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Select item 86743711.

pH and proton sensor GPR65 determine susceptibility to atopic dermatitis

Liang Xie, Craig I. Mckenzie, Xinyan Qu, Yan Mu, Quanbo Wang, Nan Bing, Karmella Naidoo, Md Jahangir Alam, Di Yu, Fang Gong, Caroline Ang, Remy Robert, Francine Z. Marques, Nicholas Furlotte, David Hinds, Olivier Gasser, 23andMe Research Team, Ramnik J. Xavier, Charles R. Mackay

J Immunol. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: J Immunol. 2021 Jul 1; 207(1): 101–109. Published online 2021 Jun 16. doi: 10.4049/jimmunol.2001363

PMCID:: PMC8674371

Article PDF–1.9M

Select item 86299322.

GPR65 (TDAG8) inhibits intestinal inflammation and colitis-associated colorectal cancer development in experimental mouse models

Mona A. Marie, Edward J. Sanderlin, Swati Satturwar, Heng Hong, Kvin Lertpiriyapong, Deepak Donthi, Li V. Yang

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2022 Jan 1; 1868(1): 166288. Published online 2021 Oct 8. doi: 10.1016/j.bbadis.2021.166288

PMCID:: PMC8629932

Article PDF–4.1M

Select item 72572433.

TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain

Shih-Ping Dai, Wei-Shan Hsieh, Chien-Hua Chen, Yueh-Hao Lu, Hsu-Shan Huang, Der-Ming Chang, Shir-Ly Huang, Wei-Hsin Sun

J Neuroinflammation. 2020; 17: 170. Published online 2020 May 29. doi: 10.1186/s12974-020-01851-z

PMCID:: PMC7257243

Article PDF–11M

Select item 52864364.

TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice

Shih-Ping Dai, Ya-Han Huang, Chung-Jen Chang, Yu-Fen Huang, Wei-Shan Hsieh, Yasuhiko Tabata, Satoshii Ishii, Wei-Hsin Sun

Sci Rep. 2017; 7: 41415. Published online 2017 Feb 1. doi: 10.1038/srep41415

PMCID:: PMC5286436

Article PDF–2.1M

Select item 50145995.

Microglial Acid Sensing Regulates Carbon Dioxide Evoked Fear

Lauren Larke Vollmer, Sriparna Ghosal, Jennifer L. McGuire, Rebecca L. Ahlbrand, Ke-Yong Li, Joseph M. Santin, Christine A. Ratliff-Rang, Luis G. A. Patrone, Jennifer Rush, Ian P. Lewkowich, James P Herman, Robert W. Putnam, Renu Sah

Biol Psychiatry. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Biol Psychiatry. 2016 Oct 1; 80(7): 541–551. Published online 2016 May 12. doi: 10.1016/j.biopsych.2016.04.022

PMCID:: PMC5014599

Article PDF–1.3M

Select item 48291066.

Neutralization of tumor acidity improves anti-tumor responses to immunotherapies

Shari Pilon-Thomas, Krithika Kodumudi, Asmaa El-Kenawi, Shonagh Russell, Amy Weber, Kim Luddy, Mehdi Damaghi, Jon Wojtkowiak, James Mulé, Arig Ibrahim-Hashim, Robert J. Gillies

Cancer Res. Author manuscript; available in PMC 2017 Mar 15.

Published in final edited form as: Cancer Res. 2016 Mar 15; 76(6): 1381–1390. Published online 2015 Dec 30. doi: 10.1158/0008-5472.CAN-15-1743

Correction in:: Cancer Res. 2017 May 1; 77(9): 2552.

PMCID:: PMC4829106

Article PDF–505K

Select item 46910927.

Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury

Hiroaki Tsurumaki, Chihiro Mogi, Haruka Aoki-Saito, Masayuki Tobo, Yosuke Kamide, Masakiyo Yatomi, Koichi Sato, Kunio Dobashi, Tamotsu Ishizuka, Takeshi Hisada, Masanobu Yamada, Fumikazu Okajima

Int J Mol Sci. 2015 Dec; 16(12): 28931–28942. Published online 2015 Dec 4. doi: 10.3390/ijms161226145

PMCID:: PMC4691092

Article PDF–2.0M

Select item 45468998.

A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior

Lauren Larke Vollmer, Sarah N. Schmeltzer, Rebecca Ahlbrand, Renu Sah

Physiol Behav. Author manuscript; available in PMC 2016 Oct 15.

Published in final edited form as: Physiol Behav. 2015 Oct 15; 150: 78–82. Published online 2015 Mar 11. doi: 10.1016/j.physbeh.2015.03.012

PMCID:: PMC4546899

Article PDF–403K

Select item 40421149.

Differential eosinophil and mast cell regulation: Mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65

Xiang Zhu, Eucabeth Mose, Simon P. Hogan, Nives Zimmermann

Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1; 306(11): G974–G982. Published online 2014 Apr 17. doi: 10.1152/ajpgi.00341.2013

PMCID:: PMC4042114

Article

Select item 275613210.

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner

Leah C. Kottyan, Ann R. Collier, Khanh H. Cao, Kathryn A. Niese, Megan Hedgebeth, Caius G. Radu, Owen N. Witte, Gurjit K. Khurana Hershey, Marc E. Rothenberg, Nives Zimmermann

Blood. 2009 Sep 24; 114(13): 2774–2782. Prepublished online 2009 Jul 29. doi: 10.1182/blood-2009-05-220681

PMCID:: PMC2756132

Article

Select item 134691211.

Normal Immune Development and Glucocorticoid-Induced Thymocyte Apoptosis in Mice Deficient for the T-Cell Death-Associated Gene 8 Receptor

Caius G. Radu, Donghui Cheng, Amar Nijagal, Mireille Riedinger, Jami McLaughlin, Li V. Yang, James Johnson, Owen N. Witte

Mol Cell Biol. 2006 Jan; 26(2): 668–677. doi: 10.1128/MCB.26.2.668-677.2006

PMCID:: PMC1346912

Article PDF–1.1M

Select item 1067591812.

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

Kun Zhang, Meng-Xia Zhang, Xiao-Xiang Meng, Jing Zhu, Jia-Jun Wang, Yi-Fan He, Ye-Hua Li, Si-Cong Zhao, Zhe-Min Shi, Li-Na Zheng, Tao Han, Wei Hong

Mil Med Res. 2023; 10: 56. Published online 2023 Nov 25. doi: 10.1186/s40779-023-00494-4

PMCID:: PMC10675918

Article PDF–21M

Select item 1052477913.

Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease

Gengfeng Li, Jian Lin, Xiang Gao, Huiling Su, Ritian Lin, Han Gao, Zhongsheng Feng, Huili Wu, Baisui Feng, Keqiang Zuo, Yingchuan Li, Wei Wu, Leilei Fang, Zhanju Liu

Gut Microbes. 2023; 15(2): 2257269. Published online 2023 Sep 25. doi: 10.1080/19490976.2023.2257269

PMCID:: PMC10524779

Article PDF–10M

Select item 972067514.

pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells

Xiangjun Chen, Alok Jaiswal, Zachary Costliow, Paula Herbst, Elizabeth A. Creasey, Noriko Oshiro-Rapley, Mark J. Daly, Kimberly L. Carey, Daniel B. Graham, Ramnik J. Xavier

Nat Immunol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Nat Immunol. 2022 Jul; 23(7): 1063–1075. Published online 2022 Jun 6. doi: 10.1038/s41590-022-01231-0

PMCID:: PMC9720675

Article PDF–8.8M

Select item 555270315.

The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction

Akiomi Nagasaka, Chihiro Mogi, Hiroki Ono, Toshihide Nishi, Yuma Horii, Yuki Ohba, Koichi Sato, Michio Nakaya, Fumikazu Okajima, Hitoshi Kurose

Sci Rep. 2017; 7: 7812. Published online 2017 Aug 10. doi: 10.1038/s41598-017-07573-2

PMCID:: PMC5552703

Article PDF–5.5M

Select item 493641516.

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Kara G. Lassen, Craig I. McKenzie, Muriel Mari, Tatsuro Murano, Jakob Begun, Leigh A. Baxt, Gautam Goel, Eduardo J. Villablanca, Szu-Yu Kuo, Hailiang Huang, Laurence Macia, Atul K. Bhan, Marcel Batten, Mark J. Daly, Fulvio Reggiori, Charles R. Mackay, Ramnik J. Xavier

Immunity. Author manuscript; available in PMC 2017 Jun 21.

Published in final edited form as: Immunity. 2016 Jun 21; 44(6): 1392–1405. Published online 2016 Jun 7. doi: 10.1016/j.immuni.2016.05.007

PMCID:: PMC4936415

Article PDF–1.1M

Select item 343163717.

Acidosis Promotes Bcl-2 Family-mediated Evasion of Apoptosis: INVOLVEMENT OF ACID-SENSING G PROTEIN-COUPLED RECEPTOR GPR65 SIGNALING TO MEK/ERK

Christopher Ryder, Karen McColl, Fei Zhong, Clark W. Distelhorst

J Biol Chem. 2012 Aug 10; 287(33): 27863–27875. Published online 2012 Jun 8. doi: 10.1074/jbc.M112.384685

PMCID:: PMC3431637

Article PDF–813K

Select item 295143318.

The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor

Yuichiro Ihara, Yasuyuki Kihara, Fumie Hamano, Keisuke Yanagida, Yasuyuki Morishita, Akiko Kunita, Takao Yamori, Masashi Fukayama, Hiroyuki Aburatani, Takao Shimizu, Satoshi Ishii

Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40): 17309–17314. Published online 2010 Sep 20. doi: 10.1073/pnas.1001165107

PMCID:: PMC2951433

Article PDF–1012K

Select item 1096280519.

The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis

Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska

PLoS One. 2024; 19(3): e0283060. Published online 2024 Mar 25. doi: 10.1371/journal.pone.0283060