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Select item 14704581.

B Cell Antigen Receptor Signaling and Internalization Are Mutually Exclusive Events

Ping Hou, Elizabeth Araujo, Tong Zhao, Miao Zhang, Don Massenburg, Margaret Veselits, Colleen Doyle, Aaron R Dinner, Marcus R Clark

PLoS Biol. 2006 Jul; 4(7): e200. Published online 2006 May 30. doi: 10.1371/journal.pbio.0040200

PMCID:: PMC1470458

Abstract Article PDF–399K

Select item 388402.

Evidence for a preformed transducer complex organized by the B cell antigen receptor.

J Wienands, O Larbolette, M Reth

Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15): 7865–7870. doi: 10.1073/pnas.93.15.7865

PMCID:: PMC38840

Summary Page Browse PDF–1.6M

Select item 160023.

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

Katsuhiko Hayashi, Ryo Nittono, Noriaki Okamoto, Sachiyo Tsuji, Yasushi Hara, Ryo Goitsuka, Daisuke Kitamura

Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6): 2755–2760. Published online 2000 Feb 25. doi: 10.1073/pnas.040575697

PMCID:: PMC16002

Abstract Article PDF–211K

Select item 33228774.

Down-regulation of B Cell Receptor Signaling by Hematopoietic Progenitor Kinase 1 (HPK1)-mediated Phosphorylation and Ubiquitination of Activated B Cell Linker Protein (BLNK)

Xiaohong Wang, Ju-Pi Li, Hui-Kai Kuo, Li-Li Chiu, Gregory A. Dement, Joung-Liang Lan, Der-Yuan Chen, Chia-Yu Yang, Hongbo Hu, Tse-Hua Tan

J Biol Chem. 2012 Mar 30; 287(14): 11037–11048. Published online 2012 Feb 10. doi: 10.1074/jbc.M111.310946

PMCID:: PMC3322877

Abstract Article PDF–3.1M

Select item 26440755.

BLNK suppresses pre–B-cell leukemogenesis through inhibition of JAK3

Joji Nakayama, Mutsumi Yamamoto, Katsuhiko Hayashi, Hitoshi Satoh, Kenji Bundo, Masato Kubo, Ryo Goitsuka, Michael A. Farrar, Daisuke Kitamura

Blood. 2009 Feb 12; 113(7): 1483–1492. Prepublished online 2008 Dec 1. doi: 10.1182/blood-2008-07-166355

PMCID:: PMC2644075

Abstract Article

Select item 21960766.

Bruton's Tyrosine Kinase Cooperates with the B Cell Linker Protein SLP-65 as a Tumor Suppressor in Pre-B Cells

Rogier Kersseboom, Sabine Middendorp, Gemma M. Dingjan, Katarina Dahlenborg, Michael Reth, Hassan Jumaa, Rudolf W. Hendriks

J Exp Med. 2003 Jul 7; 198(1): 91–98. doi: 10.1084/jem.20030615

PMCID:: PMC2196076

Abstract Article PDF–225K

Select item 86457137.

C/EBPβ induces B‐cell acute lymphoblastic leukemia and cooperates with BLNK mutations

Morito Kurata, Iichiro Onishi, Tomoko Takahara, Yukari Yamazaki, Sachiko Ishibashi, Ryo Goitsuka, Daisuke Kitamura, Junko Takita, Yasuhide Hayashi, David A Largaesapda, Masanobu Kitagawa, Takuro Nakamura

Cancer Sci. 2021 Dec; 112(12): 4920–4930. Published online 2021 Oct 23. doi: 10.1111/cas.15164

PMCID:: PMC8645713

Abstract Article PDF–1.4M

Select item 48134948.

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia

Naoto Imoto, Fumihiko Hayakawa, Shingo Kurahashi, Takanobu Morishita, Yuki Kojima, Takahiko Yasuda, Keiki Sugimoto, Shinobu Tsuzuki, Tomoki Naoe, Hitoshi Kiyoi

J Biol Chem. 2016 Feb 26; 291(9): 4723–4731. Published online 2015 Dec 24. doi: 10.1074/jbc.M115.637835

PMCID:: PMC4813494

Abstract Article PDF–2.1M

Select item 39280349.

Pre-B Cell Receptor Signaling Induces Immunoglobulin κ Locus Accessibility by Functional Redistribution of Enhancer-Mediated Chromatin Interactions

Ralph Stadhouders, Marjolein J. W. de Bruijn, Magdalena B. Rother, Saravanan Yuvaraj, Claudia Ribeiro de Almeida, Petros Kolovos, Menno C. Van Zelm, Wilfred van Ijcken, Frank Grosveld, Eric Soler, Rudi W. Hendriks

PLoS Biol. 2014 Feb; 12(2): e1001791. Published online 2014 Feb 18. doi: 10.1371/journal.pbio.1001791

PMCID:: PMC3928034

Abstract Article PDF–2.3M

Select item 328369010.

Identification of CMTM7 as a Transmembrane Linker of BLNK and the B-Cell Receptor

Atsuko Miyazaki, Satomi Yogosawa, Akikazu Murakami, Daisuke Kitamura

PLoS One. 2012; 7(2): e31829. Published online 2012 Feb 21. doi: 10.1371/journal.pone.0031829

PMCID:: PMC3283690

Abstract Article PDF–656K

Select item 288282911.

BCL6 is critical for the development of a diverse primary B cell repertoire

Cihangir Duy, J. Jessica Yu, Rahul Nahar, Srividya Swaminathan, Soo-Mi Kweon, Jose M. Polo, Ester Valls, Lars Klemm, Seyedmehdi Shojaee, Leandro Cerchietti, Wolfgang Schuh, Hans-Martin Jäck, Christian Hurtz, Parham Ramezani-Rad, Sebastian Herzog, Hassan Jumaa, H. Phillip Koeffler, Ignacio Moreno de Alborán, Ari M. Melnick, B. Hilda Ye, Markus Müschen

J Exp Med. 2010 Jun 7; 207(6): 1209–1221. doi: 10.1084/jem.20091299

PMCID:: PMC2882829

Abstract Article PDF–3.4M

Select item 284034712.

Premature replacement of μ with α immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation

Sophie Duchez, Rada Amin, Nadine Cogné, Laurent Delpy, Christophe Sirac, Virginie Pascal, Blaise Corthésy, Michel Cogné

Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7): 3064–3069. Published online 2010 Jan 28. doi: 10.1073/pnas.0912393107

PMCID:: PMC2840347

Abstract Article PDF–611K

Select item 272217213.

Pre–B cell receptor–mediated cell cycle arrest in Philadelphia chromosome–positive acute lymphoblastic leukemia requires IKAROS function

Daniel Trageser, Ilaria Iacobucci, Rahul Nahar, Cihangir Duy, Gregor von Levetzow, Lars Klemm, Eugene Park, Wolfgang Schuh, Tanja Gruber, Sebastian Herzog, Yong-mi Kim, Wolf-Karsten Hofmann, Aihong Li, Clelia Tiziana Storlazzi, Hans-Martin Jäck, John Groffen, Giovanni Martinelli, Nora Heisterkamp, Hassan Jumaa, Markus Müschen

J Exp Med. 2009 Aug 3; 206(8): 1739–1753. doi: 10.1084/jem.20090004

PMCID:: PMC2722172

Abstract Article PDF–4.8M

Select item 221335314.

SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation

Jürgen Wienands, Jutta Schweikert, Bernd Wollscheid, Hassan Jumaa, Peter J. Nielsen, Michael Reth

J Exp Med. 1998 Aug 17; 188(4): 791–795. doi: 10.1084/jem.188.4.791

PMCID:: PMC2213353

Abstract Article PDF–138K

Select item 219414315.

Identification of a Pre-BCR Lacking Surrogate Light Chain

Yu-wen Su, Alexandra Flemming, Thomas Wossning, Elias Hobeika, Michael Reth, Hassan Jumaa

J Exp Med. 2003 Dec 1; 198(11): 1699–1706. doi: 10.1084/jem.20031428

PMCID:: PMC2194143

Abstract Article PDF–205K

Select item 219392416.

Delayed Cellular Maturation and Decreased Immunoglobulin κ Light Chain Production In Immature B Lymphocytes Lacking B Cell Linker Protein

Shengli Xu, Kong-Peng Lam

J Exp Med. 2002 Jul 15; 196(2): 197–206. doi: 10.1084/jem.20020172

PMCID:: PMC2193924

Abstract Article PDF–189K

Select item 775708317.

Involvement of Blnk and Foxo1 in tumor suppression in BCR-ABL1-transformed pro-B cells

Ping Zhang, Yang Wang, Mengting Qin, Dandan Li, Woodvine Otieno Odhiambo, Meng Yuan, Zhuangwei Lv, Chengcheng Liu, Yunfeng Ma, Yanying Dong, Yanhong Ji

Oncol Rep. 2021 Feb; 45(2): 693–705. Published online 2020 Dec 8. doi: 10.3892/or.2020.7888

PMCID:: PMC7757083

Abstract Article PDF–1.7M

Select item 348614418.

A Novel Mechanism for the Autonomous Termination of Pre-B Cell Receptor Expression via Induction of Lysosome-Associated Protein Transmembrane 5

Yohei Kawano, Rika Ouchida, Ji-Yang Wang, Soichiro Yoshikawa, Mutsumi Yamamoto, Daisuke Kitamura, Hajime Karasuyama

Mol Cell Biol. 2012 Nov; 32(21): 4462–4471. doi: 10.1128/MCB.00531-12

PMCID:: PMC3486144

Abstract Article PDF–1.6M

Select item 320473519.

Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

Rahul Nahar, Parham Ramezani-Rad, Maximilian Mossner, Cihangir Duy, Leandro Cerchietti, Huimin Geng, Sinisa Dovat, Hassan Jumaa, B. Hilda Ye, Ari Melnick, Markus Müschen

Blood. 2011 Oct 13; 118(15): 4174–4178. Prepublished online 2011 Aug 19. doi: 10.1182/blood-2011-01-331181