40078111.

N-myc is frequently activated by proviral insertion in MuLV-induced T cell lymphomas.

M van Lohuizen, M Breuer, A Berns

EMBO J. 1989 Jan; 8(1): 133–136. doi: 10.1002/j.1460-2075.1989.tb03357.x

PMCID:: PMC400781

Summary Page Browse PDF–798K

Select item 39058812.

N-myc can cooperate with ras to transform normal cells in culture.

G D Yancopoulos, P D Nisen, A Tesfaye, N E Kohl, M P Goldfarb, F W Alt

Proc Natl Acad Sci U S A. 1985 Aug; 82(16): 5455–5459. doi: 10.1073/pnas.82.16.5455

PMCID:: PMC390588

Summary Page Browse PDF–1.3M

Select item 36295313.

Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells.

B R Stanton, S W Reid, L F Parada

Mol Cell Biol. 1990 Dec; 10(12): 6755–6758. doi: 10.1128/mcb.10.12.6755

PMCID:: PMC362953

Summary Page Browse PDF–890K

Select item 36253614.

Insertional activation of N-myc by endogenous Moloney-like murine retrovirus sequences in macrophage cell lines derived from myeloma cell line-macrophage hybrids.

M Setoguchi, Y Higuchi, S Yoshida, N Nasu, Y Miyazaki, S Akizuki, S Yamamoto

Mol Cell Biol. 1989 Oct; 9(10): 4515–4522. doi: 10.1128/mcb.9.10.4515

PMCID:: PMC362536

Summary Page Browse PDF–1.6M

Select item 33652915.

Complete nucleotide sequence and exon-intron boundaries of the 5' non-coding region of the mouse N-myc gene.

K Katoh, S Sawai, K Ueno, H Kondoh

Nucleic Acids Res. 1988 Apr 25; 16(8): 3589. doi: 10.1093/nar/16.8.3589

PMCID:: PMC336529

Summary Page Browse PDF–120K

Select item 32317716.

Structure and expression of the murine N-myc gene.

R A DePinho, E Legouy, L B Feldman, N E Kohl, G D Yancopoulos, F W Alt

Proc Natl Acad Sci U S A. 1986 Mar; 83(6): 1827–1831. doi: 10.1073/pnas.83.6.1827

PMCID:: PMC323177

Summary Page Browse PDF–1.1M

Select item 886490317.

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice

Zhuo Huang, Ruihuan Yang, Ruyi Li, Yining Zuo, Fan Gu, Miao He, Zhuan Bian

Stem Cell Res Ther. 2022; 13: 78. Published online 2022 Feb 22. doi: 10.1186/s13287-022-02749-8

PMCID:: PMC8864903

Article PDF–16M

Select item 634300618.

Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling

Loretta Dorstyn, Emily Hackett-Jones, Andrej Nikolic, Murray D. Norris, Yoon Lim, John Toubia, Michelle Haber, Sharad Kumar

Cell Death Dis. 2019 Feb; 10(2): 56. Published online 2019 Jan 22. doi: 10.1038/s41419-018-1296-0

PMCID:: PMC6343006

Article PDF–3.1M

Select item 583382719.

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent

Tingting Wang, Lingling Liu, Xuyong Chen, Yuqing Shen, Gaojian Lian, Nilay Shah, Andrew M Davidoff, Jun Yang, Ruoning Wang

Cell Death Dis. 2018 Feb; 9(2): 220. Published online 2018 Feb 14. doi: 10.1038/s41419-018-0295-5

PMCID:: PMC5833827

Article PDF–1.6M

Select item 553634820.

Transcriptional Profiling Reveals a Common Metabolic Program for Tumorigenicity in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Mengling Liu, Yingfeng Xia, Jane Ding, Bingwei Ye, Erhu Zhao, Jeong-Hyeon Choi, Ahmet Alptekin, Chunhong Yan, Zheng Dong, Shuang Huang, Liqun Yang, Hongjuan Cui, Yunhong Zha, Han-Fei Ding

Cell Rep. Author manuscript; available in PMC 2017 Oct 4.

Published in final edited form as: Cell Rep. 2016 Oct 4; 17(2): 609–623. doi: 10.1016/j.celrep.2016.09.021