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Select item 107261351.

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek

Front Endocrinol (Lausanne) 2023; 14: 1266527. Published online 2023 Dec 4. doi: 10.3389/fendo.2023.1266527

PMCID:: PMC10726135

Article PDF–7.0M

Select item 101820802.

Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice

Swati Ghosh, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol

Sci Rep. 2023; 13: 7752. Published online 2023 May 12. doi: 10.1038/s41598-023-33994-3

Correction in:: Sci Rep. 2023; 13: 11673.

PMCID:: PMC10182080

Article PDF–6.6M

Select item 94264903.

Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

Sage E. Foley, Michael J. Dente, Xuqiu Lei, Benjamin F. Sallis, Ethan B. Loew, Mario Meza-Segura, Katherine A. Fitzgerald, Beth A. McCormick

mBio. 2022 Jul-Aug; 13(4): e01993-22. Published online 2022 Aug 15. doi: 10.1128/mbio.01993-22

PMCID:: PMC9426490

Article PDF–2.3M

Select item 88272174.

Conjunction of G-quadruplex and Stem-Loop in the 5` Untranslated Region of Mouse Hepatocyte Nuclear Factor 4-alpha1 Mediates Strong Inhibition of Protein Expression

Shangdong Guo, Hong Lu

Mol Cell Biochem. Author manuscript; available in PMC 2022 Feb 9.

Published in final edited form as: Mol Cell Biochem. 2018 Sep; 446(1-2): 73–81. Published online 2018 Jan 13. doi: 10.1007/s11010-018-3274-3

PMCID:: PMC8827217

Article PDF–1.1M

Select item 87527705.

The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage

Romain Girard, Sarah Tremblay, Christophe Noll, Stéphanie St-Jean, Christine Jones, Yves Gélinas, Faïza Maloum-Rami, Nathalie Perreault, Mathieu Laplante, André C. Carpentier, François Boudreau

Nat Commun. 2022; 13: 224. Published online 2022 Jan 11. doi: 10.1038/s41467-021-27934-w

PMCID:: PMC8752770

Article PDF–6.1M

Select item 82016586.

Hepatocyte-Specific Hepatocyte Nuclear Factor 4 Alpha (HNF4α) Deletion Decreases Resting Energy Expenditure by Disrupting Lipid and Carbohydrate Homeostasis

Ian Huck, E. Matthew Morris, John Thyfault, Udayan Apte

Gene Expr. 2021; 20(3): 157–168. Published online 2021 Jun 11. doi: 10.3727/105221621X16153933463538

PMCID:: PMC8201658

Article PDF–15M

Select item 76089767.

Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney

Sierra S. Marable, Eunah Chung, Joo-Seop Park

J Am Soc Nephrol. 2020 Nov; 31(11): 2543–2558. Published online 2020 Aug 6. doi: 10.1681/ASN.2020020184

PMCID:: PMC7608976

Article

Select item 73012008.

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration

Paula S. Montenegro-Miranda, Jonathan H.M. van der Meer, Christine Jones, Sander Meisner, Jacqueline L.M. Vermeulen, Jan Koster, Manon E. Wildenberg, Jarom Heijmans, Francois Boudreau, Agnes Ribeiro, Gijs R. van den Brink, Vanesa Muncan

Cell Mol Gastroenterol Hepatol. 2020; 10(2): 209–223. Published online 2020 Mar 5. doi: 10.1016/j.jcmgh.2020.02.007

PMCID:: PMC7301200

Article PDF–4.8M

Select item 68815539.

HNF4α-deficient Fatty Liver Provides a Permissive Environment for Sex-independent Hepatocellular Carcinoma

Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Alaa M.T. Mohamed, Mikhail G. Kolonin, Frances M. Sladek, Mamoun Younes, Kristin Eckel-Mahan

Cancer Res. Author manuscript; available in PMC 2020 May 15.

Published in final edited form as: Cancer Res. 2019 Nov 15; 79(22): 5860–5873. Published online 2019 Oct 1. doi: 10.1158/0008-5472.CAN-19-1277

PMCID:: PMC6881553

Article PDF–1.1M

Select item 619011710.

HNF4α Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice

Yifeng Wang, David Matye, Nga Nguyen, Yuxia Zhang, Tiangang Li

Gene Expr. 2018; 18(3): 187–196. Published online 2018 Aug 22. doi: 10.3727/105221618X15277685544442

PMCID:: PMC6190117

Article PDF–2.0M

Select item 522493111.

Physiological Ranges of Matrix Rigidity Modulate Primary Mouse Hepatocyte Function In Part Through Hepatocyte Nuclear Factor 4 Alpha

Seema S. Desai, Jason C. Tung, Vivian X. Zhou, James P. Grenert, Yann Malato, Milad Rezvani, Regina Español-Suñer, Holger Willenbring, Valerie M. Weaver, Tammy T. Chang

Hepatology. Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: Hepatology. 2016 Jul; 64(1): 261–275. Published online 2016 Mar 9. doi: 10.1002/hep.28450

PMCID:: PMC5224931

Article PDF–2.1M

Select item 500729212.

Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium

Benjamin D. Moore, Shradha S. Khurana, Won Jae Huh, Jason C. Mills

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1; 311(2): G267–G275. Published online 2016 Jun 23. doi: 10.1152/ajpgi.00195.2016

PMCID:: PMC5007292

Article

Select item 436155213.

Hepatocyte Nuclear Factor 4 Alpha Is a Key Factor Related to Depression and Physiological Homeostasis in the Mouse Brain

Kyosuke Yamanishi, Nobutaka Doe, Miho Sumida, Yuko Watanabe, Momoko Yoshida, Hideyuki Yamamoto, Yunfeng Xu, Wen Li, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga

PLoS One. 2015; 10(3): e0119021. Published online 2015 Mar 16. doi: 10.1371/journal.pone.0119021

PMCID:: PMC4361552

Article PDF–1.8M

Select item 413555714.

Chromatin Profiling Reveals Regulatory Network Shifts and a Protective Role for Hepatocyte Nuclear Factor 4α during Colitis

Sanjay Chahar, Vishal Gandhi, Shiyan Yu, Kinjal Desai, Richard Cowper-Sal·lari, Yona Kim, Ansu O. Perekatt, Namit Kumar, Joshua K. Thackray, Anthony Musolf, Nikhil Kumar, A. Hoffman, Douglas Londono, Berta N. Vazquez, Lourdes Serrano, Hyunjin Shin, Mathieu Lupien, Nan Gao, Michael P. Verzi

Mol Cell Biol. 2014 Sep; 34(17): 3291–3304. doi: 10.1128/MCB.00349-14

PMCID:: PMC4135557

Article PDF–3.5M

Select item 366964615.

Hepatocyte Nuclear Factor 4 alpha Deletion Promotes Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice

Chad Walesky, Genea Edwards, Prachi Borude, Sumedha Gunewardena, Maura O’Neil, Byunggil Yoo, Udayan Apte

Hepatology. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Hepatology. 2013 Jun; 57(6): 2480–2490. doi: 10.1002/hep.26251

PMCID:: PMC3669646

Article PDF–3.9M

Select item 354363416.

Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

Chad Walesky, Sumedha Gunewardena, Ernest F. Terwilliger, Genea Edwards, Prachi Borude, Udayan Apte

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1; 304(1): G26–G37. Published online 2012 Oct 25. doi: 10.1152/ajpgi.00064.2012

PMCID:: PMC3543634

Article

Select item 283607717.

Hepatocyte Nuclear Factor-4α Induces Transdifferentiation of Hematopoietic Cells into Hepatocytes

Satish Khurana, Amit K. Jaiswal, Asok Mukhopadhyay

J Biol Chem. 2010 Feb 12; 285(7): 4725–4731. Published online 2009 Dec 16. doi: 10.1074/jbc.M109.058198

PMCID:: PMC2836077

Article PDF–1.3M

Select item 267456818.

Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α

Lie Li, Claudia E. Oropeza, Bruno Sainz, Jr., Susan L. Uprichard, Frank J. Gonzalez, Alan McLachlan

PLoS One. 2009; 4(5): e5489. Published online 2009 May 8. doi: 10.1371/journal.pone.0005489

PMCID:: PMC2674568

Article PDF–553K

Select item 183852819.

Expansion of adult β-cell mass in response to increased metabolic demand is dependent on HNF-4α

Rana K. Gupta, Nan Gao, Regina K. Gorski, Peter White, Olga T. Hardy, Kiran Rafiq, John E. Brestelli, Guang Chen, Christian J. Stoeckert, Jr., Klaus H. Kaestner

Genes Dev. 2007 Apr 1; 21(7): 756–769. doi: 10.1101/gad.1535507

PMCID:: PMC1838528

Article PDF–688K

Select item 141357620.

Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α

Yusuke Inoue, Ai-Ming Yu, Sun Hee Yim, Xiaochao Ma, Kristopher W. Krausz, Junko Inoue, Charlie C. Xiang, Michael J. Brownstein, Gösta Eggertsen, Ingemar Björkhem, Frank J. Gonzalez

J Lipid Res. Author manuscript; available in PMC 2006 Mar 27.

Published in final edited form as: J Lipid Res. 2006 Jan; 47(1): 215–227. Published online 2005 Nov 1. doi: 10.1194/jlr.M500430-JLR200