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Select item 77540321.

Chronic shift‐lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122

Xiaokang Zeng, Caiying Liang, Jie Yao

J Cell Mol Med. 2020 Dec; 24(24): 14583–14595. Published online 2020 Nov 13. doi: 10.1111/jcmm.16088

PMCID:: PMC7754032

Article PDF–2.1M

Select item 61599722.

CD122 signaling in CD8⁺ memory T cells drives costimulation-independent rejection

David V. Mathews, Ying Dong, Laura B. Higginbotham, Steven C. Kim, Cynthia P. Breeden, Elizabeth A. Stobert, Joseph Jenkins, J. Yun Tso, Christian P. Larsen, Andrew B. Adams

J Clin Invest. 2018 Oct 1; 128(10): 4557–4572. Published online 2018 Sep 17. doi: 10.1172/JCI95914

PMCID:: PMC6159972

Article PDF–5.0M

Select item 57410963.

IL-2Rβ Abundance Differentially Tunes IL-2 Signaling Dynamics in CD4⁺ and CD8⁺ T Cells

Geoffrey A. Smith, Jack Taunton, Arthur Weiss

Sci Signal. Author manuscript; available in PMC 2018 Jun 19.

Published in final edited form as: Sci Signal. 2017 Dec 19; 10(510): eaan4931. Published online 2017 Dec 19. doi: 10.1126/scisignal.aan4931

PMCID:: PMC5741096

Article PDF–1.4M

Select item 33515734.

Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and Experimental Autoimmune Encephalomyelitis severity in the absence of IL-12 receptor signaling

Denise C. Fitzgerald, Guang-Xian Zhang, Shuo Yu, Melissa L. Cullimore, Zhao Zhao, Abdolmohamad Rostami

J Neuroimmunol. Author manuscript; available in PMC 2013 Jun 15.

Published in final edited form as: J Neuroimmunol. 2012 Jun 15; 247(1-2): 32–37. Published online 2012 Apr 21. doi: 10.1016/j.jneuroim.2012.03.021

PMCID:: PMC3351573

Article PDF–1.0M

Select item 29624465.

A low IL-2R signaling threshold supports the development and homeostasis of T regulatory cells

Aixin Yu, Linjian Zhu, Norman H. Altman, Thomas R. Malek

Immunity. Author manuscript; available in PMC 2010 Oct 22.

Published in final edited form as: Immunity. 2009 Feb 20; 30(2): 204–217. Published online 2009 Jan 29. doi: 10.1016/j.immuni.2008.11.014

PMCID:: PMC2962446

Article PDF–1.7M

Select item 21960406.

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

Haruhiko Suzuki, Gordon S. Duncan, Hiroaki Takimoto, Tak W. Mak

J Exp Med. 1997 Feb 3; 185(3): 499–506. doi: 10.1084/jem.185.3.499

PMCID:: PMC2196040

Article PDF–139K

Select item 21957417.

Normal Regulatory α/β T Cells Effectively Eliminate Abnormally Activated T Cells Lacking the Interleukin 2 Receptor β in Vivo

Haruhiko Suzuki, Yan Wen Zhou, Masashi Kato, Tak W. Mak, Izumi Nakashima

J Exp Med. 1999 Dec 6; 190(11): 1561–1572. doi: 10.1084/jem.190.11.1561

PMCID:: PMC2195741

Article PDF–170K

Select item 21935878.

Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8⁺ Cells

Xiaohong Zhang, Hideki Fujii, Hidehiro Kishimoto, Eric LeRoy, Charles D. Surh, Jonathan Sprent

J Exp Med. 2002 Feb 4; 195(3): 283–293. doi: 10.1084/jem.20011267

PMCID:: PMC2193587

Article PDF–165K

Select item 21917559.

Induction of interleukin 2 receptor beta chain expression by self- recognition in the thymus

J Exp Med. 1994 Nov 1; 180(5): 1629–1636. doi: 10.1084/jem.180.5.1629

PMCID:: PMC2191755

Summary PDF–758K

Select item 9801210.

Mice Lacking Interleukin-2 (IL-2)/IL-15 Receptor β Chain Are Susceptible to Infection with Avirulent Salmonella enterica subsp. enterica Serovar Choleraesuis but Mice Lacking IL-2 Are Resistant

Hitoshi Nishimura, Mitsuhiko Tagaya, Hironaka Tsunobuchi, Haruhiko Suzuki, Izumi Nakashima, Yasunobu Yoshikai

Infect Immun. 2001 Feb; 69(2): 1226–1229. doi: 10.1128/IAI.69.2.1226-1229.2001

PMCID:: PMC98012

Article PDF–208K

Select item 5357211.

Murine interleukin 2 receptor beta chain: dysregulated gene expression in lymphoma line EL-4 caused by a promoter insertion.

T Kono, T Doi, G Yamada, M Hatakeyama, S Minamoto, M Tsudo, M Miyasaka, T Miyata, T Taniguchi

Proc Natl Acad Sci U S A. 1990 Mar; 87(5): 1806–1810. doi: 10.1073/pnas.87.5.1806

PMCID:: PMC53572

Summary Page Browse PDF–1.1M

Select item 507957212.

IL-12/IL-23p40 Is Highly Expressed in Secondary Lymphoid Organs and the CNS during All Stages of EAE, but Its Deletion Does Not Affect Disease Perpetuation

Petra D. Cravens, Rehana Z. Hussain, William A. Miller-Little, Li-Hong Ben, Benjamin M. Segal, Emily Herndon, Olaf Stüve

PLoS One. 2016; 11(10): e0165248. Published online 2016 Oct 25. doi: 10.1371/journal.pone.0165248

PMCID:: PMC5079572

Article PDF–1.9M

Select item 308254413.

Continuous Activation of the CD122/STAT-5 Signaling Pathway during Selection of Antigen-Specific Regulatory T Cells in the Murine Thymus

Jérémie D. Goldstein, Robert S. Balderas, Gilles Marodon

PLoS One. 2011; 6(4): e19038. Published online 2011 Apr 26. doi: 10.1371/journal.pone.0019038

PMCID:: PMC3082544

Article PDF–427K

Select item 294723114.

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

Taylor H. Schreiber, Dietlinde Wolf, Matthew S. Tsai, Jackie Chirinos, Vadim V. Deyev, Louis Gonzalez, Thomas R. Malek, Robert B. Levy, Eckhard R. Podack

J Clin Invest. 2010 Oct 1; 120(10): 3629–3640. Published online 2010 Sep 20. doi: 10.1172/JCI42933

PMCID:: PMC2947231

Article PDF–1.9M

Select item 269327915.

Lack of nuclear translocation of cytoplasmic domains of IL-2/IL-15 receptor subunits

Hodaka Fujii, Akemi Hoshino

Cytokine. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Cytokine. 2009 Jun; 46(3): 302–308. Published online 2009 Mar 28. doi: 10.1016/j.cyto.2009.02.014

PMCID:: PMC2693279

Article PDF–2.0M

Select item 221186916.

Essential Roles of CD8⁺CD122⁺ Regulatory T Cells in the Maintenance of T Cell Homeostasis

Muhaimin Rifa'i, Yoshiyuki Kawamoto, Izumi Nakashima, Haruhiko Suzuki

J Exp Med. 2004 Nov 1; 200(9): 1123–1134. doi: 10.1084/jem.20040395

PMCID:: PMC2211869

Article PDF–2.7M

Select item 32046417.

Organization and structure of the mouse interleukin-2 gene.

A Fuse, T Fujita, H Yasumitsu, N Kashima, K Hasegawa, T Taniguchi

Nucleic Acids Res. 1984 Dec 21; 12(24): 9323–9331. doi: 10.1093/nar/12.24.9323

PMCID:: PMC320464

Summary Page Browse PDF–867K

Select item 733490018.

The abundance and availability of cytokine receptor IL-2Rβ (CD122) constrain the lymphopenia-induced homeostatic proliferation of naïve CD4 T cells

Hilary R. Keller, Hye Kyung Kim, Yuna Jo, Ronald E. Gress, Changwan Hong, Jung-Hyun Park

J Immunol. Author manuscript; available in PMC 2021 Jun 15.

Published in final edited form as: J Immunol. 2020 Jun 15; 204(12): 3227–3235. Published online 2020 May 11. doi: 10.4049/jimmunol.1901276

PMCID:: PMC7334900

Article PDF–1.7M

Select item 590384819.

Altered homeostasis and development of regulatory T cell subsets represents an IL-2R–dependent risk for diabetes in NOD mice

Connor J. Dwyer, Allison L. Bayer, Carmen Fotino, Liping Yu, Cecilia Cabello-Kindelan, Natasha C. Ward, Kevin H. Toomer, Zhibin Chen, Thomas R. Malek

Sci Signal. Author manuscript; available in PMC 2018 Dec 19.

Published in final edited form as: Sci Signal. 2017 Dec 19; 10(510): eaam9563. Published online 2017 Dec 19. doi: 10.1126/scisignal.aam9563

PMCID:: PMC5903848

Article PDF–1.6M

Select item 549795420.

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Deborah Charych, Samira Khalili, Vidula Dixit, Peter Kirk, Thomas Chang, John Langowski, Werner Rubas, Stephen K. Doberstein, Michael Eldon, Ute Hoch, Jonathan Zalevsky

PLoS One. 2017; 12(7): e0179431. Published online 2017 Jul 5. doi: 10.1371/journal.pone.0179431