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Items: 1 to 20 of 62

1.
Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase
Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton, Alexandria M. Doerfler, Ayrea Hurley, Ang Li, Rachel H. Hsu, Mia Furgurson, Kalyani R. Patel, Jun Han, Christoph H. Borchers, William R. Lagor
J Lipid Res. 2020 Dec; 61(12): 1675–1686. Published online 2020 Oct 27. doi: 10.1194/jlr.RA120001006
PMCID:
PMC7707164
AbstractArticlePDF–2.1M
2.
Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver
Seonghwan Hwang, Isamu Z. Hartman, Leona N. Calhoun, Kristina Garland, Gennipher A. Young, Matthew A. Mitsche, Jeffrey McDonald, Fang Xu, Luke Engelking, Russell A. DeBose-Boyd
J Biol Chem. 2016 Jun 24; 291(26): 13479–13494. Published online 2016 Apr 29. doi: 10.1074/jbc.M116.728469
PMCID:
PMC4919435
AbstractArticlePDF–1.3M
3.
Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation
Nikolaos Manitsopoulos, Stylianos E Orfanos, Anastasia Kotanidou, Ioanna Nikitopoulou, Ilias Siempos, Christina Magkou, Ioanna Dimopoulou, Spyros G Zakynthinos, Apostolos Armaganidis, Nikolaos A Maniatis
Respir Res. 2015; 16(1): 24. Published online 2015 Feb 14. doi: 10.1186/s12931-015-0173-y
PMCID:
PMC4336762
AbstractArticlePDF–1.1M
4.
Functional Promoter Polymorphisms Govern Differential Expression of HMG-CoA Reductase Gene in Mouse Models of Essential Hypertension
Parshuram J. Sonawane, Bhavani S. Sahu, Binu K. Sasi, Parimala Geedi, Govinda Lenka, Nitish R. Mahapatra
PLoS One. 2011; 6(1): e16661. Published online 2011 Jan 31. doi: 10.1371/journal.pone.0016661
PMCID:
PMC3031630
AbstractArticlePDF–934K
5.
Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone
Yuval Yogev, Zamir Shorer, Arie Koifman, Ohad Wormser, Max Drabkin, Daniel Halperin, Vadim Dolgin, Regina Proskorovski-Ohayon, Noam Hadar, Geula Davidov, Hila Nudelman, Raz Zarivach, Ilan Shelef, Yonatan Perez, Ohad S. Birk
Proc Natl Acad Sci U S A. 2023 Feb 14; 120(7): e2217831120. Published online 2023 Feb 6. doi: 10.1073/pnas.2217831120
PMCID:
PMC9963716
AbstractArticlePDF–2.9M
6.
Intestinal deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase promotes expansion of the resident stem cell compartment
Alexandria M. Doerfler, Jun Han, Kelsey E. Jarrett, Li Tang, Antrix Jain, Alexander Saltzman, Marco De Giorgi, Marcel Chuecos, Ayrea E. Hurley, Ang Li, Pauline Morand, Claudia Ayala, David R. Goodlett, Anna Malovannaya, James F. Martin, Thomas Q. de Aguiar Vallim, Noah Shroyer, William R. Lagor
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Apr 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Apr; 42(4): 381–394. Published online 2022 Feb 17. doi: 10.1161/ATVBAHA.122.317320
PMCID:
PMC8957608
AbstractArticlePDF–2.2M
7.
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver
Shanshan Zhong, Luxiao Li, Ningning Liang, Lili Zhang, Xiaodong Xu, Shiting Chen, Huiyong Yin
Redox Biol. 2021 May; 41: 101919. Published online 2021 Mar 10. doi: 10.1016/j.redox.2021.101919
PMCID:
PMC7995661
AbstractArticlePDF–9.8M
8.
Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice
Youngah Jo, Jason S Hamilton, Seonghwan Hwang, Kristina Garland, Gennipher A Smith, Shan Su, Iris Fuentes, Sudha Neelam, Bonne M Thompson, Jeffrey G McDonald, Russell A DeBose-Boyd
eLife. 2019; 8: e44396. Published online 2019 Feb 20. doi: 10.7554/eLife.44396
PMCID:
PMC6402834
AbstractArticlePDF–3.3M
9.
Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-equation M1 in primary macrophages requires endogenous 25-hydroxycholesterol synthesis
Hongjin Lu, Simon Talbot, Kevin A. Robertson, Steven Watterson, Thorsten Forster, Douglas Roy, Peter Ghazal
Steroids. 2015 Jul; 99: 219–229. doi: 10.1016/j.steroids.2015.02.022
PMCID:
PMC4503878
AbstractArticle
10.
Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver
Xiujuan Zhang, Yongfeng Song, Mei Feng, Xinli Zhou, Yingli Lu, Ling Gao, Chunxiao Yu, Xiuyun Jiang, Jiajun Zhao
J Lipid Res. 2015 May; 56(5): 963–971. doi: 10.1194/jlr.M047654
PMCID:
PMC4409286
AbstractArticlePDF–924K
11.
Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression
Zhekang Ying, Rajagopal Desikan, Xiaohua Xu, Andrei Maiseyeu, Cuiqing Liu, Qinghua Sun, Ouiliana Ziouzenkova, Sampath Parthasarathy, Sanjay Rajagopalan
J Lipid Res. 2012 May; 53(5): 879–887. doi: 10.1194/jlr.M022806
PMCID:
PMC3329387
AbstractArticlePDF–1.1M
12.
Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses
Dana Schiefelbein, Itamar Goren, Beate Fisslthaler, Helmut Schmidt, Gerd Geisslinger, Josef Pfeilschifter, Stefan Frank
J Biol Chem. 2008 May 30; 283(22): 15479–15490. doi: 10.1074/jbc.M709841200
PMCID:
PMC3258881
AbstractArticlePDF–1.0M
13.
Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse
Jiaxi Ding, DeChen Jiang, Michael Kurczy, Jennifer Nalepka, Brian Dudley, Erin I Merkel, Forbes D Porter, Andrew G Ewing, Nicholas Winograd, James Burgess, Kathleen Molyneaux
BMC Dev Biol. 2008; 8: 120. Published online 2008 Dec 31. doi: 10.1186/1471-213X-8-120
PMCID:
PMC2631600
AbstractArticlePDF–1.7M
14.
Renal Ischemia-Induced Cholesterol Loading : Transcription Factor Recruitment and Chromatin Remodeling along the HMG CoA Reductase Gene
Masayo Naito, Karol Bomsztyk, Richard A. Zager
Am J Pathol. 2009 Jan; 174(1): 54–62. doi: 10.2353/ajpath.2009.080602
PMCID:
PMC2631318
AbstractArticlePDF–1.5M
15.
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system
Yien Che Tsai, Gil S. Leichner, Margaret M. P. Pearce, Gaye Lynn Wilson, Richard J. H. Wojcikiewicz, Joseph Roitelman, Allan M. Weissman
Mol Biol Cell. 2012 Dec 1; 23(23): 4484–4494. doi: 10.1091/mbc.E12-08-0631
PMCID:
PMC3510011
AbstractArticlePDF–1.5M
16.
NRIF is a Regulator of Neuronal Cholesterol Biosynthesis Genes
Zeljka Korade, Rajappa S. Kenchappa, Karoly Mirnics, Bruce D. Carter
J Mol Neurosci. Author manuscript; available in PMC 2011 Jun 20.
Published in final edited form as: J Mol Neurosci. 2009 Jun; 38(2): 152–158. Published online 2008 Aug 2. doi: 10.1007/s12031-008-9136-9
PMCID:
PMC3118441
AbstractArticlePDF–914K
17.
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival
Sonja M Lacher, Julia Bruttger, Bettina Kalt, Jean Berthelet, Krishnaraj Rajalingam, Simone Wörtge, Ari Waisman
Cell Death Dis. 2017 May; 8(5): e2824. Published online 2017 May 25. doi: 10.1038/cddis.2017.221
PMCID:
PMC5520735
AbstractArticlePDF–2.0M
18.
A suppressor screen in mouse Mecp2 implicates cholesterol metabolism in Rett Syndrome
Christie M. Buchovecky, Stephen D. Turley, Hannah M. Brown, Stephanie M. Kyle, Jeffrey G. McDonald, Benny Liu, Andrew A. Pieper, Wenhui Huang, David M. Katz, David W. Russell, Jay Shendure, Monica J. Justice
Nat Genet. Author manuscript; available in PMC 2014 Mar 1.
Published in final edited form as: Nat Genet. 2013 Sep; 45(9): 1013–1020. Published online 2013 Jul 28. doi: 10.1038/ng.2714
PMCID:
PMC3837522
AbstractArticlePDF–1.4M
19.
PEG3 controls lipogenesis through ACLY
Subash Ghimire, Joomyeong Kim
PLoS One. 2021; 16(5): e0252354. Published online 2021 May 28. doi: 10.1371/journal.pone.0252354
PMCID:
PMC8162686
AbstractArticlePDF–2.3M
20.
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
Peer W F Karmaus, Xiang Chen, Seon Ah Lim, Andrés A Herrada, Thanh-Long M Nguyen, Beisi Xu, Yogesh Dhungana, Sherri Rankin, Wenan Chen, Celeste Rosencrance, Kai Yang, Yiping Fan, Yong Cheng, John Easton, Geoffrey Neale, Peter Vogel, Hongbo Chi
Nature. Author manuscript; available in PMC 2019 Jun 19.
Published in final edited form as: Nature. 2019 Jan; 565(7737): 101–105. Published online 2018 Dec 19. doi: 10.1038/s41586-018-0806-7
PMCID:
PMC6420879
AbstractArticlePDF–2.7M

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