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Select item 106224341.

The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males

Sandra Rogala, Tamer Ali, Maria-Theodora Melissari, Sandra Währisch, Peggy Schuster, Alexandre Sarre, Rebeca Cordellini Emídio, Thomas Boettger, Eva-Maria Rogg, Jaskiran Kaur, Jaya Krishnan, Gabrijela Dumbović, Stefanie Dimmeler, Samir Ounzain, Thierry Pedrazzini, Bernhard G. Herrmann, Phillip Grote

Nat Commun. 2023; 14: 7024. Published online 2023 Nov 2. doi: 10.1038/s41467-023-42760-y

PMCID:: PMC10622434

Article PDF–2.7M

Select item 84677142.

The Genetic Architecture of a Congenital Heart Defect Is Related to Its Fitness Cost

Ehiole Akhirome, Suk D. Regmi, Rachel A. Magnan, Nelson Ugwu, Yidan Qin, Claire E. Schulkey, James M. Cheverud, Patrick Y. Jay

Genes (Basel) 2021 Sep; 12(9): 1368. Published online 2021 Aug 31. doi: 10.3390/genes12091368

PMCID:: PMC8467714

Article PDF–1.9M

Select item 72725733.

Extracellular Matrix Disparities in an Nkx2-5 Mutant Mouse Model of Congenital Heart Disease

Deanna Bousalis, Christopher S. Lacko, Nora Hlavac, Fariz Alkassis, Rebecca A. Wachs, Sahba Mobini, Christine E. Schmidt, Hideko Kasahara

Front Cardiovasc Med. 2020; 7: 93. Published online 2020 May 29. doi: 10.3389/fcvm.2020.00093

PMCID:: PMC7272573

Article PDF–1.5M

Select item 63314464.

Trabecular Architecture Determines Impulse Propagation Through the Early Embryonic Mouse Heart

Veronika Olejníčková, Barbora Šaňková, David Sedmera, Jiří Janáček

Front Physiol. 2018; 9: 1876. Published online 2019 Jan 8. doi: 10.3389/fphys.2018.01876

PMCID:: PMC6331446

Article PDF–4.0M

Select item 62790785.

Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis

Marcus-André Deutsch, Stefanie A Doppler, Xinghai Li, Harald Lahm, Gianluca Santamaria, Giovanni Cuda, Stefan Eichhorn, Thomas Ratschiller, Elda Dzilic, Martina Dreßen, Annekathrin Eckart, Konstantin Stark, Steffen Massberg, Anna Bartels, Christoph Rischpler, Ralf Gilsbach, Lutz Hein, Bernd K Fleischmann, Sean M Wu, Rüdiger Lange, Markus Krane

Cardiovasc Res. 2018 Jul; 114(8): 1098–1114. Published online 2018 Mar 20. doi: 10.1093/cvr/cvy069

PMCID:: PMC6279078

Article PDF–2.1M

Select item 53584966.

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Milena B. Furtado, Julia C. Wilmanns, Anjana Chandran, Joelle Perera, Olivia Hon, Christine Biben, Taylor J. Willow, Hieu T. Nim, Gurpreet Kaur, Stephanie Simonds, Qizhu Wu, David Willians, Ekaterina Salimova, Nicolas Plachta, James M. Denegre, Stephen A. Murray, Diane Fatkin, Michael Cowley, James T. Pearson, David Kaye, Mirana Ramialison, Richard P. Harvey, Nadia A. Rosenthal, Mauro W. Costa

JCI Insight. 2017 Mar 23; 2(6): e88271. Published online 2017 Mar 23. doi: 10.1172/jci.insight.88271

PMCID:: PMC5358496

Article PDF–1.5M

Select item 51987847.

Single-cell Resolution of Temporal Gene Expression during Heart Development

Daniel M. DeLaughter, Alexander G. Bick, Hiroko Wakimoto, David McKean, Joshua M. Gorham, Irfan S. Kathiriya, John T. Hinson, Jason Homsy, Jesse Gray, William Pu, Benoit G. Bruneau, J. G. Seidman, Christine E. Seidman

Dev Cell. Author manuscript; available in PMC 2017 Nov 21.

Published in final edited form as: Dev Cell. 2016 Nov 21; 39(4): 480–490. Published online 2016 Nov 10. doi: 10.1016/j.devcel.2016.10.001

PMCID:: PMC5198784

Article PDF–2.3M

Select item 46180208.

A Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

Rajib Chowdhury, Hassan Ashraf, Michelle Melanson, Yohei Tanada, Minh Nguyen, G. Michael Silberbach, Hiroko Wakimoto, D. Woodrow Benson, Robert H. Anderson, Hideko Kasahara

Circ Arrhythm Electrophysiol. Author manuscript; available in PMC 2016 Oct 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Oct; 8(5): 1255–1264. Published online 2015 Jul 30. doi: 10.1161/CIRCEP.115.002720

PMCID:: PMC4618020

Article PDF–1.5M

Select item 45457339.

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via the nuclear exit of a mechanorepressor

P. C. Dave P. Dingal, Andrew M. Bradshaw, Sangkyun Cho, Matthew Raab, Amnon Buxboim, Joe Swift, Dennis E. Discher

Nat Mater. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Nat Mater. 2015 Sep; 14(9): 951–960. Published online 2015 Jul 13. doi: 10.1038/nmat4350

PMCID:: PMC4545733

Article PDF–2.7M

Select item 439337010.

The Maternal Age-Associated Risk of Congenital Heart Disease Is Modifiable

Claire E. Schulkey, Suk D. Regmi, Rachel A. Magnan, Megan T. Danzo, Herman Luther, Alayna K. Hutchinson, Adam A. Panzer, Mary M. Grady, David B. Wilson, Patrick Y. Jay

Nature. Author manuscript; available in PMC 2015 Oct 9.

Published in final edited form as: Nature. 2015 Apr 9; 520(7546): 230–233. Published online 2015 Apr 1. doi: 10.1038/nature14361

PMCID:: PMC4393370

Article PDF–640K

Select item 352156811.

Complex Trait Analysis of Ventricular Septal Defects Caused by Nkx2-5 Mutation

Julia B. Winston, Claire E. Schulkey, Iuan-Bor D. Chen, Suk D. Regmi, Maria Efimova, Jonathan M. Erlich, Courtney A. Green, Ashley Aluko, Patrick Y. Jay

Circ Cardiovasc Genet. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2012 Jun; 5(3): 293–300. Published online 2012 Apr 24. doi: 10.1161/CIRCGENETICS.111.961136

PMCID:: PMC3521568

Article PDF–1.6M

Select item 337611212.

Cardiac Transcription Factor Nkx2.5 Is Downregulated under Excessive O-GlcNAcylation Condition

Hoe Suk Kim, Ji Soo Woo, Hyun Jung Joo, Woo Kyung Moon

PLoS One. 2012; 7(6): e38053. Published online 2012 Jun 15. doi: 10.1371/journal.pone.0038053

PMCID:: PMC3376112

Article PDF–651K

Select item 312507113.

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation

Ryota Terada, Sonisha Warren, Jonathan T. Lu, Kenneth R. Chien, Andy Wessels, Hideko Kasahara

Cardiovasc Res. 2011 Jul 15; 91(2): 289–299. Published online 2011 Feb 1. doi: 10.1093/cvr/cvr037

PMCID:: PMC3125071

Article PDF–1.0M

Select item 310899814.

Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects

Eun Young Kim, Li Chen, Yanlin Ma, Wei Yu, Jiang Chang, Ivan P. Moskowitz, Jun Wang

PLoS One. 2011; 6(6): e20803. Published online 2011 Jun 3. doi: 10.1371/journal.pone.0020803

PMCID:: PMC3108998

Article PDF–2.5M

Select item 295385015.

Heterogeneity of genetic modifiers ensures normal cardiac development

Julia B. Winston, Jonathan M. Erlich, Courtney A. Green, Ashley Aluko, Kristine A. Kaiser, Mai Takematsu, Robert S. Barlow, Ashish O. Sureka, Martin J. LaPage, Luc L. Janss, Patrick Y. Jay

Circulation. Author manuscript; available in PMC 2011 Mar 23.

Published in final edited form as: Circulation. 2010 Mar 23; 121(11): 1313–1321. Published online 2010 Mar 8. doi: 10.1161/CIRCULATIONAHA.109.887687

PMCID:: PMC2953850

Article PDF–2.2M

Select item 23119216.

Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the NKx transcription factor family members thyroid transciption factor 1 and cardiac muscle-specific homeobox protein (CSX).

M K Ray, C Y Chen, R J Schwartz, F J DeMayo

Mol Cell Biol. 1996 May; 16(5): 2056–2064. doi: 10.1128/mcb.16.5.2056

PMCID:: PMC231192

Summary PDF–410K

Select item 4730517.

Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

I Komuro, S Izumo

Proc Natl Acad Sci U S A. 1993 Sep 1; 90(17): 8145–8149. doi: 10.1073/pnas.90.17.8145

PMCID:: PMC47305

Summary Page Browse PDF–2.0M

Select item 752583018.

Second Heart Field-specific expression of Nkx2-5 requires promoter proximal interaction with Srf

Christopher D. Clark, Kyu-Ho Lee

Mech Dev. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Mech Dev. 2020 Jun; 162: 103615. Published online 2020 May 22. doi: 10.1016/j.mod.2020.103615

PMCID:: PMC7525830

Article PDF–732K

Select item 729187919.

Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential

Wei Huang, Jialiang Liang, Yuliang Feng, Zhanfeng Jia, Lin Jiang, Wenfeng Cai, Christian Paul, Jianguo G. Gu, Peter J. Stambrook, Ronald W. Millard, Xiao-Lan Zhu, Ping Zhu, Yigang Wang

Exp Cell Res. Author manuscript; available in PMC 2020 Jun 12.

Published in final edited form as: Exp Cell Res. 2018 Oct 1; 371(1): 20–30. Published online 2018 May 26. doi: 10.1016/j.yexcr.2018.05.028

PMCID:: PMC7291879

Article PDF–1.4M

Select item 680589220.

Dietary protein restriction throughout intrauterine and postnatal life results in potentially beneficial myocardial tissue remodeling in the adult mouse heart

Maria Hennig, Lea Ewering, Simon Pyschny, Shinya Shimoyama, Maja Olecka, Dominik Ewald, Manuela Magarin, Anselm Uebing, Ludwig Thierfelder, Christian Jux, Jörg-Detlef Drenckhahn

Sci Rep. 2019; 9: 15126. Published online 2019 Oct 22. doi: 10.1038/s41598-019-51654-3

PMCID:: PMC6805892

Article PDF–8.4M

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