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Select item 83165521.

Gαq activation modulates autophagy by promoting mTORC1 signaling

Sofía Cabezudo, Maria Sanz-Flores, Alvaro Caballero, Inmaculada Tasset, Elena Rebollo, Antonio Diaz, Anna M. Aragay, Ana María Cuervo, Federico Mayor, Jr, Catalina Ribas

Nat Commun. 2021; 12: 4540. Published online 2021 Jul 27. doi: 10.1038/s41467-021-24811-4

PMCID:: PMC8316552

Article PDF–3.3M

Select item 67722692.

Calcium-Dependent Persistent Facilitation of Spike Backpropagation in the CA1 Pyramidal Neurons

Hiroshi Tsubokawa, Stefan Offermanns, Melvin Simon, Masanobu Kano

J Neurosci. 2000 Jul 1; 20(13): 4878–4884. doi: 10.1523/JNEUROSCI.20-13-04878.2000

PMCID:: PMC6772269

Article PDF–140K

Select item 67468193.

Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma

Zhaoming Li, Xudong Zhang, Weili Xue, Yanjie Zhang, Chaoping Li, Yue Song, Mei Mei, Lisha Lu, Yingjun Wang, Zhiyuan Zhou, Mengyuan Jin, Yangyang Bian, Lei Zhang, Xinhua Wang, Ling Li, Xin Li, Xiaorui Fu, Zhenchang Sun, Jingjing Wu, Feifei Nan, Yu Chang, Jiaqin Yan, Hui Yu, Xiaoyan Feng, Guannan Wang, Dandan Zhang, Xuefei Fu, Yuan Zhang, Ken H. Young, Wencai Li, Mingzhi Zhang

Nat Commun. 2019; 10: 4209. Published online 2019 Sep 16. doi: 10.1038/s41467-019-12032-9

PMCID:: PMC6746819

Article PDF–2.4M

Select item 55188184.

Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation

Weiming Lai, Yingying Cai, Jinfeng Zhou, Shuai Chen, Chaoyan Qin, Cuixia Yang, Junling Liu, Xin Xie, Changsheng Du

Cell Mol Immunol. 2017 Jun; 14(6): 557–567. Published online 2017 Feb 20. doi: 10.1038/cmi.2016.65

PMCID:: PMC5518818

Article PDF–7.8M

Select item 52072585.

Potent and Selective Peptide-based Inhibition of the G Protein Gα_q

Thomas H. Charpentier, Gary L. Waldo, Emily G. Lowery-Gionta, Krzysztof Krajewski, Brian D. Strahl, Thomas L. Kash, T. Kendall Harden, John Sondek

J Biol Chem. 2016 Dec 2; 291(49): 25608–25616. Published online 2016 Oct 14. doi: 10.1074/jbc.M116.740407

PMCID:: PMC5207258

Article PDF–2.2M

Select item 48726396.

G_q-dependent signalling by the lysophosphatidic acid receptor LPA₃ in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA

Wimolpak Sriwai, Huiping Zhou, Karnam S. Murthy

Biochem J. Author manuscript; available in PMC 2016 May 19.

Published in final edited form as: Biochem J. 2008 May 1; 411(3): 543–551. doi: 10.1042/bj20071299

PMCID:: PMC4872639

Article PDF–2.2M

Select item 36389967.

Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gα_q Complex

Mark R. Nance, Barry Kreutz, Valerie M. Tesmer, Rachel Sterne-Marr, Tohru Kozasa, John J.G. Tesmer

Structure. Author manuscript; available in PMC 2014 Mar 5.

Published in final edited form as: Structure. 2013 Mar 5; 21(3): 438–448. Published online 2013 Feb 21. doi: 10.1016/j.str.2012.12.016

PMCID:: PMC3638996

Article PDF–2.9M

Select item 33779788.

Neurobehavioral phenotyping of G_αq knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair

Aliya L. Frederick, Tommy P. Saborido, Gregg D. Stanwood

Front Behav Neurosci. 2012; 6: 29. Published online 2012 Jun 19. doi: 10.3389/fnbeh.2012.00029

PMCID:: PMC3377978

Article PDF–1.9M

Select item 29161369.

G_αq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity

Ravi S. Misra, Guixiu Shi, Miguel E. Moreno-Garcia, Anil Thankappan, Michael Tighe, Betty Mousseau, Kim Kusser, Shirly Becker-Herman, Kelly L. Hudkins, Robert Dunn, Marilyn R. Kehry, Thi-Sau Migone, Ann Marshak-Rothstein, Melvin Simon, Troy D. Randall, Charles E. Alpers, Denny Liggitt, David J. Rawlings, Frances E. Lund

J Exp Med. 2010 Aug 2; 207(8): 1775–1789. doi: 10.1084/jem.20092735

PMCID:: PMC2916136

Article PDF–5.6M

Select item 290934710.

Oxidative Post-Translational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in Gαq-Overexpressing Mice

Steve Lancel, Fuzhong Qin, Shannon L. Lennon, Jingmei Zhang, XiaoYong Tong, Michael J. Mazzini, Y. James Kang, Deborah A Siwik, Richard A. Cohen, Wilson S. Colucci

Circ Res. Author manuscript; available in PMC 2011 Jul 23.

Published in final edited form as: Circ Res. 2010 Jul 23; 107(2): 228–232. Published online 2010 May 27. doi: 10.1161/CIRCRESAHA.110.217570

PMCID:: PMC2909347

Article PDF–1.2M

Select item 217281011.

Repression of slow myosin heavy chain 2 gene expression in fast skeletal muscle fibers by muscarinic acetylcholine receptor and Gαq signaling

Theresa Jordan, Jinyuan Li, Hongbin Jiang, Joseph X. DiMario

J Cell Biol. 2003 Sep 1; 162(5): 843–850. doi: 10.1083/jcb.200303164

PMCID:: PMC2172810

Article PDF–281K

Select item 198771012.

Role of G_q protein in behavioral effects of the hallucinogenic drug 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane

Efrain E. Garcia, Randy L. Smith, Elaine Sanders-Bush

Neuropharmacology. Author manuscript; available in PMC 2008 Jun 1.

Published in final edited form as: Neuropharmacology. 2007 Jun; 52(8): 1671–1677. Published online 2007 Apr 4. doi: 10.1016/j.neuropharm.2007.03.013

PMCID:: PMC1987710

Article PDF–989K

Select item 2156713.

Transgenic Gαq overexpression induces cardiac contractile failure in mice

Drew D. D’Angelo, Yoshihito Sakata, John N. Lorenz, Gregory P. Boivin, Richard A. Walsh, Stephen B. Liggett, Gerald W. Dorn, II

Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15): 8121–8126. doi: 10.1073/pnas.94.15.8121

PMCID:: PMC21567

Article PDF–407K

Select item 1025966114.

Stretch regulates alveologenesis and homeostasis via mesenchymal G_αq/11-mediated TGFβ2 activation

Amanda T. Goodwin, Alison E. John, Chitra Joseph, Anthony Habgood, Amanda L. Tatler, Katalin Susztak, Matthew Palmer, Stefan Offermanns, Neil C. Henderson, R. Gisli Jenkins

Development. 2023 May 1; 150(9): dev201046. Published online 2023 May 12. doi: 10.1242/dev.201046

PMCID:: PMC10259661

Article

Select item 675849315.

Functional Specificity of Gα_q and Gα₁₁ in the Cholinergic and Glutamatergic Modulation of Potassium Currents and Excitability in Hippocampal Neurons

Michael Krause, Stefan Offermanns, Martin Stocker, Paola Pedarzani

J Neurosci. 2002 Feb 1; 22(3): 666–673. doi: 10.1523/JNEUROSCI.22-03-00666.2002

PMCID:: PMC6758493

Article PDF–308K

Select item 675780716.

Group I Metabotropic Glutamate Receptor Signaling via Gαq/Gα11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1

Masami Miura, Masahiko Watanabe, Stefan Offermanns, Melvin I. Simon, Masanobu Kano

J Neurosci. 2002 Oct 1; 22(19): 8379–8390. doi: 10.1523/JNEUROSCI.22-19-08379.2002

PMCID:: PMC6757807

Article PDF–393K

Select item 672919517.

Distinct Roles of Gα_q and Gα₁₁ for Purkinje Cell Signaling and Motor Behavior

J. Hartmann, R. Blum, Y. Kovalchuk, H. Adelsberger, R. Kuner, G. M. Durand, M. Miyata, M. Kano, S. Offermanns, A. Konnerth

J Neurosci. 2004 Jun 2; 24(22): 5119–5130. doi: 10.1523/JNEUROSCI.4193-03.2004

PMCID:: PMC6729195

Article PDF–710K

Select item 667358418.

Early Life Stress Alters Adult Serotonin 2C Receptor Pre-mRNA Editing and Expression of the α Subunit of the Heterotrimeric G-Protein Gq

Punita Bhansali, Jane Dunning, Sarah E. Singer, Leora David, Claudia Schmauss

J Neurosci. 2007 Feb 7; 27(6): 1467–1473. doi: 10.1523/JNEUROSCI.4632-06.2007

PMCID:: PMC6673584

Article PDF–357K

Select item 661001719.

Skeletal Muscle–Specific Activation of G_q Signaling Maintains Glucose Homeostasis

Derek B.J. Bone, Jaroslawna Meister, Jonas R. Knudsen, Diptadip Dattaroy, Amanda Cohen, Regina Lee, Huiyan Lu, Daniel Metzger, Thomas E. Jensen, Jürgen Wess

Diabetes. 2019 Jun; 68(6): 1341–1352. Published online 2019 Apr 1. doi: 10.2337/db18-0796